IT1247953B - Process for the preparation of L-&alpha-glyceryl phosphoryl ethanolamine and L-&alpha-(diacetyl)-glyceryl phosphoryl ethanolamine, in the anhydrous, monohydrated, dihydrated and trihydrated forms - Google Patents
Process for the preparation of L-&alpha-glyceryl phosphoryl ethanolamine and L-&alpha-(diacetyl)-glyceryl phosphoryl ethanolamine, in the anhydrous, monohydrated, dihydrated and trihydrated formsInfo
- Publication number
- IT1247953B IT1247953B ITMI911387A ITMI911387A IT1247953B IT 1247953 B IT1247953 B IT 1247953B IT MI911387 A ITMI911387 A IT MI911387A IT MI911387 A ITMI911387 A IT MI911387A IT 1247953 B IT1247953 B IT 1247953B
- Authority
- IT
- Italy
- Prior art keywords
- alpha
- phosphoryl ethanolamine
- glyceryl phosphoryl
- dihydrated
- monohydrated
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal cation Chemical group 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000005207 tetraalkylammonium group Chemical group 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
Abstract
A process for the preparation of L-α-glyceryl phosphoryl ethanolamine and L-α-(diacetyl)-glyceryl phosphoryl ethanolamine in the anhydrous, monohydrated, dihydrated and trihydrated forms comprising the reaction of compound II <IMAGE> in which R1 is an alkali metal cation or a tetraalkyl ammonium group with (+)-1,2-isopropylidene-sn-glyceryl tosylate, treatment of the product so obtained with a hydrohalogen acid at pH 2 to 4, acetylization of the product so obtained if required, treatment with zinc in H2O/THF in the presence of HCl at pH 4-5 and crystallization from water-alcohol mixtures to obtain the hydrated forms is described. This invention also relates to the monohydrated, dihydrated and trihydrated forms of L-α-(diacetyl)-glyceryl phosphoryl ethanolamine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI911387A IT1247953B (en) | 1991-05-21 | 1991-05-21 | Process for the preparation of L-&alpha-glyceryl phosphoryl ethanolamine and L-&alpha-(diacetyl)-glyceryl phosphoryl ethanolamine, in the anhydrous, monohydrated, dihydrated and trihydrated forms |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI911387A IT1247953B (en) | 1991-05-21 | 1991-05-21 | Process for the preparation of L-&alpha-glyceryl phosphoryl ethanolamine and L-&alpha-(diacetyl)-glyceryl phosphoryl ethanolamine, in the anhydrous, monohydrated, dihydrated and trihydrated forms |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI911387A0 ITMI911387A0 (en) | 1991-05-21 |
| ITMI911387A1 ITMI911387A1 (en) | 1992-11-21 |
| IT1247953B true IT1247953B (en) | 1995-01-05 |
Family
ID=11359943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI911387A IT1247953B (en) | 1991-05-21 | 1991-05-21 | Process for the preparation of L-&alpha-glyceryl phosphoryl ethanolamine and L-&alpha-(diacetyl)-glyceryl phosphoryl ethanolamine, in the anhydrous, monohydrated, dihydrated and trihydrated forms |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1247953B (en) |
-
1991
- 1991-05-21 IT ITMI911387A patent/IT1247953B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI911387A0 (en) | 1991-05-21 |
| ITMI911387A1 (en) | 1992-11-21 |
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