IL98300A - Oxa-thiazolidinedione as hypoglycemic and hypocholesterolemic substances and pharmaceutical preparations containing them - Google Patents

Oxa-thiazolidinedione as hypoglycemic and hypocholesterolemic substances and pharmaceutical preparations containing them

Info

Publication number
IL98300A
IL98300A IL9830091A IL9830091A IL98300A IL 98300 A IL98300 A IL 98300A IL 9830091 A IL9830091 A IL 9830091A IL 9830091 A IL9830091 A IL 9830091A IL 98300 A IL98300 A IL 98300A
Authority
IL
Israel
Prior art keywords
compound
compounds
formula
hypoglycemic
hydrogen
Prior art date
Application number
IL9830091A
Other languages
English (en)
Hebrew (he)
Other versions
IL98300A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL98300A0 publication Critical patent/IL98300A0/xx
Publication of IL98300A publication Critical patent/IL98300A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Paints Or Removers (AREA)
IL9830091A 1990-06-05 1991-05-29 Oxa-thiazolidinedione as hypoglycemic and hypocholesterolemic substances and pharmaceutical preparations containing them IL98300A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/533,615 US5037842A (en) 1990-06-05 1990-06-05 Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents

Publications (2)

Publication Number Publication Date
IL98300A0 IL98300A0 (en) 1992-06-21
IL98300A true IL98300A (en) 1996-01-31

Family

ID=24126737

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9830091A IL98300A (en) 1990-06-05 1991-05-29 Oxa-thiazolidinedione as hypoglycemic and hypocholesterolemic substances and pharmaceutical preparations containing them

Country Status (20)

Country Link
US (1) US5037842A (hu)
EP (1) EP0537300B1 (hu)
JP (1) JPH0714924B2 (hu)
AT (1) ATE121736T1 (hu)
AU (1) AU640284B2 (hu)
CA (1) CA2084195A1 (hu)
DE (1) DE69109291T2 (hu)
DK (1) DK0537300T3 (hu)
ES (1) ES2071339T3 (hu)
FI (1) FI94756C (hu)
HU (1) HUT65676A (hu)
IE (1) IE65628B1 (hu)
IL (1) IL98300A (hu)
MY (1) MY135758A (hu)
NO (1) NO924696D0 (hu)
NZ (1) NZ238382A (hu)
PT (1) PT97856A (hu)
TW (1) TW200481B (hu)
WO (1) WO1991019704A2 (hu)
ZA (1) ZA914188B (hu)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
NO179246C (no) * 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
US5498621A (en) * 1992-05-01 1996-03-12 Pfizer Inc. Oxazolidinedione hypoglycemic agents
CZ287027B6 (en) * 1992-08-31 2000-08-16 Sankyo Co Oxazolidine derivatives, process of their preparation and pharmaceutical preparations containing thereof
US5594016A (en) * 1992-12-28 1997-01-14 Mitsubishi Chemical Corporation Naphthalene derivatives
TW268952B (hu) * 1993-02-26 1996-01-21 Takeda Pharm Industry Co Ltd
EP0645387A1 (en) * 1993-04-07 1995-03-29 Taiho Pharmaceutical Co., Ltd. Thiazolidine derivative and pharmaceutical composition containing the same
US5641796A (en) * 1994-11-01 1997-06-24 Eli Lilly And Company Oral hypoglycemic agents
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5889032A (en) * 1996-05-06 1999-03-30 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
USRE39266E1 (en) * 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
KR100579765B1 (ko) 1996-07-01 2006-12-28 닥터 레디스 레보러터리즈 리미티드 신규헤테로고리형화합물의제조방법,이를함유하는약제조성물및당뇨병및이와관련된질병의치료에있어서그의용도
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6011036A (en) * 1997-04-15 2000-01-04 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them
EP0894089B9 (en) * 1997-05-02 2003-04-02 Dr. Reddy's Laboratories Ltd. Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
WO1997041119A1 (en) * 1997-05-02 1997-11-06 Dr. Reddy's Research Foundation Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6011031A (en) * 1997-05-30 2000-01-04 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
AU7595298A (en) * 1997-12-02 1998-12-11 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hy pertension
JP2003040877A (ja) * 2001-07-24 2003-02-13 Sumika Fine Chemicals Co Ltd ５−［６−（２−フルオロベンジルオキシ）−２−ナフチル］メチル−２，４−チアゾリジンジオンの製造方法及びその精製方法
CA2510455C (en) * 2002-12-19 2013-03-12 The Scripps Research Institute Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
JP2007538095A (ja) * 2004-05-20 2007-12-27 フォールドアールエックス ファーマシューティカルズ インコーポレイテッド トランスサイレチンを安定化し、トランスサイレチンのミスフォールディングを阻害するための、２−（（ヘテロ）アリール）−ベンゾオキサゾール化合物および誘導体、組成物、ならびに方法
EP2074223A4 (en) * 2006-09-15 2010-03-10 Foldrx Pharmaceuticals Inc TEST PROCEDURE FOR THE DETECTION OF PROTEINS IN THE NATIVE CONDITION AND FOR THE IDENTIFICATION OF THE STABILITY OF PROTEINS IN THE NATIVE CONDITION MODULATING COMPOUNDS
ATE537157T1 (de) * 2007-03-07 2011-12-15 Janssen Pharmaceutica Nv Substituierte phenoxy-n-alkylierte thiazoledindione als östrogenassoziierte rezeptor-alpha-modulatoren
EP2134698A1 (en) 2007-03-07 2009-12-23 Janssen Pharmaceutica, N.V. Substituted phenoxy aminothiazolones as estrogen related receptor-alpha modulators
TW200902508A (en) 2007-03-07 2009-01-16 Janssen Pharmaceutica Nv Substituted phenoxy thiazolidinediones as estrogen related receptor-α modulators
CA2763536C (en) * 2008-05-30 2017-05-09 Marvin J. Miller Anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria
US8263781B2 (en) 2009-12-18 2012-09-11 Janssen Pharmaceutica Nv Substituted aminothiazolone indazoles as estrogen related receptor-alpha modulators
RU2586330C2 (ru) 2011-09-16 2016-06-10 Пфайзер Инк. Твердые формы ингибитора диссоциации транстиретина
US20170298081A1 (en) * 2014-08-08 2017-10-19 Kasuma Partners Inc. Condensed heterocyclic compound

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5430171A (en) * 1977-08-10 1979-03-06 Taiho Pharmaceutical Co Ltd Isooxazole derivative and production
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
US4753956A (en) * 1981-01-02 1988-06-28 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4689336A (en) * 1981-01-02 1987-08-25 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine 2,4-diones
US4550172A (en) * 1984-09-21 1985-10-29 American Home Products Corporation Novel heterocyclic compounds as antiallergic agents
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
HU210339B (en) * 1985-05-21 1995-03-28 Pfizer Process for preparing thiazolidinediones and their pharmaceutical compositions haring hypoglycemic effect
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
JPS62234085A (ja) * 1985-12-18 1987-10-14 Sankyo Co Ltd チアゾリジン誘導体を有効成分とする糖尿病性合併症治療剤
FI91869C (fi) * 1987-03-18 1994-08-25 Tanabe Seiyaku Co Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi
DE3856378T2 (de) * 1987-09-04 2000-05-11 Beecham Group P.L.C., Brentford Substituierte Thiazolidindionderivate
US4791125A (en) * 1987-12-02 1988-12-13 Pfizer Inc. Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents
WO1989008650A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Thiazolidinedione hypoglycemic agents

Also Published As

Publication number Publication date
MY135758A (en) 2008-06-30
ATE121736T1 (de) 1995-05-15
IL98300A0 (en) 1992-06-21
WO1991019704A3 (en) 1992-03-19
EP0537300A1 (en) 1993-04-21
NZ238382A (en) 1995-12-21
IE911885A1 (en) 1991-12-18
TW200481B (hu) 1993-02-21
FI94756B (fi) 1995-07-14
FI94756C (fi) 1995-10-25
ZA914188B (en) 1993-01-27
CA2084195A1 (en) 1991-12-06
HUT65676A (en) 1994-07-28
DE69109291D1 (de) 1995-06-01
AU640284B2 (en) 1993-08-19
IE65628B1 (en) 1995-11-01
HU9203837D0 (en) 1993-03-29
FI925522A (fi) 1992-12-04
JPH05506456A (ja) 1993-09-22
EP0537300B1 (en) 1995-04-26
US5037842A (en) 1991-08-06
AU8753191A (en) 1992-01-07
NO924696L (no) 1992-12-04
PT97856A (pt) 1992-03-31
FI925522A0 (fi) 1992-12-04
JPH0714924B2 (ja) 1995-02-22
WO1991019704A2 (en) 1991-12-26
DK0537300T3 (da) 1995-07-03
DE69109291T2 (de) 1995-08-31
ES2071339T3 (es) 1995-06-16
NO924696D0 (no) 1992-12-04

Similar Documents

Publication Publication Date Title
EP0537300B1 (en) Oxazolidinedione hypoglycemic and hypocholesterolemic agents
CA2029703C (en) Oxazolidinedione hypoglycemic agents
US5330998A (en) Thiazolidinedione derivatives as hypoglycemic agents
US5498621A (en) Oxazolidinedione hypoglycemic agents
RU2122002C1 (ru) Новые тиазолидиндионы и содержащие их лекарственные средства
US5036079A (en) Hypoglycemic thiazolidinedione derivatives
EP0389699B1 (en) Thiazolidinedione derivatives as hypoglycemic agents
US4968707A (en) Oxazolidin-2-one derivatives as hypoglycemic agents
US5130379A (en) Hypoglycemic thiazolidinedione derivatives
AU665775B2 (en) Hypoglycemic thiazolidinediones and intermediates
EP0591252B1 (en) Thiazolidinedione hypoglycemic agents
US5401761A (en) Thiazolidinedione hypoglycemic agents
WO1991003474A1 (en) Hypoglycemic thiazolidinedione derivatives
IE63187B1 (en) Thiazolidinedione derivatives as hypoglycemic agents

Legal Events

Date Code Title Description
FF Patent granted
RH Patent void