IL96304D0 - Method for preparation of taxol using oxazinone - Google Patents

Method for preparation of taxol using oxazinone

Info

Publication number
IL96304D0
IL96304D0 IL96304A IL9630490A IL96304D0 IL 96304 D0 IL96304 D0 IL 96304D0 IL 96304 A IL96304 A IL 96304A IL 9630490 A IL9630490 A IL 9630490A IL 96304 D0 IL96304 D0 IL 96304D0
Authority
IL
Israel
Prior art keywords
oxazinone
taxol
Prior art date
Application number
IL96304A
Other versions
IL96304A (en
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US07/436,235 priority Critical patent/US5015744A/en
Priority to US07/603,041 priority patent/US5136060A/en
Application filed by Univ Florida State filed Critical Univ Florida State
Publication of IL96304D0 publication Critical patent/IL96304D0/en
Publication of IL96304A publication Critical patent/IL96304A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atoms as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/64Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/041,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/061,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/56Ring systems containing bridged rings
    • C07C2603/58Ring systems containing bridged rings containing three rings
    • C07C2603/76Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/84Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing rings with more than eight members
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
IL9630490A 1989-11-14 1990-11-11 Oxazinone and a process for the preparation of taxol from it IL96304A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US07/436,235 US5015744A (en) 1989-11-14 1989-11-14 Method for preparation of taxol using an oxazinone
US07/603,041 US5136060A (en) 1989-11-14 1990-10-30 Method for preparation of taxol using an oxazinone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL10924690A IL109246A (en) 1989-11-14 1990-11-11 Process for producing beta-amido esters from an oxazinone and an alcohol

Publications (2)

Publication Number Publication Date
IL96304D0 true IL96304D0 (en) 1991-08-16
IL96304A IL96304A (en) 1995-06-29

Family

ID=27030868

Family Applications (3)

Application Number Title Priority Date Filing Date
IL10924690A IL109246A (en) 1989-11-14 1990-11-11 Process for producing beta-amido esters from an oxazinone and an alcohol
IL9630490A IL96304A (en) 1989-11-14 1990-11-11 Oxazinone and a process for the preparation of taxol from it
IL10924694A IL109246D0 (en) 1989-11-14 1994-04-07 Process for producing beta -amido-esters

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL10924690A IL109246A (en) 1989-11-14 1990-11-11 Process for producing beta-amido esters from an oxazinone and an alcohol

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL10924694A IL109246D0 (en) 1989-11-14 1994-04-07 Process for producing beta -amido-esters

Country Status (27)

Country Link
US (3) US5136060A (en)
EP (1) EP0428376B1 (en)
JP (1) JP2507830B2 (en)
KR (1) KR0161499B1 (en)
CN (1) CN1043528C (en)
AT (1) AT132860T (en)
AU (1) AU633375B2 (en)
BG (1) BG60478B1 (en)
CA (2) CA2347588C (en)
CZ (2) CZ283539B6 (en)
DE (1) DE69024757T2 (en)
DK (1) DK0428376T3 (en)
EG (1) EG19641A (en)
ES (1) ES2083438T3 (en)
FI (1) FI104487B (en)
GR (1) GR3019192T3 (en)
HU (1) HU209299B (en)
IE (2) IE74154B1 (en)
IL (3) IL109246A (en)
NO (1) NO177902C (en)
NZ (1) NZ235993A (en)
OA (1) OA9327A (en)
PL (1) PL167898B1 (en)
PT (1) PT95870B (en)
RO (1) RO110491B1 (en)
RU (1) RU2033994C1 (en)
YU (1) YU48232B (en)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
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UA27690C2 (en) * 1989-05-31 2000-10-16 Флоріда Стейт Юніверсіті Beta-lactam or enethiomer thereof for taxols synthesis and process for the preparation of taxol
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5475120A (en) * 1990-11-02 1995-12-12 University Of Florida Method for the isolation and purification of taxol and its natural analogues
US5380916A (en) * 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
CA2071160A1 (en) * 1991-07-31 1993-02-01 Vittorio Farina Asymmetric synthesis of taxol side chain
CA2418125C (en) * 1991-09-23 2007-12-04 Florida State University Beta-lactams useful in the preparation of substituted isoserine esters
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
SG46582A1 (en) * 1991-09-23 1998-02-20 Univ Florida State 10-Desacetoxytaxol derivatives
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US6005138A (en) 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5274124A (en) * 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6335362B1 (en) * 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US6710191B2 (en) * 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US6339164B1 (en) 1993-01-29 2002-01-15 Florida State University C2 substituted phenyl taxane derivatives and pharmaceutical compositions containing them
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US7074945B2 (en) * 1991-09-23 2006-07-11 Florida State University Metal alkoxide taxane derivatives
US6521660B2 (en) 1991-09-23 2003-02-18 Florida State University 3′-alkyl substituted taxanes and pharmaceutical compositions containing them
US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
ES2149800T3 (en) * 1992-01-15 2000-11-16 Squibb & Sons Inc Enzymatic procedures for the resolution of enantiomeric mixtures of compounds useful as intermediaries in the preparation of taxanes.
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5254703A (en) * 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
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US6187916B1 (en) * 1993-02-01 2001-02-13 Research Foundation Of State University Of New York Process for the preparation of taxane derivatives and β-lactam intermediates therefor
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US5442065A (en) * 1993-09-09 1995-08-15 Board Of Regents, The University Of Texas System Synthesis of tetrahydroquinoline enediyne core analogs of dynemicin
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US4631340A (en) * 1984-09-06 1986-12-23 Pennwalt Corporation 1,4-oxazinone derivatives
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US4552585A (en) * 1984-10-04 1985-11-12 Fmc Corporation Herbicidal 2-(aminophenyl)methyl derivatives of 3-isoxazolidinones or 3-oxazinones
FR2601675B1 (en) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Taxol derivatives, their preparation and the pharmaceutical compositions containing them
FR2601676B1 (en) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Process for the preparation of taxol and desacetyl-10 taxol
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US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
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Also Published As

Publication number Publication date
CZ563490A3 (en) 1998-01-14
EG19641A (en) 1995-08-30
IL96304A (en) 1995-06-29
PT95870A (en) 1991-09-30
CA2029787C (en) 2001-10-09
FI905609A0 (en) 1990-11-13
HU907131D0 (en) 1991-05-28
OA09327A (en) 1992-09-15
PL167898B1 (en) 1995-12-30
OA9327A (en) 1992-09-15
US5136060A (en) 1992-08-04
CZ283539B6 (en) 1998-04-15
EP0428376A1 (en) 1991-05-22
CA2029787A1 (en) 1991-05-15
HUT57200A (en) 1991-11-28
BG60478B1 (en) 1995-05-31
FI104487B1 (en)
CZ313695A3 (en) 1997-11-12
YU216090A (en) 1993-10-20
GR3019192T3 (en) 1996-06-30
CN1043528C (en) 1999-06-02
IE76279B1 (en) 1997-10-08
CA2347588A1 (en) 1991-05-15
CN1053427A (en) 1991-07-31
IL109246A (en) 1998-01-04
RO110491B1 (en) 1996-01-30
US5384399A (en) 1995-01-24
DE69024757D1 (en) 1996-02-22
PT95870B (en) 1997-04-30
NO177902C (en) 1995-12-13
IE904061A1 (en) 1991-05-22
KR910009681A (en) 1991-06-28
EP0428376B1 (en) 1996-01-10
DK0428376T3 (en) 1996-02-05
NZ235993A (en) 1992-10-28
YU48232B (en) 1997-08-22
FI104487B (en) 2000-02-15
NO177902B (en) 1995-09-04
IE74154B1 (en) 1997-07-02
PL287757A1 (en) 1991-12-16
AU6590490A (en) 1991-05-23
KR0161499B1 (en) 1998-12-01
HU209299B (en) 1994-04-28
CZ283581B6 (en) 1998-05-13
NO904923D0 (en) 1990-11-13
DE69024757T2 (en) 1996-05-15
US5532363A (en) 1996-07-02
JPH03232869A (en) 1991-10-16
ES2083438T3 (en) 1996-04-16
IL109246D0 (en) 1994-07-31
FI905609D0 (en)
JP2507830B2 (en) 1996-06-19
RU2033994C1 (en) 1995-04-30
AU633375B2 (en) 1993-01-28
NO904923L (en) 1991-05-15
AT132860T (en) 1996-01-15
CA2347588C (en) 2005-08-16

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