IT988052B - Procedimento di fluorurazione - Google Patents

Procedimento di fluorurazione

Info

Publication number
IT988052B
IT988052B IT51835/71A IT5183571A IT988052B IT 988052 B IT988052 B IT 988052B IT 51835/71 A IT51835/71 A IT 51835/71A IT 5183571 A IT5183571 A IT 5183571A IT 988052 B IT988052 B IT 988052B
Authority
IT
Italy
Prior art keywords
acid
alpha
acetic acid
fluoro
reacted
Prior art date
Application number
IT51835/71A
Other languages
English (en)
Italian (it)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of IT988052B publication Critical patent/IT988052B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04Polysiloxanes
    • C08G77/38Polysiloxanes modified by chemical after-treatment
    • C08G77/382Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon
    • C08G77/385Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon containing halogens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00Halogenation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/013Preparation of halogenated hydrocarbons by addition of halogens
    • C07C17/02Preparation of halogenated hydrocarbons by addition of halogens to unsaturated hydrocarbons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/12Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01Preparation of ethers
    • C07C41/18Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/16Halogenated acetic acids
    • C07C53/18Halogenated acetic acids containing fluorine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/50Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/38Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/12Organo silicon halides
    • C07F7/121Preparation or treatment not provided for in C07F7/14, C07F7/16 or C07F7/20
    • C07F7/127Preparation or treatment not provided for in C07F7/14, C07F7/16 or C07F7/20 by reactions not affecting the linkages to the silicon atom
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/18Introducing halogen atoms or halogen-containing groups
    • C08F8/20Halogenation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24Anthracenes; Hydrogenated anthracenes
IT51835/71A 1970-08-03 1971-07-22 Procedimento di fluorurazione IT988052B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6064570A 1970-08-03 1970-08-03
US15469571A 1971-06-18 1971-06-18

Publications (1)

Publication Number Publication Date
IT988052B true IT988052B (it) 1975-04-10

Family

ID=26740158

Family Applications (1)

Application Number Title Priority Date Filing Date
IT51835/71A IT988052B (it) 1970-08-03 1971-07-22 Procedimento di fluorurazione

Country Status (9)

Country Link
JP (1) JPS5544048B1 (ja)
AU (1) AU465026B2 (ja)
CA (1) CA967982A (ja)
CH (1) CH575354A5 (ja)
FR (1) FR2103901A5 (ja)
GB (1) GB1353519A (ja)
HU (1) HU163751B (ja)
IT (1) IT988052B (ja)
NL (1) NL173388C (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3186820B2 (ja) * 1992-02-28 2001-07-11 ダウ・コ−ニング・コ−ポレ−ション 反応性ポリシロキサンおよびその製造方法
US6203671B1 (en) * 1999-03-10 2001-03-20 Alliedsignal Inc. Method of producing fluorinated compounds
ES2498293T3 (es) * 2010-11-12 2014-09-24 Bayer Intellectual Property Gmbh Procedimiento para la preparación de 2,2-difluoroetilamina partiendo de prop-2-en-1-amina
ES2636776T3 (es) * 2010-11-12 2017-10-09 Bayer Intellectual Property Gmbh Procedimiento para la preparación de 2,2-difluoroetilamina partiendo de un compuesto de bencilamina
CN114908360B (zh) * 2022-06-21 2023-08-15 浙江诺亚氟化工有限公司 一种全氟异丁腈的合成工艺

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3585218A (en) * 1967-05-24 1971-06-15 Minnesota Mining & Mfg Preparation of difluoramines by oxidation with 1,1-bis(fluoroxy)perfluoroalkane
IL30681A (en) * 1967-09-11 1973-10-25 Res Inst Medicine Chem Process for the introduction of fluorine into unsaturated organic compounds

Also Published As

Publication number Publication date
JPS5544048B1 (ja) 1980-11-10
AU3146371A (en) 1973-01-25
NL7109946A (ja) 1972-02-07
NL173388B (nl) 1983-08-16
FR2103901A5 (ja) 1972-04-14
CA967982A (en) 1975-05-20
CH575354A5 (ja) 1976-05-14
GB1353519A (en) 1974-05-22
DE2136008A1 (de) 1972-02-10
DE2136008B2 (de) 1976-02-12
AU465026B2 (en) 1975-09-18
NL173388C (nl) 1984-01-16
HU163751B (ja) 1973-10-27

Similar Documents

Publication Publication Date Title
KR880001625A (ko) 탁솔 유도체, 그 제법 및 그들을 함유한 약제학적 조성물
FR2103901A5 (ja)
GB1328696A (en) 1-azazyclopentano-1,2-a-adamantane compounds and derivatives thereof
TW201827407A (zh) 作爲Caspase抑制劑的聯環化合物
Brynes et al. Potential inhibitors of L-asparagine biosynthesis. 4. Substituted sulfonamide and sulfonylhydrazide analogs of L-asparagine
US3956367A (en) 3-Fluoro-D-alanine and pharmacologically acceptable esters, and pharmacologically acceptable salts thereof
US3948896A (en) N-mono(alkoxymethyl) phenobarbitals, process therefor and therapeutic composition and method containing same
Harris et al. The alkaline hydrolysis of fluorenone-spirohydantoin
GB588108A (en) Manufacture of bacteriostatic substances
GB1451902A (en) Bromo dihydrolysergic acid
US3637837A (en) Gamma-alkylthiolysines
Subluskey et al. Isobornylisothiuronium Salts1
Overberger et al. STEREOCHEMISTRY OF THE DECOMPOSITION OF OPTICALLY ACTIVE N-NITROSO AND N-AMINO α, α'-DIMETHYLIDIBENZYLAMINE
Jarman et al. Synthesis of tritium-labeled chlorambucil and aniline mustard of high specific activity
Hansen Chloro and fluoro compounds related to adrenalone
US4087529A (en) Therapeutic composition containing an N-mono (alkoxy-methyl) phenobarbital and a method of treating convulsions therewith
Seligman et al. Synthesis of Peptides and Esters of Phenylalanine as Chromogenic Substrates for Chymotrypsin1
US4054565A (en) Process for preparing N-mono(alkoxymethyl) phenobarbitals
FR1756M (ja)
JPS60132956A (ja) S−アルキルチオ−l−システインスルフオキサイド化合物及びその製造方法並びにこれを含有する抗高脂血症及び強肝剤
IT9021697A1 (it) Derivato di mentolo ad azione spasmolitica
KR970008113B1 (ko) 엔(n)-노르말-알카노일아만타딘 유도체
HORI et al. Syntheses of DL-Isoleucine Based on the Darapsky and the Hofmann Degradations
GB1501356A (en) Process for the continuous preparation of organic solutions of percarboxylic acids
JPS60185763A (ja) 非対称ジスルフイド化合物