IT1148008B - Composti di n-(cicloalchil)ammino acido utili come inibitori dell'enzima di conversione dell'angiotensina i - Google Patents
Composti di n-(cicloalchil)ammino acido utili come inibitori dell'enzima di conversione dell'angiotensina iInfo
- Publication number
- IT1148008B IT1148008B IT48270/81A IT4827081A IT1148008B IT 1148008 B IT1148008 B IT 1148008B IT 48270/81 A IT48270/81 A IT 48270/81A IT 4827081 A IT4827081 A IT 4827081A IT 1148008 B IT1148008 B IT 1148008B
- Authority
- IT
- Italy
- Prior art keywords
- cycloalkyl
- inhibitors
- amino acid
- acid compounds
- compounds useful
- Prior art date
Links
- -1 AMINO ACID COMPOUNDS Chemical class 0.000 title 1
- 102000015427 Angiotensins Human genes 0.000 title 1
- 108010064733 Angiotensins Proteins 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15742080A | 1980-06-09 | 1980-06-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8148270A0 IT8148270A0 (it) | 1981-04-13 |
| IT1148008B true IT1148008B (it) | 1986-11-26 |
Family
ID=22563635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT48270/81A IT1148008B (it) | 1980-06-09 | 1981-04-13 | Composti di n-(cicloalchil)ammino acido utili come inibitori dell'enzima di conversione dell'angiotensina i |
Country Status (16)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4256761A (en) * | 1979-07-13 | 1981-03-17 | Usv Pharmaceutical Corporation | Antihypertensive amides |
| JPS57142962A (en) * | 1981-02-28 | 1982-09-03 | Santen Pharmaceut Co Ltd | Cyclodextrin clathrate compound of sulfur-containing compound |
| US4507316A (en) * | 1981-06-01 | 1985-03-26 | Usv Pharmaceutical Corporation | Antihypertensive compounds |
| IN163391B (enrdf_load_stackoverflow) * | 1981-11-13 | 1988-09-17 | Exxon Research Engineering Co | |
| US4661515A (en) * | 1982-07-21 | 1987-04-28 | Usv Pharmaceutical Corporation | Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity |
| IL69228A0 (en) * | 1982-07-21 | 1983-11-30 | Usv Pharma Corp | Compounds having diuretic activity and angiotensin converting inhibitory activity,methods of the preparation thereof and pharmaceutical compositions containing the same |
| US4442038A (en) * | 1982-09-17 | 1984-04-10 | Norwich Eaton Pharmaceuticals, Inc. | Converting enzyme inhibitors |
| FR2562068B1 (fr) * | 1984-03-29 | 1987-07-17 | Roussel Uclaf | Nouveaux derives de l'o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus |
| EP0384636A1 (en) * | 1989-02-21 | 1990-08-29 | FISONS plc | Pharmaceutically active compounds |
| DE4337600A1 (de) * | 1993-11-01 | 1995-05-04 | Diagnostikforschung Inst | N-Alkyl-Peptidchelatbildner, deren Metallkomplexe mit Radionukliden, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Zusammesetzungen |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053651A (en) * | 1976-05-10 | 1977-10-11 | E. R. Squibb & Sons, Inc. | Compounds and method for alleviating angiotensin related hypertension |
| US4108886A (en) * | 1977-03-11 | 1978-08-22 | E. R. Squibb & Sons, Inc. | Thiopropanoylamino acid derivatives |
| US4256761A (en) * | 1979-07-13 | 1981-03-17 | Usv Pharmaceutical Corporation | Antihypertensive amides |
-
1981
- 1981-02-27 ZA ZA00811340A patent/ZA811340B/xx unknown
- 1981-03-04 IL IL62293A patent/IL62293A0/xx unknown
- 1981-03-04 AU AU68081/81A patent/AU6808181A/en not_active Abandoned
- 1981-03-10 NL NL8101163A patent/NL8101163A/nl not_active Application Discontinuation
- 1981-03-24 GB GB8109261A patent/GB2077719A/en not_active Withdrawn
- 1981-04-13 IT IT48270/81A patent/IT1148008B/it active
- 1981-04-15 SE SE8102455A patent/SE8102455L/xx not_active Application Discontinuation
- 1981-05-12 ES ES502153A patent/ES8206457A1/es not_active Expired
- 1981-05-22 DD DD81230198A patent/DD159069A5/de unknown
- 1981-05-26 JP JP7995581A patent/JPS5726656A/ja active Pending
- 1981-06-04 DK DK247181A patent/DK247181A/da unknown
- 1981-06-05 DE DE19813122541 patent/DE3122541A1/de not_active Withdrawn
- 1981-06-08 GR GR65177A patent/GR82349B/el unknown
- 1981-06-08 PT PT73156A patent/PT73156B/pt unknown
- 1981-06-09 BE BE0/205048A patent/BE889152A/fr unknown
- 1981-06-09 FR FR8111333A patent/FR2483916A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5726656A (en) | 1982-02-12 |
| DD159069A5 (de) | 1983-02-16 |
| FR2483916A1 (fr) | 1981-12-11 |
| PT73156A (en) | 1981-07-01 |
| ES502153A0 (es) | 1982-08-16 |
| GB2077719A (en) | 1981-12-23 |
| ZA811340B (en) | 1982-03-31 |
| DK247181A (da) | 1981-12-10 |
| PT73156B (en) | 1982-07-16 |
| AU6808181A (en) | 1981-12-17 |
| ES8206457A1 (es) | 1982-08-16 |
| IT8148270A0 (it) | 1981-04-13 |
| BE889152A (fr) | 1981-12-09 |
| IL62293A0 (en) | 1981-05-20 |
| DE3122541A1 (de) | 1982-03-25 |
| SE8102455L (sv) | 1981-12-10 |
| NL8101163A (nl) | 1982-01-04 |
| GR82349B (enrdf_load_stackoverflow) | 1984-12-13 |
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