JP2002282230A - Biological information collecting device, biological information data processing device and method of processing - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a vital data processing device capable of automatically producing a synthesized electrocardiographic waveform equivalent to the standard 12 lead waveform corrected in the personal difference among subjects and the displacement of electrodes based on prescribed inducted waveform data. SOLUTION: X, Y, and X component waveforms of the heart-induced electric vectors are produced from the induced waveform (S120), and plural candidate waveforms for each induced waveform are produced from a unipolar induction vector for the electrode position to be used for the standard 12 leads and a synthesized bipolar lead vector of the standard 12 leads produced by using the unipolar lead vector (S130). The interrelation between each candidate waveform and a previously stored standard waveform is found and the similarity is calculated based on the interrelation (S160). Then, the candidate waveform with the largest similarity is determined and selected as the synthesized standard induced waveform (S190).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a biological information processing apparatus and processing method, and more particularly to a biological information processing apparatus and processing method capable of synthesizing a standard 12-lead waveform from electrocardiogram information collected using a small number of electrodes.

[0002] The present invention also relates to a biological information collecting apparatus, and more particularly to a biological information collecting apparatus that is portable for a subject and collects electrocardiographic waveform information suitable for synthesizing a 12-lead waveform.

[0003]

2. Description of the Related Art Conventionally, electrocardiograms have been widely used for medical treatment of heart diseases and the like. In general, an electrocardiogram recorded at a hospital or the like is composed of 12 types of lead waveforms called standard 12 lead waveforms, and is recorded for a short time with the subject wearing electrodes on both wrists, ankles and chest while in a resting state. On the other hand, paroxysmal arrhythmias are less likely to be found during a short recording period,
A portable electrocardiograph such as a Holta electrocardiograph is attached to the subject, and long-term continuous recording, for example, 24 hours is performed.

[0004]

However, in the conventional Holter monitor, since the subject performs a long-term recording such as 24 hours while performing a normal life, the standard 12 ECG is required.
The electrodes required to record the induced waveform cannot be used, and only three channels (three induced waveforms) are recorded at the same time. In addition, the recorded lead waveform is different from the waveform included in the standard 12 lead waveform, and it is necessary to acquire knowledge for the appropriate diagnosis from the lead waveform recorded by the Holter monitor. .

For this reason, it has been proposed to generate a waveform equivalent to a normal standard 12-lead waveform from electrocardiographic information recorded by a Holter monitor. For example, Japanese Electrocardiographic Society "Electrocardiogram" Volume 20, Number 1, 2000, 20-26 pages,
The “Study on Ischemic ST Deviation of Synthetic 12-Lead ECG Output from 3-Channel Digital Holter Electrocardiograph” describes the relationship between the recording unit (main body) and electrodes of a conventionally used 3-channel digital Holter monitor. Attach a Frank induction box (Frank's resistance net) to the Franc
An example is described in which electrocardiogram information corresponding to k XYZ lead waveforms is recorded, and a composite lead electrocardiogram corresponding to a standard 12-lead waveform is generated from the recorded electrocardiogram information.

However, when synthesizing a waveform corresponding to the standard 12-lead waveform from the Frank's XYZ-lead waveform, a waveform synthesis process is performed for a certain model body under the assumption that the human body is a uniform conductor. Therefore, the displacement of the electrode position, the individual difference of the subject, and the like are not considered. Therefore, in the above-mentioned literature, nine waveforms in which the electrode positions are shifted for each composite waveform are obtained and compared with the corresponding waveforms of the actually measured standard 12-lead waveform, and the most similar waveform from the nine waveforms is visually observed. After the selection, the amplitude was corrected by manual calculation, and the final synthesized 12-lead waveform was determined.

As described above, the conventional Holter monitor has a Fra
It is necessary to add a Frank lead box for recording NK XYZ lead waveforms, and because the number of electrodes is also eight, it takes time and effort to attach the electrocardiograph to the subject, and the subject feels comfortable to wear. Not as good as a regular Holta monitor. Furthermore, select the best waveform from the synthesized waveform,
In addition, since the waveform shaping process is performed manually, the process of generating a synthesized waveform is complicated.

The present invention has been made in view of the above-mentioned problems of the prior art, and has as its object to obtain a waveform suitable for synthesizing a lead waveform corresponding to a standard 12 lead waveform,
Another object of the present invention is to provide a biological information collecting apparatus having a simple configuration.

Another object of the present invention is to provide a biomedical system capable of automatically generating a synthetic lead electrocardiographic waveform corresponding to a standard 12-lead waveform in which individual differences between subjects and electrode displacements are corrected from predetermined lead waveform information. An information processing apparatus and method are provided.

[0010]

That is, the gist of the present invention is a biological information collecting apparatus for recording biological information, comprising at least three positive electrodes, one ground electrode, one negative electrode, The biological information collecting apparatus includes a recording unit that records data representing a potential difference between each of the three positive electrodes and one negative electrode as biological information.

Further, another gist of the present invention is that a predetermined 3
A means for generating X, Y, and Z component waveforms of an electromotive force vector from a lead waveform and a lead vector corresponding to the third lead waveform; and a predetermined means corresponding to a standard 12-lead waveform. A waveform synthesizing means for synthesizing a plurality of candidate waveforms for each of the standard 12-lead waveforms using the lead vector and the X, Y, Z component waveforms of the electromotive force vector; And determining means for determining, for each of the reference waveforms, a candidate waveform determined to be closest to the reference waveform from the plurality of candidate waveforms, using the corresponding plurality of candidate waveforms, as a synthesized standard induction waveform. In the biological information processing apparatus.

Further, another gist of the present invention is that a predetermined 3
A step of generating an electromotive force vector waveform for generating X, Y, and Z component waveforms of the electromotive force vector from the lead waveform and the lead vector corresponding to the third lead waveform, and a predetermined step corresponding to the standard 12-lead waveform A waveform synthesizing step of synthesizing a plurality of candidate waveforms for each of the standard 12-lead waveforms using the X-, Y-, and Z-component waveforms of the lead electromotive force vector; Determining a candidate waveform determined to be closest to the reference waveform from each of the plurality of candidate waveforms as a synthesized standard guide waveform for each of the reference waveforms using the corresponding plurality of candidate waveforms. In the biological information processing method.

[0013]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described based on preferred embodiments with reference to the drawings. FIG. 1 is a diagram showing a configuration of a Holter monitor and an electrode connection as an example of a biological information collecting apparatus according to an embodiment of the present invention.

The Holter monitor has a main body 100 and a lead 150.
The main body 1 and the lead are connected at the time of use. A power switch 110, an information input switch 101 for inputting information such as a subject name, and a selection switch 10 for moving a selection item during menu display are provided on the main body 1.
2. Menu switch 10 for displaying various menus
3, a display device 104 for displaying electrocardiogram waveforms and internal setting information of the device, an event switch 105 for recording the time when the subject is aware of an abnormality during recording of an electrocardiogram, and a lead 2 for connecting the lead 2. A connector 106 and a connector 107 for connecting an external device such as an external event switch or a monitor device are provided.

The lead 150 has an electrode 21 to be attached to the subject and a connector 22 for connecting the main body 100 to the electrode 21. In this embodiment, the lead 150
Is a magnelead provided on the electrode 21 with a magnet for connection to a magnerose attached to a subject with an adhesive or the like. In the present embodiment, five electrodes 2
As shown in FIG. 1 (c), each of the reference numerals 1 includes a plus (+) electrode for three channels, a minus (-) electrode common to each channel, and a ground electrode used for circuit installation.

FIG. 2 is a block diagram showing an example of a circuit configuration of the Holter monitor shown in FIG. In FIG. 2, 1 is R
A CPU that executes a control program stored in the OM 2 to control the entire Holter monitor, a ROM 2 that stores a program executed by the CPU 1 and parameters necessary for processing, and a ROM 3 that temporarily stores progress of various processes. RA to remember
M and 4 are storage devices for storing electrocardiogram information and the like collected from the subject in the form of digital data. In the present embodiment, the storage device 4 uses a removable recording medium such as a flash memory. By removing this storage medium from the electrocardiograph main body and setting it in a biological information processing apparatus described later, the biological information processing apparatus can read out and process electrocardiogram information and the like recorded in the storage medium. Of course, in addition to the method of directly setting the storage medium in the biological information processing apparatus, a communication interface is provided between the Holter electrocardiograph and the biological information processing apparatus, which are connected to the biological information processing apparatus together with the collection device, and the communication interface is provided through this communication interface. It is needless to say that any method can be used, such as transferring recorded information from a Holter monitor to a biological information processing apparatus.

Reference numeral 5 denotes a timekeeping unit which is a real-time clock for displaying time. Reference numeral 6 denotes a display unit for displaying a detected electrocardiogram waveform or the like from a biological electrode. In this embodiment, a liquid crystal display LC is used.
D. Reference numeral 7 denotes a switch circuit for setting various operation conditions. In the present embodiment, the switch setting state of the switch circuit 7 is connected to the input port of the CPU 1, and the CPU 1 can always recognize the setting state of the switch circuit 7 by reading this input port.

An analog-digital converter (A / D converter) 10 converts analog detection information from a living body into corresponding digital information, and 11 detects movement information of the living body (posture information of the living body, etc.). Acceleration data detector,
Reference numeral 12 denotes an ECG electrode for collecting ECG information.
And a third channel.

The A / D converter 10 can be connected to an acceleration data detector 11 and an electrocardiogram electrode 12 at all times. Further, reference numeral 20 denotes a serial communication control unit which can be provided as an option. The serial communication control unit 20 can directly perform data communication with another device via a communication medium. For example, as shown in FIG. 2, it is possible to connect to a communication network 30 such as a LAN, a public switched telephone network or the Internet.
It is also possible to transfer the collected electrocardiogram information directly to 0.
In this case, even if communication is performed in accordance with a control program stored in advance in the ROM 2, for example, data is transferred by another communication device, for example, the communication device 40, for example, by the communication control instructed to execute. You may do it.

(Recording of Electrocardiographic Information) When the present apparatus is used for collecting electrocardiographic information, if the flash memory is not mounted on the storage device 4, the flash memory is mounted on the storage device 4.
Then, the electrocardiogram electrode 12 is attached to a predetermined part of the chest of the subject, which will be described later. Then, the device is activated to start collecting electrocardiogram information.

The A / D converter 10 amplifies the detected biological signal from the electrocardiogram electrode 12 to a predetermined level, samples it at a predetermined frequency and bit number, converts it into a digital signal, and the CPU 1 measures this digital signal. The information is sequentially written into a predetermined area of the flash memory together with the timekeeping time information of the unit 5. The CPU 1 displays the signal level of the digital electrocardiogram signal on the LCD display unit 6 in the form of, for example, a bar graph. Thus, the subject can determine whether the electrocardiogram electrode is worn properly.

In this manner, the detection and recording operation of the electrocardiogram signal is continuously performed as long as the storage capacity of the flash memory permits. In addition, when the storage capacity of the flash memory is exhausted, even if it operates to stop the measurement here,
Or, overwrite from the first written again,
The control may be such that the electrocardiogram signal for the latest predetermined time is always recorded.

Here, the electrode positions when using the Holter monitor in this embodiment will be described with reference to FIG. In the present invention, the XYZ lead waveforms (X, ECG of the electromotive force vector) are obtained from the lead waveform data of three channels collected without using the conventionally used Frank resistance network.
In order to obtain the Y and Z component waveforms), it is preferable that the collected three-channel lead waveform data include the XYZ lead waveforms in an appropriate balance.

For this reason, in the present embodiment, the channel 1 (c) containing a relatively large amount of X (horizontal and horizontal) induced waveforms is used.
h1), a channel 2 (ch2) containing a relatively large amount of Y (vertical direction) lead waveforms, and a channel 3 (ch3) containing a relatively large amount of Z (horizontal longitudinal direction) lead waveforms are collected.
Specifically, as shown in FIG. 3, the minus electrode (indifferent electrode) of each channel is shared with the V7R position, the plus electrode of ch1 is at the V5 position, the plus electrode of ch2 is a perpendicular line lowered from the V4 position, At the intersection of the line extending horizontally from the navel of the subject, the plus electrode of ch3 was set to the V1 position. ch2
The positive electrode position of the left ankle (L
L: LeftLeg). Further, the position of the ground electrode N may be any position.

With such an electrode arrangement, the leads collected in each channel are as follows. Channel Lead name Correspondence with standard 12-lead waveform ch1 eV5 Corresponds to V5 waveform ch2 eVF Corresponds to aVF waveform ch3 eV1 Corresponds to V1 waveform In this way, by acquiring eV lead, the acquired waveform is almost equal to standard 12 lead Since the waveform is a waveform, even if only the acquired waveform is used, the same diagnosis as the standard 12-lead waveform can be performed, unlike the acquired waveform by the conventional Holter monitor. The process of generating a combined 12-lead waveform from the acquired lead waveform will be described later.

(Configuration of Biological Information Processing Apparatus) Next, the configuration of the biological information processing apparatus that reads out and processes the electrocardiographic information recorded as described above will be described with reference to FIG. FIG. 4 is a block diagram illustrating a configuration example of the biological information processing apparatus according to the present embodiment.

In FIG. 4, reference numeral 100 denotes a Holter monitor described with reference to FIGS.
0 is a biological information processing apparatus that reads collected electrocardiographic information and performs predetermined analysis processing and the like. The biometric information processing apparatus 200 may have a function of processing biometric information other than electrocardiographic information. It is shown in FIG.

Referring to FIG.
Is responsible for overall control of the apparatus, and includes a CPU, ROM,
A control circuit 210 composed of a RAM or the like, a reading circuit 220 for reading recorded contents recorded by the storage device 4 of the Holter monitor 100, electrocardiographic information read by the reading circuit 220 (personal information of a subject, pure heart, etc.) Information that may include information other than electrical information) to generate a candidate waveform for a synthesized 12-lead waveform, and to automatically select a waveform that is considered optimal from the synthesized waveform in consideration of individual differences among subjects. The electronic information processing circuit 221 is provided. The electrocardiogram information processing circuit 221 analyzes the finally generated composite 12-lead waveform, extracts a necessary characteristic waveform portion (eg, extracts an ST waveform), and outputs the analysis result to the control circuit 210. May be provided.

In order to output from the display device 250 or the printing device 240 corresponding image data to output the synthesized lead waveform generated by the electrocardiogram information processing circuit 221 and past electrocardiographic information stored in the external storage device 260, And an electrocardiogram information demodulation circuit 223 for demodulating (analog display or demodulation into a printable waveform image) and outputting the demodulated information to the biological information output control circuit 230.

Further, in accordance with an instruction from the control circuit 210, the signal is formatted into a predetermined output format using the electrocardiogram waveform from the electrocardiogram information demodulation circuit 223 and predetermined information, and is designated to a specified output device (the printing device 240 or the display device). 2
50) a biometric information output control circuit 230 for outputting the processed biometric information, a printing device 240 for printing out the processed biometric information, a display device 250 for displaying and outputting the processed biometric information and operation guidance of the device, and a candidate waveform of the synthesized 12-lead waveform. An external storage device 260 stores standard 12-lead waveform data used as a reference waveform when automatically selecting an appropriate waveform.

The biological information processing apparatus 200 is provided with the above-described configuration, and is capable of attaching and detaching the electrocardiographic information collected and recorded by the Holter monitor 100, for example, by the storage device 4 of the Holter monitor 100. The storage medium is read by a reading circuit 220 that can read the storage medium. Of course, as described above, the Holter monitor may communicate with the Holter monitor via a communication control unit (optional) and a communication network to read recorded information. May be directly connected to read the recorded information.

Then, the electrocardiogram information processing circuit 221 generates a synthesized 12-lead waveform candidate waveform from the read electrocardiogram information by a method described later, and uses the previously stored reference waveform and each candidate waveform to generate the synthesized 12-lead waveform. An optimal waveform is determined, and a final composite 12-lead waveform is generated. In addition, synthesis 12
A well-known analysis process such as feature waveform extraction may be performed on the induced waveform.

The analysis result is output to the control circuit 210, and the control circuit 210 prints out or displays the analysis result as necessary, so that the biological information output control circuit 230
And the electrocardiogram information demodulation circuit 223. The control circuit 210 is configured to be able to take in the analysis results of the electrocardiographic information processing circuit 221 as necessary, and can perform various processes by using these processing results as needed.

The printing device 240 and the display device 250
Not only output to the external storage device 2, but also
60 (or a holter electrocardiograph that records information read by the reading circuit 220), which is communicably connected via a communication network using an optional communication control unit. (Or a device other than the Holter monitor).

(Waveform Synthesis Process) Next, a process of generating a synthesized 12-lead waveform performed by the biological information processing apparatus 200 in this embodiment will be described. The following waveform synthesizing process and waveform selecting process are performed by the CPU included in the control circuit 210 by the ROM or the external storage device 2 also included in the control circuit 210.
This is realized by executing a program stored in 60 and using and controlling necessary resources in the biological information processing apparatus.

Frank indicates that the electrocardiogram signal potential (E) on the body surface is the XYZ component (H) of the cardiac electromotive force vector (H).
x, Hy, Hz) and the inner product of the XYZ components (Jx, Jy, Jz) of the induction vector (J) to a point on the body surface. That is, it was assumed that E = HJ = HxJx + HyJy + HzJz (1).

Then, in order to determine the induction vector (J), the XYZ space in which the electrocardiogram vector (H) is fixed and the potential (E) on the body surface is projected is converted into an image surface (Ima).
ge Surface). It has been proved by Dower that a lead vector is obtained by using this image surface, and a waveform corresponding to a standard 12 lead waveform can be synthesized from the XYZ lead waveform and the lead vector.

In the present invention, X, Y, and Z lead waveforms can be generated from the three lead waveforms by obtaining a lead vector for an arbitrary three lead waveform using the image surface. Standard 1 using induction waveform
It is characterized in that a waveform corresponding to the two-lead waveform is synthesized.

Therefore, as described above, a lead waveform containing more X, Y, and Z lead waveforms than the other lead waveforms is selected as the three lead waveforms acquired by the Holter monitor. In this embodiment, the lead vector of each channel is Frank.E: THE IMAGE SURFACE ON A HOMOGENEOUS
Based on TORSO, Am Heart J 47: 757, 1954, the position of the electrode on the torso was determined by projecting it on the image surface. Specific values are as follows. Channel Lead name Lead vector (Jx, Jy, Jz) ch1 eV5 (195, -7, -10) ch2 eVF (51, 111, -27) ch3 eV1 (-19, -47, -94)

By substituting this induction vector into equation (1), eV5 = 195Hx-7Hy-10Hz (2) eVF = 51Hx + 111Hy-27Hz (3) eV1 = -19Hx-47Hy-94Hz (4) By substituting the recorded sample data of each lead waveform into each equation and calculating Hx, Hy, and Hz, the X, Y, and Z lead waveforms can be obtained.

FIGS. 5 (a) to 5 (c) show the recorded eV
Examples of 1, 1, eV5, and eVF lead waveforms are shown in FIGS.
(C) shows examples of the X, Y, and Z lead waveforms obtained using the lead waveforms of FIG.

Next, a waveform corresponding to a standard 12-lead waveform is synthesized from the X, Y, and Z lead waveforms. In order to synthesize a waveform corresponding to the standard 12 leads from the X, Y, and Z lead waveforms, it is necessary to determine a lead vector for each waveform. In the present embodiment, the torso model and the image surface described in the Frank's paper are used, and the image surface corresponding to the electrode position used for the standard 12 lead in the torso model is used in the same manner as the above-described induction vector for the induction waveforms of ch1 to ch3. After obtaining the above coordinates, a lead vector (synthetic bipolar lead vector) for the standard 12 lead waveform is determined from the coordinates of the electrode position. At this time, CT (c
The coordinates of the central terminal were the coordinates of the center of gravity of a triangle having the coordinates of RA (right hand), LA (left hand) and LL (left foot) as vertices. Then, for each x,
Using the y, z components and the X, Y, Z lead waveforms,
Generate an induction waveform.

As described above, in the present invention, a three-lead waveform is obtained by individual differences between subjects or an electrocardiograph from a lead waveform synthesized using a lead vector determined under the assumption of a specific body type or the like. It is characterized in that the displacement of the electrode position at the time of collection is corrected, and the most appropriate synthesized waveform is automatically selected. Therefore, when generating the composite 12-lead waveform, a plurality of candidate waveforms are generated for each lead waveform.

Although the generation method of the candidate waveform may be arbitrary, in this embodiment, the waveform is collected while shifting the position of the virtual electrode on the image surface. Although the way of shifting the electrode position can be set arbitrarily, in the present embodiment, as shown in FIG. 7, the electrode position on the torso model is set at 3 cm intervals with the reference electrode position as the center (position 5). Nine candidate waveforms are generated for each induced waveform using the coordinates (converted to coordinates on the image surface) where each electrode position is projected onto the image surface (converted to coordinates on the image surface) by changing the electrode positions to rectangular electrode positions 1 to 9 (9 positions in total). did. 8 to 16 show composite 12-lead waveforms for each of the electrode positions 1 to 9. Note that FIGS. 8 to 16 show a case in which three lead waveforms that are the basis of the combined waveform are read for 10 seconds from the same time and the combining process is performed. Synchronization between the three lead waveforms is performed by synchronizing the time information of the RTC clock unit 5 with the Holter electrocardiograph at the time of recording and recording the lead waveform data with the biological information processing apparatus based on the time information. This can be realized by unifying the read start data.

(Processing for Determining Synthetic 12 Lead Waveform) Next, a process for automatically selecting an optimum waveform from the composite 12 lead waveform will be described. As described above, the image surface is considered to be strictly different for each subject depending on the physique, age, gender, etc., but in the process of generating the synthetic 12-lead waveform, Frank uses the image surface obtained for a specific model. The actual measured standard 12
It may be different from the induced waveform. In addition, since the induction vector used for synthesis is calculated for an electrode position having a specific coordinate, the induction waveform also changes if the electrode position worn on the subject deviates from the calculated position when acquiring the three-lead waveform. I do.

Therefore, in the present embodiment, each of the syntheses 12
By combining nine candidate waveforms for each lead waveform and selecting the most appropriate waveform from those waveforms, a combined 12-lead waveform that reflects the electrode position shift and the individual difference of the subject when collecting the three-lead waveform To determine.

More specifically, a standard 12-lead waveform previously obtained by a normal method from a subject is stored in advance as a reference waveform, and a waveform having the highest similarity with the corresponding reference waveform among the nine candidate waveforms is stored. Select

The method of calculating the degree of similarity is arbitrary, but in this embodiment, the characteristic portion of the waveform is extracted, the corresponding portion of the reference waveform and the cross-correlation coefficient are determined for each characteristic portion, and the characteristic portion is determined for each characteristic portion. The candidate waveform having the largest average value of the cross-correlation coefficient is selected as the waveform having the highest similarity. In the present embodiment, the characteristic parts for obtaining the cross-correlation are the QRS wave part and the ST part + T wave (referred to as ST-T part).

When calculating the cross-correlation coefficient, first, the maximum amplitude of the QRS wave portion of the reference waveform and the Q
The combined waveform is shaped so that the maximum amplitude of the RS wave portion is the same. Thereafter, the QRS wave portion and the ST-T portion are extracted from both the reference waveform and the composite waveform by a known method. Specifically, measure the section points in each lead,
The QRS wave part is from the start point of the Q wave to the end point of the S wave, and the ST-T part is from the S wave end point to the end point of the T wave.

Next, a cross-correlation coefficient is obtained for each of the QRS wave portion and the ST-T portion. First, a reference point for calculating a cross-correlation coefficient is searched for each of the QRS wave portion and the ST-T portion of the reference waveform, the candidate waveform. The calculation reference point is, for example, the maximum value in each feature portion,
It can be determined by any criteria. Then, the candidate waveform is shifted with respect to the reference waveform by ± several ms to several tens ms with the obtained reference point as the center, and the cross-correlation coefficient is obtained based on the width of the reference waveform. And QR
The average value of the cross-correlation coefficient of the S-wave part and the cross-correlation coefficient of the ST-T part was obtained, and the result was used as the similarity between the candidate waveform and the reference waveform.

These processes are performed for each candidate waveform.
A candidate waveform having the highest similarity is selected. The same process is performed for each of the composite 12-lead waveforms, and the selected candidate waveform is determined as the final composite 12-lead waveform.

As shown in FIGS. 8 to 16, when the candidate waveform includes a plurality of cycles, the similarity is obtained in the entire cycle or a predetermined plurality of cycles, and the average thereof may be used as the final similarity. The similarity may be obtained only for one cycle of.

FIG. 17 shows an example of a standard 12-lead waveform acquired as a reference waveform, and FIG. 18 shows a composite 12-lead waveform selected from the candidate waveforms shown in FIGS. 8 to 16 by the above-described automatic selection processing. . As is clear from the comparison between FIG. 17 and FIG. 18, it can be seen that a highly accurate synthesized 12-lead waveform is obtained.

Finally, the entire waveform synthesizing process and the automatic selecting process performed by the biological information processing apparatus according to the present embodiment will be described with reference to the flowchart shown in FIG.
First, eV1, eV1, eV acquired by an electrocardiograph such as a Holta electrocardiograph
The V5 and eVF induction waveform data (FIG. 5) are read for each induction waveform for a predetermined time from the same time (step S11).
0). Next, each of the induced waveform data is expressed by the above-described equations (2) to
Substitute (4) to generate X, Y, Z lead waveforms (FIG. 6) (step S120). Then, the virtual electrode position is changed in nine ways, and FIGS.
Are combined (step S13).
0).

Then, a QRS wave part and an ST-T part are extracted from each candidate waveform (step S140), and the QRS part of the reference waveform previously stored in the external storage device 260 is extracted.
The characteristic portion of the candidate waveform is shaped so that the maximum amplitude of the wave portion is equal to the maximum amplitude of the QRS wave portion of the candidate waveform (step S150).

Next, the reference positions of the characteristic portions of the reference waveform and the candidate waveform are determined. Then, for each characteristic portion, a cross-correlation coefficient between the reference waveform and the candidate waveform is obtained, and a similarity obtained by averaging the cross-correlation coefficients obtained for each characteristic portion is obtained (step S160).

The processes in steps S140 to S160 are repeated until the calculation of the similarity is completed for all the candidate waveforms (steps S170 and S180). A waveform is selected (step S190).

The processes of steps S140 to S190 are further repeated until the selection of the candidate waveform having the maximum similarity is completed for each of the synthesized 12 lead waveforms (steps S200 and S210). The waveform synthesis and selection processing ends.

[0059]

[Other Embodiments] In the above-described embodiment, by sharing the minus electrode among the three channel electrodes, seven electrodes (two for each channel + circuit ground) required for a normal three-channel Holter monitor are used. Although only an example using a Holter electrocardiograph that performs three-channel recording with five electrodes, which is two electrodes less than one used, has been described, electrocardiographic information recorded using a conventional seven-electrode Holter electrocardiograph is used. The present invention can also be applied to the present invention. In this case, all the negative electrodes of each channel may be attached near the V7R position to record electrocardiographic information.

As an index of the degree of similarity, the average value of the cross-correlation coefficient for each characteristic portion is used. However, an arbitrary value such as using the correlation coefficient of the entire waveform in the same section without extracting the characteristic portion is used. Indicators can be used. It is also possible to weight each characteristic part. Of course, when extracting a characteristic part, any section of the waveform can be used. It is also possible to use an index other than the cross-correlation coefficient or to combine a plurality of indexes.

Further, 3 which is the source of the X, Y, Z lead waveform
The electrocardiograph for recording the lead waveform is not limited to the Holter monitor, but may be obtained using an electrocardiograph capable of collecting a normal standard 12-lead waveform. Further, as long as the X, Y, and Z lead waveforms can be generated, a lead waveform other than the three-lead waveform described in the embodiment (including a lead waveform other than the eV lead waveform) may be used.

In the above-described embodiment, the formats for outputting the candidate waveforms of the 12-lead waveforms with the virtual electrode position fixed are shown as the output formats of the candidate waveforms as shown in FIGS. The type of the induction waveform may be fixed, and the candidate waveforms at each virtual electrode position may be output collectively.

[0063]

As described above, according to the present invention,
High-accuracy synthesis 12 in which individual differences and electrode position shifts are corrected.
An induced waveform can be obtained.

[Brief description of the drawings]

FIG. 1 is a diagram showing a configuration of a Holter electrocardiograph as an example of a biological information collecting apparatus according to an embodiment of the present invention and electrode connections thereof.

FIG. 2 is a block diagram illustrating a circuit configuration example of the Holter monitor shown in FIG. 1;

FIG. 3 is a diagram illustrating electrode positions when collecting lead waveform data using the Holter monitor shown in FIG. 1;

FIG. 4 is a block diagram illustrating a configuration example of a biological information processing apparatus according to an embodiment of the present invention.

FIG. 5 is a diagram illustrating examples of recorded eV1, eV5, and eVF induction waveforms.

FIG. 6 is a diagram showing an example of an X, Y, Z lead waveform obtained using the lead waveform of FIG. 5;

FIG. 7 is a diagram illustrating virtual electrode positions used for generating a candidate waveform in the embodiment of the present invention.

8 is a diagram showing a candidate waveform corresponding to virtual electrode position 1 in FIG.

9 is a diagram showing a candidate waveform corresponding to virtual electrode position 2 in FIG.

FIG. 10 is a diagram showing a candidate waveform corresponding to virtual electrode position 3 in FIG. 7;

11 is a diagram showing a candidate waveform corresponding to virtual electrode position 4 in FIG.

12 is a diagram showing a candidate waveform corresponding to a virtual electrode position 5 in FIG.

13 is a diagram showing a candidate waveform corresponding to a virtual electrode position 6 in FIG.

14 is a diagram showing a candidate waveform corresponding to virtual electrode position 7 in FIG.

FIG. 15 is a diagram showing candidate waveforms corresponding to virtual electrode positions 8 in FIG. 7;

16 is a diagram showing a candidate waveform corresponding to the virtual electrode position 9 in FIG.

FIG. 17 shows a standard 12 recorded as a reference waveform.
It is a figure showing an example of a guidance waveform.

FIG. 18: Synthesis 12 finally determined by the present invention
It is a figure showing an example of a guidance waveform.

FIG. 19 is a flowchart illustrating waveform synthesis and selection processing according to the embodiment of the present invention.

Claims (15)

[Claims] 1. A biological information collecting apparatus for recording biological information, comprising: at least three positive electrodes; one ground electrode; one negative electrode; each of said at least three positive electrodes; Recording means for recording data representing a potential difference from a negative electrode as the biological information. 2. An electromotive force vector waveform generating means for generating X, Y, and Z component waveforms of an electromotive force vector from predetermined three-lead waveforms and lead vectors corresponding to the three-lead waveforms, A waveform synthesizing means for synthesizing a plurality of candidate waveforms for each of the standard 12-lead waveforms using a predetermined lead vector corresponding to the lead waveform and the X, Y, Z component waveforms of the cardiac electromotive force vector; Using the previously stored reference waveform of the standard 12-lead waveform and the corresponding plurality of candidate waveforms, from the plurality of candidate waveforms, a candidate waveform determined to be closest to the reference waveform is used as the synthesized standard guide waveform. A biological information processing apparatus comprising: a determination unit configured to determine each of the reference waveforms. 3. The method according to claim 2, wherein the waveform synthesizing unit uses the plurality of lead vectors corresponding to a plurality of positions in a predetermined area including a virtual electrode position used for determining a lead vector corresponding to the standard 12 lead waveform. The biological information processing apparatus according to claim 2, wherein the candidate waveform is generated. 4. The correlation means for determining a cross-correlation coefficient between each of the reference waveform and each of the plurality of candidate waveforms, wherein the correlation means calculates a cross-phase relationship calculated by the correlation coefficient calculation means. The biological information processing apparatus according to claim 2, wherein the synthesized standard guide waveform is determined based on the number. 5. The method according to claim 5, wherein the determining unit includes a region extracting unit that extracts a predetermined characteristic region for each of the reference waveform and the plurality of candidate waveforms. 5. A cross-correlation coefficient for a region is calculated.
The biological information processing apparatus according to claim 1. 6. The region extracting unit extracts a plurality of characteristic regions for each of the reference waveform and the plurality of candidate waveforms, and the correlation coefficient calculating unit determines a mutual phase for each of the plurality of characteristic regions. The biological information processing apparatus according to claim 5, wherein a relation number is calculated. 7. A waveform livelihood means for shaping each of the plurality of candidate waveforms such that a maximum amplitude of a corresponding reference waveform and a maximum amplitude of the plurality of candidate waveforms are equal to each other. The biological information processing apparatus according to claim 2. 8. The biological information processing apparatus according to claim 2, wherein the predetermined three-lead waveform is an eV lead waveform. 9. An electromotive force vector waveform generating step of generating X, Y, Z component waveforms of an electromotive force vector from a predetermined three-lead waveform and a lead vector corresponding to the three-lead waveform, A waveform synthesizing step of synthesizing a plurality of candidate waveforms for each of the standard 12-lead waveforms using a predetermined lead vector corresponding to the lead waveform and an X, Y, Z component waveform of the cardiac electromotive force vector; Using the previously stored reference waveform of the standard 12-lead waveform and the corresponding plurality of candidate waveforms, from the plurality of candidate waveforms, a candidate waveform determined to be closest to the reference waveform is used as the synthesized standard guide waveform. A determining step of determining each of the reference waveforms. 10. The plurality of lead vectors corresponding to a plurality of positions in a predetermined area including a virtual electrode position used for determining a lead vector corresponding to the standard 12 lead waveform in the waveform synthesizing step. The biological information processing method according to claim 9, wherein the candidate waveform is generated. 11. The determining step includes a correlation coefficient calculating step of obtaining a cross-correlation coefficient with each of the reference waveform and the plurality of candidate waveforms, and the cross-phase relationship calculated by the correlation coefficient calculating step is provided. The biological information processing method according to claim 9, wherein the determination of the synthesized standard guide waveform is performed based on the number. 12. The method according to claim 12, wherein the determining step includes a region extracting step of extracting a predetermined characteristic region with respect to each of the reference waveform and the plurality of candidate waveforms. 13. The biological information processing method according to claim 12, wherein a cross-correlation coefficient for the region is calculated. 13. The region extracting step extracts a plurality of characteristic regions for each of the reference waveform and the plurality of candidate waveforms, and the correlation coefficient calculating step includes a step of calculating a mutual phase for each of the plurality of characteristic regions. 13. The biological information processing method according to claim 12, wherein a relation number is calculated. 14. Each of the plurality of candidate waveforms
2. The waveform livelihood step of shaping the waveform so that the maximum amplitude of the corresponding reference waveform is equal to the maximum amplitude of the plurality of candidate waveforms.
4. The biological information processing method according to any one of 3. 15. The biological information processing method according to claim 9, wherein the predetermined three-lead waveform is an eV lead waveform.