JP2002121129A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin care preparation having excellent touch of use without deteriorating bleaching effects in the skin care preparation comprising L-ascorbic acid and its derivative, a hydroquinone glycoside and its derivative and kojic acid and its derivative. SOLUTION: This skin care preparation comprises an oil which is a liquid at 25 deg.C and dissolving 1-15 wt.% thereof in water at 25 deg.C and dissolving >=5 wt.% thereof in glyceryl 2-ethylhexanoate at 25 deg.C and one or more kinds selected from the group consisting of L-ascorbic acid or its derivative, a hydroquinone glycoside or its derivative and kojic acid or its derivative.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an external preparation for skin. More specifically, the present invention relates to a skin whitening external preparation excellent in use feel.

[0002]

2. Description of the Related Art The mechanism of the occurrence of skin spots and the like is unknown, but in general, melanin pigments are formed due to abnormal hormones and the stimulation of ultraviolet rays from sunlight.
It is believed that this is abnormally deposited in the skin.

[0003] In order to improve such stains and bruises, a substance that suppresses the production of melanin, for example, JP-A-9-263
No. 514 discloses a method of blending L-ascorbic acid and its derivatives, glycosides of hydroquinone and its derivatives, and kojic acid and its derivatives with cosmetics.

[0004]

However, although the above-mentioned method has an excellent whitening effect and an effect of improving skin roughness, it tends to give a sticky feeling in use and a feeling of smoothness when applied to the skin. There is a problem in usability for such reasons as not being able to be used, and there is a problem to be solved that would be avoided from consumers.

The present inventors have conducted intensive studies in view of the above-mentioned problems, and as a result, have found that a skin external preparation containing L-ascorbic acid and its derivatives, hydroquinone glycoside and its derivatives, or kojic acid and its derivatives. It has been found that, when a specific oil component is blended, an external preparation for skin which is excellent in the feel in use, particularly excellent in smoothness and has no sticky feeling can be obtained without impairing the whitening effect, and has completed the present invention.

An object of the present invention is to provide a skin preparation for external use containing L-ascorbic acid and its derivatives, glycosides of hydroquinone and its derivatives, or kojic acid and its derivatives without impairing the whitening effect. An object of the present invention is to provide an excellent external preparation for skin.

[0007]

That is, the present invention provides a method of
A liquid oil at 25 ° C. which is dissolved in water at 5 ° C. in an amount of 1 to 15% by weight in water and 5% by weight or more in glyceryl tri-2-ethylhexanoate, and L-ascorbic acid or a derivative thereof;
An object of the present invention is to provide a skin external preparation containing one or two or more selected from the group consisting of hydroquinone glycosides or derivatives thereof, kojic acid or derivatives thereof.

In the present invention, the oil component may be a polyoxyethylene fatty acid polyhydric alcohol ester, a polyoxyethylene alkyl polyhydric alcohol ether, a dialkyl dipolyoxyethylene alkylene ether, a polyoxyethylene dialkyl ester, or a polyoxyethylene dialkyl ether. And at least one oil component selected from the group consisting of:

Further, in the present invention, the polyoxyethylene fatty acid polyhydric alcohol ester is a polyoxyethylene fatty acid glycerin represented by the following chemical formula (1), and the polyoxyethylene alkyl polyhydric alcohol ether is represented by the following chemical formula (2) Wherein the dialkyldipolyoxyethylene alkylene ether is a dialkyldipolyoxyethylene alkylene ether represented by the following chemical formula (3), and the polyoxyethylene dialkyl ester is a polyoxyethylene dialkyl ester represented by the following chemical formula (4) ), Wherein the polyoxyethylene dialkyl ether is a polyoxyethylene dialkyl ether represented by the following chemical formula (5): It is intended to provide.

Embedded image (1) (In the formula, R1, R2, and R3 are hydrogen or an alkyl or branched alkyl group having 1 to 9 carbon atoms, l, m, and n are 0 to 5 and the total represents an integer of 3 to 15.)

Embedded image (2) (wherein, R1, R2, and R3 are hydrogen or carbon atoms having 1 to 10
Alkyl or branched alkyl groups of l, m and n are from 0 to 8
And the sum represents an integer of 9 to 21. )

Embedded image (3) (wherein, R 1 and R 2 are hydrogen or an alkyl or branched alkyl group having 1 to 4 carbon atoms, m and n are 0 to 8 and the total is an integer of 4 to 10, and X is an integer of 1 to 4 Represents.)

Embedded image (4) (wherein, R1 and R2 represent hydrogen or an alkyl or branched alkyl group having 1 to 7 carbon atoms, and n represents an integer of 3 to 20.)

Embedded image (5) (wherein, R1 and R2 represent hydrogen or an alkyl or branched alkyl group having 1 to 4 carbon atoms, and n represents an integer of 6 to 23.)

[0010] The present invention also relates to the present invention, wherein the oil component is a polyhydric alcohol ester, diethoxy polyoxyethyl dihydric carboxylate, ditertiary alkyl ester of dihydric carboxylic acid,
Dineopentyl dicarboxylic acid, polyhydric alcohol ester of carboxylic acid, alcohol ester of divalent carboxylic acid, 3
It is intended to provide the above-mentioned external preparation for skin, characterized in that it is one or more oils selected from the group consisting of polyhydric carboxylic acid alcohol esters and tetracarboxylic acid pentaerythritol.

Further, in the present invention, the polyhydric alcohol ester is represented by the following chemical formula (6), and the dihydric carboxylic acid diethoxypolyoxyethyl is represented by the following chemical formula (7).
The divalent alkyl carboxylic acid ester is represented by the following chemical formula (8), the dicarboxylic acid dineopentyl is represented by the following chemical formula (9), and the carboxylic acid polyhydric alcohol ester is represented by the following chemical formula (10). The ester is represented by the following chemical formula (11), the trihydric carboxylic acid alcohol ester is represented by the following chemical formula (12), and the tetracarboxylic acid pentaerythritol is represented by the following chemical formula (1)
The present invention provides the above-mentioned skin external preparation represented by 3).

Embedded image (6) (where n = 1 to 3, R1, R2, and R3 each have 2 to 5 carbon atoms)
Represents a monocarboxylic acid, hydroxymonocarboxylic acid, or oxymonocarboxylic acid residue, and R4 represents hydrogen or a hydroxyl group. )

Embedded image (7) (wherein, R is a dicarboxylic acid, hydroxydicarboxylic acid, or oxydicarboxylic acid residue having 2 to 6 carbon atoms, x and y are from 0 to 2, and the sum of x and y represents an integer of 4 or less. )

Embedded image (8) (wherein, R is a dicarboxylic acid having 2 to 6 carbon atoms, hydroxydicarboxylic acid, oxydicarboxylic acid residue, and m and n are 0 to 0)
In 1, the sum of m and n represents an integer of 2 or less. )

Embedded image (9) (wherein, R represents a dicarboxylic acid, hydroxydicarboxylic acid, or oxydicarboxylic acid residue having 2 to 6 carbon atoms.)

Embedded image (10) (wherein, R1 and R3 are monocarboxylic acids having 2 to 5 carbon atoms,
Hydroxymonocarboxylic acid, oxymonocarboxylic acid residue residue, R2 is a dihydric or trihydric alcohol residue having 2 to 6 carbon atoms and may have a hydroxyl group in the molecule. )

Embedded image (11) (wherein, R1 and R3 are an alcohol having 2 to 5 carbon atoms and an ethoxyethanol or ethyl carbitol residue;
2 represents a dicarboxylic acid, hydroxydicarboxylic acid or oxydicarboxylic acid residue having 2 to 6 carbon atoms. )

Embedded image (12) (wherein, R1, R3, and R4 are linear or branched alcohols having 2 to 5 carbon atoms and may have an ether group in the molecule. R2 is a tricarboxylic acid having 2 to 5 carbon atoms.) , A hydroxytricarboxylic acid or an oxytricarboxylic acid residue.)

Embedded image (13) (In the formula, R1, R2, R3, and R4 represent a monocarboxylic acid, hydroxymonocarboxylic acid, or oxymonocarboxylic acid residue residue having 2 to 5 carbon atoms.)

Further, the present invention provides the above-mentioned external preparation for skin, which further contains a humectant.

Further, the present invention provides the above-mentioned skin external preparation, wherein the skin external preparation is a whitening skin external preparation.

[0014]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

The oil used in the present invention is a water-soluble oil which is liquid at 25 ° C. It must be soluble in water from 1 to 15% by weight and in glyceryl tri-2-ethylhexanoate at least 5% by weight.
If it is solid at 25 ° C., the intended feeling of use cannot be obtained. In addition, dissolution exceeding 15% by weight in water
5% by weight based on glyceryl tri-2-ethylhexanoate
If the oil content is less than less, the lipophilicity is poor and the feeling of use, especially the smooth feeling, is lost.

Preferably, the oil component satisfying the above conditions is polyoxyethylene fatty acid polyhydric alcohol ester, polyoxyethylene alkyl polyhydric alcohol ether, dialkyl dipolyoxyethylene alkylene ether, polyoxyethylene dialkyl ester, polyoxyethylene dialkyl. Ethers.

More preferably, the fatty acid polyhydric alcohol ester is a polyoxyethylene fatty acid glycerin represented by the above chemical formula (1). Specifically, polyoxyethylene (9 mol) glyceryl propionate, polyoxyethylene ( 6 mol) glycerin caproate, polyoxyethylene (15 mol) glycerin caprylate,
And polyoxyethylene (9 mol) glyceryl caprate.

Further, the polyoxyethylene alkyl polyhydric alcohol ether is a polyoxyethylene glyceryl alkyl ether represented by the above chemical formula (2), and specifically, polyoxyethylene (9 mol) glyceryl methyl ether, polyoxyethylene (9 mol) Ethylene (12 mol) glyceryl ethyl ether, polyoxyethylene (15 mol) propyl ether, polyoxyethylene (18 mol) butyl ether, polyoxyethylene (21 mol)
Hexyl ether, polyoxyethylene (12 mol) glyceryl octyl ether and the like can be mentioned.

Further, the dialkyldipolyoxyethylene alkylene ether is a dialkyldipolyoxyethylene alkylene ether represented by the chemical formula (3), and specifically, dimethyldipolyoxyethylene (4 mol) ethylene ether, diethyl ether Examples thereof include dipolyoxyethylene (6 mol) propylene ether, dipropylene dipolyoxyethylene (8 mol) butylene ether, and dibutyldipolyoxyethylene (10 mol) ethylene ether.

The polyoxyethylene dialkyl ester is a polyoxyethylene dialkyl ester represented by the chemical formula (4). Specifically, polyoxyethylene (5 mol) dipropionate, polyoxyethylene (10 Mol) dicaproic acid ester and the like.

The polyoxyethylene dialkyl ether is a polyoxyethylene dialkyl ether represented by the above chemical formula (5), specifically, polyoxyethylene (6 mol) methyl ether, polyoxyethylene (10 mol) Examples include ethyl ether, polyoxyethylene (12 mol) propyl ether, and polyoxyethylene (8 mol) butyl ether.

Preferably, the oil component satisfying the above conditions is a polyhydric alcohol ester, diethoxypolyoxyethyl dihydric carboxylate, dialkyl alkyl carboxylic acid, dineopentyl divalent carboxylate, polyhydric alcohol carboxylic acid ester. And dihydric carboxylic acid alcohol esters, trivalent carboxylic acid alcohol esters, and tetracarboxylic acid pentaerythritol.

More preferably, the polyhydric alcohol ester is represented by the above chemical formula (6), and specific examples include triacetin, glyceryl tripropionate, glyceryl triacetate, and glyceryl tributyrate.

The above-mentioned diethoxypolyoxyethyl dicarboxylate is represented by the above chemical formula (7), and specifically, diethoxypolyoxyethyl glutarate, diethoxypolyoxyethyl adipate, diethoxy tartrate. And polyethoxyethyl glutaric acid diethoxypolyoxyethyl.

Furthermore, the divalent carboxylic acid di-tert-alkyl ester is represented by the above-mentioned chemical formula (8), and specifically, di-t-butyl succinate, di-t-butyl glutarate, di-t-butyl adipate , Di-tert-butyl pimerate,
Examples include di-t-butyl suberate and di-t-butyl tartrate.

The divalent pentyl dicarboxylate is represented by the above chemical formula (9), and specifically includes dineopentyl succinate, dineopentyl glutarate, dineopentyl adipate, dineopentyl pimerate, dineopentyl suberate, dineopentyl tartrate and the like. Is mentioned.

The carboxylic acid polyhydric alcohol ester is represented by the above chemical formula (10). Specifically, diethylene glycol propanoate, propylene glycol propanoate, dibutylene glycol propanoate, diethylene glycol butanoate, diethylene butanoate, Examples thereof include propylene glycol, dibutylene glycol butyrate, diethylene glycol dilevulinate, dipropylene glycol dilevulinate, and dibutylene glycol diblenate.

The dihydric carboxylic acid alcohol ester is represented by the above chemical formula (11). Specifically, diethylene glycol succinate, dipropylene glycol succinate, dibutylene succinate, diethylene glycol glutarate, glutaric acid Dipropylene glycol, dibutylene glycol glutarate, diethylene glycol adipate, dipropylene glycol adipate, dibutylene adipate, diethylene glycol pimerate, dipropylene glycol pimerate, dibutylene glycol pimerate, diethylene glycol suberate, dipropylene suberate Glycol, dibutylene suberate, diethylene glycol tartrate, dipropylene glycol tartrate, dibutylene glycol tartrate And the like.

The trivalent carboxylic acid alcohol ester is represented by the above chemical formula (12), and specific examples include triethyl citrate, tripropyl citrate, and tributyl citrate.

Further, the pentaerythritol tetracarboxylate is represented by the above chemical formula (13), and pentaerythrit tetra-2-ethylhexanoate, pentaerythrit tetrahydroxyethaneanoate, pentaerythrit tetrahydroxypropanoate, Pentaerythritol hydroxybutanoate and the like.

The amount of the oil component is not particularly limited, but is preferably 0.001 to 20.0 with respect to the total amount of the external preparation for skin.
%, More preferably 0.1 to 10.0% by weight. When the amount is less than 0.001% by weight, the effect of the present invention is small, and when the amount exceeds 20.0% by weight, stickiness is felt after use.

L-ascorbic acid used in the present invention is generally referred to as vitamin C, and due to its strong reducing action, has a cell respiratory action, an enzyme activating action, a collagen-forming action and a melanin reducing action. Examples of the L-ascorbic acid derivative include L-ascorbic acid alkyl ester,
Examples include L-ascorbic acid phosphate, L-ascorbic acid sulfate, and the like. Specific examples thereof include L-ascorbyl palmitate, L-ascorbyl isopalmitate, L-ascorbyl dipalmitate, and L-ascorbyl acid. Ascorbyl, L-ascorbyl stearate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate, L-ascorbyl myristate, L-ascorbyl isomyristate, L-ascorbyl dimyristate, diisomyristate L-ascorbic acid alkyl ethers such as L-ascorbyl, L-ascorbyl 2-ethylhexanoate, L-ascorbyl di-2-ethylhexanoate, L-ascorbyl oleate and L-ascorbyl dioleate; Ascorbic acid-2-phosphate, L- ascorbic acid 3-phosphate ester, DL-
L-ascorbic acid phosphates such as α-tocophenol-2-L-ascorbic acid phosphate diester;
L-ascorbic acid sulfates such as ascorbic acid-2-sulfate and L-ascorbic acid-3-sulfate are exemplified. These salts can also be used, and alkali metal salts such as sodium salt and potassium salt, and alkaline earth metal salts such as calcium salt and magnesium salt are preferably used. The above-mentioned L-ascorbic acid or a derivative thereof is mainly obtained by known synthetic means, but it is needless to say that those obtained by other methods can also be used. It is possible.

The kojic acid derivative used in the present invention includes:
For example, kojic acid esters such as kojic acid alkyl ester and kojic acid ethers such as kojic acid alkyl ether can be exemplified.

The hydroquinone glycoside used in the present invention includes, for example, hydroquinone α-D-glucose,
Hydroquinone β-D-glucose, hydroquinone α
Hexacarbon sugar glycosides such as L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, hydroquinone α -D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-
Ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D-
Arabinose, hydroquinone α-L-arabinose,
Pentose glycosides such as hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L-glucosamine, hydroquinone α-D-galactosamine, Amino acid glycosides such as hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D-glucuronic acid, hydroquinone α-L-glucuronic acid , Hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid,
Examples thereof include uronic acid glycosides such as hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, and hydroquinone β-L-galacturonic acid, and derivatives thereof, such as acetylated esters and methylated products. And the like. Of these, use of hydroquinone β-D-glucose is preferred from the viewpoints of whitening effect, availability, and stability.

The above-mentioned L-ascorbic acid and its derivatives, hydroquinone glycosides and its derivatives, and kojic acid and its derivatives may be any one or two or more kinds, and the amount thereof is not particularly limited. Is 0.001 to 15.0% by mass, more preferably 0.1% by mass of the total amount of the external preparation for skin.
110.0% by mass.

In the present invention, it is preferable to further add a humectant. Examples of humectants include polyethylene glycol, propylene glycol, glycerin, 1,
3-butylene glycol, xylitol, sorbitol,
Maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate,
Examples include bile salts, dl-pyrrolidone carboxylate, short-chain soluble collagen, adducts of diglycerin (EO) PO, extract of radish, extract of Achillea millefolium, and extract of melilot.

The amount of the humectant is not particularly limited, but is preferably 0.001 to 20.0% by mass, more preferably 0.1 to 10.0% by mass, based on the total amount of the external preparation for skin.

The external preparation for skin of the present invention is prepared by mixing the above essential components with the existing base for external preparation for skin.
In addition to the essential components described above, the skin external preparation of the present invention usually contains other components used in skin external preparations such as cosmetics and quasi-drugs, for example, powder components, liquid oils and fats, solid oils and fats, waxes,
Hydrocarbons, higher fatty acids, higher alcohols, esters, silicones, anionic surfactants, cationic surfactants,
Amphoteric surfactant, nonionic surfactant, humectant, water-soluble polymer, thickener, coating agent, ultraviolet absorber, sequestering agent, lower alcohol, polyhydric alcohol, sugar, amino acid, organic amine, high Molecular emulsion, pH adjuster, skin nutrition, vitamin, antioxidant, antioxidant aid, fragrance,
Water and the like can be appropriately compounded as necessary, and can be produced by a conventional method according to the intended dosage form. Specific compoundable components are listed below. The external preparation for skin of the present invention can be prepared by mixing the above-mentioned essential components and any one or more of the following components.

As the powder component, for example, inorganic powders (for example, talc, kaolin, mica, sericite (sericite),
Muscovite, phlogopite, synthetic mica, rhombite, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, Silica, zeolite, barium sulfate, calcined calcium sulfate (baked gypsum), calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, metal soap (eg, zinc myristate, calcium palmitate, aluminum stearate), boron nitride, etc .; organic Powders (eg, polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene Powders, cellulose powders, etc.); inorganic white pigments (eg, titanium dioxide, zinc oxide, etc.); inorganic red pigments (eg, iron oxide (iron oxide), iron titanate, etc.); inorganic brown pigments (eg, γ-oxidized) Inorganic yellow pigments (eg, yellow iron oxide, loess, etc.); inorganic black pigments (eg, black iron oxide, lower titanium oxide, etc.); inorganic purple pigments (eg, mango violet, cobalt violet, etc.) ); Inorganic green pigments (for example, chromium oxide,
Chromium hydroxide, cobalt titanate, etc .; inorganic blue pigments (eg, ultramarine, navy blue, etc.); pearl pigments (eg, titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica) , Bismuth oxychloride, fish scale foil, etc.); metal powder pigments (eg, aluminum powder,
Organic pigments such as zirconium, barium or aluminum lake (for example, red 201)
No., Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405
Organic pigments such as No. 203, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401 and Blue No. 404;
No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange 205
No. 4, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203
, Green No. 3 and blue No. 1); natural pigments (eg, chlorophyll, β-carotene, etc.).

Examples of liquid fats and oils include avocado oil,
Camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, eno oil, Examples include soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, sinagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin and the like.

Examples of solid fats and oils include cocoa butter, coconut oil, horse fat, hardened coconut oil, palm oil, tallow, sheep fat, hardened tallow, palm kernel oil, lard, beef bone oil, mokuro kernel oil, hardened kernel oil Oil, beef tallow, mocro, hardened castor oil and the like.

Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin,
Sugarcane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, etc. Can be

Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax and the like.

The higher fatty acids include, for example, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, tallic acid, isostearic acid, linoleic acid, linoleic acid, eicosapentaenoic acid (EPA), Docosahexaenoic acid (DHA)
And the like.

Examples of the higher alcohol include straight-chain alcohols (eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, etc.); and branched-chain alcohols (eg, monostearyl glycerin ether). (Bacyl alcohol), 2-
Decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldecanol,
Isostearyl alcohol, octyl dodecanol, etc.)
And the like.

As synthetic ester oils, isopropyl myristate, cetyl octoate, octyl dodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate,
Decyl oleate, hexyl decyl dimethyl octoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, 12
-Cholesteryl hydroxystearate, ethylene glycol di-2-ethylhexanoate, fatty acid ester of dipentaerythritol, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate , Trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate,
Pentaerythritol tetra-2-ethylhexanoate, glycerin tri-2-ethylhexanoate, glycerin trioctanoate, glycerin triisopalmitate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, Glycerin trimyristate, glyceride tri-2-heptylundecanoate, methyl ester of castor oil fatty acid, oleyl oleate, acetoglyceride, palmitate 2-
Heptylundecyl, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester,
Di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-myristate
Hexyldecyl, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate,
2-ethylhexyl succinate, triethyl citrate and the like can be mentioned.

Examples of the silicone oil include linear polysiloxanes (eg, dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, etc.); cyclic polysiloxanes (eg, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, Dodecamethylcyclohexasiloxane, etc.) Silicone resin, silicone rubber, and various modified polysiloxanes forming a three-dimensional network structure (amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc.) And the like.

Examples of the anionic surfactant include fatty acid soaps (eg, sodium laurate, sodium palmitate, etc.); higher alkyl sulfates (eg, sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (For example,
POE-triethanolamine lauryl sulfate, POE-sodium lauryl sulfate, etc.); N-acyl sarcosine acids (for example,
Higher fatty acid amide sulfonates (eg, sodium N-myristoyl-N-methyltaurine, sodium coconut fatty acid methyltauride, sodium laurylmethyltauride, etc.); phosphate ester salts (POE-oleyl ether) Sodium phosphate, POE-stearyl ether phosphoric acid, etc.); sulfosuccinates (eg, sodium di-2-ethylhexylsulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.);
Alkylbenzene sulfonates (eg, sodium linear dodecylbenzenesulfonate, triethanolamine linear dodecylbenzenesulfonate, linear dodecylbenzenesulfonic acid, etc.); higher fatty acid ester sulfates (eg, hydrogenated coconut oil fatty acid sodium glycerin sulfate, etc.); N-acylglutamate (for example, monosodium N-lauroylglutamate, disodium N-stearoylglutamate, monosodium N-myristoyl-L-glutamate), sulfated oil (for example, funnel oil), and POE-alkyl ether carboxylic acid Acid; POE-alkyl allyl ether carboxylate; α-olefin sulfonate; higher fatty acid ester sulfonate; secondary alcohol sulfate; salt of higher fatty acid alkylolamide sulfate; lauroyl mono Sodium ethanolamidosuccinate; N-palmitoyl aspartate ditriethanolamine; sodium caseinate;

Examples of the cationic surfactant include an alkyltrimethylammonium salt (eg, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride); and an alkylpyridinium salt (eg,
Cetylpyridinium chloride, etc.); distearyldimethylammonium dialkyldimethylammonium chloride; poly (N, N'-dimethyl-3,5-methylenepiperidinium chloride);
Alkyl quaternary ammonium salts; alkyl dimethyl benzyl ammonium salts; alkyl isoquinolinium salts; dialkyl morphonium salts; POE-alkylamines; alkyl amine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride; benzethonium chloride And the like.

Examples of the amphoteric surfactant include imidazoline amphoteric surfactants (eg, 2-undecyl-N, N, N
-(Hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc .; betaine surfactants (eg, 2-heptadecyl-N- Carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryl dimethylaminoacetic acid betaine, alkyl betaine, amido betaine, sulfo betaine, etc.).

Examples of the lipophilic nonionic surfactant include sorbitan fatty acid esters (eg, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan monostearate) Oleate, sorbitan trioleate, diglycerol penta-2-ethylhexylate sorbitan, diglycerol sorbitan tetra-2-ethylhexylate, etc .; glycerin polyglycerin fatty acids (for example, mono-cottonseed oil fatty acid glycerin, glycerin monoerucate, glycerin sesquioleate , Glyceryl monostearate, α, α '
-Glycerin pyroglutamate oleate, glycerin malate monostearate, etc.); propylene glycol fatty acid esters (eg, propylene glycol monostearate); hydrogenated castor oil derivatives; glycerin alkyl ether;

Examples of the hydrophilic nonionic surfactant include POE-sorbitan fatty acid esters (for example, POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate). POE sorbit fatty acid esters (eg, POE-sorbit monolaurate, POE-sorbit monooleate, POE-sorbit pentaoleate, POE-sorbit monostearate, etc.); POE-glycerin fatty acid esters (eg, POE-glycerin monostearate, POE-glycerin monoisostearate, PO
POE-monooleate such as E-glycerin triisostearate); POE-fatty acid esters (eg, POE-distearate, POE-monodioleate, ethylene glycol distearate, etc.); POE-alkyl ethers (eg, POE-lauryl ether) , POE-oleyl ether, PO
E-stearyl ether, POE-behenyl ether, POE-2-
Octyldodecyl ether, POE-cholestanol ether, etc.); Pluronic type (eg, Pluronic etc.); POE.POP-alkyl ethers (eg, POE.PO)
P-cetyl ether, POE / POP-2-decyltetradecyl ether, POE / POP-monobutyl ether, POE / POP-hydrogenated lanolin, POE / POP-glycerin ether, etc.); Tetra P
OE.tetra-POP-ethylenediamine condensates (eg, tetronic); POE-castor oil-hardened castor oil derivatives (eg, POE-castor oil, POE-hardened castor oil, POE-hardened castor oil monoisostearate, POE) -Hydrogenated castor oil triisostearate, POE-hydrogenated castor oil monopyroglutamic acid monoisostearate diester, POE-hydrogenated castor oil maleic acid, etc.); POE-beeswax lanolin derivative (eg, POE-sorbit beeswax, etc.); alkanolamide (For example, coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE-propylene glycol fatty acid ester; PO
E-alkylamine; POE-fatty acid amide; sucrose fatty acid ester; alkylethoxydimethylamine oxide; trioleyl phosphoric acid and the like.

Examples of natural water-soluble polymers include, for example, vegetable polymers (eg, gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), alge colloid (cassow extract) ), Starch (rice, corn, potato, wheat), glycyrrhizic acid); microbial polymers (eg, xanthan gum, dextran, succinoglucan, burlan, etc.); animal polymers (eg, collagen, casein,
Albumin, gelatin, etc.).

As the semi-synthetic water-soluble polymer, for example,
Starch-based polymers (for example, carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose-based polymers (methylcellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, Crystalline cellulose,
Alginic acid-based polymers (eg, sodium alginate, propylene glycol alginate, etc.);

Examples of the synthetic water-soluble polymer include vinyl polymers (eg, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer, etc.); polyoxyethylene polymers (eg, polyethylene glycol 20,000, 40,000, 6
Acrylic polymers (for example, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.); polyethylene imine; cationic polymers, and the like.

As the thickener, for example, gum arabic,
Carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose,
CMC, hydroxyethylcellulose, hydroxypropylcellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium cellulose sulfate, xanthan gum, aluminum magnesium silicate, bentonite,
Hectorite, silicic acid A1Mg (bee gum), laponite, silicic anhydride and the like.

As the ultraviolet absorber, for example, benzoic acid-based ultraviolet absorbers (for example, para-aminobenzoic acid (hereinafter referred to as P
ABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N- Dimethyl PABA ethyl ester, etc.); anthranilic acid type ultraviolet absorbers (eg, homomenthyl-N-acetylanthranilate); salicylic acid type ultraviolet absorbers (eg, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate) Benzyl salicylate, p-isopropanol phenyl salicylate, etc.); cinnamic acid ultraviolet absorbers (eg, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-
2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate Mate, octyl-p-methoxycinnamate
(2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-
p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, etc.); benzophenone UV absorbers (for example, 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4 ′ -Tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-
Methoxy-4'-methylbenzophenone, 2-hydroxy-4-
Methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone Etc.); 3- (4'-methylbenzylidene) -d, l-
Camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-
Methylphenylbenzotriazole; 2- (2'-hydroxy
-5'-t-octylphenyl) benzotriazole; 2- (2'-
Hydroxy-5'-methylphenylbenzotriazole;dibenzalazine;dianisoylmethane;4-methoxy-4'-t-
Butyldibenzoylmethane; 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one;

Examples of sequestering agents include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, edetate Tetrasodium acid, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid,
Ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyltriacetate and the like.

Examples of the lower alcohol include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.

Examples of the polyhydric alcohol include dihydric alcohols (eg, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3- Butylene glycol, pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, octylene glycol, etc.); trihydric alcohols (eg, glycerin, trimethylolpropane, etc.);
Tetrahydric alcohols (eg, pentaerythritol such as 1,2,6-hexanetriol); pentahydric alcohols (eg, xylitol); hexahydric alcohols (eg, sorbitol, mannitol); polyhydric alcohol polymers (eg, Diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycerin, polyglycerin, etc.); dihydric alcohol alkyl ethers (eg, ethylene glycol monomethyl ether, Ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol Coal mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, etc.); dihydric alcohol alkyl ethers (eg, diethylene glycol monomethyl) Ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, pro Pyrene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether,
Dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol butyl ether, etc .; dihydric alcohol ether esters (eg, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl) Ether acetate, ethylene glycol diazibate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate , Propylene glycol monophenyl ether acetate); glycerol monoalkyl ethers (e.g., hexyl alcohol, selachyl alcohol, batyl alcohol); sugar alcohols (e.g.,
Sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, starch-degrading sugar, maltose, xylitol, starch-degrading sugar reducing alcohol, etc.); glysolid; tetrahydrofurfuryl alcohol; POE-tetrahydrofur Furyl alcohol; POP-butyl ether; POP / POE-butyl ether; Tripolyoxypropylene glycerin ether; POP-glycerin ether; P
OP-glycerin ether phosphate; POP / POE-pentaneerythritol ether, polyglycerin and the like.

As the monosaccharide, for example, tricarbonate (for example,
D-glyceryl aldehyde, dihydroxyacetone, etc.);
Tetracarbons (eg, D-erythrose, D-erythrulose,
Pentose (eg, D-threose, erythritol, etc.)
L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L-xylulose, etc.); hexose (eg, D-glucose, D-talose, D- Bucose, D-galactose, D-fructose, L-galactose, L-mannose, D-tagatose, etc.); heptose sugars (eg, aldheptose, heptrose etc.); octose sugars (eg, octulose etc.); deoxy sugars (eg, , 2-deoxy-D-ribose, 6-deoxy-L-
Galactose, 6-deoxy-L-mannose, etc.); amino sugars (eg, D-glucosamine, D-galactosamine, sialic acid, aminouronic acid, muramic acid, etc.); uronic acids (eg, D-glucuronic acid, D-mannuronic acid) , L-guluronic acid, D-galacturonic acid, L-iduronic acid, etc.).

Examples of the oligosaccharide include sucrose, guntianose, umbelliferose, lactose, planteose, isoliqunoses, α, α-trehalose,
Raffinose, liqunoses, umbilicin, stachyose bell bath courses and the like.

Examples of the polysaccharide include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guar gum, dextran Keratosulfuric acid, locust bingham, succinoglucan, caronic acid and the like.

Examples of the amino acids include neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.). Examples of the amino acid derivative include acyl sarcosine sodium (sodium lauroyl sarcosine), acyl glutamate, sodium acyl β-alanine, glutathione, and pyrrolidone carboxylic acid.

Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1 -Propanol and the like.

Examples of the polymer emulsion include an acrylic resin emulsion, a polyethyl acrylate emulsion, an acrylic resin solution, a polyacryl alkyl ester emulsion, a polyvinyl acetate resin emulsion,
Natural rubber latex and the like.

Examples of the pH adjusting agent include lactic acid-sodium lactate, citric acid-sodium citrate, succinic acid-
Buffers such as sodium succinate and the like can be mentioned.

Examples of the vitamins include vitamins A, B1, B2, B6, E and derivatives thereof, pantothenic acid and derivatives thereof, and biotin.

Examples of the antioxidant include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic esters and the like.

As the antioxidant aid, for example, phosphoric acid,
Examples thereof include citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.

Other compoundable components include, for example,
Antiseptics (eg, glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.); whitening agents (eg, placenta extracts,
Various extracts (for example, oak, spinach, shikon, peonies, assembly, birch, sage, loquat, carrot, aloe, mallow, iris, grape, yokinin, loofah, lily, saffron, senkyu, showkyu) , Hypericum, ononis, garlic, capsicum, chimpanzee, touki, seaweed, etc., activators (eg, royal jelly, photosensitizers, cholesterol derivatives, etc.); blood circulation promoters (eg, nonylate warenylamide, nicotinic acid benzyl ester, nicotinic acid β) -Butoxyethyl ester, capsaicin, gingerone, canthari tincture, itactamol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandate, cinnarizine, trazoline, acetyl Anticholinergic agents (eg, sulfur, thiantol, etc.); anti-inflammatory agents (eg, tranexamic acid, thiotaurine, hypotaurine, etc.)
And the like.

The dosage form of the external preparation for skin of the present invention is arbitrary,
Any dosage form such as a solution system, a solubilizing system, an emulsifying system, a powder dispersing system, a water-oil two-layer system, a water-oil-powder three-layer system may be used. In addition, the product form of the present invention is also arbitrary, and can be used, for example, in lotions, emulsions, creams, packs, foundations, ointments, and the like, and is particularly useful as a skin whitening external preparation.

[0073]

Next, the present invention will be described more specifically with reference to examples. The present invention is not limited by this. The compounding amount is% by weight. First, the evaluation method employed in each of the examples and comparative examples will be described.

For the liquid oil used in the examples, water and 2
The solubility of glyceryl ethylhexanoate was confirmed as follows. “Solubility test” A sample mixed and stirred at room temperature (25 ° C.) was filled in a 50 ml sample tube (glass bottle), and the solubility (appearance) was visually confirmed to evaluate the solubility. ：: dissolves (clear) ×: does not dissolve (turbidity or oil droplets are observed)

[Good Skin Familiarity] An actual use test was conducted by ten expert panelists on good skin familiarity during use. The evaluation criteria are as follows. ◎: Eight or more specialized panelists recognized that the skin had good adaptation to the skin during use. …: Six or more and less than eight specialized panelists recognized that the familiarity with the skin during use was good. Δ: 3 or more and less than 6 specialized panelists recognized that the skin was well adapted to the skin during use. X: Less than 3 professional panelists recognized that the adaptation to the skin during use was good.

[Smoothness of Skin] The actual use test was carried out by 10 specialized panelists on the smoothness of the skin during and after use. The evaluation criteria are as follows. A: Eight or more specialized panelists recognized that the skin was smooth during and after use. …: 6 or more and less than 8 specialized panelists recognized that the skin was smooth during and after use. Δ: Three or more and less than six professional panelists recognized that the skin was smooth during and after use. ×: Less than 3 professional panelists recognized that the skin was smooth during and after use.

"Non-stickiness to skin" A practical use test was conducted by ten expert panelists on non-stickiness to skin during and after use. The evaluation criteria are as follows. A: Eight or more specialized panelists recognized that there was no stickiness to the skin during and after use. …: Six or more and less than eight specialized panelists recognized that there was no stickiness to the skin during and after use. Δ: Three or more and less than six professional panelists recognized that there was no stickiness to the skin during and after use. ×: Less than 3 professional panelists recognized that there was no stickiness to the skin during and after use.

"Whitening effect test by accumulation etc." One group of subjects suffering from black and white, spots, freckles, etc.
It was applied to the face every day for 3 months and its whitening effect was examined at 3 months. The evaluation criteria are as follows. A: Eight or more subjects recognized that pigmentation was hardly noticeable. …: Six or more and less than eight subjects recognized that pigmentation was hardly conspicuous. Δ: 3 to less than 6 subjects recognized that pigmentation was hardly noticeable. X: Less than 3 subjects recognized that pigmentation was hardly noticeable.

The solubility of the liquid oils shown in Tables 1 to 3 was tested. The results are shown in each table.

[0080]

[Table 1]

[0081]

[Table 2]

[0082]

[Table 3]

From Tables 1 to 3, it is found that polyoxyethylene (9 mol) glyceryl caprate, polyoxyethylene (12 mol) glyceryl octyl ether, dipropylene dipolyoxyethylene (8 mol) butylene ether, It can be seen that oxyethylene (5 mol) dipropionate and polyoxyethylene (8 mol) butyl ether have a solubility that meets the requirements of the liquid oil used in the present invention.

"Examples 1 to 8, Comparative Examples 1 and 2" Tables 4 to 6
Examples 1 to 8 and Comparative Example 1 having the composition described in
Skin external preparations (lotion) of No. 2 to No. 2 were produced by a conventional method, and an evaluation test was performed for the above evaluation. The results are shown in each table.

[0085]

[Table 4]

[0086]

[Table 5]

[0087]

[Table 6]

From the above results, it can be seen that the skin external preparation of the present invention has excellent effects in all evaluation items. Hereinafter, other examples of the present invention will be described.

Example 9 Cream A. Oil phase Stearic acid 10.0% by weight Stearyl alcohol 4.0 Butyl stearate 8.0 Monoglycerin stearate 2.0 Vitamin E acetate 0.5 Vitamin A palmitate 0.1 Macadamia nut oil 1.0 Tea seed oil 3. 0 Fragrance 0.4 Preservative appropriate amount B. Aqueous phase glycerin 4.0 polyoxyethylene (5 mol) dipropionate 5.0 1,1,2-pentanediol 3.0 sodium hyaluronate 1.0 potassium hydroxide 2.0 L-ascorbic acid-2-phosphate 2.0 L-arginine hydrochloride 0.01 Trisodium edetate 0.05 Succinic acid 0.1 Sodium succinate 0.9 Purified water Residue (Preparation method and evaluation) 7 each
Heat to 0 ° C to completely dissolve. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain a cream. The obtained cream was excellent in smoothness without impairing the whitening effect, and had no sticky feeling.

Example 10 Cream A. Oil phase Cetanol 4.0% by weight Vaseline 7.0 Isopropyl myristate 8.0 Squalane 15.0 Monoglycerin stearate 2.2 POE (20) Sorbitan monostearate 2.8 Vitamin E nicotinate 2.0 Fragrance 0.0 3 Antioxidant appropriate amount Preservative appropriate amount B. Aqueous phase Glycerin 10.0 Polyoxyethylene (12 mol) glyceryl octyl ether 10.0 Sodium hyaluronate 0.02 Dipropylene glycol 4.0 L-ascorbic acid-2-sulfate 1.0 Sodium pyrrolidone carboxylate 1.0 Disodium edetate 0.01 Succinic acid 0.1 Sodium succinate 0.9 Purified water residue (Production method and evaluation) A cream was obtained according to Example 9. The obtained cream was excellent in smoothness without impairing the whitening effect, and had no sticky feeling.

Example 11 Emulsion A. Oil phase Squalane 5.0% by weight Oleyl oleate 3.0 Vaseline 2.0 Sorbitan sesquioleate 0.8 Polyoxyethylene oleyl ether (20EO) 1.2 Evening primrose oil 0.5 Perfume 0.3 Preservative Appropriate amount B . Aqueous phase 1,3 butylene glycol 4.5 dipropylene dipolyoxyethylene (8 mol) butylene ether 8.0 ethanol 3.0 carboxyvinyl polymer 0.2 potassium hydroxide 0.1 kojic acid 5.0 L-arginine L -Aspartate 0.01 edetate 0.05 succinic acid 0.1 sodium succinate 0.9 purified water residue (production method and evaluation) An emulsion was obtained according to Example 9. The obtained emulsion was excellent in smoothness without impairing the whitening effect, and had no sticky feeling.

Example 12 Foundation A. Oil phase Cetanol 3.5% by weight Deodorized lanolin 4.0 Jojoba oil 5.0 Vaseline 2.0 Squalane 6.0 Monoglycerin stearate 2.5 POE (60) Hardened castor oil 1.5 POE (20) Cetyl ether 1.0 Pyridoxine tripalmitate 0.1 Preservative qs perfume 0.3 B. Water phase Propylene glycol 10.0 Polyoxyethylene (9 mol) Glyceryl caprate 2.0 Hydroquinone α-D-glucose 4.0 Compound powder 12.0 Ethylenediaminehydroxyethyl triacetate Trisodium 1.0 Purified water residue (Preparation method And evaluation) A foundation was obtained according to Example 9. The obtained foundation was excellent in smoothness without impairing the whitening effect, and had no sticky feeling.

Example 13 Toner A. Alcohol phase ethanol 5.0% by weight POE oleyl alcohol ether 2.0 polyoxyethylene (8 mol) butyl ether 3.0 2-ethylhexyl-P-dimethylaminobenzoate 0.18 fragrance 0.05 B. Aqueous phase 1,3-butylene glycol 9.5 sodium pyrrolidonecarboxylate 0.5 nicotinamide 0.3 glycerin 5.0 L-ascorbyl palmitate 1.0 succinic acid 0.1 sodium succinate 0.9 purified water balance (Production method and evaluation) The alcohol phase of A was added to the aqueous phase of B and solubilized to obtain a lotion. The obtained lotion was excellent in smoothness without impairing the whitening effect, and had no sticky feeling.

The liquid oil components shown in Tables 7 to 9 were tested for solubility. The results are shown in each table.

[0095]

[Table 7]

[0096]

[Table 8]

[0097]

[Table 9]

From Tables 7 to 9, triacetin,
Diethoxypolyoxyethyl glutarate, di-succinate
-Butyl, dineopentyl succinate, diethylene glycol dilevulinate, diethylene glycol glutarate,
It can be seen that triethyl citrate and pentaerythrit tetrahydroxybutanoate have a solubility that meets the requirements for the liquid oil used in the present invention.

"Examples 14 to 24, Comparative Examples 3 to 4" Table 1
Examples 14 to 24 having the composition described in Nos. 0 to 12
The skin external preparations (lotion) of Comparative Examples 3 and 4 were produced by a conventional method, and an evaluation test was performed for the above evaluation. The results are shown in each table.

[0100]

[Table 10]

[0101]

[Table 11]

[0102]

[Table 12]

From the above results, it can be seen that the external preparation for skin of the present invention has excellent effects in all evaluation items. Hereinafter, other examples of the present invention will be described.

Example 25 Cream A. Oil phase Stearic acid 10.0% by weight Stearyl alcohol 4.0 Butyl stearate 8.0 Monoglycerin stearate 2.0 Vitamin E acetate 0.5 Vitamin A palmitate 0.1 Macadamia nut oil 1.0 Tea seed oil 3. 0 Fragrance 0.4 Preservative appropriate amount B. Aqueous phase glycerin 4.0 pentaerythritol tetrahydroxybutanoate 3.0 1,2 pentanediol 3.0 sodium hyaluronate 1.0 potassium hydroxide 2.0 L-ascorbic acid-2-phosphate 2.0 L -Arginine hydrochloride 0.01 Trisodium edetate 0.05 Succinic acid 0.1 Sodium succinate 0.9 Purified water Residue (Production method and evaluation)
Heat to 0 ° C to completely dissolve. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain a cream. The obtained cream was excellent in smoothness without impairing the whitening effect, and had no sticky feeling.

Example 26 Cream A. Oil phase Cetanol 4.0% by weight Vaseline 7.0 Isopropyl myristate 8.0 Squalane 15.0 Monoglycerin stearate 2.2 POE (20) Sorbitan monostearate 2.8 Vitamin E nicotinate 2.0 Fragrance 0.0 3 Antioxidant appropriate amount Preservative appropriate amount B. Aqueous phase Glycerin 10.0 Diethylene glycol glutarate 4.0 Sodium hyaluronate 0.02 Dipropylene glycol 4.0 L-ascorbic acid-2-sulfate 1.0 Sodium pyrrolidonecarboxylate 1.0 Disodium edetate 0.01 Succinic acid 0.1 Sodium succinate 0.9 Purified water Residue (Production method and evaluation) A cream was obtained according to Example 25.
The obtained cream was excellent in smoothness without impairing the whitening effect, and had no sticky feeling.

Example 27 Emulsion A. Oil phase Squalane 5.0% by weight Oleyl oleate 3.0 Vaseline 2.0 Sorbitan sesquioleate 0.8 Polyoxyethylene oleyl ether (20EO) 1.2 Evening primrose oil 0.5 Perfume 0.3 Preservative Appropriate amount B . Aqueous phase 1,3 butylene glycol 4.5 diethylene glycol dilevulinate 2.0 ethanol 3.0 carboxyvinyl polymer 0.2 potassium hydroxide 0.1 kojic acid 5.0 L-arginine L-aspartate 0.01 edetic acid Salt 0.05 Succinic acid 0.1 Sodium succinate 0.9 Purified water Residue (Production method and evaluation) An emulsion was obtained according to Example 25. The obtained emulsion was excellent in smoothness without impairing the whitening effect, and had no sticky feeling.

Example 28 Foundation A. Oil phase Cetanol 3.5% by weight Deodorized lanolin 4.0 Jojoba oil 5.0 Vaseline 2.0 Squalane 6.0 Monoglycerin stearate 2.5 POE (60) Hardened castor oil 1.5 POE (20) Cetyl ether 1.0 Pyridoxine tripalmitate 0.1 Preservative qs perfume 0.3 B. Aqueous phase Propylene glycol 10.0 Dineopentyl succinate 2.0 Hydroquinone α-D-glucose 4.0 Compound powder 12.0 Ethylenediaminehydroxyethyl triacetate trisodium 1.0 Purified water residue (Production method and evaluation) A foundation was obtained according to the criteria. The obtained foundation was excellent in smoothness without impairing the whitening effect, and had no sticky feeling.

Example 29 Toner A. Alcohol phase ethanol 5.0 wt% POE oleyl alcohol ether 2.0 triacetin 3.0 2-ethylhexyl-P-dimethylaminobenzoate 0.18 fragrance 0.05 B. Aqueous phase 1,3-butylene glycol 9.5 sodium pyrrolidonecarboxylate 0.5 nicotinamide 0.3 glycerin 5.0 L-ascorbyl palmitate 1.0 succinic acid 0.1 sodium succinate 0.9 purified water balance (Production method and evaluation) The alcohol phase of A was added to the aqueous phase of B and solubilized to obtain a lotion. The obtained lotion was excellent in smoothness without impairing the whitening effect, and had no sticky feeling.

[0109]

According to the present invention, it is possible to provide an external preparation for skin which is excellent in texture, especially smoothness, and has no sticky feeling, without impairing the whitening effect.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 JX (72) Inventor Hiroyuki Kagogi 2-2 Hayabuchi, Tsuzuki-ku, Yokohama, Kanagawa Prefecture -1 Shiseido Research Center, Inc. (Shin-Yokohama) (72) Inventor Tomiyuki Namba 2-2-1 Hayabuchi, Tsuzuki-ku, Yokohama, Kanagawa Prefecture F-term (reference) in Shiseido Research Center, Shin-Yokohama 4C083 AA122 AB032 AC012 AC022 AC072 AC102 AC122 AC181 AC182 AC242 AC292 AC352 AC371 AC372 AC391 AC401 AC402 AC421 AC422 AC432 AC442 AC482 AC532 AC552 AC582 AC642 AC662 AC841 AC842 AC852 AD042 AD092 AD332 AD392 AD512 AD622 AD641 AD642 AD662 BB11 BB51 CC02 CC04 DD27 DD13 DD13 DD

Claims (7)

[Claims] 1. An oil which is soluble in water at 25 ° C. in an amount of 1 to 15% by weight in water and at least 5% by weight in glyceryl tri-2-ethylhexanoate at 25 ° C., L-ascorbic acid or a derivative thereof, hydroquinone An external preparation for skin, comprising one or more selected from the group consisting of glycosides or derivatives thereof, and kojic acid or derivatives thereof. 2. The oil component is selected from the group consisting of polyoxyethylene fatty acid polyhydric alcohol esters, polyoxyethylene alkyl polyhydric alcohol ethers, dialkyl dipolyoxyethylene alkylene ethers, polyoxyethylene dialkyl esters, and polyoxyethylene dialkyl ethers. 2. The external preparation for skin according to claim 1, which is one or more selected oil components. 3. The polyoxyethylene fatty acid polyhydric alcohol ester is polyoxyethylene fatty acid glycerin represented by the following chemical formula (1), and the polyoxyethylene alkyl polyhydric alcohol ether is represented by the following chemical formula (2). A polyoxyethylene glyceryl alkyl ether, wherein the dialkyl dipolyoxyethylene alkylene ether is a dialkyl dipolyoxyethylene alkylene ether represented by the following chemical formula (3), and the polyoxyethylene dialkyl ester is represented by the following chemical formula (4): The skin external preparation according to claim 2, wherein the polyoxyethylene dialkyl ester is a polyoxyethylene dialkyl ether represented by the following chemical formula (5). Embedded image (1) (In the formula, R1, R2, and R3 are hydrogen or an alkyl or branched alkyl group having 1 to 9 carbon atoms, l, m, and n are 0 to 5 and the total represents an integer of 3 to 15.) Embedded image (2) (wherein, R1, R2, and R3 are hydrogen or carbon atoms having 1 to 10
Alkyl or branched alkyl groups of l, m and n are from 0 to 8
And the sum represents an integer of 9 to 21. ) (3) (wherein, R 1 and R 2 are hydrogen or an alkyl or branched alkyl group having 1 to 4 carbon atoms, m and n are 0 to 8 and the total is an integer of 4 to 10, and X is an integer of 1 to 4 Represents the following.) (4) (wherein, R1 and R2 represent hydrogen or an alkyl or branched alkyl group having 1 to 7 carbon atoms, and n represents an integer of 3 to 20). (5) (wherein, R1 and R2 represent hydrogen or an alkyl or branched alkyl group having 1 to 4 carbon atoms, and n represents an integer of 6 to 23.) 4. The oil component is a polyhydric alcohol ester,
Diethoxypolyoxyethyl dicarboxylic acid, ditertiary alkyl dicarboxylic acid ester, dineopentyl dicarboxylic acid, polyhydric alcohol ester of carboxylic acid,
2. The external preparation for skin according to claim 1, which is one or more oils selected from the group consisting of dihydric carboxylic acid alcohol esters, trivalent carboxylic acid alcohol esters, and tetracarboxylic acid pentaerythritol. 5. The polyhydric alcohol ester is represented by the following chemical formula (6), the dihydric carboxylic acid diethoxypolyoxyethyl is represented by the following chemical formula (7), and the dihydric carboxylic acid dialkylalkyl is represented by the following chemical formula (8). ), The divalent penicyl carboxylate is represented by the following chemical formula (9):
The carboxylic acid polyhydric alcohol ester is represented by the following chemical formula (10), the dihydric carboxylic acid alcohol ester is represented by the following chemical formula (11), and the trivalent carboxylic acid alcohol ester is represented by the following chemical formula (12). The skin external preparation according to claim 2, wherein the erythrit is represented by the following chemical formula (13). Embedded image (6) (where n = 1 to 3, R1, R2, and R3 each have 2 to 5 carbon atoms)
Represents a monocarboxylic acid, hydroxymonocarboxylic acid, or oxymonocarboxylic acid residue, and R4 represents hydrogen or a hydroxyl group. ) (7) (wherein, R is a dicarboxylic acid, hydroxydicarboxylic acid, or oxydicarboxylic acid residue having 2 to 6 carbon atoms, x and y are from 0 to 2, and the sum of x and y represents an integer of 4 or less. ) (8) (wherein, R is a dicarboxylic acid having 2 to 6 carbon atoms, hydroxydicarboxylic acid, oxydicarboxylic acid residue, and m and n are 0 to 0)
In 1, the sum of m and n represents an integer of 2 or less. ) (9) (In the formula, R represents a dicarboxylic acid, hydroxydicarboxylic acid or oxydicarboxylic acid residue having 2 to 6 carbon atoms.) (10) (wherein, R1 and R3 are monocarboxylic acids having 2 to 5 carbon atoms,
Hydroxymonocarboxylic acid, oxymonocarboxylic acid residue residue, R2 is a dihydric or trihydric alcohol residue having 2 to 6 carbon atoms and may have a hydroxyl group in the molecule. ) (11) (wherein, R1 and R3 are an alcohol having 2 to 5 carbon atoms and an ethoxyethanol or ethyl carbitol residue;
2 represents a dicarboxylic acid, hydroxydicarboxylic acid or oxydicarboxylic acid residue having 2 to 6 carbon atoms. ) (12) (wherein, R1, R3, and R4 are linear or branched alcohols having 2 to 5 carbon atoms and may have an ether group in the molecule. R2 is a tricarboxylic acid having 2 to 5 carbon atoms.) , Hydroxytricarboxylic acid and oxytricarboxylic acid residues.) (13) (In the formula, R1, R2, R3, and R4 represent a monocarboxylic acid, hydroxymonocarboxylic acid, or oxymonocarboxylic acid residue residue having 2 to 5 carbon atoms.) 6. The method according to claim 1, further comprising a humectant.
3. The external preparation for skin according to 3, 4 or 5. 7. The skin external preparation according to claim 1, wherein the skin external preparation is a skin whitening external preparation.