IT202100021869A1 - Locust bean gum as an active texturizer, and as a rheological agent in a combination with sclerotic gum - Google Patents

Description

TITLE: ?Carob seed flour as an active texturizer, and as a rheological agent in an association with sclerotic gum?

DESCRIPTION

FIELD OF THE INVENTION

The present invention belongs to the technical field of chemistry and green cosmetics. Pi? in particular, the invention identifies a natural texturizing agent with marked properties? moisturizing, anti-wrinkle, film-forming and improvement of firmness and elasticity? skin, as well as a synergistic rheological association comprising the texturizing agent and a natural polysaccharide.

STATE OF ART

The use of polysaccharides in cosmetic formulations? growing, together with the increasing attention of manufacturing companies towards green raw materials and sustainability? of the product.

Are hydrophilic polymers among the ingredients most commonly used to impart texture to emulsions? for example in skin care products ? and are, in this sense, usually called texturizing agents (R. Y. Lochhead, The role of polymers in cosmetics: recent trends, in: Cosmetic Nanotechnology, ACS Symposium Series American Chemical Society, 961, 2007, pp.3-56).

Among the most hydrophilic polymers? widely used include polysaccharides, complex carbohydrates with many hydroxyl groups that interact strongly with water. They are widely used in food, cosmetics and pharmaceutical manufacturing, why? can they provide good properties? mechanics in applications such as fibers, adhesives, hydrogels, or drug delivery agents (Lapasin, R.; Pricl, S. Rheology of Industrial Polysaccharides, Theory and Application; Blackie Academic & Professional: London, UK, 1995.)

In personal care products, these multipurpose polymers are also used as rheological agents, i.e. thickeners, stabilizing agents, etc. (e.g. xanthan gum, cellulose); or, how already? mentioned, such as ingredients improving the skin sensation of the product or texture (e.g. hyaluronic acid, guar derivatives) (Gruber, J.V. Polysaccharide-Based Polymers in Cosmetics. In Principles of Polymer Science and Technology in Cosmetic and Personal Care; Goddard, E.D. , Gruber, J.V., Eds.; Marcel Dekker Inc.: New York, NY, USA, 1999; Volume 22, pp.339?403).

Other examples of natural polymers widely used in the cosmetic field as rheological agents are, for example, carrageenans, a family of highly biocompatible natural polysaccharides, extracted from red algae; xyloglucans from Tamarind, a hemicellulose of vegetable origin, obtained from the seeds of the Tamarindus indica L. tree (Semenzato, Alessandra & Costantini, Alessia & Baratto, Giovanni. (2014). Green Polymers in Personal Care Products: Rheological Properties of Tamarind Seed Polysaccharide.Cosmetics.2.10.3390/cosmetics2010001).

The study of properties rheological and texture of a cosmetic product? of considerable interest and importance: rheological measurements, generally conducted using viscometric, viscoelastic or structural analysis characterizations, are very useful for characterizing the properties of flow of emulsion systems and predict their behavior during production, packaging or final use (T.F. Tadros, Application of rheology for assessment and prediction of the longterm physical stability of emulsions, Adv. Colloid Interface Sci. (2004) 227?258). The texture (or consistency) of the product, on the other hand, is generally examined on the basis of the sensation that the user has when using it; the texture impacts on the pleasantness and success of the product, since? consumer preference? closely linked to the consistency of the formula.

Although treated separately since? aimed at obtaining different technical effects in the cosmetic field, it is believed that the properties? rheological and texture of a product are closely related; the selection of functional rheological agents, for example, for the stabilization of a formula, influences the texture of the final product (Laura Gilbert, C?line Picard, G?raldine Savary, Michel Grisel, Rheological and textural characterization of cosmetic emulsions containing natural and synthetic polymers: relationships between both data, Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 421, 2013, Pages 150-163, ISSN 0927-7757, https://doi.org/10.1016/j.colsurfa.2013.01.003) .

Problem of the prior art

Some of the natural substances used as rheological and/or texturizing agents in the food or cosmetic fields have limitations in terms of applications: sensitivity? to pH variations, electrolyte content or even the combination with natural or synthetic cosmetic ingredients can? affect their properties? mechanical and viscosifying agents, thus making some of these substances scarcely or difficult to use in complex formulation systems.

Furthermore, with a view to greater sustainability? of chemical products, which can be used in the food, cosmetic and/or pharmaceutical fields, there ? the need and interest in identifying new green alternatives to natural or synthetic rheological agents known to the state of the art.

SUMMARY OF THE INVENTION

The Applicant has found that carob seed flour can be effectively used as a texturizing agent in the preparation of compositions for the care and well-being of body surfaces and mucous membranes. Pi? in particular, the carob flour constitutes an active texturizing agent since, at concentrations comparable to those in which it influences the consistency of a formulation, it has remarkable properties moisturizing, anti-wrinkle, film-forming and improvement of firmness and elasticity? skin equivalent or sometimes higher than those of hyaluronic acid.

During compatibility studies? of the carob seed flour, the Applicant has also identified a rheological association consisting of carob seed flour and sclerotium gum. The association yes? proven to be stable with most of the traditional cosmetic ingredients and endowed with properties? viscosity enhancers compared to carob seed flour alone, due to a synergistic effect.

Object of the present invention ? therefore a composition for the care and well-being of body surfaces and mucous membranes comprising a texturizing agent consisting of carob seed flour, said texturizing agent being in a concentration between 0.5% and 8% by weight on the total weight of the composition ( p/p). Preferably, the composition also comprises sclerotic gum (sclerotium gum) combined with the texturizing agent in a weight ratio of between 10:90 and 30:70 (sclerotium gum/carob seed flour).

Advantages of the invention

The texturizing agent based on carob seed flour is a green, 100% natural texturizer; gives an extraordinary sensoriality to the finished product.

Based on the results obtained from the in vivo experimentation (see Example No.3, in the experimental section) ? been shown that carob seed flour ? effective in reducing roughness? skin and improve hydration in a similar way to hyaluronic acid; it has also demonstrated a better effect on skin elasticity, firmness and Tewl.

Carob seed flour? usable in a versatile way in different types of formulations (emulsions, gels, emulgels, liquids, fluids; semi-consistent or consistent products).

Has the Applicant carried out a systematic to evaluate the compatibility? of the raw material with the main cosmetic ingredients: ? emerged that the carob seed flour? stable in combination with the main formulation cosmetic ingredients (surfactants, emulsifiers, humectants, solubilizers, rheological agents).

In particular, compared with other natural texturizing / rheological agents, carob seed flour has shown greater compatibility with the skin. with known rheological additives (such as carbomer) versus xanthan gum and carrageenan.

Also, when is carob seed flour? been associated with sclerotic gum, the combination has been shown to have increased ability? viscosifiers, which make the combination of the two ingredients an interesting rheological association for the preparation of formulas suitable for the care and well-being of body surfaces and mucous membranes.

The rheological association, as such, has the following advantages:

- constitutes a 100% natural blend, of vegetable/biofermentative origin, suitable for cosmetic products or medical devices containing green ingredients;

- according to the Applicant, the rheological association exhibits a synergistic behavior in terms of texture, but above all of viscosity;

- ? usable in a versatile way, in various types of products (O/W emulsions, masks, gels, emulgels, rinse-off products, sunscreen products, oral care);

- from the systematic conducted by the Applicant to evaluate the compatibility? of the association with the main cosmetic ingredients also emerges? better compatibility? of the association compared to the texturizing agent alone.

DESCRIPTION OF THE FIGURES

Figure 1: trend of the roughness? skin at various follow-up times; stratified by type of treatment.

Figure 2: trend of skin hydration in the various follow-up times; stratified by type of treatment.

Figure 3: trend of Tewl in the various follow-up times; stratified by type of treatment.

Figure 4: trend of elasticity at the various follow-up times; stratified by type of treatment.

Figure 5: Trend of firmness at various follow-up times stratified by type of treatment.

Figure 6: roughness measurement skin after 12h from the application of a 1.5% carob flour gel on the right side of the forehead of an individual. The measurement ? relating to one of the subjects enrolled in the study, in relation to which the best results were measured? significant in terms of roughness? (measured with Antera 3D camera? (?m)). The forehead region photographed ? the central-lateral one, near? of the eyebrow: the areas pi? dark identify the depressions or bumps? that deviate from the ideal surface (such as wrinkles or the eyebrow itself). The decrease in roughness? registered after 12 hours ? amounted to 18%.

Figure 7: roughness measurement skin after 12h from the application of a 0.1% sodium hyaluronate gel (benchmark) on the left side of the forehead of the same patient photographed in figure 6 (measurement with Antera 3D camera? (?m)). The forehead region photographed ? the central-lateral one, near? of the eyebrow: the areas pi? dark identify the depressions or bumps? that deviate from the ideal surface (such as wrinkles or the eyebrow itself). The decrease in roughness? registered after 12 hours ? amounted to 6%.

DETAILED DESCRIPTION OF THE INVENTION

As previously mentioned, the object of the present invention is a composition for the care and well-being of body surfaces and mucous membranes comprising carob seed flour as a texturizing agent.

Alternatively, a further object of the present invention can be be the use of carob seed flour as a texturizing agent for compositions intended for the care and well-being of body surfaces and mucous membranes.

In the purposes of the present invention, by composition intended for the care and well-being of body surfaces and mucous membranes is meant any substance or mixture intended to be applied to external surfaces (epidermis, hair and piliferous system, nails, lips, external genital organs) or internal parts of the human body (oral, vaginal, rectal, nasal mucous membranes) or on the teeth for the exclusive or mainly purpose of cleaning them, perfuming them, changing their appearance, protecting them, keeping them in good condition.

Still preferably, by skin and mucous membranes are meant the surfaces of the human body belonging to the group consisting of: skin, oral cavity, oral mucosa, vaginal mucosa, rectal mucosa, nasal mucosa, hair, scalp, body, hands, feet.

The scientific name of the carob, Ceratonia siliqua L., derives from the Greek ?kera?, which refers to the keratomorphic shape of the fruit, and from the Latin ?siliqua?, which indicates the hardness and shape of the pods.

Carob fruits are characterized by a high sugar content (48%?56%) (mainly sucrose, glucose and fructose), 3%?4% protein, a low fat content (0.2%?0.6 %) (Batlle & Tous, 1997 ), low content of alkaloids and high content of dietary fiber, especially in seeds (Ortega et al., 2009). Specifically the pulp? composed of sugars, polyphenols (e.g. tannins, flavonoids, phenolic acids) and minerals (e.g. K, Ca, Mg, Na, Cu, Fe, Mn, Zn), while the seed contains proteins, dietary fibers, polyphenols and minerals and ? gluten free.

The endosperm of the carob seed contains a water-soluble mucus - known as locust bean gum - which is a polysaccharide (galactomannan) consisting of 16%-20% D-galactose and 80%-84% D-mannose. Carob seed flour? obtained from the processing of seeds and ? a natural additive (E410) (Salinas, Carbas, Brites and Puppo, 2015). ? widely used in the food industry as a thickener, stabilizer (Lazaridou, Biliaderis & Izydorczyk, 2001) and gelling or dispersing agent. Locust bean gum has many applications in cosmetics, pharmaceuticals, film emulsions, paints, polishes, ceramics, and adhesives (Batlle & Tous, 1997).

The carob seed flour, used for the purposes of the invention, is preferably characterized by a galactomannan content ? 75%, preferably between 75% and 95%, preferably between 75% and 85% by weight on the total weight of the flour (w/w).

Preferably, carob seed flour? characterized by a molecular weight between 50,000 and 3,000,000 Da (in accordance with JECFA and EU. Reg.231/2012).

Such carob flour ? obtainable with methods known to the expert in the sector which are based on thermo-mechanical treatments of the carob fruit, without the use of solvents or chemical substances: the pods are broken between two rollers and the seeds separated from the rest of the pods by means of special sieves. By means of mechanical abrasion and heat treatments, the separation of the germ from the endosperm is obtained. The endosperm is then ground and sold as carob bean gum (Sheweta Barak, Deepak Mudgil, Locust bean gum: Processing, properties and food applications - A review, International Journal of Biological Macromolecules, Volume 66, 2014, Pages 74-80 , ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2014.02.017.).

1? embodiment: composition comprising carob flour as a texturizing agent.

It should be noted that the composition according to the invention comprises the texturizing agent in a concentration between 0.5% and 8% by weight on the total weight of the composition (w/w), preferably in a concentration between 0.5% and 6% (w/w), preferably in a concentration between 1% and 4% (w/w), preferably in a concentration between 1% and 3% (w/w), preferably equal to 1%, 1.5%, 2 %, 2.5%, 3% (w/w).

Preferably, carob seed flour? a fine ivory colored powder, preferably characterized by a particle size ranging from values < 150 µm. Preferably, 60-80% of the powder has a particle size < 104 ?m, preferably between 104 ?m and 30 ?m.

Note that the composition, when it includes carob seed flour in a concentration between 0.5% and 8%, is ? preferably characterized by a viscosity? between 50 mPa.s and 40,000 mPa.s.

Still preferably, the composition of the invention, comprising carob seed flour in a concentration between 3% and 4% (w/w), is characterized by a viscosity between 3,000 mPa.s and 4,000 mPa.s.

According to a preferred embodiment, the texturizing agent also constitutes a moisturizing, anti-wrinkle, film-forming active ingredient and an active ingredient in improving skin firmness and elasticity. cutaneous. Has the Applicant demonstrated the properties? moisturizing, anti-wrinkle, film-forming and improvement of firmness and elasticity? treatment of the texturizing agent of the invention in the experimental study described in Example 3.

In this sense, another object of the present invention ? the use of carob seed flour as a skin active ingredient in compositions for the care and well-being of body surfaces and mucous membranes.

Preferably, the texturizing agent also constitutes a moisturizing, anti-wrinkle, film-forming active ingredient and an active ingredient in improving skin firmness and elasticity. skin in a concentration between 0.5% and 4% (w/w), preferably between 0.5% and 3% (w/w), preferably equal to 0.5%, 1%, 1.5%, 2 %, 2.5%, 3% (w/w).

Preferably, the composition object of the present invention comprises, in addition to the texturizing agent, other formulation cosmetic ingredients, wherein for formulation cosmetic ingredient is meant an ingredient suitable for the formulation of compositions for the care and well-being of body surfaces and mucous membranes which are not? biologically active, but ? functional to the technical realization of a stable and suitable formulation for the uses for which it? intended. These formulation ingredients are defined cosmetics because? they are those that are traditionally used in the production of cosmetic formulations. There? For? it does not exclude its use in the production of differently classified formulations (such as medical devices).

Said other cosmetic formulation ingredients are preferably selected from one or more of the following:

- surfactants, the surfactants being selected from the group consisting of: anionic surfactants, non-ethoxylated anionic surfactants, non-ionic surfactants, amphoteric surfactants and cationic surfactants;

- emulsifiers, the emulsifiers being selected from the group consisting of anionic emulsifiers, nonionic emulsifiers and cationic emulsifiers;

- humectants, selected from glycerin and glycols;

- solubilizers, selected from the group consisting of

non-ionic solubilizers in a concentration between 1% and 2%, preferably between 1 and 1.5%, preferably equal to 1% (w/w);

polyglyceryl-derivative solubilizers in a concentration between 1% and 2%, preferably between 1.5 and 2%, preferably equal to 2% (w/w);

lipoamino acid solubilizers in a concentration ranging from 1% to 10% (w/w), preferably ranging from 5% to 10%;

- rheological additives of natural or synthetic origin.

It should be noted that, according to a preferred embodiment, the composition according to the invention also comprises active ingredients suitable for the care and well-being of the body surfaces and mucous membranes.

Advantageously, the composition comprising the texturizing agent and one or more? of the cosmetic ingredients (formulative and/or active) listed above ? stable, where stable means a composition that maintains its viscosity? over time and which has no phase separation over time. Preferably, the composition for the care and well-being of body surfaces and mucous membranes comprising the texturizing agent in combination with one or more? of the aforementioned cosmetic ingredients? stable for a period of 3 months at a temperature between 25?C and 40?C.

According to a preferred embodiment, the composition for the care and well-being of the body surfaces and mucous membranes comprises the texturizing agent and surfactants, the surfactants being in a concentration between 3% and 15%, preferably between 5% and 15% , preferably between 5% and 10% (w/w).

Still preferably, the composition comprises the texturizing agent and surfactants at a pH between 5.9 and 7.4, preferably between 6.0 and 7.2.

According to a preferred embodiment, the composition for the care and well-being of the body surfaces and mucous membranes comprises the texturizing agent and emulsifiers, the emulsifiers being in a concentration between 5% and 15%, preferably between 5% and 10%. (p/p).

Still preferably, the composition comprises the texturizing agent and emulsifiers at a pH between 5.9 and 6.5, preferably between 5.9 and 6.3.

According to a preferred embodiment, the composition for the care and well-being of the body surfaces and mucous membranes comprises the texturizing agent and humectants, the humectants being preferably in a concentration between 3% and 10%, preferably between 5% and 10%. % (w/w).

Still preferably, the composition comprises the texturizing agent and humectants at a pH between 5.9 and 6.5, preferably between 5.9 and 6.3.

Preferably, the non-ionic solubilizers suitable for the purposes of the present invention are for example polysorbates or ethoxylated hydrogenated derivatives of fatty acids, preferably of fatty acids of vegetable origin (eg castor oil).

Note that, preferably carob seed flour which raw material? dispersible in water or in hot aqueous solutions, at temperatures preferably between 70? and 80?C.

2? embodiment: composition for the care and well-being of body surfaces and mucous membranes comprising a rheological association consisting of carob flour and sclerotic gum.

According to a preferred embodiment, the composition of the invention comprises a rheological association constituted by

- the texturizing agent made up of carob seed flour,

- sclerotic gum (sclerotium gum).

It should be noted that the aforementioned rheological association constitutes a further object of the present invention.

Sclerotic gum? a natural gelling agent, obtained by fermentation of the filamentous fungus Sclerotium rolfssii in a glucose-based medium. ? a homopolysaccharide with high molecular weight which yields only glucose residues under hydrolysis. The skeleton of this homopolysaccharide? composed of ?-D glucose residues linked by glucosidic linkages ? (1-3) with a side chain of ? (1-6)-D glucose every three glucose residues. This structure? such as to prevent the aggregation of the polysaccharide chain on itself? itself.

Still preferably, the sclerotic gum is obtained by the fermentation process described in the Chinese patent No. CN107501438.

Briefly, the preparation process includes the following steps:

(1) Preparation of crude product: Ethanol is added to the fermentation broth of Sclerotium to obtain sclerotic gum precipitate in crude form;

(2) Protein denaturation: Dissolve crude sclerotic gum in a solution and heat it;

(3) Adsorption of activated carbon: adjust the pH of the solution in step (2) to 5.0-7.0, add activated carbon to adsorb for 0.5-2 hours, adjust the pH above 8.0 again, and filter to obtain the supernatant;

(4) Alcohol precipitation: adjust the pH of the supernatant of step (3) to 5.0-7.0 and add ethanol to obtain a gelatinous fibrous precipitate of sclerotia;

(5) Drying: Sclerotium fibrous precipitate is dried under vacuum to obtain Sclerotium powder.

Preferably, the sclerotic rubber cos? obtained (as well as? used in the purposes of the invention) ? characterized by a viscosity of 1,500-2,500 mPa.s (1%), a white point ? 80% and a light transmittance ? 90%.

Preferably, the texturizing agent included in the rheological association is characterized by a galactomannan content of ?75%, preferably between 75% and 95%, preferably between 75% and 85% by weight on the total weight of the flour (w/w).

According to a preferred embodiment, the texturizing agent (carob seed flour) and the sclerotic gum are combined in a weight ratio of between 90:10 and 70:30, preferably equal to 90:10.

Preferably, the composition for the care and well-being of body surfaces and mucous membranes according to the invention comprises the rheological association in a concentration between 1% and 5%, preferably between 1% and 4%, preferably equal to 1%, 1 .5%, 2%, 2.5%, 3%, 3.5%, 4% (w/w).

It should be noted that the composition, when it includes the rheological association in a concentration between 1% and 5%, is preferably characterized by a viscosity? between 120 mPa.s and 30,000 mPa.s.

Still preferably, the composition of the invention, comprising carob seed flour in a concentration ranging from 2% to 3% (w/w), is characterized by a viscosity between 2,000 mPa.s and 26,000 mPa.s.

According to a preferred embodiment, the texturizing agent maintains the properties? moisturizing, anti-wrinkle, film-forming and improvement of firmness and elasticity? skin even when included in the rheological association of the invention.

Preferably, the composition object of the present invention comprises, in addition to the rheological association, other formulation cosmetic ingredients, where by formulation cosmetic ingredient is meant an ingredient suitable for the formulation of compositions for the care and well-being of body surfaces and mucous membranes which are not? biologically active, but ? functional to the technical realization of a stable and suitable formulation for the uses for which it? intended. These formulation ingredients are defined cosmetics because? they are those that are traditionally used in the production of cosmetic formulations. There? For? it does not exclude its use in the production of differently classified formulations (such as medical devices).

Said other cosmetic formulation ingredients are preferably selected from one or more of the following:

- surfactants, the surfactants being selected from the group consisting of: anionic surfactants, non-ethoxylated anionic surfactants, non-ionic surfactants, amphoteric surfactants and cationic surfactants;

- emulsifiers, the emulsifiers being selected from the group consisting of anionic emulsifiers, nonionic emulsifiers and cationic emulsifiers;

- humectants, selected from glycerin and glycols;

- solubilizers in concentrations between 1% and 10% (w/w).

It should be noted that, according to a preferred embodiment, the composition for the care and well-being of body surfaces and mucous membranes according to the invention comprises active ingredients for cosmetic use.

Advantageously, the composition comprising the rheological association and one or more? of the cosmetic ingredients (formulative and/or active) listed above ? stable, where stable means a composition that maintains its viscosity? over time and which has no phase separation over time. Preferably, the composition of the invention comprising the rheological association in combination with one or more of the aforementioned cosmetic ingredients? stable for a period of 3 months at a temperature between 25?C and 40?C.

According to a preferred embodiment, the composition for the care and well-being of the body surfaces and mucous membranes comprises the rheological association and surfactants, the surfactants being in a concentration between 3% and 15%, preferably between 5% and 15% , preferably between 5% and 10% (w/w).

Still preferably, the composition comprises the rheological association and surfactants at a pH between 5.5 and 7.4, preferably between 5.9 and 7.3.

According to a preferred embodiment, the composition for the care and well-being of the body surfaces and mucous membranes comprises the rheological association and emulsifiers, the emulsifiers being in a concentration ranging from 1% to 15%, preferably ranging from 5% to 15% , preferably between 5 and 10% (w/w).

Still preferably, the composition comprises the rheological association and emulsifiers at a pH between 5.7 and 6.5, preferably between 5.9 and 6.3.

According to a preferred embodiment, the composition for the care and well-being of the body surfaces and mucous membranes comprises the rheological association and humectants, the humectants being preferably in a concentration between 3% and 10%, preferably between 5% and 10%. % (w/w).

Still preferably, the composition comprises the rheological association and humectants at a pH between 5.9 and 6.5, preferably between 5.9 and 6.3.

According to a preferred embodiment, the composition for the care and well-being of the body surfaces and mucous membranes comprises the rheological association and solubilizers, the solubilizers being preferably in a concentration between 1% and 10%, preferably between 3% and 10% , preferably between 5% and 10% (w/w).

The solubilizers suitable for the purposes of the invention are preferably selected from: polysorbates, ethoxylated hydrogenated fatty acids, polyglyceryl derivatives, lipoaminoacids.

It should be noted that the active ingredients suitable for being included in the composition according to the second (II) embodiment are the same as mentioned for the first (I) embodiment.

Regardless of the embodiment, the composition for the care and well-being of body surfaces and mucous membranes of the invention comprising the texturizing agent or rheological association of the invention, in combination with one or more? of the aforementioned formulation cosmetic ingredients (surfactants, emulsifiers, humectants, solubilizers, rheological additives) ? stable at pH values between 4.0 and 9.5, preferably between 5.5 and 7.4, preferably between 5.9 and 6.5.

Still preferably, the composition of the invention, regardless of the embodiment, is stable in the presence of electrolytes (such as NaCl), said electrolytes being in concentration ? 1%.

Regardless of the embodiment, active ingredients suitable for making the composition according to the present invention are preferably selected from:

- moisturizers (e.g. hyaluronic acid, ceramides, trehalose)

- antioxidants (e.g. vitamin C, vitamin E, astaxanthin, Coenzyme Q10)

- exfoliants (e.g. alpha hydroxy acids, shikimic acid)

- purifying (e.g. clays, charcoal, plant extracts such as lemon extract)

- antibacterials (e.g. salicylic acid, shikimic acid, star anise extract)

- anti-perspirants (e.g. aluminum salts).

Regardless of the embodiment, the composition of the invention can be made in the form of oil/water emulsions, gels, emulgels, liquids and semi-consistent or consistent products.

Still preferably, the composition for the care and well-being of body surfaces and mucous membranes according to the invention can be formulated, regardless of embodiment, in the form of

- cosmetic product, as they are for example

- rinsing products for the care of the skin, oral cavity, vaginal mucosa, rectal mucosa, nasal mucosa, hair, scalp, body, hands, feet, such as balms, creams, hair masks; shampoo; face and body cleansers;

- products for the care or hygiene of the skin, oral cavity, vaginal mucosa, rectal mucosa, nasal mucosa, hair, scalp, body, hands, feet (not rinsed), such as for example detergents, creams, serums, lotions ;

- sunscreen products, preferably in the form of lotions, gels or creams;

- products for oral hygiene care, such as mouthwashes, gels or toothpastes;

- medical devices, such as class I, class IIA, IIB, class III medical devices, proctological products, products for the oral cavity, vaginal products, dermatological products in the context of skin barrier protection.

According to Directive 93/42/EEC, a medical device is any instrument, apparatus, system, software, substance or other product, used alone or in combination, including software intended by the manufacturer to be used specifically for diagnostic or therapeutic and necessary for the correct functioning of the device, intended by the manufacturer to be used on humans for the purpose of diagnosis, prevention, control, therapy or mitigation of a disease; to diagnose, monitor, treat, mitigate, or compensate for an injury or handicap; study, replacement or modification of the anatomy or of a physiological process; intervention on conception, which product does not exercise the main action, in or on the human body, which? intended, by pharmacological or immunological means n? by metabolic process but whose function can be assisted by such means.

Note that, preferably the rheological association, which raw material? dispersible in water or in hot aqueous solutions, at temperatures preferably between 70? and 80?C.

EXAMPLES

Illustrative and non-limiting examples of the composition object of the present invention are given below.

1. Formulative examples of the first embodiment of the composition according to the invention:

1.1. Emulsion O/W (basic formula suitable for body creams, face creams, hand creams):

Lipophilic phase 15.0-20.0%

Texturizer 1.0-3.0%

Preservative and chelating system 1.0-1.5%

Active principle 1.0-2.0%

Humectant System 2.0-3.0%

pH regulator to taste at desired pH

Fragrance 0.2-0.3%

Phase Water q.b.

1.2 Fluid formulation (basic formula suitable for face serums, cleansing milks):

Lipophilic phase 5.0-20.0%

Texturizer 1.0-1.5%

Preservative and chelating system 1.0-1.5%

Active principle 1.0-3.0%

Humectant System 2.0-3.0%

pH regulator to taste at desired pH

Fragrance 0.2-0.3%

Phase Water q.b.

1.3 Rinse-off product (basic formula suitable for shampoos, conditioners, body wash):

Surfactants 10.0-15.0%

Texturizer 0.5-3.0%

Preservative and chelating system 2.0-5.0%

Active principle 3.0-7.0%

Humectant System 2.0-3.0%

pH regulator to taste at desired pH

fragrance 0.2%

Phase Water q.b.

2. Formulative examples of the second embodiment of the composition according to the invention (carob flour/scelrotium gum 90:10)

2.1 Mask (basic formula for face masks):

Rheological Association 1.0-5.0%

Preservative and chelating system 2.0-4.0%

Active principle 2.0-15.0%

Humectant System 3.0-5.0%

fragrance 0.2%

pH regulator to taste at desired pH

Phase Water q.s.

2.2 Oral care product (basic formula suitable for toothpastes, toothpastes and gels):

Humectant system 60.0-70.0%

Rheological additives 5.0-7.0%

of which rheological association 3.0-4.0%

Preservative and chelating system 0.5-2.0%

Active principle 1.0-2.0%

Solubilizing agent 3.0-4.0%

pH regulator to taste at desired pH

Flavor 0.2-0.3%

Phase Water q.s.

2.3. Sunscreen cream (basic formula):

Lipophilic phase 20.0-30.0%

Rheological additive 2.0-3.0%

Preservative and chelating system 1.5-2.0%

Active principle 2.0-3.0%

Humectant System 2.0-3.0%

pH regulator to taste at desired pH

Fragrance 0.2-0.4%

Phase Water q.b.

3. EXPERIMENTAL STUDY

3.1 SUMMARY

The primary objective of this clinical trial ? to evaluate whether the cosmetic product? Gel with 1.5% carob seed flour? (hereinafter FSC) owns a? effectiveness in reducing roughness? skin and in improving hydration, elasticity? and compactness. The activity ? been evaluated by analyzing the? primary end-point: reduction of roughness? skin, increase hydration, improvement of skin Tewl, increase elasticity? skin and increased skin firmness.

The activity of the product ? been investigated by comparing it with that of a benchmark product ?Gel with 0.1% Sodium Hyaluronate? (henceforth YES).

? was therefore conducted a clinical study and the product being tested? was assigned to 20 enrolled subjects. The latter applied the gel product with 1.5% FSC to one side of the face and the benchmark gel product with 0.1% SI to the other side of the face. Specific end-point variables were analyzed at the baseline time (before using the product) and after 15 minutes and after 2 hours of applying the products: roughness? skin, skin hydration, elasticity skin, skin firmness, skin Tewl.

The results obtained demonstrate: a similar efficacy of the products in reducing roughness? skin and the hydration, and a better effect of the gel product with 1.5% FSC in improving elasticity, firmness and skin Tewl.

3.2 OBJECTIVES

The purpose of this study? that of evaluating whether a cosmetic product (gel with 1.5% FSC) has an effectiveness in reducing roughness? skin and in improving hydration, elasticity? and compactness.

The evaluation ? was carried out by comparison with benchmarks.

Primary endpoint:

- roughness? skin (quantitative endpoint)

- elasticity skin (quantitative endpoint)

- skin firmness (quantitative endpoint)

- skin hydration (quantitative endpoint)

- Cutaneous Tewl (quantitative endpoint).

3.3 FEATURES OF THE STUDY

3.3.1 Study design: ? A single-blind controlled experimental study was conducted to compare the efficacy of the study product with that of a benchmark.

3.3.2 Numerosity? sample size: On the basis of the experience acquired by BioBasic Europe, considering the type of product under analysis, the objectives of the experimentation and taking into consideration any drop-outs, the sample in question ? composed of 20 subjects.

3.3.3 Eligibility criteria: The following inclusion criteria were used for the recruitment of subjects:

? female sex;

? et? aged between 30 and 60;

? good general health/absence of psychological and/or cognitive disorders;

? absence of dermatological and allergological pathologies (cosmetological or to other specific excipients) or other pathologies (such as irritant reactions of unknown origin);

? absence of pharmacological treatments in progress that could influence the outcome of the test;

? non-participation in other clinical studies in the previous 30 days

? obtaining informed consent.

3.3.4 Randomization: not applied.

3.3.5 Concealment: The test ? was conducted in single blind: the subjects subjected to tests were in the dark about the type of products (active, benchmark), which were identical in terms of packaging, labels, appearance and method of use. This concealment has made it possible to avoid distortions caused by conditioning due to awareness of the type of treatment performed.

3.3.6 Criteria for withdrawal of subjects during the trial: The following rules have been imposed for any withdrawal of subjects during the trial:

? violation of one of the inclusion/exclusion criteria;

? development of side effects.

3.3.7 Endpoints:

? Quantitative endpoints

or Roughness? skin (instrumental evaluation)

Measured with Antera 3D? (?m)

3D anther? ? a camera capable of capturing high-resolution images in three dimensions. The roughness? of the skin? determined by the Antera software by measuring the roughness? average Ra, quantified by the vertical deviations of a real surface with respect to its ideal composition: if these are large, then the surface ? rough; if instead they are small, the surface ? smooth.

o Skin hydration (instrumental evaluation)

Measured with CORNEOMETER? CM 825 (U.A. arbitrary units)

Corneometry? a technique for measuring the electrical capacitance of the skin, and therefore expresses the state of hydration: in fact, both the capacity? electricity that the conductance of biological tissues vary according to the water content, increase as the skin water content increases. Does the instrument translate the electrical parameters into units? of hydration.

o TEWL trans epidermal water loss (instrumental evaluation)

Measured with TEWAMETER TM 300 (g/h/m2)

The instrument measures transepidermal water, in terms of water evaporated in the unit? skin considered. The method allows to evaluate the integrity? of the stratum corneum, with a skin barrier function. An increase in TEWL ? symptom of damage to the barrier function of the epidermis, while a decrease in this parameter indicates an increase in skin hydration.

or Elasticity? (instrumental evaluation)

Measured with CUTOMETER MPA 580 (%)

The measuring principle is based on the suction method. A negative pressure is created in the instrument and the skin is ?sucked? in the probe opening and released after a defined time. The skin's resistance to negative pressure? the measure of compactness, while its ability? to return to its original position, after the mechanical stress? interrupted ? the elasticity.

o Compactness (instrumental evaluation)

Measured with CUTOMETER MPA 580 (mm)

The measuring principle is based on the suction method. A negative pressure is created in the instrument and the skin is ?sucked? in the probe opening and released after a defined time. The skin's resistance to negative pressure? the measure of compactness, while its ability? to return to its original position, after the mechanical stress? interrupted ? the elasticity.

All measurements were performed following a minimum 20-minute rest period in an air-conditioned room at temperature and humidity? relative controlled and regulated (temperature = 21?C /-2?C and humidity?=40%-60%).

3.3.8 Statistical analysis:

? Quantitative endpoints

Sample data for quantitative endpoints were described using the usual measures of location and dispersion: mean and standard deviation. Normality? of quantitative endpoint variables ? been verified with the Shapiro-Wilk test.

For each quantitative endpoint ? A two-way analysis of variance model for repeated measures with a parametric approach was then applied in order to compare the products under study and their effect over time.

In the presence of a significant effect of the interaction between the product/s and time variables, the results of the two main effects (product and time) were not taken into consideration and the considerations concerning the outcome of the analysis were made.

In the presence of a significant effect of the time variable and in the absence of significance? of the interaction between the product and time variables, ? Student's t-test with Bonferroni's corrections was used to compare the various observation times.

In the presence of a significant effect of the product variable and in the absence of significance? of the interaction between the product and time variables, ? Student's t-test with Bonferroni's corrections was used to compare the products.

? was considered a level of significance? <0.05.

3.4 RESULTS

During the trial, no subject developed undesirable effects or violated the established inclusion/exclusion criteria. Furthermore, there were no cases of drop-outs. Therefore the analyzes refer to a sample of 20 subjects.

3.4.1 Roughness? cutaneous

Table 1a. Description of the roughness variable? skin at different times in the areas treated with the product and benchmarks.

In the area treated with the product, compared to the baseline value (T0), a reduction in roughness is observed. cutaneous:

- by 6% 15 minutes after applying the product;

- by 5% 2 hours after applying the product;

In the area treated with the Benchmark product, compared to the baseline value (T0), is there a reduction in roughness? cutaneous:

- by 4% 15 minutes after applying the product;

- by 4% 2 hours after applying the product.

Table 1b. 2-way Anova for repeated measurements for evaluating the effect of product type and time on the roughness variable cutaneous.

From table 1b, where ? reported the result of the analysis of variance, it is clear that not ? no statistically significant difference emerged between the product and the benchmark while a time effect appears to be relevant; also not ? no interaction effect between product and time emerged.

Therefore, the reduction over time of roughness? skin in the area treated with the product and in the area treated with the benchmark product ? the same regardless of the type of treatment (Figure 1).

Table 1c. Pairwise comparison using paired t-test

3.4.2 Skin hydration

Table 2a. description of the skin hydration variable at different times in the areas treated with the product and benchmark.

In the area treated with the product, compared to the baseline value (T0), an increase in skin hydration is observed:

- by 16% 15 minutes after applying the product;

- by 7% 2 hours after applying the product;

In the area treated with the Benchmark product, compared to the baseline value (T0), an increase in skin hydration is observed:

- by 15% 15 minutes after applying the product;

- by 8% 2 hours after applying the product.

Table 2b. 2-way Anova for repeated measurements for evaluating the effect of the type of product and time on the skin hydration variable.

From table 2b, where ? reported the result of the analysis of variance, it is clear that not ? no statistically significant difference emerged between the product and the benchmark while a time effect appears to be relevant; also not ? no interaction effect between product and time emerged.

Therefore, the increase over time of skin hydration in the area treated with the product and in the area treated with the benchmark product? the same regardless of the type of treatment (Figure 2).

Table 2c. Pairwise comparison using paired t-test

3.4.3 TEWL

Table 3a. description of the Tewl variable at different times in the areas treated with the product and benchmark.

In the area treated with the product, compared to the baseline value (T0), a reduction in skin Tewl is observed:

- by 13% 15 minutes after applying the product;

- by 7% 2 hours after applying the product;

In the area treated with the Benchmark product, compared to the baseline value (T0), a reduction in skin Tewl is observed:

- by 6% 15 minutes after applying the product;

- by 2% 2 hours after applying the product.

Table 3b. 2-way Anova for repeated measurements for evaluating the effect of product type and time on the tewl variable.

From the table where ? reported the result of the analysis of variance, it is clear that ? a statistically significant effect of the interaction between product and time emerged; therefore ? Is it possible to say that the evolution over time of Tewl ? different between the area treated with the product compared to that treated with benchmark.

In particular, in the area treated with the product, a more significant reduction is observed. marked degree of this parameter compared to the area treated with the benchmark (Figure 3).

3.4.4 Elasticity? cutaneous

Table 4a. description of the variable elasticity? at different times in the areas covered with the product and benchmarks.

In the area treated with the product, compared to the baseline value (T0), is there an increase in elasticity? cutaneous:

- by 8% 15 minutes after applying the product;

- by 5% 2 hours after applying the product;

In the area treated with the Benchmark product, compared to the baseline value (T0), is there an increase in elasticity? cutaneous:

- by 5% 15 minutes after applying the product;

- by 3% 2 hours after applying the product.

Table 4b. 2-way Anova for repeated measurements for the evaluation of the type effect

product and time on the elasticity variable.

From the table where ? reported the result of the analysis of variance, it is clear that ? a statistically significant effect of the interaction between product and time emerged; therefore ? is it possible to state that the evolution over time of the elasticity? ? different between the area treated with the product compared to that treated with benchmark.

In particular, a greater improvement is observed in the area treated with the product. of this parameter compared to the area treated with the benchmark (Figure 4).

3.4.5 Skin firmness

Table 5a. description of the compactness variable at different times in the areas treated with the product and benchmark.

In the area treated with the product, compared to the baseline value (T0), an improvement in skin firmness is observed:

- by 10% 15 minutes after applying the product;

- by 4% 2 hours after applying the product;

In the area treated with the Benchmark product, compared to the baseline value (T0), an improvement in skin firmness is observed:

- by 6% 15 minutes after applying the product;

- by 2% 2 hours after applying the product.

Table 5b. 2-way Anova for repeated measurements for evaluating the effect of product type and time on the compactness variable.

From the table where ? reported the result of the analysis of variance, it is clear that ? a statistically significant effect of the interaction between product and time emerged; therefore ? possible to state that the evolution over time of the compactness ? different between the area treated with the product compared to that treated with benchmark.

In particular, a greater improvement is observed in the area treated with the product. of this parameter compared to the area treated with the benchmark (Figure 5).

3.5 CONCLUSIONS

Based on the results obtained in this study, ? Is it possible to state that the gel cosmetic product with 1.5% FSC has been shown to be effective in reducing roughness? skin and in improving hydration similar to the benchmark product and a better effect of the gel product with 1.5% FSC in improving elasticity, firmness and skin Tewl.

The Applicant believes that the film-forming action is attributable to the presence of galactomannans, polysaccharides with moisturizing and emollient power.

4. SYSTEMATIC ANALYSIS OF COMPATIBILITY: carob flour with the most? common cosmetic ingredients

FSC raw material? was formulated in a water-based gel with the following composition:

Gels with FSC:

water at 100

texturizer 0.5-8%

preservative system 0.3-1.1%

Table 6.

To evaluate the compatibility? with surfactants, emulsifiers, solubilizers, humectants, synthetic rheologicals (carbomer), ? was chosen the 4% carob flour gel, since? characterized by a viscosity? intermediate.

The measures of viscosity? of the gels with FSC referred to in table 6 and of the preparations described in the continuation of the systematics were carried out with a Brookfield DV2+ viscometer.

4.1 Check sensitivity? at pH and electrolytes

Initial composition: Gel 4%, viscosity? = 3370mPa.s (rt 3 rpm 20), pH=6.0

The initial composition? been added, separately, of an acid, a base and a solution of sodium chloride to verify its stability? with changes in pH or electrolyte concentration.

Table 7.

Conclusions: The gel containing the rheological association has been shown to have good stability? to changes in pH and electrolyte concentration.

4.2 Compatibility evaluation? with surfactants

Initial composition: GEL 4% pH=6.0 - viscosity= 3370mPa.s (rotor 3 rpm 20)

The following surfactants were added to the initial composition separately, measuring the viscosity? of the mixture obtained.

Table 8.

Conclusions: Good compatibility? with the 5 types of surfactants considered (anionic, non-ethoxylated anionic, non-ionic, amphoteric, cationic). Are there no substantial variations in viscosity? or pH after adding surfactants to the gel.

Despite the separation noticed after 20 days in the presence of Cocoamidopropyl betaine (10%), the Applicant reconfirms the compatibility of the texturizing agent with surfactants in a concentration between 3%-15%, in consideration of the fact that, in the formula of a finished product, in addition to the primary surfactant and possibly the secondary surfactants, there are also other ingredients which contribute overall to the stability rheology of the composition.

4.3 Compatibility evaluation with emulsifiers:

In this case, the carob flour? been directly formulated, with each of the emulsifiers mentioned below, in an emulsion having the following composition:

water at 100

texturizer 0.5-8%

preservative system 0.3-1.1%

humectants 2-4%

oil phase 10-25%

pH corrector to taste at desired pH

so that could form a stable system of which to measure the viscosity.

Table 9.

Conclusions: Linear behavior towards the 3 types of emulsifiers considered (anionic, non-ionic and cationic). The stability? provisional, measured after almost 3 months under the conditions indicated, gave a positive result.

4.4 Compatibility evaluation? with humectants:

Initial composition: Gel 4% (viscosity= 5050mPa.s pH= 5.95)

The humectants listed below were added separately to the initial composition. ? was the viscosity measured? of the resulting mixture.

Table 10.

Conclusions: Does carob bean gum gel show good compatibility? with the humectants considered.

4.5 Compatibility evaluation? with solubilizers:

Initial composition for tests with Polysorbate 20 and hydrogenated castor oil: Gel 4% viscosity? = 3300 mPa.s pH=5.9;

Initial composition for trials with Cocoyl proline and polyglyceryl derivatives: Gel 4% viscosity? = 4090 mPa.s pH=6.0.

To each of the initial compositions ? the solubilizer against which compatibility was to be tested was added. ? was the viscosity measured? of the resulting mixture.

Table 11.

Conclusions: Is there a compatibility? with partial solubilizers. In particular: the FSC gel ? compatible with old generation solubilizers (Polysorbate 20 ? hydrogenated castor oil) in a concentration of about 1-2%. Poor compatibility? with polyglyceryl derivatives, in a concentration of about 2%. Good compatibility? with Cocoyl proline at the usual concentrations of use.

4.6 Compatibility evaluation? with natural and synthetic rheological additives:

The 2-4% carob flour gel? been combined with various rheological additives of a synthetic or natural nature.

The association including carob flour and carbomer gel ? it has also been compared with associations of carbomers and known rheological additives. In particular:

- carbomer xanthan gum shows an average compatibility? of the ingredients with a decrease in viscosity? of the carbomer compared to that measured for a 1% carbomer-only gel.

- carbomer Carrageenan iota shows an incompatibilit? of the ingredients with a net decrease in viscosity? of the carbomer compared to that measured for a 1% carbomer-only gel. The hypothesis? that Carrageenan iota is responsible for a ?destruction? of the carbomer structure, due to the high content of salts normally present in carrageenans.

? it is interesting to note instead that the association of carbomer and carob flour has a viscosity? very high, higher than that measured for a 1% carbomer gel only. The carob flour, therefore, is not? destructive of the structure of the carbomer with which? compatible and with which it creates a synergistic rheological association.

We point out that the viscosity? reached by the carbomer association carob flour ?, under the conditions described in the table, of little cosmetic interest, since? overly consistent.

Table 12.

Note that a gel comprising 1% carbomer gel has a viscosity of of about 50,000 mPa.s, at a pH > 6.

5. SYSTEMATIC ANALYSIS OF COMPATIBILITY: mixture based on carob flour / sclerotium gum (90:10) with the most? common cosmetic ingredients

The combination of carob seed flour (FSC) and sclerotium gum ? was formulated in a water-based gel having the following composition:

water at 100

texturizer 1-5%

preservative system 0.3-1.1%

Table 13.

The measures of viscosity? of the gels with the mixture referred to in table 13 and of the preparations described in the continuation of the systematics were carried out with a Brookfield DV2+ viscometer.

5.1 Check sensitivity? pH and electrolytes

Initial composition: Gel 3% viscosity= 3880mPa.s pH=5.9 (for sensitivity to electrolytes and acid pH)

Initial composition: Gel 3% viscosity= 3160 mPa.s pH=5.9 (for sensitivity to basic pH)

The initial compositions were separately added with an acid, a base and a sodium chloride solution to check their stability. with changes in pH or electrolyte concentration.

Table 14.

Conclusions: The gel containing the rheological association has been shown to have good stability? to changes in pH and electrolyte concentration.

5.2 Compatibility evaluation with surfactants

Initial composition: GEL 3% viscosity= 2860 mPa.s pH= 5.9

The surfactants indicated in the following table were separately added to the initial composition at the respective concentrations. ? was the viscosity measured? of the resulting mixture.

Table 15.

Conclusions: Has the gel containing the rheological association demonstrated good compatibility? with all types of surfactants. Compatibility? good with cationic surfactants (3%).

5.3 Compatibility evaluation with emulsifiers:

In this case, the rheological association? been directly formulated with each of the emulsifiers mentioned below in an emulsion having the following composition:

water at 100

rheological additive 0.5-5%

preservative system 0.3-1.1%

humectants 2-4%

oil phase 15-25%

pH corrector to taste at desired pH

so that could form a stable system of which to measure the viscosity.

Table 16.

Conclusions: The rheological association, formulated in different types of emulsions, has demonstrated good compatibility? with emulsifiers of different nature, at commonly used concentrations.

5.4 Compatibility evaluation with humectants:

Initial composition: Gel 3% viscosity= 3160 mPa.s (rotor 5, rpm 20) pH= 5.9

The humectants listed below were added separately to the initial composition. ? was the viscosity measured? of the resulting mixture.

Table 17.

Conclusions: Does the gel containing the rheological association show good compatibility? with the humectants considered.

5.5 Compatibility evaluation with solubilizers:

Initial composition: Gel 3% pH= 5.9 viscosity= 2840 mPa.s

The emulsifiers listed below were added to the initial composition, at the respective concentrations. ? was the viscosity measured? of the resulting mixture.

Table 18.

Conclusions: The gel containing the rheological association has been shown to have good compatibility with the rheological association. with all the solubilizers tested, at common concentrations of use. The data? particularly interesting when compared with that of Table 10, relating to the compatibility? of the FSC gel with the same solubilizing products: in the case of? the association is not ? no separation was recorded in the presence of Polysorbate 20 (3%), Hydrogenated castor oil (2%) or polyglyceryl derivatives (over time).

Claims (11)

CLAIMS: 1. Composition for the care and well-being of body surfaces and mucous membranes comprising a texturizing agent made from carob seed flour, said texturizing agent being in a concentration between 0.5% and 8% by weight on the total weight of the composition (w/w). 2. Composition according to claim 1, wherein the texturizing agent is? in concentrations between 0.5% and 4% (w/w) and at these concentrations it is also a moisturizing, anti-wrinkle, film-forming active ingredient and an active ingredient in improving skin firmness and elasticity. cutaneous. 3. A composition according to claim 1 or 2 further comprising one or more? of the following cosmetic-type formulation ingredients: - surfactants in a concentration ranging from 3% to 15% (w/w), the surfactants being selected from the group consisting of: anionic surfactants, non-ethoxylated anionic surfactants, non-ionic surfactants, amphoteric surfactants and cationic surfactants; - emulsifiers in a concentration ranging from 5% to 15% (w/w), the emulsifiers being selected from the group consisting of anionic emulsifiers, non-ionic emulsifiers and cationic emulsifiers; - humectants, selected from glycerin and glycols; - solubilizers, selected from the group consisting of non-ionic solubilizers in a concentration between 1-2% (w/w); polyglyceryl-derived solubilizers in a concentration between 1-2% (w/w); lipoamino acid solubilizers in a concentration between 1% and 10% (w/w); - rheological additives of natural or synthetic origin. 4. Composition according to claim 1 or 2 comprising a rheological association constituted by the texturizing agent consisting of carob seed flour, sclerotic gum (sclerotium gum). 5. Composition according to claim 4, wherein the texturizing agent and the sclerotic gum are combined in a weight ratio of between 90:10 and 70:30. 6. Composition according to claim 4 or 5, further comprising one or more? of the following cosmetic-type formulation ingredients: - surfactants in a concentration ranging from 3% to 15% (w/w), the surfactants being selected from the group consisting of: anionic surfactants, non-ethoxylated anionic surfactants, non-ionic surfactants, amphoteric surfactants and cationic surfactants; - emulsifiers in a concentration ranging from 1% to 15% (w/w), the emulsifiers being selected from the group consisting of anionic emulsifiers, non-ionic emulsifiers and cationic emulsifiers; - humectants, selected from glycerin and glycols; - solubilizers in concentrations between 1% and 10% (w/w). 7. Composition according to any one of claims 4 to 6, wherein the rheological association is ? in a concentration between 1% and 5% by weight of the total weight of the cosmetic composition. 8. Composition according to any one of claims 1 to 7, having a viscosity? between 50 mPa.s and 40,000 mPa.s 9. Composition according to any one of claims 1 to 8, wherein the composition is - stable at pH values between 4.0 and 9.5 e - stable at electrolyte concentrations ? 1% at a pH of about 6.0. 10. Composition according to any one of claims from 1 to 9, in a form selected from the group consisting of: oil/water emulsions, gels, emulgels, liquids, solid products and semi-solid products. 11. Composition according to any one of claims from 1 to 10, where by body surfaces and mucous membranes are meant the tissues selected from the group consisting of skin, oral cavity, oral mucosa, vaginal mucosa, rectal mucosa, nasal mucosa, hair, scalp, body, hands, feet.