JP2002523500A5 - - Google Patents
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- Publication number
- JP2002523500A5 JP2002523500A5 JP2000567521A JP2000567521A JP2002523500A5 JP 2002523500 A5 JP2002523500 A5 JP 2002523500A5 JP 2000567521 A JP2000567521 A JP 2000567521A JP 2000567521 A JP2000567521 A JP 2000567521A JP 2002523500 A5 JP2002523500 A5 JP 2002523500A5
- Authority
- JP
- Japan
- Prior art keywords
- iron
- pharmaceutically acceptable
- alkyl
- salt
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/144,103 US6083966A (en) | 1998-08-31 | 1998-08-31 | Thiazoline acid derivatives |
| US09/144,103 | 1998-08-31 | ||
| PCT/US1999/019691 WO2000012493A1 (en) | 1998-08-31 | 1999-08-31 | Thiazoline acid derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011095879A Division JP5520875B2 (ja) | 1998-08-31 | 2011-04-22 | チアゾリン酸誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002523500A JP2002523500A (ja) | 2002-07-30 |
| JP2002523500A5 true JP2002523500A5 (https=) | 2011-07-21 |
| JP4817498B2 JP4817498B2 (ja) | 2011-11-16 |
Family
ID=22507049
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000567521A Expired - Fee Related JP4817498B2 (ja) | 1998-08-31 | 1999-08-31 | チアゾリン酸誘導体 |
| JP2011095879A Expired - Fee Related JP5520875B2 (ja) | 1998-08-31 | 2011-04-22 | チアゾリン酸誘導体 |
| JP2013257270A Pending JP2014065730A (ja) | 1998-08-31 | 2013-12-12 | チアゾリン酸誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011095879A Expired - Fee Related JP5520875B2 (ja) | 1998-08-31 | 2011-04-22 | チアゾリン酸誘導体 |
| JP2013257270A Pending JP2014065730A (ja) | 1998-08-31 | 2013-12-12 | チアゾリン酸誘導体 |
Country Status (23)
| Country | Link |
|---|---|
| US (9) | US6083966A (https=) |
| EP (1) | EP1109795B1 (https=) |
| JP (3) | JP4817498B2 (https=) |
| KR (1) | KR20010074907A (https=) |
| CN (1) | CN100455574C (https=) |
| AT (1) | ATE317392T1 (https=) |
| AU (1) | AU759851B2 (https=) |
| BR (1) | BR9913441B1 (https=) |
| CA (1) | CA2342210C (https=) |
| CZ (1) | CZ2001711A3 (https=) |
| DE (1) | DE69929807T2 (https=) |
| EA (1) | EA200100261A1 (https=) |
| ES (1) | ES2260933T3 (https=) |
| HU (1) | HUP0103165A3 (https=) |
| IL (2) | IL141611A0 (https=) |
| NO (1) | NO321028B1 (https=) |
| NZ (1) | NZ509899A (https=) |
| PL (1) | PL346852A1 (https=) |
| PT (1) | PT1109795E (https=) |
| TR (1) | TR200100541T2 (https=) |
| UA (1) | UA57161C2 (https=) |
| WO (1) | WO2000012493A1 (https=) |
| YU (1) | YU21801A (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083966A (en) * | 1998-08-31 | 2000-07-04 | University Of Florida | Thiazoline acid derivatives |
| EP1488791A3 (en) * | 1998-09-21 | 2005-04-06 | University Of Florida Research Foundation, Inc. | Antimalarial agents |
| CN1585639A (zh) * | 1998-09-21 | 2005-02-23 | 佛罗里达大学研究基金会 | 抗疟疾制剂 |
| US6806363B1 (en) * | 1999-04-16 | 2004-10-19 | Mayo Foundation For Medical Education & Research | Cobalamin conjugates useful as antitumor agents |
| WO2001028595A1 (en) | 1999-10-15 | 2001-04-26 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging and therapeutic agents |
| US6689788B1 (en) * | 2000-08-25 | 2004-02-10 | University Of Florida | Method and composition for treatment of inflammatory bowel disease |
| CA2427146A1 (en) * | 2000-10-25 | 2002-07-18 | Mayo Foundation For Medical Education And Research | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
| US7038073B2 (en) * | 2002-05-15 | 2006-05-02 | Genzyme Corporation | Synthesis of 2-alkyl amino acids |
| US20040044220A1 (en) * | 2002-08-22 | 2004-03-04 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
| US20040132789A1 (en) * | 2002-08-22 | 2004-07-08 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
| JPWO2004031163A1 (ja) * | 2002-10-01 | 2006-02-02 | 株式会社カネカ | 光学活性α−置換システインまたはその塩の製造方法並びにその合成中間体及びその製造方法 |
| US20040185028A1 (en) * | 2003-03-19 | 2004-09-23 | Zhenze Hu | Antimicrobial compositions containing ethanolamine buffer and biguanide disinfectant |
| WO2005034949A1 (en) * | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| JP2007505044A (ja) * | 2003-09-09 | 2007-03-08 | ユニバーシティ オブ フロリダ リサーチ ファウンデイション、インコーポレイテッド | ポリアミン−金属キレーター接合体 |
| WO2005055931A2 (en) * | 2003-12-03 | 2005-06-23 | University Of Medicine And Dentistry Of New Jersey | Method of preventing survival of retrovirally cells and of inhibiting formation of infectious retroviruses |
| WO2005075475A1 (ja) * | 2004-02-04 | 2005-08-18 | Shionogi & Co., Ltd. | Hivインテグラーゼ阻害活性を有するナフチリジン誘導体 |
| TR201910900T4 (tr) * | 2005-04-04 | 2019-08-21 | Univ Florida | Desferritiyokin polieter analogları. |
| US7365371B2 (en) | 2005-08-04 | 2008-04-29 | Cree, Inc. | Packages for semiconductor light emitting devices utilizing dispensed encapsulants |
| EP2101764A4 (en) * | 2006-12-12 | 2010-02-17 | Univ Florida | ACTINIDE DECORATION AGENT WITH DESFERRITHIOCIN ANALOGON |
| WO2008115433A1 (en) * | 2007-03-15 | 2008-09-25 | University Of Florida | Desferrithiocin polyether analogues |
| MY163516A (en) * | 2008-07-14 | 2017-09-15 | Ferrokin Biosciences Inc | Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
| EP2566854A4 (en) | 2010-05-04 | 2013-11-06 | Shire Llc | DESAZADESFERROTHIOCIN AND DEAZADESFERROTHIOCIN POLYETHER ANALOGS AS METAL CHELATORS |
| CN103562379A (zh) * | 2011-05-19 | 2014-02-05 | 国立大学法人德岛大学 | 细胞分化诱导剂以及分化诱导方法 |
| EP3620161A1 (en) | 2011-12-16 | 2020-03-11 | University of Florida Research Foundation, Inc. | Uses of 4'-desferrithiocin analogs |
| JP6353751B2 (ja) * | 2013-09-25 | 2018-07-04 | 国立大学法人電気通信大学 | 新規複素環式化合物及びその塩、並びに、発光基質組成物 |
| AU2014352780A1 (en) * | 2013-11-22 | 2016-06-09 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
| KR20170140306A (ko) | 2015-04-27 | 2017-12-20 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 대사적으로 프로그램화된 금속 킬레이트화제 및 그의 용도 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3274207A (en) | 1966-09-20 | Processes for preparing thiazole carboxylic acids | ||
| US3809754A (en) | 1968-12-31 | 1974-05-07 | Medial De Toledo & Cie | Method of treating diseases of the mucous membrane using compounds of a thiazolidine carboxylic acid and pharmaceutical preparations thereof |
| US3882110A (en) | 1969-06-11 | 1975-05-06 | Roussel Uclaf | Novel 2-alkyl-5-thiazole-carboxylic acid derivatives |
| IT1050117B (it) | 1969-09-17 | 1981-03-10 | Godo Shusei Kk | Metodo per la sintesi dell acido aeruginoico |
| FR2062120A5 (https=) | 1969-10-10 | 1971-06-25 | Messier Fa | |
| FR2141526B1 (https=) | 1971-06-14 | 1975-05-30 | Roussel Uclaf | |
| DE2245560A1 (de) | 1972-09-16 | 1974-03-21 | Basf Ag | Verfahren zur herstellung von 4alkoxycarbonyl-2-thiazolinen |
| AU528115B2 (en) | 1978-04-08 | 1983-04-14 | Santen Pharmaceutical Co. Ltd. | Antihypertensive 4-thiazolidine/carboxylic acids |
| CS205217B1 (cs) | 1979-04-05 | 1981-05-29 | Zdenek Vitamvas | Dozimetr ionizujícího záření |
| DE3002989A1 (de) * | 1980-01-29 | 1981-07-30 | Hoechst Ag, 6000 Frankfurt | Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels |
| ZA815129B (en) * | 1980-07-28 | 1982-07-28 | Ciba Geigy Ag | Thiazoline derivatives and processes for their manufacture |
| DE3170401D1 (en) * | 1980-07-28 | 1985-06-13 | Ciba Geigy Ag | Triazoline derivatives and processes for their preparation |
| JPS5772975A (en) | 1980-10-24 | 1982-05-07 | Kureha Chem Ind Co Ltd | 2-substituted phenylthiazole derviative, and medicine for peptic ulcer containing said derivative as active component |
| US4367233A (en) | 1981-10-02 | 1983-01-04 | American Home Products Corporation | Inhibitors of mammalian collagenase |
| DE3586683T2 (de) | 1984-12-18 | 1993-04-08 | Clark Pharma Dev | Antitumorzusammensetzungen enthaltend ein reaktionsprodukt zwischen einem cytotoxischen aldehyd und penicillamin und deren verwendung zur herstellung von arzneimitteln. |
| HU200177B (en) | 1985-06-18 | 1990-04-28 | Biogal Gyogyszergyar | Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds |
| US4736060A (en) | 1985-08-06 | 1988-04-05 | Nippon Rikagakuyakuhin Co., Ltd. | Method for optical resolution of DL-cysteine and (R,S)-1-(1-naphthyl) ethylamine |
| EP0214933A3 (de) | 1985-09-03 | 1989-05-24 | Ciba-Geigy Ag | Kombinationspräparate zur Behandlung von Malaria |
| EP0214101A3 (de) | 1985-09-03 | 1989-05-31 | Ciba-Geigy Ag | Verwendung von Eisen(III)-Chelatoren vom Typ Desferrioxamin B und Desferriferrithiocin zur Behandlung von Malaria |
| JPS62142168A (ja) | 1985-10-16 | 1987-06-25 | Mitsubishi Chem Ind Ltd | チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤 |
| DE3735757A1 (de) | 1987-10-22 | 1989-05-03 | Degussa | Optisch aktive salze aus einem substituierten thiazolidin-4-carboxylat und 3-chlor-2-hydroxypropyltrimethylammonium, deren herstellung und verwendung |
| EP0325559B1 (de) | 1988-01-20 | 1993-12-15 | Ciba-Geigy Ag | Verfahren zur Herstellung von Komplexverbindungen |
| US5182402A (en) | 1988-11-07 | 1993-01-26 | Imperial Chemical Industries Plc | Herbicidal compositions |
| GB8826035D0 (en) | 1988-11-07 | 1988-12-14 | Ici Plc | Herbicidal compositions |
| US5106992A (en) | 1989-07-28 | 1992-04-21 | E. R. Squibb & Sons, Inc. | 3,5-dihydroxypentanoic acid derivatives useful as antihypercholesterolemic agents and method for preparing same |
| NL9001955A (nl) | 1990-09-05 | 1992-04-01 | Cedona Pharm Bv | Nieuwe thiazolidinederivaten. |
| US5393777A (en) | 1990-11-15 | 1995-02-28 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University | Deferration using anguibactin siderophore |
| DK0934937T3 (da) | 1990-11-30 | 2002-04-02 | Otsuka Pharma Co Ltd | Azolderivater som superoxidradikalinhibitor |
| DK0513379T3 (da) | 1990-11-30 | 1996-09-30 | Teijin Ltd | 2-Arylthiazolderivater og farmaceutisk præparat indeholdende sådanne |
| FR2677021B1 (fr) | 1991-05-31 | 1993-10-01 | Upsa Laboratoires | Nouveaux derives de thiazole antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| US5840739A (en) * | 1992-11-16 | 1998-11-24 | University Of Florida Research Foundation, Inc. | Thiazoline acid derivatives |
| WO1994011367A1 (en) * | 1992-11-16 | 1994-05-26 | University Of Florida Research Foundation Inc. | 2-(pyrid-2'-yl)-2-thiazoline-4(s)-carboxylic acid derivatives |
| DE4301356A1 (de) | 1993-01-20 | 1994-07-21 | Basf Ag | Verfahren zur Herstellung von 2-Alkyl-4-fluormethyl-thiazolcarbonsäure-alkylestern |
| FR2749583B1 (fr) | 1996-06-07 | 1998-08-21 | Lipha | Nouveaux derives de thiazolidine -2,4- dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant |
| US20020049316A1 (en) | 1997-04-29 | 2002-04-25 | Halbert Stacie Marie | Protease inhibitors |
| US6373912B1 (en) * | 1997-06-16 | 2002-04-16 | Legerity, Inc. | Phase-locked loop arrangement with fast lock mode |
| US6174070B1 (en) * | 1998-03-02 | 2001-01-16 | Elna Kabushiki Kaisha | Portable lighting instrument having a light emitting diode assembly |
| MA26618A1 (fr) | 1998-04-09 | 2004-12-20 | Smithkline Beecham Corp | Composes et compositions pharmaceutiques pour le traitement du paludisme |
| US6147070A (en) | 1998-06-05 | 2000-11-14 | Facchini; Francesco | Methods and compositions for controlling iron stores to treat and cure disease states |
| US6083966A (en) * | 1998-08-31 | 2000-07-04 | University Of Florida | Thiazoline acid derivatives |
| US6159983A (en) | 1998-09-18 | 2000-12-12 | University Of Florida | Method and composition for treatment of inflammatory bowel disease |
| CN1585639A (zh) * | 1998-09-21 | 2005-02-23 | 佛罗里达大学研究基金会 | 抗疟疾制剂 |
| US6251927B1 (en) * | 1999-04-20 | 2001-06-26 | Medinox, Inc. | Methods for treatment of sickle cell anemia |
| DE19919336A1 (de) | 1999-04-27 | 2000-11-16 | Consortium Elektrochem Ind | Verfahren zur Ringspaltung von Thiazolidinderivaten |
| DE19948434A1 (de) | 1999-10-08 | 2001-06-07 | Gruenenthal Gmbh | Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine |
| US20040132789A1 (en) * | 2002-08-22 | 2004-07-08 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
| US20040044220A1 (en) * | 2002-08-22 | 2004-03-04 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
| JP2007505044A (ja) | 2003-09-09 | 2007-03-08 | ユニバーシティ オブ フロリダ リサーチ ファウンデイション、インコーポレイテッド | ポリアミン−金属キレーター接合体 |
| WO2005034949A1 (en) | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| WO2006055412A1 (en) | 2004-11-19 | 2006-05-26 | Shiva Biomedical, Llc | Methods of treating erythropoietin-resistance |
| TR201910900T4 (tr) | 2005-04-04 | 2019-08-21 | Univ Florida | Desferritiyokin polieter analogları. |
| EP2101764A4 (en) * | 2006-12-12 | 2010-02-17 | Univ Florida | ACTINIDE DECORATION AGENT WITH DESFERRITHIOCIN ANALOGON |
| WO2008115433A1 (en) * | 2007-03-15 | 2008-09-25 | University Of Florida | Desferrithiocin polyether analogues |
-
1998
- 1998-08-31 US US09/144,103 patent/US6083966A/en not_active Ceased
-
1999
- 1999-08-31 KR KR1020017002702A patent/KR20010074907A/ko not_active Ceased
- 1999-08-31 JP JP2000567521A patent/JP4817498B2/ja not_active Expired - Fee Related
- 1999-08-31 YU YU21801A patent/YU21801A/sh unknown
- 1999-08-31 AU AU57897/99A patent/AU759851B2/en not_active Ceased
- 1999-08-31 UA UA2001032117A patent/UA57161C2/uk unknown
- 1999-08-31 EP EP99945267A patent/EP1109795B1/en not_active Expired - Lifetime
- 1999-08-31 WO PCT/US1999/019691 patent/WO2000012493A1/en not_active Ceased
- 1999-08-31 AT AT99945267T patent/ATE317392T1/de not_active IP Right Cessation
- 1999-08-31 EA EA200100261A patent/EA200100261A1/ru unknown
- 1999-08-31 BR BRPI9913441-1B1A patent/BR9913441B1/pt not_active IP Right Cessation
- 1999-08-31 NZ NZ509899A patent/NZ509899A/en not_active IP Right Cessation
- 1999-08-31 PL PL99346852A patent/PL346852A1/xx not_active Application Discontinuation
- 1999-08-31 CA CA002342210A patent/CA2342210C/en not_active Expired - Fee Related
- 1999-08-31 TR TR2001/00541T patent/TR200100541T2/xx unknown
- 1999-08-31 ES ES99945267T patent/ES2260933T3/es not_active Expired - Lifetime
- 1999-08-31 DE DE69929807T patent/DE69929807T2/de not_active Expired - Lifetime
- 1999-08-31 HU HU0103165A patent/HUP0103165A3/hu unknown
- 1999-08-31 CN CNB998099899A patent/CN100455574C/zh not_active Expired - Fee Related
- 1999-08-31 IL IL14161199A patent/IL141611A0/xx active IP Right Grant
- 1999-08-31 PT PT99945267T patent/PT1109795E/pt unknown
- 1999-08-31 CZ CZ2001711A patent/CZ2001711A3/cs unknown
-
2000
- 2000-03-20 US US09/531,753 patent/US6559315B1/en not_active Expired - Lifetime
- 2000-03-20 US US09/531,754 patent/US6521652B1/en not_active Expired - Lifetime
- 2000-03-20 US US09/531,755 patent/US6525080B1/en not_active Expired - Lifetime
-
2001
- 2001-02-22 IL IL141611A patent/IL141611A/en not_active IP Right Cessation
- 2001-02-27 NO NO20011003A patent/NO321028B1/no not_active IP Right Cessation
- 2001-10-17 US US09/981,586 patent/USRE39132E1/en not_active Expired - Lifetime
-
2002
- 2002-11-20 US US10/300,071 patent/US20030236417A1/en not_active Abandoned
-
2004
- 2004-09-17 US US10/944,150 patent/US7126004B2/en not_active Expired - Fee Related
-
2006
- 2006-09-15 US US11/522,299 patent/US7531563B2/en not_active Expired - Fee Related
-
2009
- 2009-03-27 US US12/383,854 patent/US8008502B2/en not_active Expired - Fee Related
-
2011
- 2011-04-22 JP JP2011095879A patent/JP5520875B2/ja not_active Expired - Fee Related
-
2013
- 2013-12-12 JP JP2013257270A patent/JP2014065730A/ja active Pending
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