IN2014CN04126A - - Google Patents

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Publication number
IN2014CN04126A
IN2014CN04126A IN4126CHN2014A IN2014CN04126A IN 2014CN04126 A IN2014CN04126 A IN 2014CN04126A IN 4126CHN2014 A IN4126CHN2014 A IN 4126CHN2014A IN 2014CN04126 A IN2014CN04126 A IN 2014CN04126A
Authority
IN
India
Prior art keywords
attachment
group
point
compounds
alkyl
Prior art date
Application number
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English (en)
Inventor
Christian Hubschwerlen
Georg Rueedi
Jean Philippe Surivet
Acklin Cornelia Zumbrunn
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of IN2014CN04126A publication Critical patent/IN2014CN04126A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Detergent Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IN4126CHN2014 2011-11-08 2012-11-07 IN2014CN04126A (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2011054968 2011-11-08
PCT/IB2012/056236 WO2013068948A1 (en) 2011-11-08 2012-11-07 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives

Publications (1)

Publication Number Publication Date
IN2014CN04126A true IN2014CN04126A (cs) 2015-07-10

Family

ID=47258051

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4126CHN2014 IN2014CN04126A (cs) 2011-11-08 2012-11-07

Country Status (21)

Country Link
US (1) US9079922B2 (cs)
EP (1) EP2776431B1 (cs)
JP (1) JP6030146B2 (cs)
KR (1) KR20140096337A (cs)
AR (1) AR088691A1 (cs)
AU (1) AU2012335207B2 (cs)
BR (1) BR112014011064A8 (cs)
CA (1) CA2854264A1 (cs)
CL (1) CL2014001154A1 (cs)
ES (1) ES2581056T3 (cs)
HK (1) HK1202288A1 (cs)
IL (1) IL232463A0 (cs)
IN (1) IN2014CN04126A (cs)
MX (1) MX344529B (cs)
PH (1) PH12014500831A1 (cs)
PL (1) PL2776431T3 (cs)
RU (1) RU2616609C2 (cs)
SG (1) SG11201401710PA (cs)
TW (1) TWI594996B (cs)
WO (1) WO2013068948A1 (cs)
ZA (1) ZA201404176B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0920895A8 (pt) 2008-10-07 2017-12-26 Actelion Pharmaceuticals Ltd Compostos antibióticos de oxazolidinona tricíclica
CA2907832A1 (en) 2013-04-16 2014-10-23 Actelion Pharmaceuticals Ltd Antibacterial biaromatic derivatives
AR096135A1 (es) 2013-05-02 2015-12-09 Actelion Pharmaceuticals Ltd Derivados de la quinolona
AR102256A1 (es) 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
MA41169A (fr) 2014-12-17 2017-10-24 Acraf Composés antibactériens à large spectre d'activité
MA41168A (fr) 2014-12-17 2017-10-24 Acraf Nouveaux composés antibactériens
GB201602235D0 (en) * 2016-02-08 2016-03-23 Redx Pharma Plc Antibacterial compounds
CA3012583A1 (en) * 2016-02-08 2017-08-17 Redx Pharma Plc Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds
CA3012569A1 (en) * 2016-02-08 2017-08-17 Redx Pharma Plc Antibacterial compounds
JP2019517546A (ja) 2016-06-08 2019-06-24 アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニAziende Chimiche Riunite Angelini Francesco A.C.R.A.F.Societa Per Azioni 新しい抗菌性化合物
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
US10912780B2 (en) 2017-06-08 2021-02-09 Bugworks Research, Inc. Heterocyclic compounds useful as anti-bacterial agents and method for production thereof
ES2952989T3 (es) 2017-11-29 2023-11-07 Bugworks Res Inc Compuestos heterocíclicos antibacterianos y su síntesis

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149104A (en) 1961-01-03 1964-09-15 Sterling Drug Inc 4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters
CA1006521A (en) 1972-12-18 1977-03-08 Minoru Sugita Piperazine derivatives and process for preparing them
GB1598915A (en) 1977-09-20 1981-09-23 Bellon Labor Sa Roger 1,4-dihydro-quinoline-3-carboxylic acid derivatives process for their preparation and composition containing them
SE444566B (sv) 1977-09-20 1986-04-21 Bellon Labor Sa Roger 7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav
CS274601B2 (en) 1983-07-27 1991-09-15 Dainippon Pharmaceutical Co Method of 1,8-naphthyridine derivative production
JPS62205060A (ja) 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd 8位置換キノロンカルボン酸誘導体
NO871333L (no) 1986-03-31 1987-10-01 Sankyo Co Kinolin-3-karboksylsyrederivater, fremgangsmaate til fremstilling og anvendelse derav.
JP2631854B2 (ja) 1987-12-23 1997-07-16 藤本製薬株式会社 新規な1,8−ナフチリジン誘導体
DE4301246A1 (de) 1993-01-19 1994-07-21 Bayer Ag Chinolon- und Naphthyridoncarbonsäurederivate
JPWO2004002973A1 (ja) 2002-06-28 2005-10-27 株式会社カネカ 光学活性1−置換アミノ−2,3−エポキシプロパンの製造方法並びにその合成中間体およびそれらの製造方法
KR101101982B1 (ko) * 2003-04-30 2012-01-02 모르포켐 악티엥게셀샤프트 퓌르 콤비나토리셰 케미 옥사졸리디논-퀴놀린 하이브리드 항생제의 탄저병 및 기타감염증의 치료용의 용도
CN106957316A (zh) * 2003-12-18 2017-07-18 莫弗凯姆联合化学股份公司 噁唑烷酮‑喹诺酮杂化物抗生素
WO2006024741A2 (fr) * 2004-07-30 2006-03-09 Palumed S.A. Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
DE602005015341D1 (de) 2004-09-01 2009-08-20 Ubitrak Inc System zum identifizieren und zählen von spieljetons
US20090156577A1 (en) 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
JP2009532504A (ja) 2006-04-06 2009-09-10 グラクソ グループ リミテッド 抗菌薬
CL2007003232A1 (es) * 2006-11-10 2008-06-27 Actelion Pharmaceuticals Ltd Compuestos derivados de 5-hidroximetil oxazolidin-2-ona; composicion farmaceutica que contiene a dichos compuestos; y su uso para tratar y prevenir infecciones bacterianas.
CL2008001003A1 (es) * 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
CL2008001002A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
JP5323088B2 (ja) * 2007-12-18 2013-10-23 アクテリオン ファーマシューティカルズ リミテッド 5−アミノシクリルメチル−オキサゾリジン−2−オン誘導体
WO2009104159A1 (en) * 2008-02-22 2009-08-27 Actelion Pharmaceuticals Ltd Oxazolidinone derivatives
BRPI0920895A8 (pt) 2008-10-07 2017-12-26 Actelion Pharmaceuticals Ltd Compostos antibióticos de oxazolidinona tricíclica
US20110195949A1 (en) * 2008-10-10 2011-08-11 Actelion Pharmaceuticals Ltd. 2-benzothiophenyl- and 2-naphthyl-oxazolidinones and their azaisostere analogues as antibacterial agents
JP5490809B2 (ja) * 2008-10-10 2014-05-14 アクテリオン ファーマシューティカルズ リミテッド オキサゾリジニル抗生物質
TW201121965A (en) 2009-09-28 2011-07-01 Lg Life Sciences Ltd Use of a quinolone derivative containing 7-(4-aminomethyl-3-oxime)pyrrolidine group that is capable of inducing granulocyte colony stimulating factor for treatment of neutropenia and recovery of hematopoiesis
CN101792443A (zh) 2010-03-09 2010-08-04 北京欧凯纳斯科技有限公司 氟代喹诺酮衍生物及其制备方法和用途

Also Published As

Publication number Publication date
JP6030146B2 (ja) 2016-11-24
TW201326166A (zh) 2013-07-01
EP2776431B1 (en) 2016-05-04
PL2776431T3 (pl) 2016-11-30
BR112014011064A2 (pt) 2017-06-13
WO2013068948A1 (en) 2013-05-16
EP2776431A1 (en) 2014-09-17
US20150051188A1 (en) 2015-02-19
US9079922B2 (en) 2015-07-14
MX344529B (es) 2016-12-19
AU2012335207B2 (en) 2017-05-25
MX2014005637A (es) 2014-06-23
IL232463A0 (en) 2014-06-30
CN103917539A (zh) 2014-07-09
HK1202288A1 (en) 2015-09-25
JP2014532754A (ja) 2014-12-08
TWI594996B (zh) 2017-08-11
SG11201401710PA (en) 2014-09-26
CL2014001154A1 (es) 2014-09-12
KR20140096337A (ko) 2014-08-05
AU2012335207A1 (en) 2014-07-03
AR088691A1 (es) 2014-06-25
ZA201404176B (en) 2016-05-25
BR112014011064A8 (pt) 2017-12-26
RU2616609C2 (ru) 2017-04-18
RU2014123109A (ru) 2015-12-20
CA2854264A1 (en) 2013-05-16
ES2581056T3 (es) 2016-08-31
PH12014500831A1 (en) 2019-08-07

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