IL95584D0 - Indole-,benzofuran-,and benzothiophene-containing lipoxygenase-inhibiting compounds - Google Patents
Indole-,benzofuran-,and benzothiophene-containing lipoxygenase-inhibiting compoundsInfo
- Publication number
- IL95584D0 IL95584D0 IL95584A IL9558490A IL95584D0 IL 95584 D0 IL95584 D0 IL 95584D0 IL 95584 A IL95584 A IL 95584A IL 9558490 A IL9558490 A IL 9558490A IL 95584 D0 IL95584 D0 IL 95584D0
- Authority
- IL
- Israel
- Prior art keywords
- lipoxygenase
- benzothiophene
- benzofuran
- indole
- inhibiting compounds
- Prior art date
Links
- FCEHBMOGCRZNNI-UHFFFAOYSA-N Benzothiophene Chemical compound 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9zdmc+Cg== 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4KPC9zdmc+Cg== C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 1
- 102000003820 Lipoxygenases Human genes 0.000 title 1
- 108090000128 Lipoxygenases Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N indole Chemical compound 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C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 230000002401 inhibitory effects Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40430089A true | 1989-09-07 | 1989-09-07 | |
| US57245190A true | 1990-08-28 | 1990-08-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL95584D0 true IL95584D0 (en) | 1991-06-30 |
| IL95584A IL95584A (en) | 1995-03-15 |
Family
ID=27018591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9558490A IL95584A (en) | 1989-09-07 | 1990-09-04 | Indole-, benzofuran-, and benzothiophene-containing lipoxygenase- inhibiting compounds, and pharmaceutical compositions containing them. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0416609B1 (en) |
| JP (1) | JP2923014B2 (en) |
| KR (1) | KR0173116B1 (en) |
| AT (1) | AT147383T (en) |
| AU (1) | AU631244B2 (en) |
| CA (1) | CA2024672C (en) |
| DE (1) | DE69029626T2 (en) |
| DK (1) | DK0416609T3 (en) |
| ES (1) | ES2099079T3 (en) |
| GR (1) | GR3022833T3 (en) |
| IE (1) | IE903206A1 (en) |
| IL (1) | IL95584A (en) |
| PH (1) | PH30133A (en) |
| PT (1) | PT95231B (en) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5461072A (en) * | 1990-08-02 | 1995-10-24 | Burroughs Wellcome Co. | Use of aryl hydroxyurea compounds for the treatment of atherosclerosis |
| US5095031A (en) * | 1990-08-20 | 1992-03-10 | Abbott Laboratories | Indole derivatives which inhibit leukotriene biosynthesis |
| US5530141A (en) * | 1992-03-04 | 1996-06-25 | Center For Innovative Technology | 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
| US5639782A (en) * | 1992-03-04 | 1997-06-17 | Center For Innovative Technology | Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors |
| FR2674522B1 (en) * | 1991-03-26 | 1993-07-16 | Lipha | Novel indole derivatives, preparation methods and medicaments containing them. |
| DE4125270A1 (en) * | 1991-07-31 | 1993-02-04 | Bayer Ag | QUINOLINE-2-YL-METHOXYBENZYLHYDROXYHARNSTOFFE |
| DE4128871A1 (en) * | 1991-08-30 | 1993-03-04 | Boehringer Mannheim Gmbh | BENZO (B) THIOPHENE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS |
| EP0770617A1 (en) * | 1992-06-18 | 1997-05-02 | Boulder Scientific Company | Process for producing amine-boranes |
| US5463083A (en) * | 1992-07-13 | 1995-10-31 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| US5358938A (en) * | 1992-07-13 | 1994-10-25 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
| DE69329550T2 (en) | 1992-07-13 | 2001-05-31 | Cytomed Inc | 2,5-DIARYL TETRAHYDRO-THIOPENE, -FURANE AND ANALOGUE FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISEASES |
| JP2661841B2 (en) * | 1992-07-23 | 1997-10-08 | ファイザー製薬株式会社 | Indoline derivatives |
| US5541218A (en) * | 1992-07-23 | 1996-07-30 | Pfizer Inc. | Indolinyl N-hydroxyurea and N-hydroxamic acid derivatives as lipoxygenase inhibitors |
| US5434151A (en) * | 1992-08-24 | 1995-07-18 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
| US5439923A (en) * | 1993-12-21 | 1995-08-08 | Eli Lilly And Company | Method of inhibiting seborrhea and acne |
| US5792776A (en) * | 1994-06-27 | 1998-08-11 | Cytomed, Inc., | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| US5514703A (en) * | 1995-03-13 | 1996-05-07 | Eli Lilly And Company | Benzothiophene compounds useful for inhibiting lipoxygenase |
| US5514704A (en) * | 1995-03-13 | 1996-05-07 | Eli Lilly And Company | Benzothiophenes to inhibit leukotrienes |
| US5532382A (en) * | 1995-03-13 | 1996-07-02 | Eli Lilly And Company | Benzothiophenes substituted at the 3-carbonyl |
| US5516789A (en) * | 1995-04-12 | 1996-05-14 | Abbott Laboratories | Lipoxygenase and cyclooxygenase inhibiting compounds |
| US5750565A (en) * | 1995-05-25 | 1998-05-12 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| US5703093A (en) * | 1995-05-31 | 1997-12-30 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| EP1397130B1 (en) | 2001-06-20 | 2007-07-25 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| DK1569899T3 (en) | 2002-12-10 | 2006-10-23 | Wyeth Corp | Substituted 3-alkyl and 3-arylalkyl-1H-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| EP1569639A2 (en) | 2002-12-10 | 2005-09-07 | Wyeth | Substituted dihydropyrano indole-3,4-dione derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| BR0316584A (en) | 2002-12-10 | 2005-10-04 | Wyeth Corp | Substituted oxo-acetyl amino indole acetic acid derivatives as plasminogen activator inhibitor-1 inhibitors (parent-1) |
| MXPA05006283A (en) | 2002-12-10 | 2005-08-19 | Wyeth Corp | Aryl, aryloxy, and alkyloxy substituted 1h. |
| ES2266907T3 (en) | 2002-12-10 | 2007-03-01 | Wyeth | Substituted derivatives of the 3-carbonil-indol-1-il-acetic acid as inhibitor of the plasminogen-1 activator (pal-1). |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7534894B2 (en) | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| TW200616967A (en) | 2004-06-24 | 2006-06-01 | Smithkline Beecham Corp | Novel indazole carboxamides and their use |
| BRPI0514572A (en) | 2004-08-23 | 2008-06-17 | Wyeth Corp | thiazole naphthyl acids |
| BRPI0514544A (en) | 2004-08-23 | 2008-06-17 | Wyeth Corp | oxazol-naphthyl acids as modulators of plasminogen activator inhibitor type-1 (pai-1) |
| CN101044136A (en) | 2004-08-23 | 2007-09-26 | 惠氏公司 | Pyrrolo-naphthyl acids as pai-1 inhibitors |
| TW200626142A (en) | 2004-09-21 | 2006-08-01 | Glaxo Group Ltd | Chemical compounds |
| MX2007008952A (en) | 2005-01-27 | 2007-09-18 | Wyeth Corp | Processes and compounds for the preparation of substituted naphthylindole derivatives. |
| CA2617372A1 (en) | 2005-08-17 | 2007-02-22 | Wyeth | Substituted indoles and use thereof |
| PE20081889A1 (en) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indole carboxamides as ikk2 inhibitors |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| WO2010102968A1 (en) | 2009-03-10 | 2010-09-16 | Glaxo Group Limited | Indole derivatives as ikk2 inhibitors |
| CA2926950A1 (en) | 2013-10-10 | 2015-04-16 | Eastern Virginia Medical School | 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as 12-lipoxygenase inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2059408T3 (en) * | 1987-02-10 | 1994-11-16 | Abbott Lab | A PROCESS FOR THE PREPARATION OF A COMPOUND. |
| US4873259A (en) * | 1987-06-10 | 1989-10-10 | Abbott Laboratories | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds |
| US4822811A (en) * | 1987-11-13 | 1989-04-18 | Abbott Laboratories | Carbazole lipoxygenase inhibiting compounds, compositions and use |
| CA1334975C (en) * | 1987-11-13 | 1995-03-28 | James H. Holms | Furan and pyrrole containing lipoxygenase inhibiting compounds |
-
1990
- 1990-09-04 PH PH41128A patent/PH30133A/en unknown
- 1990-09-04 IL IL9558490A patent/IL95584A/en unknown
- 1990-09-04 IE IE320690A patent/IE903206A1/en not_active IP Right Cessation
- 1990-09-05 CA CA002024672A patent/CA2024672C/en not_active Expired - Lifetime
- 1990-09-05 AU AU62201/90A patent/AU631244B2/en not_active Expired
- 1990-09-06 JP JP2238819A patent/JP2923014B2/en not_active Expired - Lifetime
- 1990-09-06 EP EP90117171A patent/EP0416609B1/en not_active Expired - Lifetime
- 1990-09-06 ES ES90117171T patent/ES2099079T3/en not_active Expired - Lifetime
- 1990-09-06 DK DK90117171.0T patent/DK0416609T3/en active
- 1990-09-06 AT AT90117171T patent/AT147383T/en not_active IP Right Cessation
- 1990-09-06 DE DE69029626T patent/DE69029626T2/en not_active Expired - Lifetime
- 1990-09-06 PT PT95231A patent/PT95231B/en not_active IP Right Cessation
- 1990-09-07 KR KR1019900014102A patent/KR0173116B1/en not_active IP Right Cessation
-
1997
- 1997-03-17 GR GR970400508T patent/GR3022833T3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69029626D1 (en) | 1997-02-20 |
| IE903206A1 (en) | 1991-03-13 |
| EP0416609B1 (en) | 1997-01-08 |
| DE69029626T2 (en) | 1997-07-17 |
| PT95231A (en) | 1991-05-22 |
| IL95584A (en) | 1995-03-15 |
| ES2099079T3 (en) | 1997-05-16 |
| AU631244B2 (en) | 1992-11-19 |
| PH30133A (en) | 1997-01-21 |
| KR910006271A (en) | 1991-04-29 |
| KR0173116B1 (en) | 1999-02-01 |
| GR3022833T3 (en) | 1997-06-30 |
| EP0416609A2 (en) | 1991-03-13 |
| EP0416609A3 (en) | 1992-01-02 |
| DK0416609T3 (en) | 1997-06-30 |
| AT147383T (en) | 1997-01-15 |
| CA2024672C (en) | 2002-02-26 |
| JP2923014B2 (en) | 1999-07-26 |
| PT95231B (en) | 1997-06-30 |
| JPH03148272A (en) | 1991-06-25 |
| AU6220190A (en) | 1991-03-14 |
| CA2024672A1 (en) | 1991-03-08 |
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