IT1037122B - Derivati alogenati dell 1 3 dios solano ad attivita mucolitica - Google Patents
Derivati alogenati dell 1 3 dios solano ad attivita mucoliticaInfo
- Publication number
- IT1037122B IT1037122B IT2192975A IT2192975A IT1037122B IT 1037122 B IT1037122 B IT 1037122B IT 2192975 A IT2192975 A IT 2192975A IT 2192975 A IT2192975 A IT 2192975A IT 1037122 B IT1037122 B IT 1037122B
- Authority
- IT
- Italy
- Prior art keywords
- dioxolanes
- haloalkyl
- hydroxymethyl
- alkyl
- derivs
- Prior art date
Links
- 239000003172 expectorant agent Substances 0.000 title abstract 2
- 230000003419 expectorant effect Effects 0.000 title abstract 2
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000006083 1-bromoethyl group Chemical group 0.000 abstract 1
- LWCIBYRXSHRIAP-UHFFFAOYSA-N 3-phenylmethoxypropane-1,2-diol Chemical compound OCC(O)COCC1=CC=CC=C1 LWCIBYRXSHRIAP-UHFFFAOYSA-N 0.000 abstract 1
- YCPXWRQRBFJBPZ-UHFFFAOYSA-N 5-sulfosalicylic acid Chemical compound OC(=O)C1=CC(S(O)(=O)=O)=CC=C1O YCPXWRQRBFJBPZ-UHFFFAOYSA-N 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
- 229910001516 alkali metal iodide Inorganic materials 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 abstract 1
- 229940066493 expectorants Drugs 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000002346 iodo group Chemical group I* 0.000 abstract 1
- -1 iodomethyl Chemical group 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2192975A IT1037122B (it) | 1975-04-01 | 1975-04-01 | Derivati alogenati dell 1 3 dios solano ad attivita mucolitica |
| DE2610704A DE2610704C2 (de) | 1975-04-01 | 1976-03-13 | 4-Hydroxymethyl-2-iodmethyl-1,3-dioxolan, Verfahren zu seiner Herstellung und diese Verbindung enthaltende Arzneimittel |
| GB11467/76A GB1487165A (en) | 1975-04-01 | 1976-03-22 | Halogenated 1,3-dioxolane derivatives their preparation and use |
| CA248,738A CA1064044A (en) | 1975-04-01 | 1976-03-24 | Halogenated derivatives of 1,3-dioxolane having mucolytic activity |
| US05/670,174 US4085223A (en) | 1975-04-01 | 1976-03-24 | Halogenated derivatives of 1,3-dioxolane having mucolytic activity |
| FR7609398A FR2305979A1 (fr) | 1975-04-01 | 1976-03-31 | Derives de 1,3-dioxolane, procede pour leur preparation, et compositions pharmaceutiques contenant de tels derives |
| JP51037034A JPS51122065A (en) | 1975-04-01 | 1976-04-01 | Preparation and use of halogenated 1*33 dioxorane derivatives |
| BE0/198474A BE880492Q (fr) | 1975-04-01 | 1979-12-07 | Derives de 1,3-dioxolane, procede pour leur preparation, et compositions pharmaceutiques contenant de tels derives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2192975A IT1037122B (it) | 1975-04-01 | 1975-04-01 | Derivati alogenati dell 1 3 dios solano ad attivita mucolitica |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IT1037122B true IT1037122B (it) | 1979-11-10 |
Family
ID=11188946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2192975A IT1037122B (it) | 1975-04-01 | 1975-04-01 | Derivati alogenati dell 1 3 dios solano ad attivita mucolitica |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4085223A (enExample) |
| JP (1) | JPS51122065A (enExample) |
| BE (1) | BE880492Q (enExample) |
| CA (1) | CA1064044A (enExample) |
| DE (1) | DE2610704C2 (enExample) |
| FR (1) | FR2305979A1 (enExample) |
| GB (1) | GB1487165A (enExample) |
| IT (1) | IT1037122B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4861764A (en) * | 1986-11-17 | 1989-08-29 | Macro Chem. Corp. | Percutaneous absorption enhancers, compositions containing same and method of use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2589296A (en) * | 1950-06-02 | 1952-03-18 | Searle & Co | 2-trihalomethyl-1, 3-dioxolane-4-carboxybenzoate and carboxyalkanoate |
| US2872378A (en) * | 1954-05-10 | 1959-02-03 | Denver Chemical Mfg Company | Therapeutic compositions containing iodopropylideneglycerol |
| US3812261A (en) * | 1972-03-15 | 1974-05-21 | Ici America Inc | Method of producing tranquilization with dioxolanyl alcohols and their halogen derivatives |
| US3996376A (en) * | 1972-03-28 | 1976-12-07 | Ici United States Inc. | Halogenated dioxolane tranquilizers |
| ES417572A1 (es) * | 1973-08-03 | 1976-03-16 | Boehringer Mannheim Gmbh | Procedimiento para la obtencion del 2-(iodoetil)-1,3-dioxo-lano-4-metanol. |
-
1975
- 1975-04-01 IT IT2192975A patent/IT1037122B/it active
-
1976
- 1976-03-13 DE DE2610704A patent/DE2610704C2/de not_active Expired
- 1976-03-22 GB GB11467/76A patent/GB1487165A/en not_active Expired
- 1976-03-24 CA CA248,738A patent/CA1064044A/en not_active Expired
- 1976-03-24 US US05/670,174 patent/US4085223A/en not_active Expired - Lifetime
- 1976-03-31 FR FR7609398A patent/FR2305979A1/fr active Granted
- 1976-04-01 JP JP51037034A patent/JPS51122065A/ja active Pending
-
1979
- 1979-12-07 BE BE0/198474A patent/BE880492Q/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2610704A1 (de) | 1976-10-14 |
| GB1487165A (en) | 1977-09-28 |
| JPS51122065A (en) | 1976-10-25 |
| BE880492Q (fr) | 1980-04-01 |
| CA1064044A (en) | 1979-10-09 |
| US4085223A (en) | 1978-04-18 |
| DE2610704C2 (de) | 1985-04-11 |
| FR2305979B1 (enExample) | 1979-03-09 |
| FR2305979A1 (fr) | 1976-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ITCP | Complementary protection certificate |
Free format text: CCP 346 |
|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19940428 |