JP2000080104A - Preparation of chitin or chitosan powder or granule - Google Patents
Preparation of chitin or chitosan powder or granuleInfo
- Publication number
- JP2000080104A JP2000080104A JP34767098A JP34767098A JP2000080104A JP 2000080104 A JP2000080104 A JP 2000080104A JP 34767098 A JP34767098 A JP 34767098A JP 34767098 A JP34767098 A JP 34767098A JP 2000080104 A JP2000080104 A JP 2000080104A
- Authority
- JP
- Japan
- Prior art keywords
- powder
- chitin
- drying
- chitosan
- chitosan powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000843 powder Substances 0.000 title claims abstract description 94
- 229920001661 Chitosan Polymers 0.000 title claims abstract description 51
- 229920002101 Chitin Polymers 0.000 title claims abstract description 50
- 239000008187 granular material Substances 0.000 title claims abstract description 23
- 238000001035 drying Methods 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 230000033001 locomotion Effects 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 230000005540 biological transmission Effects 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims 1
- 241000238557 Decapoda Species 0.000 abstract description 6
- 239000007901 soft capsule Substances 0.000 abstract description 5
- 239000003826 tablet Substances 0.000 abstract description 4
- 241000238366 Cephalopoda Species 0.000 abstract description 2
- 235000013305 food Nutrition 0.000 abstract description 2
- 239000002245 particle Substances 0.000 abstract description 2
- 241001658874 Squilla Species 0.000 abstract 1
- 238000007605 air drying Methods 0.000 abstract 1
- 230000000593 degrading effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000005484 gravity Effects 0.000 description 18
- 235000013402 health food Nutrition 0.000 description 5
- 239000002904 solvent Substances 0.000 description 4
- 241000238424 Crustacea Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 235000013325 dietary fiber Nutrition 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004898 kneading Methods 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000251730 Chondrichthyes Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 239000008235 industrial water Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000003021 water soluble solvent Substances 0.000 description 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は含水キチン粉末又は
含水キトサン粉末に回転運動を与えた後に乾燥する事
で、嵩比重、粉体流動性、油分散性を改善し、錠剤、ソ
フトカプセル、顆粒などのいわゆる健康食品原料として
の加工特性を改善する技術に関するものである。[0001] The present invention relates to a hydrous chitin powder or a hydrous chitosan powder which is subjected to a rotary motion and then dried to improve bulk specific gravity, powder flowability, oil dispersibility, tablets, soft capsules, granules, etc. And a technology for improving processing characteristics as a so-called health food raw material.
【０００２】キチンはカニ、エビ等の甲殻類の甲皮等、
昆虫の甲殻、キノコ、糸状菌等の細胞壁に含まれる食物
繊維で、保水性を有することから便通改善効果を示す。
また、キトサンはキチンをさらにアルカリ処理すること
で脱アセチル化を行い得られる物質で、コレステロール
調整機能、血圧上昇抑制機能、糞便中の有害物質濃度低
減作用など様々な生理機能を有する食物繊維であり、キ
チンは食物繊維源として、キトサンは生活習慣病を予防
する機能性食材として食品分野、特に手軽に摂取できる
錠剤、ソフトカプセル、顆粒などのいわゆる健康食品に
加工されることが多い。Chitin is used in crustaceans such as crabs and shrimps.
It is a dietary fiber contained in cell walls of insect crustaceans, mushrooms, fungi, etc., and has a water-retaining property and thus has an effect of improving bowel movement.
In addition, chitosan is a substance obtained by deacetylation by further treating chitin with alkali, and is a dietary fiber having various physiological functions such as cholesterol regulating function, blood pressure increase suppressing function, harmful substance concentration reducing function in feces. Chitin is used as a dietary fiber source, and chitosan is often used as a functional food for preventing lifestyle-related diseases in the food field, particularly in so-called health foods such as tablets, soft capsules, and granules that can be easily taken.
【０００３】キチン又はキトサンは工業的にはカニ、エ
ビ等の甲殻類の甲皮等から製造されるが、得られたキチ
ン、キトサンは嵩比重が小さく、粉体流動性が悪いため
錠剤、顆粒等には加工しにくく、油分散性が悪いためソ
フトカプセルに充填する量が限られる。[0003] Chitin or chitosan is industrially produced from crustaceans such as crabs and shrimps, but the resulting chitin and chitosan have low bulk specific gravity and poor powder fluidity, so that tablets and granules are poorly prepared. It is difficult to process and the like, and the oil dispersibility is poor, so that the amount to be filled in the soft capsule is limited.
【０００４】この様な場合、キチン粉末又はキトサン粉
末を水分と接触させた後、そのまま棚式乾燥機などで乾
燥したり、混合機能を有する乾燥機すなわち、ナウター
乾燥機やコニカル乾燥機、スクリュー式乾燥機で乾燥す
ることでこれらの物性を改善することができる。（特開
平８−２６９１０４）In such a case, after the chitin powder or the chitosan powder is brought into contact with moisture, it is dried as it is with a shelf type drier or the like, or a drier having a mixing function, that is, a Nauter drier, a conical drier, a screw type drier. These physical properties can be improved by drying with a dryer. (JP-A-8-269104)
【０００５】[0005]
【発明が解決しようとする課題】しかしながら、水分と
接触させた後そのまま棚式乾燥をする場合、嵩比重が
０．２０ｇ／ｍｌ程度にしか改善されない。混合機能を
有する乾燥機すなわち、ナウター乾燥機やコニカル乾燥
機、スクリュー式乾燥機は嵩比重を０．２０ｇ／ｍｌ以
上にすることが可能であるが、広い設置場所が必要であ
ることに加え、機器の価格も高価であり、一般の健康食
品製造工場では実施が難しい。これらの事から、一般の
健康食品製造工場で製造する事が可能で安価なキチン粉
末又は顆粒又はキトサン粉末又は顆粒の製造方法が望ま
れていた。本発明の目的は、キチン粉末又はキトサン粉
末の嵩比重、粉体流動性、油分散性を改善する方法を提
供することにある。However, when the tray-type drying is performed as it is after contacting with water, the bulk specific gravity is improved only to about 0.20 g / ml. A dryer having a mixing function, that is, a Nauter dryer, a conical dryer, and a screw dryer can have a bulk specific gravity of 0.20 g / ml or more, but in addition to a large installation space, The equipment is expensive and difficult to implement in a general health food manufacturing plant. For these reasons, there has been a demand for an inexpensive method for producing chitin powder or granules or chitosan powder or granules that can be produced at a general health food production plant. An object of the present invention is to provide a method for improving the bulk specific gravity, powder fluidity, and oil dispersibility of chitin powder or chitosan powder.
【０００６】[0006]
【課題を解決するための手段】そこで本発明者らは、種
々検討した結果、含水キチン粉末又は含水キトサン粉末
に回転運動を与えた後に乾燥することにより嵩比重が
０．２５ｇ／ｍｌ以上となり、かつ粉体流動性や油分散
性が改善されることを見出した。Means for Solving the Problems The present inventors have made various studies and found that the bulk specific gravity became 0.25 g / ml or more by rotating the hydrous chitin powder or the hydrous chitosan powder and then drying it. It was also found that powder fluidity and oil dispersibility were improved.
【０００７】即ち、本発明は、 （１）含水キチン粉末又は含水キトサン粉末に回転運動
を与えた後、乾燥する事を特徴とする物性の改良された
キチン粉末又は顆粒又はキトサン粉末又は顆粒の製造方
法、 （２）含水キチン粉末又は含水キトサン粉末の含水率が
２０％から４５％の範囲である（１）記載の方法 （３）含水キチン粉末又は含水キトサン粉末に回転運動
を与える時間が１〜６０分間である（１）又は（２）記
載の方法 （４）含水キチン粉末又は含水キトサン粉末が４５％を
超える含水量のキチン粉末又はキトサン粉末を部分乾燥
して得られたものである（２）記載の方法 （５）２０％を超えて４５％までの含水量のキチン粉末
又はキトサン粉末を水分量が２０％から４５％未満にな
るように部分乾燥し、回転運動を与えた後、更に乾燥す
る事を特徴とするキチン粉末又は顆粒又はキトサン粉末
又は顆粒の製造方法 （６）乾燥方法が自然乾燥、天日乾燥、棚式乾燥機、透
過式乾燥機、凍結乾燥機又は減圧乾燥機を使用する乾燥
である（１）〜（５）のいずれかに記載の方法 （７）回転運動を与える方法がＶ型混合機、混合パン、
リボンミキサ−、ナウタ−混合機又はコニカル混合機を
用いるものである（１）〜（６）のいずれかに記載の方
法、に関する。That is, the present invention relates to (1) a method for producing a chitin powder or granules or chitosan powder or granules having improved physical properties, which comprises rotating a hydrous chitin powder or a hydrous chitosan powder, followed by drying. (2) The method according to (1), wherein the water content of the hydrated chitin powder or hydrated chitosan powder is in the range of 20% to 45%. The method according to (1) or (2), which is for 60 minutes. (4) The hydrated chitin powder or hydrated chitosan powder is obtained by partially drying a chitin powder or chitosan powder having a water content exceeding 45% (2). ) Described method (5) After partially drying chitin powder or chitosan powder having a water content of more than 20% and up to 45% so that the water content becomes from 20% to less than 45%, and giving a rotary motion, Method for producing chitin powder or granules or chitosan powder or granules, characterized in that drying is carried out naturally (6) The drying method is natural drying, sun drying, shelf dryer, transmission dryer, freeze dryer or vacuum dryer. (7) The method according to any one of (1) to (5), wherein drying is performed by using a V-type mixer, a mixing pan,
The present invention relates to the method according to any one of (1) to (6), wherein a ribbon mixer, a Nauta mixer or a conical mixer is used.
【０００８】[0008]
【発明の実施の形態】本発明で用いられるキチン、キト
サンの起源は海老、蟹、シャコ、イカ等、特に制限はな
く、粉末の平均粒子径は、３００μｍ以下の粉末であれ
ば何れでも良いが、好ましくは３０〜１８０μｍであ
る。BEST MODE FOR CARRYING OUT THE INVENTION The origin of chitin and chitosan used in the present invention is not particularly limited, such as shrimp, crab, shark, squid, etc., and any powder having an average particle diameter of 300 μm or less may be used. , Preferably 30 to 180 μm.
【０００９】キチン粉末又はキトサン粉末に含まれる水
としては、工業用水、水道水、ミネラル水、純水等、水
であれば如何なる水であっても良い。又、水は蒸気、氷
結水等に加工して用いても良い。又、含水溶媒であって
もよく、その溶媒の種類としては、例えば、アセトン、
メタノ−ル、エチルアルコール等の水溶性溶媒が挙げら
れ、キチン、キトサンを溶解しないものであれば何れで
もよい。又、キチン粉末又はキトサン粉末の製造の際に
得られる未乾燥の含水キチン粉末又は含水キトサン粉末
をそのまま用いてもよい。The water contained in the chitin powder or chitosan powder may be any water such as industrial water, tap water, mineral water, pure water, and the like. The water may be processed into steam, frozen water, or the like before use. The solvent may be a water-containing solvent. Examples of the type of the solvent include acetone,
Examples thereof include water-soluble solvents such as methanol and ethyl alcohol, and any solvent may be used as long as it does not dissolve chitin and chitosan. Further, an undried hydrated chitin powder or hydrated chitosan powder obtained in the production of chitin powder or chitosan powder may be used as it is.
【００１０】また、水にメチルセルロース、アラビアガ
ム、糊化デンプンなどの結着剤を溶解した後、これをキ
チン粉末又はキトサン粉末に加え均一に混合して使用す
る事により、打錠用に顆粒を製造する事もでき、粉末を
製造する事もできる。[0010] After dissolving a binder such as methylcellulose, gum arabic and gelatinized starch in water, adding the resulting mixture to a chitin powder or a chitosan powder and mixing them uniformly, granules for tableting can be obtained. It can be manufactured and powder can be manufactured.
【００１１】本発明で含水キチン粉末又は含水キトサン
粉末に含まれる水の量としては、含水キチン粉末又は含
水キトサン粉末の全体重量に対して２０％から４５％の
範囲が好ましく、より好ましくは３５％から４５％の範
囲である。また、含水率が４５％を超えるキチン粉末又
はキトサン粉末を水分が２０％から４５％の範囲まで部
分乾燥、又は、含水率が２０％を超えて４５％までのキ
チン粉末又はキトサン粉末を水分量が２０％から４５％
未満になるように部分乾燥した後、取り出し、混合機で
回転運動を与えた後に、更に乾燥を行っても良いし、回
転運動を与えた後、別の乾燥方法によって再び乾燥を再
開する事もできる。In the present invention, the amount of water contained in the hydrated chitin powder or hydrated chitosan powder is preferably in the range of 20% to 45%, more preferably 35%, based on the total weight of the hydrated chitin powder or hydrated chitosan powder. To 45%. In addition, chitin powder or chitosan powder having a water content of more than 45% is partially dried to have a water content of 20% to 45%, or chitin powder or chitosan powder having a water content of more than 20% to 45% is subjected to water content. 20% to 45%
After being partially dried so as to be less than, take out and give a rotating motion by a mixer, further drying may be performed, or after giving a rotating motion, drying may be restarted again by another drying method. it can.
【００１２】回転運動を与える方法としては特に制限は
ないが、Ｖ型混合機、混合パン、リボンミキサー、ナウ
ター混合機、コニカル混合機等の粉体混合機を使用する
事が好ましく、減圧状態で回転運動を与える事もでき、
少量であればビニール袋に空気と共に封入し手で混合し
ながら回転運動を行ってもよい。また、回転を与える時
の温度は特に制限はなく、また回転運動を行う時間は通
常１分間以上であれば良く、好ましくは１〜６０分間、
より好ましくは１〜３０分間、特に好ましくは５〜１０
分間である。Although there is no particular limitation on the method of imparting the rotational motion, it is preferable to use a powder mixer such as a V-type mixer, a mixing pan, a ribbon mixer, a Nauta mixer, a conical mixer, etc. You can also give a rotational movement,
If it is a small amount, it may be sealed in a plastic bag with air and rotated by hand while mixing. The temperature at which the rotation is given is not particularly limited, and the time for the rotation is usually 1 minute or more, preferably 1 to 60 minutes.
More preferably for 1 to 30 minutes, particularly preferably 5 to 10 minutes
Minutes.
【００１３】本発明に用いる乾燥は、自然乾燥や天日乾
燥、または乾燥機を使用する事ができる。乾燥機を使用
する場合は棚式乾燥機、透過式乾燥機、凍結乾燥機、減
圧乾燥機等、静置状態で乾燥する乾燥機であれば如何な
る乾燥機を用いてもよく、一般の健康食品製造工場に設
置されている乾燥機も使用できる。The drying used in the present invention may be natural drying, solar drying, or a dryer. If a dryer is used, any dryer may be used as long as it is a stationary dryer, such as a shelf dryer, a permeation dryer, a freeze dryer, a vacuum dryer, etc. Dryers installed in manufacturing plants can also be used.
【００１４】乾燥機の温度は乾燥機内の温度がキチン粉
末又は顆粒又はキトサン粉末又は顆粒を変質させない温
度であれば特に制限はないが、効率等の点から乾燥機内
の温度は３０〜１８０℃が好ましく、より好ましくは６
０〜１５０℃であり、特に好ましくは８０〜１２０℃で
ある。The temperature of the dryer is not particularly limited as long as the temperature in the dryer does not deteriorate the chitin powder or granules or the chitosan powder or granules, but the temperature in the dryer is preferably 30 to 180 ° C. from the viewpoint of efficiency and the like. Preferably, more preferably 6
It is 0-150 degreeC, Especially preferably, it is 80-120 degreeC.
【００１５】[0015]
【発明の効果】本発明のすぐれた効果を以下の実験によ
り示す。実験試料はキトサン粉末を８０メッシュの篩い
を全量通過するまで粉砕し用いた。The excellent effects of the present invention are shown by the following experiments. The experimental sample was used by pulverizing chitosan powder until the whole amount passed through an 80-mesh sieve.
【００１６】方法 キトサン粉末２００ｇを乳ばちに採取 ↓ 水３００ｇを加え５分間練合。 ↓ １１０℃で静置乾燥 ↓ ５分おきに取りだしＶ型混合機で回転処理（５分） ↓ １１０℃で完全に乾燥（静置） ↓ 比重（比重測定機使用）、安息角、油流動性を測定Method 200 g of chitosan powder is collected in a milk stick ↓ Add 300 g of water and knead for 5 minutes. ↓ Stationary drying at 110 ° C ↓ Take out every 5 minutes and rotate with a V-type mixer (5 minutes) ↓ Completely dry at 110 ° C (stationary) ↓ Specific gravity (using a specific gravity measuring machine), angle of repose, oil fluidity Measure
【００１７】結果 結果を下記表に示すResults The results are shown in the table below.
【００１８】[0018]
【表１】 乾燥時間 回転時の含水率 嵩比重 安息角 油流動性 （分） （％） （ｇ／ｍｌ） （度） ０ ６０．０ ０．１９５ ４８ 不良 ５ ５２．０ ０．２３１ ４７ 良 １０ ３８．９ ０．２８０ ４５ 良 １５ ３１．７ ０．２６９ ４６ 良 ２０ １５．１ ０．２３５ ４８ 良 ６０ ０．０ ０．１８９ ４８ 不良Table 1 Drying time Moisture content during rotation Bulk specific gravity Angle of repose Oil fluidity (min) (%) (g / ml) (degree) 0 60.0 0.195 48 Poor 5 52.0 0.231 47 Good 10 38.9 0.280 45 Good 15 31.7 0.269 46 Good 20 15.1 0.235 48 Good 60 0.0 0.189 48 Poor
【００１９】この実験結果より明らかなように、含水キ
チン粉末又は含水キトサン粉末に、好ましくは水分含量
が２０％から４５％、より好ましくは３５％から４５％
のときに回転運動を与える事でキチン粉末又はキトサン
粉末の嵩比重、粉体流動性、油分散性が改善され、錠
剤、ソフトカプセル、顆粒などのいわゆる健康食品原料
としての最適な粉末が得られた。As apparent from the experimental results, the water content of the hydrated chitin powder or hydrated chitosan powder is preferably 20% to 45%, more preferably 35% to 45%.
By giving a rotary motion at the time of, the bulk specific gravity, powder fluidity, oil dispersibility of chitin powder or chitosan powder were improved, and the most suitable powder as a so-called health food raw material such as tablets, soft capsules and granules was obtained. .
【００２０】[0020]
【実施例】以下に実施例を挙げて本発明を具体的に説明
するが、本発明はこれらに限定されるものではない。 実施例１ ５０メッシュの篩いを全通するように粉砕したキチン粉
末（嵩比重０．１９５ｇ／ｍｌ）４８ｋｇに水３４ｋｇ
を加えてスピードニーダーで５分間練合した後、８０℃
の棚式乾燥機で乾燥減量が３８％になるまで乾燥し、混
合パンに移しかえて１５分間、１５ｒｐｍで回転運動を
与えた後、再び８０℃で乾燥することで、キチン粉末の
嵩比重を０．１９５ｇ／ｍｌから０．２６７ｇ／ｍｌに
改善した。EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples. Example 1 34 kg of water was added to 48 kg of chitin powder (bulk specific gravity: 0.195 g / ml) pulverized so as to pass through a 50-mesh sieve.
And kneaded with a speed kneader for 5 minutes, then 80 ℃
Of the chitin powder by transferring the mixture to a mixing pan and rotating at 15 rpm for 15 minutes, and then drying at 80 ° C. again to reduce the bulk specific gravity of the chitin powder. It improved from 0.195 g / ml to 0.267 g / ml.
【００２１】実施例２ ８０メッシュの篩いを全通するように粉砕したキトサン
粉末（嵩比重０．１６ｇ／ｍｌ）２０ｋｇにメチルセル
ロース１ｋｇを加え混合パンで１分間混合した後、水２
０ｋｇを加え、スピードニーダーで３分間練合し、スピ
ードミルで整粒後、Ｖ型混合機で５分間回転を与えた
後、６０℃の真空乾燥機で乾燥し１４メッシュの篩いで
篩過することで打錠用顆粒を得た。得られた顆粒は、嵩
比重が０．１６ｇ／ｍｌから０．２７ｇ／ｍｌに改善さ
れ、粉体流動性も良好であった。Example 2 1 kg of methylcellulose was added to 20 kg of chitosan powder (bulk specific gravity 0.16 g / ml) pulverized so as to pass through an 80-mesh sieve, and mixed for 1 minute in a mixing pan.
After adding 0 kg, kneading with a speed kneader for 3 minutes, sizing with a speed mill, spinning with a V-type mixer for 5 minutes, drying with a 60 ° C. vacuum dryer and sieving with a 14 mesh sieve. Thus, granules for tableting were obtained. The obtained granules had improved bulk specific gravity from 0.16 g / ml to 0.27 g / ml, and also had good powder fluidity.
【００２２】実施例３ １５０メッシュの篩いを全通するように粉砕したキトサ
ン粉末（嵩比重０．１５５ｇ／ｍｌ）５０ｋｇに、水６
０ｋｇ加え２０分間混合した後、８０℃の透過式乾燥機
で水分含量を３５％まで乾燥した。乾燥後、混合パンに
取りだし２０分間１５ｒｐｍで回転運動を与えた後、再
び８０℃の透過式乾燥機で乾燥減量７％以下になるまで
乾燥し１４メッシュの篩いで篩過することでキトサン顆
粒の嵩比重を０．１５５ｇ／ｍｌから０．３０４ｇ／ｍ
ｌに改善した。Example 3 50 kg of chitosan powder (bulk specific gravity 0.155 g / ml) pulverized so as to pass through a 150-mesh sieve was added to water 6
After 0 kg was added and mixed for 20 minutes, the water content was dried to 35% with a permeation dryer at 80 ° C. After drying, the mixture was taken out into a mixing pan, subjected to a rotational motion at 15 rpm for 20 minutes, dried again with a permeation drier at 80 ° C. until the loss on drying was reduced to 7% or less, and sieved with a 14-mesh sieve to obtain chitosan granules. Bulk specific gravity of 0.155 g / ml to 0.304 g / m
improved to 1.
【００２３】実施例４ ８０メッシュの篩いを全通するように粉砕したキチン粉
末１ｋｇ及びキトサン粉末１ｋｇの混合物（安息角４９
度）を混合パンで１分間混合した後、水２ｋｇを加えス
ピードニーダーで５分間練合後、５０Ｌのビニール袋に
取りだし空気を封入し、手で混合しながら５分間回転運
動を与えた。その後、６０℃の減圧乾燥機乾燥で水分３
％にまで乾燥し、キチン粉末及びキトサン粉末混合物の
安息角を４９度から４５度に改善した。Example 4 A mixture of 1 kg of chitin powder and 1 kg of chitosan powder ground to pass through an 80 mesh sieve (angle of repose: 49)
Was mixed with a mixing pan for 1 minute, 2 kg of water was added, and the mixture was kneaded with a speed kneader for 5 minutes. The mixture was taken out into a 50 L plastic bag, sealed with air, and rotated by hand for 5 minutes while mixing. After that, drying at 60 ° C. in a vacuum drier
% And improved the angle of repose of the chitin powder and chitosan powder mixture from 49 degrees to 45 degrees.
【００２４】実施例５ ５０メッシュの篩いを全通するように粉砕したキトサン
粉末（嵩比重０．１７０ｇ／ｍｌ）４８ｋｇに水９０ｋ
ｇを加えてスピードニーダーで５分間練合した後、８０
℃の棚式乾燥機で乾燥減量が３８％になるまで乾燥し、
混合パンに移しかえて１０分間、１５ｒｐｍで回転運動
を与えた後、再び８０℃で乾燥することで、キチン粉末
の嵩比重を０．１７０ｇ／ｍｌから０．２９０ｇ／ｍｌ
に改善した。Example 5 48 kg of chitosan powder (0.170 g / ml in bulk specific gravity) pulverized so as to pass through a 50-mesh sieve and 90 k of water
g and kneading for 5 minutes with a speed kneader.
Dry in a shelf dryer at 38 ° C until the loss on drying is 38%.
The mixture was transferred to a mixing pan and subjected to a rotational motion at 15 rpm for 10 minutes, and then dried again at 80 ° C., so that the bulk specific gravity of the chitin powder was 0.170 g / ml to 0.290 g / ml.
Improved.
Claims (7)
回転運動を与えた後、乾燥する事を特徴とするキチン粉
末又は顆粒又はキトサン粉末又は顆粒の製造方法1. A method for producing chitin powder or granules or chitosan powder or granules, which comprises rotating the hydrous chitin powder or the hydrous chitosan powder and then drying.
含水率が２０％から４５％の範囲である請求項１記載の
方法2. The method according to claim 1, wherein the water content of the hydrated chitin powder or hydrated chitosan powder is in the range of 20% to 45%.
回転運動を与える時間が１〜６０分間である請求項１又
は２記載の方法3. The method according to claim 1, wherein the time for rotating the hydrated chitin powder or hydrated chitosan powder is 1 to 60 minutes.
４５％を超える含水量のキチン粉末又はキトサン粉末を
部分乾燥して得られたものである請求項２記載の方法4. The method according to claim 2, wherein the hydrated chitin powder or hydrated chitosan powder is obtained by partially drying a chitin powder or chitosan powder having a water content of more than 45%.
チン粉末又はキトサン粉末を水分量が２０％から４５％
未満になるように部分乾燥し、回転運動を与えた後、更
に乾燥する事を特徴とするキチン粉末又は顆粒又はキト
サン粉末又は顆粒の製造方法5. A chitin or chitosan powder having a water content of more than 20% and up to 45% with a water content of 20% to 45%.
A method for producing chitin powder or granules or chitosan powder or granules, wherein the mixture is partially dried so as to have a rotational movement, and then further dried.
燥機、透過式乾燥機、凍結乾燥機又は減圧乾燥機を使用
する乾燥である請求項１〜５のいずれかに記載の方法6. The method according to claim 1, wherein the drying method is natural drying, solar drying, shelf drying, transmission drying, freeze drying, or drying using a reduced pressure dryer.
合パン、リボンミキサ−、ナウタ−混合機又はコニカル
混合機を用いるものである請求項１〜６のいずれかに記
載の方法7. The method according to any one of claims 1 to 6, wherein the method for imparting a rotary motion is to use a V-type mixer, a mixing pan, a ribbon mixer, a Nauta mixer or a conical mixer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34767098A JP4215224B2 (en) | 1998-07-01 | 1998-12-08 | Method for producing chitin powder or granule or chitosan powder or granule |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10-185506 | 1998-07-01 | ||
| JP18550698 | 1998-07-01 | ||
| JP34767098A JP4215224B2 (en) | 1998-07-01 | 1998-12-08 | Method for producing chitin powder or granule or chitosan powder or granule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000080104A true JP2000080104A (en) | 2000-03-21 |
| JP4215224B2 JP4215224B2 (en) | 2009-01-28 |
Family
ID=26503147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP34767098A Expired - Fee Related JP4215224B2 (en) | 1998-07-01 | 1998-12-08 | Method for producing chitin powder or granule or chitosan powder or granule |
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| Country | Link |
|---|---|
| JP (1) | JP4215224B2 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100470715B1 (en) * | 2002-04-04 | 2005-03-08 | 주식회사 자광 | A capsule of porous bead of water soluble chitosan and the preparation method thereof |
| JP2009507514A (en) * | 2005-09-14 | 2009-02-26 | キム，ジン−マン | Supplementary food composition for reducing body odor |
| US20120277183A1 (en) * | 2008-04-08 | 2012-11-01 | Cypress Pharmaceutical, Inc. | Phosphate-binding chitosan and uses thereof |
| JP5969680B1 (en) * | 2015-10-28 | 2016-08-17 | 日本化薬フードテクノ株式会社 | Chitosan powder, method for producing the same, and preparation containing chitosan |
| JP2019218322A (en) * | 2018-06-22 | 2019-12-26 | 大日精化工業株式会社 | Easily dispersible compression molded product and method for producing the same |
| JP2019218321A (en) * | 2018-06-22 | 2019-12-26 | 大日精化工業株式会社 | Method for producing easily dispersible compression molded product |
-
1998
- 1998-12-08 JP JP34767098A patent/JP4215224B2/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100470715B1 (en) * | 2002-04-04 | 2005-03-08 | 주식회사 자광 | A capsule of porous bead of water soluble chitosan and the preparation method thereof |
| JP2009507514A (en) * | 2005-09-14 | 2009-02-26 | キム，ジン−マン | Supplementary food composition for reducing body odor |
| US20120277183A1 (en) * | 2008-04-08 | 2012-11-01 | Cypress Pharmaceutical, Inc. | Phosphate-binding chitosan and uses thereof |
| JP5969680B1 (en) * | 2015-10-28 | 2016-08-17 | 日本化薬フードテクノ株式会社 | Chitosan powder, method for producing the same, and preparation containing chitosan |
| JP2019218322A (en) * | 2018-06-22 | 2019-12-26 | 大日精化工業株式会社 | Easily dispersible compression molded product and method for producing the same |
| JP2019218321A (en) * | 2018-06-22 | 2019-12-26 | 大日精化工業株式会社 | Method for producing easily dispersible compression molded product |
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| Publication number | Publication date |
|---|---|
| JP4215224B2 (en) | 2009-01-28 |
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