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JP2002370939A - Hair growth tonic - Google Patents

Hair growth tonic

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Publication number
JP2002370939A
JP2002370939A JP2001177439A JP2001177439A JP2002370939A JP 2002370939 A JP2002370939 A JP 2002370939A JP 2001177439 A JP2001177439 A JP 2001177439A JP 2001177439 A JP2001177439 A JP 2001177439A JP 2002370939 A JP2002370939 A JP 2002370939A
Authority
JP
Grant status
Application
Patent type
Prior art keywords
hair
growth
tonic
tetrahydro
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001177439A
Other languages
Japanese (ja)
Inventor
進 ▲高▼安
Koji Imamura
Susumu Morioka
Tadashige Sonoda
Susumu Takayasu
康二 今村
忠重 園田
進 森岡
Original Assignee
Taisho Pharmaceut Co Ltd
大正製薬株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

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Abstract

PROBLEM TO BE SOLVED: To provide a hair growth tonic having excellent effect. SOLUTION: The hair growth tonic contains one or more compounds selected from efegatran, efegatran sulfate, napsgatran, melagtran, ximelagtran, argatroban, gabexate mesilate, N-acetyl-D-phenylalanyl-N-[(1 R)-4-[(aminoiminomethyl)amino]-1-boronobutyl-N2-cyclopentylglycinemide, 1-[(2 S)-3-[4-aminoiminomethyl]phenyl]-1-oxo-2-[[(1,2,3,4-tetrahydro-2-methy l-7- isoquinolinyl)sulfonyl]amino]propyl]-1,2,5,6-tetrahydro-4-methyl-2- pyridinecarboxylic acid, Bivalirudin, polypropylene glycol monooleate, decitabine, 4-methoxy-2,4-dimethyl-2-(phenylazo)-pentanenitrile, inogatran and N-(4-formyl-6- oxo-6-pyrrolidin-2-yl-hexyl)-quanidine as active components.

Description

【発明の詳細な説明】 DETAILED DESCRIPTION OF THE INVENTION

【0001】 [0001]

【発明の属する技術分野】本発明は、優れた有効性を示す育毛剤に関する。 The present invention relates to relates to hair tonic show superior efficacy.

【0002】 [0002]

【従来の技術】従来、男性型脱毛を治療または予防するために、多くの薬剤の使用が提案されてきた。 Conventionally, in order to treat or prevent male pattern hair loss, it has been proposed use of many drugs.

【0003】従来知られているものとしては、血管拡張剤、男性ホルモン受容体阻害剤、ステロイド−5α−レダクターゼ阻害剤、ビタミン類、免疫抑制剤などが知られているが、それらの有用性は十分満足できるものではないのが現状である。 [0003] As those known conventionally, vasodilators, androgen receptor inhibitors, steroids -5α- reductase inhibitors, vitamins, and the like are known immunosuppressive agents, their usefulness not something that can be fully satisfactory at present.

【0004】 [0004]

【発明が解決しようとする課題】本発明の目的は優れた効果の育毛剤を提供することにある。 An object of the present invention is to provide a to provide a hair restorer excellent effects.

【0005】 [0005]

【課題を解決するための手段】本発明者らは、優れた有効性を有する育毛成分を見出すため種々検討した結果、 The present inventors Means for Solving the Problems] As a result of various investigations to find a hair growth component having excellent efficacy,
ある種の化合物に優れた育毛効果があることを見出し本発明を完成した。 And it completed the present invention found that there is a superior hair-growth effect on certain compounds.

【0006】すなわち本発明は、エフェガトラン、エフェガトラン硫酸塩、ナプサガトラン、メラガトラン、キシメラガトラン、アルガトロバン、メシル酸ガベキサート、N-アセチル-D-フェニルアラニル-N-[(1R)-4-[(アミノイミノメチル)アミノ]-1-ボロノブチル]-N2-シクロペンチルグリシナミド、1-[(2S)-3-[4-アミノイミノメチル)フェニル]-1-オキソ-2-[[(1,2,3,4-テトラヒドロ-2- That is, the present invention provides Efegatoran, Efegatoran sulfates, Napusagatoran, melagatran, ximelagatran, argatroban, gabexate mesilate, N- acetyl -D- phenylalanyl -N - [(1R) -4 - [(aminoiminomethyl ) amino] -1-Boronobuchiru]-N2- cyclopentyl caprylyl Sina bromide, 1 - [(2S)-3-[4-aminoiminomethyl) phenyl] -1-oxo-2 - [[(1,2,3, 4-tetrahydro-2
メチル-7-イソキノリニル)スルホニル]アミノ]プロピル]-1,2,5,6-テトラヒドロ-4-メチル-2-ピリジンカルボン酸、エノキサバリンまたはその塩、ポリプロピレングリコールモノオレエート、デシタビン、4-メトキシ-2,4 Methyl-7-isoquinolinyl) sulphonyl] amino] propyl] -1,2,5,6-tetrahydro-4-methyl-2-pyridinecarboxylic acid, Enokisabarin or a salt thereof, polypropylene glycol monooleate, decitabine, 4-methoxy - 2,4
-ジメチル-2-(フェニルアゾ)-ペンタンニトリル、イノガトラン、N-(4-フォルミル-6-オキソ-6-ピロリジン-2- - Dimethyl-2- (phenylazo) - pentanenitrile, inogatran, N-(4-formyl-6-oxo-6-pyrrolidin-2
イル-ヘキシル)-グアニジンからなる群から選ばれる1 Yl - hexyl) - 1 selected from the group consisting of guanidine
種または2種以上の化合物を有効成分とする育毛剤である。 It is a hair growth agent comprising as an active ingredient the species or two or more compounds.

【0007】 [0007]

【発明の実施の形態】本発明の有効成分である化合物はそれぞれ公知であり、医薬品、試薬などで市販されている。 The compound which is the active ingredient of the present invention DETAILED DESCRIPTION OF THE INVENTION are known, respectively, medicines, are commercially available in such reagents. 例えば、アルガトロバンは注射液としてロンノン注、ノバスタン注、アルガロン注(いずれも商品名)などの名称で販売されている。 For example, argatroban Ron'non Note, Novastan Note, Arugaron Note sold under the name, such as (trade name) as an injectable solution. メシル酸ガベキサートは、 Gabexate mesylate,
レミナロン注射用、アロデート注500、注射用リナレスキット1000(いずれも商品名)などの名称で販売されている。 For Reminaron injection, Arodeto Note 500, (both trade name) for injection Linares kit 1000 has been sold under the name of such.

【0008】本発明の有効成分の投与量は症状、禿頭の面積などにより異なるが、一般的な製剤としたときの配合量である製剤全体の0.01〜5%(本発明でいう「%」とは、通常は質量%のことであるが、ローション剤等の液剤においては質量/容量%を示す。)の濃度の製剤を1日1回〜数回禿頭部位に塗布する。 [0008] The dosage of the active ingredient of the present invention symptoms, and the like areas of baldness 0.01-5% of the total formulation which is the amount of time that a general formulation (referred to in the present invention, "% "and it is usually but is that of mass%, in the liquid preparation such as a lotion coating the concentration of the formulation.) which shows the mass / volume% to bald site once to several times a day.

【0009】本発明の育毛剤は、外用剤、例えばローション剤、乳剤、クリーム剤、軟膏剤、ゲル剤、エアゾール剤などの外用剤として通常の方法で製造することができる。 [0009] hair restorer of the present invention, external preparations, for example lotions, emulsions, creams, ointments, gels, can be prepared in the usual way as an external preparation, such as aerosols.

【0010】 [0010]

【実施例】以下、実施例により本発明をさらに詳細に説明する。 EXAMPLES Hereinafter, the present invention will be described more specifically by examples. 実施例1 アルガトロバン0.1gを全100mLのエタノール(95)に溶解し、ローション剤を得た。 EXAMPLE 1 Argatroban 0.1g was dissolved in ethanol (95) of the total 100 mL, to give a lotion.

【0011】実施例2 メシル酸ガベキサート1gを全100mLのエタノール(95)に溶解し、ローション剤を得た。 [0011] EXAMPLE 2 gabexate 1g was dissolved in ethanol (95) of the total 100 mL, to give a lotion.

【0012】実施例3 以下の処方で常法によりローション剤を得た。 [0012] to give a lotion in a conventional manner in Example 3 the following recipe. メシル酸ガベキサート 1g 濃グリセリン 5g エタノール(95) 60g 精製水 全100mL Gabexate 1g concentrated glycerin 5g ethanol (95) 60 g Purified water total 100mL

【0013】 [0013]

【発明の効果】本発明により、従来の育毛剤よりもより育毛効果の高められた育毛剤を提供することが可能となった。 According to the present invention, it becomes possible to provide a hair restorer elevated more of hair growth effect than conventional hair tonic.

フロントページの続き (72)発明者 今村 康二 東京都豊島区高田3丁目24番1号 大正製 薬株式会社内 (72)発明者 森岡 進 東京都豊島区高田3丁目24番1号 大正製 薬株式会社内 Fターム(参考) 4C083 AC102 AC122 AC181 AC641 AC741 AC742 AC851 AC852 CC37 DD23 EE22 4C086 AA01 AA02 BC28 GA12 MA01 MA63 NA14 ZA92 4C206 AA01 AA02 DB17 DB57 MA01 MA04 MA83 NA14 ZA92 Of the front page Continued (72) inventor Koji Imamura Toshima-ku, Tokyo Takada 3-chome 24th No. 1 Taisho made drugs within Co., Ltd. (72) inventor Susumu Morioka Toshima-ku, Tokyo Takada 3-chome 24th No. 1 Taisho made drugs stock companies in the F-term (reference) 4C083 AC102 AC122 AC181 AC641 AC741 AC742 AC851 AC852 CC37 DD23 EE22 4C086 AA01 AA02 BC28 GA12 MA01 MA63 NA14 ZA92 4C206 AA01 AA02 DB17 DB57 MA01 MA04 MA83 NA14 ZA92

Claims (2)

    【特許請求の範囲】 [The claims]
  1. 【請求項1】 エフェガトラン、エフェガトラン硫酸塩、ナプサガトラン、メラガトラン、キシメラガトラン、アルガトロバン、メシル酸ガベキサート、N-アセチル-D-フェニルアラニル-N-[(1R)-4-[(アミノイミノメチル)アミノ]-1-ボロノブチル]-N2-シクロペンチルグリシナミド、1-[(2S)-3-[4-アミノイミノメチル)フェニル]- 1. A Efegatoran, Efegatoran sulfates, Napusagatoran, melagatran, ximelagatran, argatroban, gabexate mesilate, N- acetyl -D- phenylalanyl -N - [(1R) -4 - [(Aminoiminomethyl) amino] 1-Boronobuchiru]-N2- cyclopentyl caprylyl Sina bromide, 1 - [(2S) -3- [4- aminoiminomethyl) phenyl] -
    1-オキソ-2-[[(1,2,3,4-テトラヒドロ-2-メチル-7-イソキノリニル)スルホニル]アミノ]プロピル]-1,2,5,6-テトラヒドロ-4-メチル-2-ピリジンカルボン酸、エノキサバリンまたはその塩、ポリプロピレングリコールモノオレエート、デシタビン、4-メトキシ-2,4-ジメチル-2- 1-oxo-2 - [[(1,2,3,4-tetrahydro-2-methyl-7-isoquinolinyl) sulphonyl] amino] propyl] -1,2,5,6-tetrahydro-4-methyl-2- pyridinecarboxylic acid, Enokisabarin or a salt thereof, polypropylene glycol monooleate, decitabine, 4-methoxy-2,4-dimethyl-2-
    (フェニルアゾ)-ペンタンニトリル、イノガトラン、N- (Phenylazo) - pentanenitrile, inogatran, N-
    (4-フォルミル-6-オキソ-6-ピロリジン-2-イル-ヘキシル)-グアニジンからなる群から選ばれる1種または2種以上の化合物を有効成分とする育毛剤。 (4-formyl-6-oxo-6-pyrrolidin-2-yl - hexyl) - hair growth agent comprising as an active ingredient one or more compounds selected from the group consisting of guanidine.
  2. 【請求項2】 外用剤である請求項1に記載の育毛剤。 2. A hair-growing agent according to claim 1 which is external preparation.
JP2001177439A 2001-06-12 2001-06-12 Hair growth tonic Pending JP2002370939A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2001177439A JP2002370939A (en) 2001-06-12 2001-06-12 Hair growth tonic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001177439A JP2002370939A (en) 2001-06-12 2001-06-12 Hair growth tonic

Publications (1)

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JP2002370939A true true JP2002370939A (en) 2002-12-24

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135464B2 (en) 2002-06-05 2006-11-14 Supergen, Inc. Method of administering decitabine
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
US7276228B2 (en) 2001-04-24 2007-10-02 Supergen, Inc. Methods for treating hematological disorders through inhibition of DNA methylation and histone deacetylase
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US9381207B2 (en) 2011-08-30 2016-07-05 Astex Pharmaceuticals, Inc. Drug formulations

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7276228B2 (en) 2001-04-24 2007-10-02 Supergen, Inc. Methods for treating hematological disorders through inhibition of DNA methylation and histone deacetylase
US7135464B2 (en) 2002-06-05 2006-11-14 Supergen, Inc. Method of administering decitabine
US7144873B2 (en) 2002-06-05 2006-12-05 Supergen, Inc. Kit for delivering decitabine in vivo
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US8461123B2 (en) 2005-09-29 2013-06-11 Astex Pharmaceuticals, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US9358248B2 (en) 2005-09-29 2016-06-07 Astex Pharmaceuticals, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US9480698B2 (en) 2005-09-29 2016-11-01 Astex Pharmaceuticals, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US9381207B2 (en) 2011-08-30 2016-07-05 Astex Pharmaceuticals, Inc. Drug formulations
US9913856B2 (en) 2011-08-30 2018-03-13 Astex Pharmaceuticals, Inc. Drug formulations

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