ITTO20110561A1 - Vector for the release of an active agent, fotoscindibile by radiation in the visible - Google Patents

Vector for the release of an active agent, fotoscindibile by radiation in the visible

Info

Publication number
ITTO20110561A1
ITTO20110561A1 IT000561A ITTO20110561A ITTO20110561A1 IT TO20110561 A1 ITTO20110561 A1 IT TO20110561A1 IT 000561 A IT000561 A IT 000561A IT TO20110561 A ITTO20110561 A IT TO20110561A IT TO20110561 A1 ITTO20110561 A1 IT TO20110561A1
Authority
IT
Italy
Prior art keywords
active agent
vector
visible
surfactant
group
Prior art date
Application number
IT000561A
Other languages
Italian (it)
Inventor
Fabio Beltram
Stefano Luin
Riccardo Nifosi
Fernanda Ricci
Giovanni Signore
Valerio Voliani
Original Assignee
Consiglio Nazionale Ricerche
Fond Istituto Italiano Di Tecnologia
Scuola Normale Superiore Di Pisa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consiglio Nazionale Ricerche, Fond Istituto Italiano Di Tecnologia, Scuola Normale Superiore Di Pisa filed Critical Consiglio Nazionale Ricerche
Priority to IT000561A priority Critical patent/ITTO20110561A1/en
Publication of ITTO20110561A1 publication Critical patent/ITTO20110561A1/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation; Therapies using these preparations
    • A61K41/0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/008Two-Photon or Multi-Photon PDT, e.g. with upconverting dyes or photosensitisers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb

Abstract

A vector for the spatially and temporally controlled release of an active agent comprising nanoparticles of gold coated with a surfactant and an active agent bound to the said surfactant by means of a photocleavable bond, the said vector being capable of releasing the active agent when exposed to light radiation of wavelength greater than 400 nm included in the region of the visible or the region of the near infrared (NIR) through a multiple photon effect. In particular a vector in which the group having a photolabile bond is 1,2,3-triazole, which can for example be obtained by a click chemistry reaction between gold particles on the surface of which peptide molecules having a free carboxyl terminal group and an alkyne side group are chemiadsorbed and an azide of the active agent is described.
IT000561A 2011-06-27 2011-06-27 Vector for the release of an active agent, fotoscindibile by radiation in the visible ITTO20110561A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IT000561A ITTO20110561A1 (en) 2011-06-27 2011-06-27 Vector for the release of an active agent, fotoscindibile by radiation in the visible

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000561A ITTO20110561A1 (en) 2011-06-27 2011-06-27 Vector for the release of an active agent, fotoscindibile by radiation in the visible
PCT/IB2012/053220 WO2013001451A1 (en) 2011-06-27 2012-06-26 Vector for the release of an active agent which is photocleavable by irradiation in the visible

Publications (1)

Publication Number Publication Date
ITTO20110561A1 true ITTO20110561A1 (en) 2012-12-28

Family

ID=44555428

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000561A ITTO20110561A1 (en) 2011-06-27 2011-06-27 Vector for the release of an active agent, fotoscindibile by radiation in the visible

Country Status (2)

Country Link
IT (1) ITTO20110561A1 (en)
WO (1) WO2013001451A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015099624A1 (en) * 2013-12-26 2015-07-02 Yavuz Mustafa Selman Nanostructures covered with species having photothermally cleavable linkers for controlled delivery of cargo

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008127743A2 (en) * 2007-01-05 2008-10-23 William Marsh Rice University Composition for targeted drug delivery and controlled release
WO2010046377A2 (en) * 2008-10-23 2010-04-29 Fundació Privada Institut Català De Nanotecnologia Immunoactivating conjugates comprising nanoparticles coated with peptides
WO2011070333A2 (en) * 2009-12-10 2011-06-16 Trillion Genomics Limited Probes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100233224A1 (en) 2009-02-23 2010-09-16 Epir Technologies, Inc. Photolytic release of biocides for high efficiency decontamination through phospholipid nanoparticles
CN102421418A (en) 2009-03-09 2012-04-18 得克萨斯系统大学评议会 Hollow gold nanospheres (haunss) and haunss-loaded microspheres useful in drug delivery

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008127743A2 (en) * 2007-01-05 2008-10-23 William Marsh Rice University Composition for targeted drug delivery and controlled release
WO2010046377A2 (en) * 2008-10-23 2010-04-29 Fundació Privada Institut Català De Nanotecnologia Immunoactivating conjugates comprising nanoparticles coated with peptides
WO2011070333A2 (en) * 2009-12-10 2011-06-16 Trillion Genomics Limited Probes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GANG HAN ET AL.: "Light-regulated DNA transcription and delivery using photolabilegold nanoparticles", ABSTRACTS OF PAPERS, 231ST ACS NATIONAL MEETING, ATLANTA,GA, UNITED STATES, MARCH 26-30, 2006 (2006), 1 April 2006 (2006-04-01), XP008145405 *
JUN NAKANISHI ET AL: "Light-Regulated Activation of Cellular Signaling by Gold Nanoparticles That Capture and Release Amines", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 131, no. 11, 25 March 2009 (2009-03-25), pages 3822 - 3823, XP055012539, ISSN: 0002-7863, DOI: 10.1021/ja809236a *
SARIT S. AGASTI ET AL: "Photoregulated Release of Caged Anticancer Drugs from Gold Nanoparticles", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 131, no. 16, 29 April 2009 (2009-04-29), pages 5728 - 5729, XP055012506, ISSN: 0002-7863, DOI: 10.1021/ja900591t *

Also Published As

Publication number Publication date
WO2013001451A1 (en) 2013-01-03

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