IT1261231B - IMPROVED PROCEDURE FOR THE PREPARATION OF L - (-) - CARNITINE FROM A WASTE PRODUCT WITH OPPOSITE CONFIGURATION. - Google Patents

IMPROVED PROCEDURE FOR THE PREPARATION OF L - (-) - CARNITINE FROM A WASTE PRODUCT WITH OPPOSITE CONFIGURATION.

Info

Publication number
IT1261231B
IT1261231B ITRM930227A ITRM930227A IT1261231B IT 1261231 B IT1261231 B IT 1261231B IT RM930227 A ITRM930227 A IT RM930227A IT RM930227 A ITRM930227 A IT RM930227A IT 1261231 B IT1261231 B IT 1261231B
Authority
IT
Italy
Prior art keywords
carnitine
preparation
waste product
improved procedure
opposite configuration
Prior art date
Application number
ITRM930227A
Other languages
Italian (it)
Inventor
Fabio Giannessi
Maria Ornella Tinti
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ITRM930227A0 publication Critical patent/ITRM930227A0/en
Priority to ITRM930227A priority Critical patent/IT1261231B/en
Priority to DE69400978T priority patent/DE69400978T2/en
Priority to EP94830151A priority patent/EP0624568B1/en
Priority to AT94830151T priority patent/ATE145641T1/en
Priority to ES94830151T priority patent/ES2095144T3/en
Priority to DK94830151.0T priority patent/DK0624568T3/en
Priority to US08/224,513 priority patent/US5532410A/en
Priority to KR1019940007251A priority patent/KR100301952B1/en
Priority to CA002120812A priority patent/CA2120812C/en
Priority to TW083103009A priority patent/TW284753B/zh
Priority to JP06928794A priority patent/JP3635102B2/en
Priority to ZA942429A priority patent/ZA942429B/en
Publication of ITRM930227A1 publication Critical patent/ITRM930227A1/en
Application granted granted Critical
Publication of IT1261231B publication Critical patent/IT1261231B/en
Priority to GR960402830T priority patent/GR3021790T3/en
Priority to HK98104923A priority patent/HK1005723A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton

Abstract

A process for preparing L-(-)-carnitine is disclosed which comprises converting D-(+)-carnitinamide to an ester, acylating said ester, converting the ester group to carboxyl group thus obtaining D-(+)-carnitine, converting this latter compound to the lactone of L-(-)-carnitine which treated in a basic environment yields L-(-)-carnitine inner salt.
ITRM930227A 1993-04-08 1993-04-08 IMPROVED PROCEDURE FOR THE PREPARATION OF L - (-) - CARNITINE FROM A WASTE PRODUCT WITH OPPOSITE CONFIGURATION. IT1261231B (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ITRM930227A IT1261231B (en) 1993-04-08 1993-04-08 IMPROVED PROCEDURE FOR THE PREPARATION OF L - (-) - CARNITINE FROM A WASTE PRODUCT WITH OPPOSITE CONFIGURATION.
DE69400978T DE69400978T2 (en) 1993-04-08 1994-03-31 Process for producing L - (-) - carnitine from waste products with opposite configuration
EP94830151A EP0624568B1 (en) 1993-04-08 1994-03-31 Improved process for manufacturing L-(-)-carnitine from a waste product having opposite configuration
AT94830151T ATE145641T1 (en) 1993-04-08 1994-03-31 METHOD FOR PRODUCING L-(-)-CARNITINE FROM WASTE PRODUCTS WITH OPPOSITE CONFIGURATION
ES94830151T ES2095144T3 (en) 1993-04-08 1994-03-31 IMPROVED PROCEDURE FOR PREPARATION OF L - (-) - CARNITINE FROM A WASTE PRODUCT THAT HAS AN OPPOSITE CONFIGURATION.
DK94830151.0T DK0624568T3 (en) 1993-04-08 1994-03-31 Improved method for preparing L - (-) - carnitine from a waste product of opposite configuration
US08/224,513 US5532410A (en) 1993-04-08 1994-04-04 Process for manufacturing L(-)-carnitine from a waste product having opposite configuration
KR1019940007251A KR100301952B1 (en) 1993-04-08 1994-04-07 Process for the production of L-(-)-carnitine from wastes with opposite arrangement
CA002120812A CA2120812C (en) 1993-04-08 1994-04-07 Improved process for manufacturing l-(-)-carnitine from a waste product having opposite configuration
TW083103009A TW284753B (en) 1993-04-08 1994-04-07
JP06928794A JP3635102B2 (en) 1993-04-08 1994-04-07 Improved process for producing L-(-)-carnitine from wastes of opposite configuration
ZA942429A ZA942429B (en) 1993-04-08 1994-04-08 Improved process for manufacturing L(-) carnitine from a product having opposite configuration
GR960402830T GR3021790T3 (en) 1993-04-08 1996-11-28 Improved process for manufacturing L-(-)-carnitine from a waste product having opposite configuration.
HK98104923A HK1005723A1 (en) 1993-04-08 1998-06-05 Improved process for manufacturing l-(-)-carnitine from a waste product having opposite configuration

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM930227A IT1261231B (en) 1993-04-08 1993-04-08 IMPROVED PROCEDURE FOR THE PREPARATION OF L - (-) - CARNITINE FROM A WASTE PRODUCT WITH OPPOSITE CONFIGURATION.

Publications (3)

Publication Number Publication Date
ITRM930227A0 ITRM930227A0 (en) 1993-04-08
ITRM930227A1 ITRM930227A1 (en) 1994-10-08
IT1261231B true IT1261231B (en) 1996-05-09

Family

ID=11401705

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM930227A IT1261231B (en) 1993-04-08 1993-04-08 IMPROVED PROCEDURE FOR THE PREPARATION OF L - (-) - CARNITINE FROM A WASTE PRODUCT WITH OPPOSITE CONFIGURATION.

Country Status (14)

Country Link
US (1) US5532410A (en)
EP (1) EP0624568B1 (en)
JP (1) JP3635102B2 (en)
KR (1) KR100301952B1 (en)
AT (1) ATE145641T1 (en)
CA (1) CA2120812C (en)
DE (1) DE69400978T2 (en)
DK (1) DK0624568T3 (en)
ES (1) ES2095144T3 (en)
GR (1) GR3021790T3 (en)
HK (1) HK1005723A1 (en)
IT (1) IT1261231B (en)
TW (1) TW284753B (en)
ZA (1) ZA942429B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1276207B1 (en) * 1995-09-29 1997-10-27 Sigma Tau Ind Farmaceuti PROCEDURE FOR THE PREPARATION OF (S) -B-HYDROXY-GAMMA- BUTYROLACTONE
IT1297120B1 (en) * 1997-12-16 1999-08-03 Sigma Tau Ind Farmaceuti PROCEDURE FOR THE PRODUCTION OF (R) -3-HYDROXY-4-BUTYROLACTONE USEFUL IN THE PREPARATION OF (R) -CARNITINE
IT1306184B1 (en) * 1999-08-05 2001-05-30 Sigma Tau Ind Farmaceuti NITRILOSSI DERIVATIVES OF (R) AND (S) -CARNITINE.
EP2409965A1 (en) * 2010-07-21 2012-01-25 Lonza Ltd. A process for the production of carnitine by cycloaddition
CN108863845B (en) * 2018-08-21 2021-01-01 湖南大学 Preparation method of trifloxystrobin and intermediate thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3096368A (en) * 1958-07-30 1963-07-02 Process for preparing hydrolysis products of gamma-dimethyl amin-beta-hydroxybutyroni
IT1116037B (en) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti ACIL CARNITINE ESTERS AND AMIDS THEIR PREPARATION PROCEDURES AND THERAPEUTIC USE
IT1144077B (en) * 1980-01-29 1986-10-29 Sigma Tau Ind Farmaceuti CARNITINAMIDES OF OPTICALLY ACTIVE AMINO ACIDS AND PROCEDURE FOR THEIR PREPARATION
IT1136945B (en) * 1981-03-18 1986-09-03 Anic Spa PROCESS FOR THE PREPARATION OF L-CARNITINA
IT1191945B (en) * 1986-06-04 1988-03-31 Avantgarde Spa N-ALCHYLAMIDS OF D (+) - CARNITINE EQUIPPED WITH ANTIBACTERIAL ACTIVITY, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM
JPH0291049A (en) * 1988-09-21 1990-03-30 Lonza Ag Production of gamma-butyrobetaine
IT1258370B (en) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti ESTERS OF L-CARNITINE AND ACIL L-CARNITINE EQUIPPED WITH SELECTIVE MYO-RELAXING ACTIVITY ON THE GASTRO-INTESTINAL APPARATUS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Also Published As

Publication number Publication date
ES2095144T3 (en) 1997-02-01
JPH06306028A (en) 1994-11-01
DK0624568T3 (en) 1996-12-16
CA2120812C (en) 2004-10-26
TW284753B (en) 1996-09-01
US5532410A (en) 1996-07-02
EP0624568A1 (en) 1994-11-17
DE69400978D1 (en) 1997-01-09
CA2120812A1 (en) 1994-10-09
ATE145641T1 (en) 1996-12-15
GR3021790T3 (en) 1997-02-28
JP3635102B2 (en) 2005-04-06
ITRM930227A0 (en) 1993-04-08
HK1005723A1 (en) 1999-01-22
KR100301952B1 (en) 2001-10-22
ITRM930227A1 (en) 1994-10-08
DE69400978T2 (en) 1997-04-03
EP0624568B1 (en) 1996-11-27
ZA942429B (en) 1994-11-29

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960307