IT201800003313A1 - Bottle capping device for storing substances to be kept separate until their application and for taking the mixture obtained by syringe. - Google Patents
Bottle capping device for storing substances to be kept separate until their application and for taking the mixture obtained by syringe. Download PDFInfo
- Publication number
- IT201800003313A1 IT201800003313A1 IT102018000003313A IT201800003313A IT201800003313A1 IT 201800003313 A1 IT201800003313 A1 IT 201800003313A1 IT 102018000003313 A IT102018000003313 A IT 102018000003313A IT 201800003313 A IT201800003313 A IT 201800003313A IT 201800003313 A1 IT201800003313 A1 IT 201800003313A1
- Authority
- IT
- Italy
- Prior art keywords
- bottle
- piston
- membrane
- syringe
- tank
- Prior art date
Links
- 239000000126 substance Substances 0.000 title claims description 24
- 239000000203 mixture Substances 0.000 title claims description 8
- 239000012528 membrane Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 4
- 239000004033 plastic Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 description 9
- 239000000843 powder Substances 0.000 description 5
- 239000002775 capsule Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
- B65D51/28—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
- B65D51/2807—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container
- B65D51/2814—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it
- B65D51/2828—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it said element being a film or a foil
- B65D51/2835—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it said element being a film or a foil ruptured by a sharp element, e.g. a cutter or a piercer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Basic Packing Technique (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Description
"Dispositivo di tappatura di un falcone atto alla conservazione di sostanze da mantenersi separate fino alla loro applicazione ed atto al prelievo della miscela ottenuta tramite siringa.” "Bottle capping device suitable for storing substances to be kept separate until their application and suitable for withdrawing the mixture obtained by syringe."
La presente invenzione si riferisce ad un dispositivo di tappatura di un flacone atto alla conservazione di sostanze, ad esempio in polvere o liquide, da mantenersi separate fino al momento del loro utilizzo, quando vengono miscelate tra loro. The present invention relates to a bottle capping device suitable for storing substances, for example in powder or liquid form, to be kept separate until the moment of their use, when they are mixed together.
Sono attualmente presenti in commercio contenitori che permettono di mantenere separate sostanze in esso contenute fino al momento dell’utilizzo. Questa necessità si avverte, ad esempio, nel caso di conservazione per prodotti farmaceutici che, se proposti in vendita già miscelati e pronti all’uso, perderebbero il loro potere terapeutico in un limitato lasso di tempo. Containers are currently on the market that allow the substances contained therein to be kept separate until the time of use. This need is felt, for example, in the case of storage for pharmaceutical products which, if offered for sale already mixed and ready for use, would lose their therapeutic power in a limited period of time.
Tali contenitori sono dotati, di solito, di un dispositivo di tappatura del flacone costituito da una capsula all’interno della quale è presente un serbatoio cilindrico per una prima sostanza, ad esempio in polvere, la quale deve essere miscelata con una seconda sostanza presente nel flacone, ad esempio una sostanza liquida. A tale capsula è associato, inoltre, un elemento di rottura, la cui sommità può essere premuta in modo che un gambo di tale elemento penetri nel serbatoio e che l’estremità inferiore del gambo rompa la base inferiore del serbatoio cilindrico lungo almeno parte del suo perimetro circolare. In tale modo, si libera la prima sostanza all’interno del flacone formando la miscela desiderata con la seconda sostanza in esso contenuta. These containers are usually equipped with a bottle capping device consisting of a capsule inside which there is a cylindrical tank for a first substance, for example in powder, which must be mixed with a second substance present in the bottle, such as a liquid substance. Also associated with this capsule is a rupture element, the top of which can be pressed so that a stem of this element penetrates into the tank and that the lower end of the stem breaks the lower base of the cylindrical tank along at least part of its circular perimeter. In this way, the first substance is released inside the bottle, forming the desired mixture with the second substance contained therein.
Il perimetro della base del serbatoio presenta una membrana che è vantaggiosamente provvista di elementi di indebolimento o prefrattura che facilitano la sua rottura. The perimeter of the base of the tank has a membrane which is advantageously provided with weakening or pre-fracturing elements which facilitate its breaking.
Il dispositivo solitamente è connesso al flacone mediante un accoppiamento filettato, in modo che il flacone stesso possa essere aperto per utilizzare il prodotto in esso contenuto dopo la formazione della miscela. Talvolta la capsula, il serbatoio e i mezzi di rottura sono realizzati in un unico pezzo. The device is usually connected to the bottle by means of a threaded coupling, so that the bottle itself can be opened to use the product contained therein after the formation of the mixture. Sometimes the capsule, the reservoir and the rupture means are made in one piece.
Inoltre, la base del serbatoio è una membrana di separazione saldata al serbatoio stesso ed è realizzata in un materiale atto a impedire il passaggio di vapore acqueo, dall’esterno all’interno del serbatoio e viceversa. In addition, the base of the tank is a separation membrane welded to the tank itself and is made of a material designed to prevent the passage of water vapor, from the outside to the inside of the tank and vice versa.
Son peraltro noti flaconi atti a contenere farmaci liquidi, o in polvere che debbono essere miscelati con un liquido prima dell’utilizzo, che debbono essere assunti tramite una siringa. In tali flaconi il tappo è provvisto di una porzione anulare di aggraffaggio al collo del falcone e di una porzione centrale, ad esempio in gomma, che può essere forata dall’ago della siringa, evitando l’immissione di aria dall’esterno del flacone. In ogni caso il tappo nel suo complesso è provvisto di mezzi di sigillatura al collo del falcone per la conservazione del suo contenuto. Nel caso in cui il contenuto in polvere debba essere miscelato con un liquido, ad esempio una soluzione fisiologica, normalmente tale liquido viene introdotto per mezzo della siringa stessa e poi dopo aver agitato il flacone per miscelare le due componenti sempre con la stessa siringa si preleva il farmaco miscelato. Moreover, bottles are known to contain liquid or powder drugs that must be mixed with a liquid before use, which must be taken with a syringe. In these bottles, the cap is provided with an annular gripping portion to the neck of the bottle and a central portion, for example in rubber, which can be pierced by the syringe needle, avoiding the entry of air from the outside of the bottle. In any case, the cap as a whole is provided with sealing means at the neck of the bottle for the conservation of its contents. In the event that the powder content must be mixed with a liquid, for example a physiological solution, this liquid is normally introduced by means of the syringe itself and then after shaking the bottle to mix the two components, always with the same syringe it is taken the mixed drug.
La presente invenzione propone un dispositivo di tappatura per un flacone che sia nel contempo in grado di conservare due sostanze separate fino alla loro applicazione ed in grado di contenente il prelievo della miscela ottenuta tramite una siringa. The present invention proposes a capping device for a bottle which is at the same time capable of storing two separate substances until their application and capable of containing the withdrawal of the mixture obtained by means of a syringe.
Un aspetto della presente invenzione riguarda un dispositivo di tappatura per un flacone avente le caratteristiche della allegata rivendicazione 1. An aspect of the present invention relates to a capping device for a bottle having the characteristics of the attached claim 1.
Le caratteristiche ed i vantaggi del dispositivo di tappatura per un flacone secondo la presente invenzione risulteranno maggiormente evidenti dalla descrizione seguente, esemplificativa e non limitativa, riferita ai disegni schematici allegati, nei quali: The characteristics and advantages of the capping device for a bottle according to the present invention will become more evident from the following, exemplary and non-limiting description, referring to the attached schematic drawings, in which:
• la figura 1 mostra una vista laterale di un dispositivo di tappatura per un flacone secondo l’invenzione; • figure 1 shows a side view of a capping device for a bottle according to the invention;
• la figura 2 mostra una sezione lungo la linea A-A di figura 1 del dispositivo secondo la presente invenzione; Figure 2 shows a section along the line A-A of figure 1 of the device according to the present invention;
• la figura 3 illustra una mostra una vista dall’alto del dispositivo secondo la presente invenzione. • Figure 3 shows a top view of the device according to the present invention.
Con riferimento alle citate figure, si illustra una forma di realizzazione del dispositivo di tappatura che si associa ad un flacone ad esempio di forma cilindrica (non mostrato). La presente invenzione può essere in modo equivalente applicabile a flaconi aventi differenti forme. Inoltre, nel caso specifico il dispositivo di tappatura è internamente filettato e viene di conseguenza avvitato sul contenitore. In una ulteriore forma di realizzazione, il dispositivo di chiusura potrebbe essere applicato sul contenitore a pressione o in modi equivalenti che garantiscano l’ermeticità della chiusura. With reference to the aforementioned figures, an embodiment of the capping device is illustrated which is associated with a bottle, for example having a cylindrical shape (not shown). The present invention can be equivalently applicable to bottles having different shapes. Furthermore, in the specific case the capping device is internally threaded and is consequently screwed onto the container. In a further embodiment, the closure device could be applied to the pressure container or in equivalent ways that ensure the tightness of the closure.
In dettaglio il dispositivo di tappatura 2 è preferibilmente di forma cilindrica internamente cava, avente una porzione superiore 21, la quale forma al suo interno un serbatoio 3 per una prima sostanza da miscelare con una seconda sostanza presente nel flacone . In detail, the capping device 2 is preferably cylindrical in shape internally hollow, having an upper portion 21, which forms inside it a reservoir 3 for a first substance to be mixed with a second substance present in the bottle.
Tali prima e seconda sostanza possono essere formate ad esempio da polvere, liquido, granulato o altre sostanze da miscelare con liquido. Il dispositivo comprende inoltre mezzi di rottura della base del serbatoio azionabili a pressione e manualmente dalla sommità di detto dispositivo. Such first and second substances can be formed, for example, by powder, liquid, granulate or other substances to be mixed with liquid. The device further comprises means of rupture of the base of the tank which can be operated by pressure and manually from the top of said device.
Il dispositivo di tappatura 2 comprende inoltre una porzione inferiore 22, di diametro maggiore del diametro della porzione superiore, provvista di mezzi di vincolo al flacone, quali ad esempio una filettatura interna 221, o alternativamente mezzi di vincolo a pressione sul contenitore 2. The capping device 2 also comprises a lower portion 22, with a diameter greater than the diameter of the upper portion, provided with means for securing the bottle, such as for example an internal thread 221, or alternatively means for securing pressure on the container 2.
Tale porzione inferiore comprende, eventualmente, un sigillo di chiusura anulare 222 con il flacone, del tipo di quelli presenti sui tappi delle bevande contenute nelle bottiglie in plastica. This lower portion optionally comprises an annular closure seal 222 with the bottle, of the type present on the caps of the drinks contained in plastic bottles.
La base del serbatoio presenta una pellicola 31 saldata su un bordo situato in prossimità della congiunzione della porzione superiore con quella inferiore. Detta pellicola è ad esempio termosaldata o ad induzione o incollata su tale bordo ed è realizzata in un materiale plastico accoppiato a film di alluminio. The base of the tank has a film 31 welded to an edge located near the junction of the upper portion with the lower one. Said film is, for example, heat-sealed or induction-bonded or glued on said edge and is made of a plastic material coupled to aluminum film.
Tale pellicola, quando il dispositivo di separazione è chiuso sul flacone, separa la prima sostanza contenuta nel serbatoio 3 dalla seconda sostanza contenuta nel flacone. This film, when the separation device is closed on the bottle, separates the first substance contained in the tank 3 from the second substance contained in the bottle.
Nel caso in cui una delle due sostanze sia liquido, la pellicola impedisce un eventuale passaggio di vapore acqueo attraverso essa, e quindi una pre-miscelazione indesiderata tra le due sostanze, che renderebbe inefficace il prodotto nel momento del suo utilizzo. In the event that one of the two substances is liquid, the film prevents a possible passage of water vapor through it, and therefore an undesired pre-mixing between the two substances, which would make the product ineffective when it is used.
Tali mezzi di rottura del serbatoio sono realizzati da un pistone 4 in grado di scorrere verso il basso all’interno della porzione superiore cava ed è provvisto sulla sua terminazione inferiore almeno una punta di frattura 41 che durante la discesa del pistone fora la suddetta pellicola liberando il contenuto del serbatoio. Said means of rupture of the tank are made by a piston 4 capable of sliding downwards inside the hollow upper portion and is provided on its lower end at least one fracture tip 41 which, during the descent of the piston, pierces the aforementioned film, releasing the contents of the tank.
Vantaggiosamente, la porzione inferiore 22 comprende una pluralità di nervature e/o di incavi, disposti sostanzialmente in verticale, atti a facilitare la manipolazione del dispositivo durante l’operazione di apertura e chiusura del contenitore. Advantageously, the lower portion 22 comprises a plurality of ribs and / or recesses, arranged substantially vertically, designed to facilitate the manipulation of the device during the opening and closing of the container.
Secondo la presente invenzione, la sommità del pistone 4 comprende una membrana 42 forabile da un ago di una siringa che quando il pistone stesso ha forato il serbatoio stesso consente a tale ago di prelevare il contenuto della miscela nel falcone. According to the present invention, the top of the piston 4 comprises a membrane 42 which can be pierced by a needle of a syringe which, when the piston itself has pierced the reservoir itself, allows this needle to take the contents of the mixture from the bottle.
Tale membrana può essere realizzata in gomma, plastica, in generale in un materiale che garantisca ermeticità e che sia facilmente forabile. This membrane can be made of rubber, plastic, in general of a material that guarantees airtightness and that is easily pierced.
Tale membrana occupa una zona sostanzialmente centrale della sommità del pistone. Inoltre essa è preferibilmente di forma discoidale ed è incassata in una sede ricavata sulla sommità del pistone in modo da non sporgere rispetto ad una corona circolare che delimita tale sede. Vantaggiosamente la membrana viene costampata assieme al pistone o al dispositivo quando quest’ultimo sia realizzato in un solo pezzo. La membrana nella sua zona centrale presenta una porzione rastremata 43, preferibilmente concava, che è la zona dove viene inserito l’ago della siringa. In questo modo si facilita la penetrazione dell’ago anche quando questo sia di un tipo molto sottile. This membrane occupies a substantially central area of the top of the piston. Furthermore, it is preferably discoidal in shape and is recessed in a seat obtained on the top of the piston so as not to protrude with respect to a circular crown that delimits this seat. Advantageously, the membrane is co-molded together with the piston or the device when the latter is made in one piece. The membrane in its central area has a tapered portion 43, preferably concave, which is the area where the syringe needle is inserted. This facilitates the penetration of the needle even when it is of a very thin type.
Il dispositivo secondo la presente invenzione opera nel modo seguente. The device according to the present invention operates in the following way.
Quando si vogliono miscelare le due sostanze è sufficiente premere sul pistone del dispositivo. Quest’ultimo è quindi costretto a scendere fino a che la punta di frattura penetra nella membrana, determinandone la rottura pressoché completa e provocando la caduta per gravità della prima sostanza contenuta nel serbatoio nel flacone a contatto quindi con la seconda sostanza. Una volta miscelate le sostanze, è sufficiente infilare un ago di una siringa nella membrana 42 e raggiungere la miscela nel flacone, in quanto il fratturatore 41 ha già aperto la pellicola 31 e non vi sono ulteriori barriere tra l’ago e l’interno del flacone. When you want to mix the two substances, simply press on the piston of the device. The latter is then forced to descend until the fracture tip penetrates the membrane, causing it to break almost completely and causing the first substance contained in the tank to fall into the bottle in contact with the second substance by gravity. Once the substances have been mixed, it is sufficient to insert a needle of a syringe into the membrane 42 and reach the mixture in the bottle, as the fracturer 41 has already opened the film 31 and there are no further barriers between the needle and the inside of the bottle.
Claims (7)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102018000003313A IT201800003313A1 (en) | 2018-03-06 | 2018-03-06 | Bottle capping device for storing substances to be kept separate until their application and for taking the mixture obtained by syringe. |
| EP19160847.0A EP3536631B1 (en) | 2018-03-06 | 2019-03-05 | Device for capping a bottle suited to the preservation of substances to be kept separate until their application and suited to the collection of the mixture obtained by means of a syringe |
| ES19160847T ES2927500T3 (en) | 2018-03-06 | 2019-03-05 | A device for stopping a vial, adapted to preserve substances that must be kept separate until their application and also adapted to collect the mixture obtained through a syringe |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102018000003313A IT201800003313A1 (en) | 2018-03-06 | 2018-03-06 | Bottle capping device for storing substances to be kept separate until their application and for taking the mixture obtained by syringe. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IT201800003313A1 true IT201800003313A1 (en) | 2019-09-06 |
Family
ID=62386769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT102018000003313A IT201800003313A1 (en) | 2018-03-06 | 2018-03-06 | Bottle capping device for storing substances to be kept separate until their application and for taking the mixture obtained by syringe. |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP3536631B1 (en) |
| ES (1) | ES2927500T3 (en) |
| IT (1) | IT201800003313A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210114086A (en) * | 2020-03-09 | 2021-09-23 | 주식회사 태성산업 | A airless type mixing container for two kinds of contents capable of exhausting the whole volume |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2495942A (en) * | 1947-06-14 | 1950-01-31 | William A Nosik | Multiple chamber container |
| GB676492A (en) * | 1949-08-13 | 1952-07-30 | Paul Hauduroy | Device for mixing together two substances normally retained separate from each other in a common container without having to open said container |
| US3136440A (en) * | 1963-06-25 | 1964-06-09 | Becton Dickinson Co | Self sealing pierceable stopper for sealed containers |
| WO2008036889A2 (en) * | 2006-09-22 | 2008-03-27 | Anderson Michael R | Liquid chamber cap with compartment for use with injectables |
| DE102011079031A1 (en) * | 2011-07-12 | 2013-01-17 | Algeta Asa | liquid container |
| US20130333796A1 (en) * | 2012-06-13 | 2013-12-19 | Daniel Py | Device with penetrable septum, filling needle and penetrable closure, and related method |
| WO2016038357A1 (en) * | 2014-09-08 | 2016-03-17 | Eulysis Uk Limited | Container and closure |
-
2018
- 2018-03-06 IT IT102018000003313A patent/IT201800003313A1/en unknown
-
2019
- 2019-03-05 EP EP19160847.0A patent/EP3536631B1/en active Active
- 2019-03-05 ES ES19160847T patent/ES2927500T3/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2495942A (en) * | 1947-06-14 | 1950-01-31 | William A Nosik | Multiple chamber container |
| GB676492A (en) * | 1949-08-13 | 1952-07-30 | Paul Hauduroy | Device for mixing together two substances normally retained separate from each other in a common container without having to open said container |
| US3136440A (en) * | 1963-06-25 | 1964-06-09 | Becton Dickinson Co | Self sealing pierceable stopper for sealed containers |
| WO2008036889A2 (en) * | 2006-09-22 | 2008-03-27 | Anderson Michael R | Liquid chamber cap with compartment for use with injectables |
| DE102011079031A1 (en) * | 2011-07-12 | 2013-01-17 | Algeta Asa | liquid container |
| US20130333796A1 (en) * | 2012-06-13 | 2013-12-19 | Daniel Py | Device with penetrable septum, filling needle and penetrable closure, and related method |
| WO2016038357A1 (en) * | 2014-09-08 | 2016-03-17 | Eulysis Uk Limited | Container and closure |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3536631A1 (en) | 2019-09-11 |
| ES2927500T3 (en) | 2022-11-07 |
| EP3536631B1 (en) | 2022-08-10 |
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