ITFI20130128A1 - SOLUTION FOR THE HYGIENE OF THE SPREADING MARGINS AND DEVICE FOR ITS APPLICATION. - Google Patents

SOLUTION FOR THE HYGIENE OF THE SPREADING MARGINS AND DEVICE FOR ITS APPLICATION.

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Publication number
ITFI20130128A1
ITFI20130128A1 IT000128A ITFI20130128A ITFI20130128A1 IT FI20130128 A1 ITFI20130128 A1 IT FI20130128A1 IT 000128 A IT000128 A IT 000128A IT FI20130128 A ITFI20130128 A IT FI20130128A IT FI20130128 A1 ITFI20130128 A1 IT FI20130128A1
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IT
Italy
Prior art keywords
solution
hygiene
eyelid
kit according
kit
Prior art date
Application number
IT000128A
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Italian (it)
Inventor
Daniele Giammaria
Original Assignee
Biodue S P A
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Publication date
Application filed by Biodue S P A filed Critical Biodue S P A
Priority to IT000128A priority Critical patent/ITFI20130128A1/en
Priority to EP14738603.1A priority patent/EP3003300A1/en
Priority to PCT/IB2014/061842 priority patent/WO2014191969A1/en
Publication of ITFI20130128A1 publication Critical patent/ITFI20130128A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
    • A45D34/04—Appliances specially adapted for applying liquid, e.g. using roller or ball
    • A45D34/042—Appliances specially adapted for applying liquid, e.g. using roller or ball using a brush or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D2200/00—Details not otherwise provided for in A45D
    • A45D2200/10—Details of applicators
    • A45D2200/1009—Applicators comprising a pad, tissue, sponge, or the like
    • A45D2200/1018—Applicators comprising a pad, tissue, sponge, or the like comprising a pad, i.e. a cushion-like mass of soft material, with or without gripping means
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D2200/00—Details not otherwise provided for in A45D
    • A45D2200/10—Details of applicators
    • A45D2200/1009—Applicators comprising a pad, tissue, sponge, or the like
    • A45D2200/1036—Applicators comprising a pad, tissue, sponge, or the like containing a cosmetic substance, e.g. impregnated with liquid or containing a soluble solid substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Natural Medicines & Medicinal Plants (AREA)
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Description

Soluzione per l’igiene dei margini palpebrali e dispositivo per la sua applicazione Campo dell’invenzione Solution for the hygiene of the eyelid margins and device for its application Field of the invention

La presente invenzione si riferisce a prodotti per l’igiene palpebrale ed in particolare l’igiene dei margini palpebrali. The present invention refers to products for eyelid hygiene and in particular the hygiene of the eyelid margins.

Stato della tecnica State of the art

Con il termine generico di igiene palpebrale si intendono comunemente tutte quelle norme, attività e pratiche mirate alla detersione e/o disinfezione della cute palpebrale, delle ciglia e dei margini palpebrali. Le indicazioni più comuni per le quali i medici oculisti consigliano di eseguire procedure di igiene palpebrale sono le dermatiti palpebrali, le blefariti anteriori, le blefariti posteriori, la disfunzione delle ghiandole di Meibomio (MGD), gli orzaioli e i calazi ricorrenti, la detersione palpebrale post-operatoria. The generic term of eyelid hygiene commonly means all those rules, activities and practices aimed at cleansing and / or disinfecting the eyelid skin, eyelashes and eyelid margins. The most common indications for which ophthalmologists recommend to perform eyelid hygiene procedures are eyelid dermatitis, anterior blepharitis, posterior blepharitis, meibomian gland dysfunction (MGD), sty and recurrent chalazion, post eyelid cleansing. -operative.

Quando l’igiene palpebrale ha come obiettivo la detersione degli orifizi delle ghiandole di Meibomio, come nel caso di blefariti posteriori, MGD, orzaioli interni e calazi, à ̈ fondamentale che questa venga eseguita nel modo più preciso ed efficace possibile a livello dei margini palpebrali. Infatti, nei pazienti affetti da tali patologie e disfunzioni à ̈ possibile osservare un’ostruzione degli orifizi delle ghiandole di Meibomio per l’accumulo di cellule epiteliali (ipercheratinizzazione) e per la presenza di sebo meibomiano addensato. When eyelid hygiene aims to cleanse the orifices of the meibomian glands, as in the case of posterior blepharitis, MGD, internal styes and chalazion, it is essential that this is performed as accurately and effectively as possible at the marginal level. eyelids. In fact, in patients suffering from such pathologies and dysfunctions it is possible to observe an obstruction of the orifices of the meibomian glands due to the accumulation of epithelial cells (hyperkeratinization) and the presence of thickened meibomian sebum.

I prodotti e i dispositivi per l’igiene palpebrale presenti oggi sul mercato sono costituiti principalmente da garze di cotone o di tessuto non tessuto (TNT) medicate e confezionate singolarmente e sterilmente. Alcuni prodotti in forma liquida, di gel o di schiuma sono venduti per essere usati come detergenti palpebrali con o senza garze di cotone accessorie. The products and devices for eyelid hygiene on the market today are mainly made up of medicated cotton or non-woven fabric (TNT) gauze, individually and sterile packed. Some products in liquid, gel, or foam form are sold for use as eyelid cleansers with or without accessory cotton gauze.

Come alternativa ai prodotti e dispositivi suddetti spesso i medici oculisti consigliano ai pazienti di imbibire con sostanze liquide disparate (acqua calda, shampoo per bambini, camomilla, colliri antibiotici, lacrime artificiali) la punta cotonata di un cotton fioc ed usarlo per detergere i margini palpebrali nel tentativo di mantenere puliti gli orifizi ghiandolari. As an alternative to the aforementioned products and devices, ophthalmologists often advise patients to soak the cotton tip of a cotton swab with disparate liquid substances (hot water, baby shampoo, chamomile, antibiotic eye drops, artificial tears) and use it to clean the eyelid margins. in an effort to keep the glandular orifices clean.

Sia le garze pre-medicate che i prodotti detergenti sono utilissimi e facili da usare quando il paziente ha bisogno di detergere la cute palpebrale e le ciglia. Al contrario, i pazienti lamentano grandi difficoltà quando gli stessi prodotti vengono prescritti per l’igiene del margine palpebrale. La dimensione delle garze, la loro consistenza e maneggevolezza non consentono di detergere con sufficiente precisione ed efficacia i margini palpebrali. Both pre-medicated gauze and cleansing products are very useful and easy to use when the patient needs to cleanse the eyelid skin and eyelashes. On the contrary, patients complain of great difficulty when the same products are prescribed for the hygiene of the eyelid margin. The size of the gauze, its consistency and ease of handling do not allow cleaning the eyelid margins with sufficient precision and effectiveness.

D’altra parte le pratiche alternative suddette spesso espongono il paziente ai più classici rischi del fai da te: i cotton-fioc non sono mai sterili e possono essere fonte di contaminazione palpebrale e oculare; non sempre le sostanze impiegate sono indicate per l’uso oftalmico; raramente il paziente comprende perfettamente quale sia la procedura corretta da eseguire e ciò può esporlo a manovre infruttuose o pericolose. On the other hand, the aforementioned alternative practices often expose the patient to the most classic risks of do-it-yourself: cotton-buds are never sterile and can be a source of eyelid and ocular contamination; the substances used are not always indicated for ophthalmic use; the patient rarely understands perfectly what the correct procedure to perform is and this may expose him to fruitless or dangerous maneuvers.

La conseguenza di tutto questo à ̈ che l’igiene palpebrale eseguita con i prodotti attualmente in commercio non à ̈ efficace per il trattamento di patologie come la MGD, le blefariti posteriori, la blefarite seborroica, gli orzaioli e i calazi ricorrenti ed à ̈ quindi evidente l’interesse a disporre di prodotti e dispositivi adatti alla pulizia dei margini palpebrali facili da utilizzare e finalizzati a questo scopo. The consequence of all this is that eyelid hygiene performed with the products currently on the market is not effective for the treatment of diseases such as MGD, posterior blepharitis, seborrheic blepharitis, styes and recurrent chalazion and is therefore there is an evident interest in having products and devices suitable for cleaning the eyelid margins that are easy to use and aimed at this purpose.

Breve descrizione delle figure Brief description of the figures

La figura 1 rappresenta un particolare del dispositivo dell’invenzione Figure 1 represents a detail of the device of the invention

Sommario dell’invenzione Summary of the invention

Sono descritti una soluzione per l’igiene dei margini palpebrali ed un kit comprendente detta soluzione e applicatori per la sua applicazione sui margini palpebrali. A solution for the hygiene of the eyelid margins and a kit including said solution and applicators for its application on the eyelid margins are described.

Descrizione dettagliata dell’invenzione Detailed description of the invention

La presente invenzione consente di risolvere i problemi suddetti grazie ad una soluzione per l’igiene dei margini palpebrali e ad un kit comprendente detta soluzione ed un applicatore per la sua applicazione sui margini palpebrali. The present invention allows to solve the above problems thanks to a solution for the hygiene of the eyelid margins and to a kit comprising said solution and an applicator for its application on the eyelid margins.

La soluzione secondo l’invenzione à ̈ costituta da olio di Jojoba, preferibilmente estratto a freddo da semi di Simmondsia Chinensis, eventualmente in combinazione con: antibatterici naturali o di sintesi, antiinfiammatori, antiossidanti, diluenti, conservanti. The solution according to the invention consists of Jojoba oil, preferably cold extracted from Simmondsia Chinensis seeds, possibly in combination with: natural or synthetic antibacterials, anti-inflammatories, antioxidants, diluents, preservatives.

Gli antibatterici utili secondo l’invenzione possono essere scelti, ad esempio, fra: terpinen-4-olo, timolo, estratto liposolubile di Mimosa Tenuiflora, piroctone olamina, azitromicina, tetracicline e loro derivati. The antibacterials useful according to the invention can be selected, for example, from: terpinen-4-ol, thymol, fat-soluble extract of Mimosa Tenuiflora, piroctone olamine, azithromycin, tetracyclines and their derivatives.

Quando presenti questi prodotti sono normalmente in quantità compresa fra 0,01 – 0,05 % , preferibilmente 0,03 % (w/V calcolato sul volume totale della soluzione). Un esempio di antiinfiammatori utili secondo l’invenzione à ̈ l’α-bisabololo, che, se presente, à ̈ normalmente in quantità compresa fra 0,01 – 1%, preferibilmente 0,5% (w/V calcolato sul volume totale della soluzione). When present these products are normally in quantities between 0.01 - 0.05%, preferably 0.03% (w / V calculated on the total volume of the solution). An example of useful anti-inflammatories according to the invention is Î ± -bisabolol, which, if present, is normally in an amount between 0.01 - 1%, preferably 0.5% (w / V calculated on the total volume of the solution).

Gli antiossidanti utili secondo l’invenzione possono essere scelti, ad esempio, tra vitamina E (fra 0,1 - 0,5%), butilidrossianisolo (BHA) e butilidrossitoluene (BHT) (fra 0,01-0,05%). The antioxidants useful according to the invention can be chosen, for example, from vitamin E (between 0.1 - 0.5%), butylhydroxyanisole (BHA) and butylhydroxytoluene (BHT) (between 0.01-0.05%) .

Come diluenti secondo l’invenzione si intendono oli di tipo vegetale (ad esempio olio di ricino), oli minerali (come ad esempio olio di vaselina) o oli di sintesi (come ad esempio dicaprililcarbonato); i diluenti verranno ovviamente aggiunti nelle quantità necessarie a raggiungere la densità finale desiderata. As diluents according to the invention are meant vegetable oils (for example castor oil), mineral oils (such as vaseline oil) or synthetic oils (such as dicaprilyl carbonate); the thinners will obviously be added in the quantities necessary to reach the desired final density.

Infine i conservanti sono quelli comunemente usati per le soluzioni ad uso oftalmico, quali ad esempio miscela di parabeni, nelle quantità comunemente usate a questo scopo. Finally, the preservatives are those commonly used for solutions for ophthalmic use, such as a mixture of parabens, in the quantities commonly used for this purpose.

Una soluzione secondo l’invenzione potrà quindi essere costituita da olio di Jojoba al 100% estratto a freddo da semi di Simmondsia Chinensis oppure avere, ad esempio, la seguente formulazione: Olio di Jojoba 99,97%, terpinen-4-olo 0,03%. Come mostrato in Figura 1 l’applicatore 10 secondo l’invenzione à ̈ normalmente costituito da un bastoncino 11 che funge da impugnatura recante ad almeno una delle sue estremità un fiocco 12 di materiale atto ad impregnare la soluzione al momento dell’uso. A solution according to the invention could therefore be made up of 100% Jojoba oil cold extracted from Simmondsia Chinensis seeds or have, for example, the following formulation: Jojoba oil 99.97%, terpinen-4-ol 0 , 03%. As shown in Figure 1, the applicator 10 according to the invention is normally constituted by a stick 11 which acts as a handle bearing at least one of its ends a ribbon 12 of material suitable for impregnating the solution at the moment of use. .

Il bastoncino 11 sarà di un qualsiasi materiale rigido adatto allo scopo come plastica, legno, metallo ecc. (preferibilmente plastica rigida) mentre il materiale del/dei fiocco/fiocchi 12 sarà costituito da cotone, tessuto non tessuto, setole naturali o sintetiche ecc. The stick 11 will be of any rigid material suitable for the purpose such as plastic, wood, metal, etc. (preferably rigid plastic) while the material of the staple (s) 12 will consist of cotton, non-woven fabric, natural or synthetic bristles, etc.

Preferibilmente i fiocchi 12 saranno in forma rastremata con estremità a punta smussa che renda ancora più facile seguire il perimetro del margine palpebrale. Gli applicatori saranno preferibilmente contenuti singolarmente o in coppia in involucri sterili adatti allo scopo, ad esempio bustine in plastica, carta, carta plastificata, cellophane, o altro materiale adatto allo scopo. Preferably the flakes 12 will be in a tapered shape with a blunt tip that makes it even easier to follow the perimeter of the eyelid margin. The applicators will preferably be contained individually or in pairs in sterile packaging suitable for the purpose, for example bags made of plastic, paper, plasticized paper, cellophane, or other material suitable for the purpose.

La soluzione potrà essere contenuta in un contenitore contagocce multi-dose (ed in tal caso à ̈ preferibile che questa contenga gli opportuni conservanti come sopra indicati) o in singoli flaconcini (oftioli) monodose in polietilene normalmente di volume pari a 0,35 – 1 ml, preferibilmente 0,5 ml, preconfezionati e contenenti un volume di soluzione pari ad esempio a 0,15 – 0,5 ml, preferibilmente 0,25 ml. ed in questo caso non sarà necessario aggiungere i conservanti. The solution can be contained in a multi-dose dropper container (and in this case it is preferable that this contains the appropriate preservatives as indicated above) or in single single-dose polyethylene vials (ophthyols) normally with a volume of 0.35 â € 1 ml, preferably 0.5 ml, pre-packaged and containing a volume of solution equal for example to 0.15 - 0.5 ml, preferably 0.25 ml. and in this case it will not be necessary to add preservatives.

L’utilizzatore, al momento dell’uso, potrà, una volta estratto l’applicatore dal suo contenitore sterile, medicare uno dei fiocchi con la soluzione contenuta nella monodose o con il numero di gocce necessarie prelevate dal contenitore contagocce multi-dose e applicare la soluzione strofinando l’estremità medicata dell’applicatore sui margini delle palpebre opportunamente distanziate dal bulbo oculare. The user, at the time of use, can, once the applicator has been extracted from its sterile container, dress one of the flakes with the solution contained in the single-dose or with the number of drops required taken from the multi-dose dropper container and apply the solution by rubbing the medicated end of the applicator on the edges of the eyelids suitably spaced from the eyeball.

La forma, la maneggevolezza e la rigidità dell’applicatore consentiranno di eseguire con semplicità un’accurata detersione meccanica degli orifizi delle ghiandole di Meibomio allontanando dai margini palpebrali residui cellulari, sebo addensato, batteri e loro metaboliti tossici. L’olio di Jojoba, grazie al suo elevato contenuto di cere esterificate, consentirà la detersione per affinità del sebo meibomiano alterato ed il reintegro della componente lipidica del film lacrimale. The shape, the manageability and the rigidity of the applicator will allow to perform with simplicity an accurate mechanical cleaning of the orifices of the meibomian glands, removing cell residues, thickened sebum, bacteria and their toxic metabolites from the eyelid margins. Jojoba oil, thanks to its high content of esterified waxes, will allow the cleansing by affinity of the altered meibomian sebum and the reintegration of the lipid component of the tear film.

Claims (12)

RIVENDICAZIONI 1. Soluzione per l’igiene del margine palpebrale costituta da olio di Jojoba eventualmente in combinazione con: antibatterici naturali o di sintesi, antiinfiammatori, antiossidanti, diluenti, conservanti. CLAIMS 1. Solution for the hygiene of the eyelid margin consisting of Jojoba oil possibly in combination with: natural or synthetic antibacterials, anti-inflammatories, antioxidants, diluents, preservatives. 2. Soluzione secondo la rivendicazione 1 in cui detto olio di Jojoba à ̈ estratto a freddo da semi di Simmondsia Chinensis. 2. Solution according to claim 1 wherein said Jojoba oil is cold extracted from Simmondsia Chinensis seeds. 3. Soluzione secondo le rivendicazioni 1 e 2 in cui detti antibatterici sono scelti fra: terpinen-4-olo, timolo, estratto liposolubile di Mimosa Tenuiflora, piroctone olamina, acido usnico, azitromicina, tetracicline e loro derivati o loro miscele e sono presenti in quantità compresa fra 0,01 – 0,05 % , preferibilmente 0,03 % (w/V calcolato sul volume totale della soluzione). 3. Solution according to claims 1 and 2 in which said antibacterials are selected from: terpinen-4-ol, thymol, fat-soluble extract of Mimosa Tenuiflora, piroctone olamine, usnic acid, azithromycin, tetracyclines and their derivatives or their mixtures and are present in quantity between 0.01 - 0.05%, preferably 0.03% (w / V calculated on the total volume of the solution). 4. Soluzione secondo le rivendicazioni 1 – 3 in cui detto antiinfiammatorio à ̈ α-bisabololo in quantità compresa fra 0,01 – 1%, preferibilmente 0,5% (w/V calcolato sul volume totale della soluzione). 4. Solution according to claims 1 - 3 wherein said anti-inflammatory is Î ± -bisabolol in a quantity comprised between 0.01 - 1%, preferably 0.5% (w / V calculated on the total volume of the solution) . 5. Soluzione secondo le rivendicazioni 1 – 4 in cui detti antiossidanti sono scelti fra vitamina E fra 0,1 - 0,5%, Butilidrossianisolo (BHA) e Butilidrossitoluene (BHT) fra 0,01-0,05%. 5. Solution according to claims 1 - 4 wherein said antioxidants are selected from vitamin E between 0.1 - 0.5%, Butylhydroxyanisole (BHA) and Butylhydroxytoluene (BHT) between 0.01-0.05%. 6. Kit comprendente una soluzione secondo le rivendicazioni 1 – 6 ed un applicatore per applicazione di detta soluzione sui margini palpebrali. 6. Kit comprising a solution according to claims 1 to 6 and an applicator for applying said solution on the eyelid margins. 7. Kit secondo la rivendicazione 6 in cui la soluzione, preferibilmente contenente gli opportuni conservanti à ̈ contenuta in un contenitore contagocce multi-dose o in singoli flaconcini, oftioli, monodose. 7. Kit according to claim 6 wherein the solution, preferably containing the suitable preservatives, is contained in a multi-dose dropper container or in single vials, ophthyols, single-dose. 8. Kit secondo le rivendicazioni 6 e 7 in cui detto applicatore (10) à ̈ costituito da un bastoncino (11) che funge da impugnatura recante su almeno una delle sue estremità un fiocco (12) di materiale atto ad impregnare la soluzione al momento dell’uso. 8. Kit according to claims 6 and 7 wherein said applicator (10) consists of a stick (11) which acts as a handle bearing on at least one of its ends a ribbon (12) of material suitable for impregnating the solution at the moment of use. 9. Kit secondo la rivendicazione 8 in cui detto bastoncino (11) à ̈ in materiale rigido adatto allo scopo mentre il/i fiocco/fiocchi (12) à ̈ costituito da cotone, tessuto non tessuto, setole naturali o sintetiche e simili. 9. Kit according to claim 8 wherein said stick (11) is made of rigid material suitable for the purpose while the bow (s) (12) consists of cotton, non-woven fabric, natural or synthetic bristles and the like. 10. Kit secondo la rivendicazione 9 in cui detti fiocchi (12) hanno forma rastremata con estremità a punta smussa. 10. Kit according to claim 9 wherein said flakes (12) have a tapered shape with blunt tip ends. 11. Kit secondo le rivendicazioni 1 – 10 in cui gli applicatori sono contenuti singolarmente o in coppia in involucri sterili adatti allo scopo. 11. Kit according to claims 1 - 10 in which the applicators are contained individually or in pairs in sterile packages suitable for the purpose. 12. Uso di una soluzione secondo le rivendicazioni 1 – 5 per l’igiene dei margini palpebrali.12. Use of a solution according to claims 1 - 5 for the hygiene of the eyelid margins.
IT000128A 2013-05-30 2013-05-30 SOLUTION FOR THE HYGIENE OF THE SPREADING MARGINS AND DEVICE FOR ITS APPLICATION. ITFI20130128A1 (en)

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EP14738603.1A EP3003300A1 (en) 2013-05-30 2014-05-30 A solution for eyelid margin hygiene and a device for its application
PCT/IB2014/061842 WO2014191969A1 (en) 2013-05-30 2014-05-30 A solution for eyelid margin hygiene and a device for its application

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HK1256692A1 (en) * 2015-12-31 2019-10-04 Amorepacific Corporation Sponge having antibacterial activity
US11478437B2 (en) 2016-07-05 2022-10-25 Jenivision Inc. Formulations for hair growth
GB2606486B (en) * 2017-06-30 2023-03-22 Jenivision Inc Formulations for relieving dry eye
FR3131214A1 (en) * 2021-12-23 2023-06-30 Laboratoires Thea TOPICAL COMPOSITION AND ITS APPLICATOR, INTENDED TO RELIEVE CHALAZION

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