IT201900020240A1 - Procedure for the preparation of Filgotinib and synthetic intermediates - Google Patents

Procedure for the preparation of Filgotinib and synthetic intermediates

Info

Publication number
IT201900020240A1
IT201900020240A1 IT102019000020240A IT201900020240A IT201900020240A1 IT 201900020240 A1 IT201900020240 A1 IT 201900020240A1 IT 102019000020240 A IT102019000020240 A IT 102019000020240A IT 201900020240 A IT201900020240 A IT 201900020240A IT 201900020240 A1 IT201900020240 A1 IT 201900020240A1
Authority
IT
Italy
Prior art keywords
filgotinib
procedure
preparation
synthetic intermediates
intermediates
Prior art date
Application number
IT102019000020240A
Other languages
Italian (it)
Inventor
Jiri Stohandl
Jaroslav Frantisek
Jana Marková
Sylvie Rumreichova
Ilaria Ferrando
Original Assignee
Advitech Advisory And Tech Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advitech Advisory And Tech Sa filed Critical Advitech Advisory And Tech Sa
Priority to IT102019000020240A priority Critical patent/IT201900020240A1/en
Publication of IT201900020240A1 publication Critical patent/IT201900020240A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
IT102019000020240A 2019-11-04 2019-11-04 Procedure for the preparation of Filgotinib and synthetic intermediates IT201900020240A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IT102019000020240A IT201900020240A1 (en) 2019-11-04 2019-11-04 Procedure for the preparation of Filgotinib and synthetic intermediates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102019000020240A IT201900020240A1 (en) 2019-11-04 2019-11-04 Procedure for the preparation of Filgotinib and synthetic intermediates

Publications (1)

Publication Number Publication Date
IT201900020240A1 true IT201900020240A1 (en) 2021-05-04

Family

ID=69811622

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102019000020240A IT201900020240A1 (en) 2019-11-04 2019-11-04 Procedure for the preparation of Filgotinib and synthetic intermediates

Country Status (1)

Country Link
IT (1) IT201900020240A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010149769A1 (en) 2009-06-26 2010-12-29 Galapagos Nv 5-phenyl-[1,2,4 ]triazolo[1,5-a]pyridin-2-yl carboxamides as jak inhibitors
CN104987333A (en) * 2015-07-14 2015-10-21 苏州富士莱医药股份有限公司 Filgotinib synthetic method
CN110204542A (en) * 2019-05-23 2019-09-06 四川伊诺达博医药科技有限公司 A kind of synthetic method of JAK1 inhibitor Filgotinib

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010149769A1 (en) 2009-06-26 2010-12-29 Galapagos Nv 5-phenyl-[1,2,4 ]triazolo[1,5-a]pyridin-2-yl carboxamides as jak inhibitors
CN104987333A (en) * 2015-07-14 2015-10-21 苏州富士莱医药股份有限公司 Filgotinib synthetic method
CN110204542A (en) * 2019-05-23 2019-09-06 四川伊诺达博医药科技有限公司 A kind of synthetic method of JAK1 inhibitor Filgotinib

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Greene's protective Groups in organic Synthesis", 2013, WILEY

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