IL95584D0 - Indole-,benzofuran-,and benzothiophene-containing lipoxygenase-inhibiting compounds - Google Patents

Indole-,benzofuran-,and benzothiophene-containing lipoxygenase-inhibiting compounds

Info

Publication number
IL95584D0
IL95584D0 IL95584A IL9558490A IL95584D0 IL 95584 D0 IL95584 D0 IL 95584D0 IL 95584 A IL95584 A IL 95584A IL 9558490 A IL9558490 A IL 9558490A IL 95584 D0 IL95584 D0 IL 95584D0
Authority
IL
Israel
Prior art keywords
lipoxygenase
benzothiophene
benzofuran
indole
inhibiting compounds
Prior art date
Application number
IL95584A
Other versions
IL95584A (en
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US40430089A priority Critical
Priority to US57245190A priority
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of IL95584D0 publication Critical patent/IL95584D0/en
Publication of IL95584A publication Critical patent/IL95584A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58Radicals substituted by nitrogen atoms
IL9558490A 1989-09-07 1990-09-04 Indole-, benzofuran-, and benzothiophene-containing lipoxygenase- inhibiting compounds, and pharmaceutical compositions containing them. IL95584A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US40430089A true 1989-09-07 1989-09-07
US57245190A true 1990-08-28 1990-08-28

Publications (2)

Publication Number Publication Date
IL95584D0 true IL95584D0 (en) 1991-06-30
IL95584A IL95584A (en) 1995-03-15

Family

ID=27018591

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9558490A IL95584A (en) 1989-09-07 1990-09-04 Indole-, benzofuran-, and benzothiophene-containing lipoxygenase- inhibiting compounds, and pharmaceutical compositions containing them.

Country Status (14)

Country Link
EP (1) EP0416609B1 (en)
JP (1) JP2923014B2 (en)
KR (1) KR0173116B1 (en)
AT (1) AT147383T (en)
AU (1) AU631244B2 (en)
CA (1) CA2024672C (en)
DE (1) DE69029626T2 (en)
DK (1) DK0416609T3 (en)
ES (1) ES2099079T3 (en)
GR (1) GR3022833T3 (en)
IE (1) IE903206A1 (en)
IL (1) IL95584A (en)
PH (1) PH30133A (en)
PT (1) PT95231B (en)

Families Citing this family (53)

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Publication number Priority date Publication date Assignee Title
US5461072A (en) * 1990-08-02 1995-10-24 Burroughs Wellcome Co. Use of aryl hydroxyurea compounds for the treatment of atherosclerosis
US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
US5530141A (en) * 1992-03-04 1996-06-25 Center For Innovative Technology 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5639782A (en) * 1992-03-04 1997-06-17 Center For Innovative Technology Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
FR2674522B1 (en) * 1991-03-26 1993-07-16 Lipha Novel indole derivatives, preparation methods and medicaments containing them.
DE4125270A1 (en) * 1991-07-31 1993-02-04 Bayer Ag QUINOLINE-2-YL-METHOXYBENZYLHYDROXYHARNSTOFFE
DE4128871A1 (en) * 1991-08-30 1993-03-04 Boehringer Mannheim Gmbh BENZO (B) THIOPHENE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS
EP0770617A1 (en) * 1992-06-18 1997-05-02 Boulder Scientific Company Process for producing amine-boranes
US5463083A (en) * 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5358938A (en) * 1992-07-13 1994-10-25 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
DE69329550T2 (en) 1992-07-13 2001-05-31 Cytomed Inc 2,5-DIARYL TETRAHYDRO-THIOPENE, -FURANE AND ANALOGUE FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISEASES
JP2661841B2 (en) * 1992-07-23 1997-10-08 ファイザー製薬株式会社 Indoline derivatives
US5541218A (en) * 1992-07-23 1996-07-30 Pfizer Inc. Indolinyl N-hydroxyurea and N-hydroxamic acid derivatives as lipoxygenase inhibitors
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5439923A (en) * 1993-12-21 1995-08-08 Eli Lilly And Company Method of inhibiting seborrhea and acne
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5514703A (en) * 1995-03-13 1996-05-07 Eli Lilly And Company Benzothiophene compounds useful for inhibiting lipoxygenase
US5514704A (en) * 1995-03-13 1996-05-07 Eli Lilly And Company Benzothiophenes to inhibit leukotrienes
US5532382A (en) * 1995-03-13 1996-07-02 Eli Lilly And Company Benzothiophenes substituted at the 3-carbonyl
US5516789A (en) * 1995-04-12 1996-05-14 Abbott Laboratories Lipoxygenase and cyclooxygenase inhibiting compounds
US5750565A (en) * 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
TWI224101B (en) 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
EP1397130B1 (en) 2001-06-20 2007-07-25 Wyeth Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
DK1569899T3 (en) 2002-12-10 2006-10-23 Wyeth Corp Substituted 3-alkyl and 3-arylalkyl-1H-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
EP1569639A2 (en) 2002-12-10 2005-09-07 Wyeth Substituted dihydropyrano indole-3,4-dione derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
BR0316584A (en) 2002-12-10 2005-10-04 Wyeth Corp Substituted oxo-acetyl amino indole acetic acid derivatives as plasminogen activator inhibitor-1 inhibitors (parent-1)
MXPA05006283A (en) 2002-12-10 2005-08-19 Wyeth Corp Aryl, aryloxy, and alkyloxy substituted 1h.
ES2266907T3 (en) 2002-12-10 2007-03-01 Wyeth Substituted derivatives of the 3-carbonil-indol-1-il-acetic acid as inhibitor of the plasminogen-1 activator (pal-1).
US7411083B2 (en) 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
US7141592B2 (en) 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7265148B2 (en) 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7342039B2 (en) 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
US7446201B2 (en) 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7163954B2 (en) 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7332521B2 (en) 2003-09-25 2008-02-19 Wyeth Substituted indoles
US7582773B2 (en) 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7268159B2 (en) 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7534894B2 (en) 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
TW200616967A (en) 2004-06-24 2006-06-01 Smithkline Beecham Corp Novel indazole carboxamides and their use
BRPI0514572A (en) 2004-08-23 2008-06-17 Wyeth Corp thiazole naphthyl acids
BRPI0514544A (en) 2004-08-23 2008-06-17 Wyeth Corp oxazol-naphthyl acids as modulators of plasminogen activator inhibitor type-1 (pai-1)
CN101044136A (en) 2004-08-23 2007-09-26 惠氏公司 Pyrrolo-naphthyl acids as pai-1 inhibitors
TW200626142A (en) 2004-09-21 2006-08-01 Glaxo Group Ltd Chemical compounds
MX2007008952A (en) 2005-01-27 2007-09-18 Wyeth Corp Processes and compounds for the preparation of substituted naphthylindole derivatives.
CA2617372A1 (en) 2005-08-17 2007-02-22 Wyeth Substituted indoles and use thereof
PE20081889A1 (en) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indole carboxamides as ikk2 inhibitors
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
WO2010102968A1 (en) 2009-03-10 2010-09-16 Glaxo Group Limited Indole derivatives as ikk2 inhibitors
CA2926950A1 (en) 2013-10-10 2015-04-16 Eastern Virginia Medical School 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as 12-lipoxygenase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2059408T3 (en) * 1987-02-10 1994-11-16 Abbott Lab A PROCESS FOR THE PREPARATION OF A COMPOUND.
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US4822811A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Carbazole lipoxygenase inhibiting compounds, compositions and use
CA1334975C (en) * 1987-11-13 1995-03-28 James H. Holms Furan and pyrrole containing lipoxygenase inhibiting compounds

Also Published As

Publication number Publication date
DE69029626D1 (en) 1997-02-20
IE903206A1 (en) 1991-03-13
EP0416609B1 (en) 1997-01-08
DE69029626T2 (en) 1997-07-17
PT95231A (en) 1991-05-22
IL95584A (en) 1995-03-15
ES2099079T3 (en) 1997-05-16
AU631244B2 (en) 1992-11-19
PH30133A (en) 1997-01-21
KR910006271A (en) 1991-04-29
KR0173116B1 (en) 1999-02-01
GR3022833T3 (en) 1997-06-30
EP0416609A2 (en) 1991-03-13
EP0416609A3 (en) 1992-01-02
DK0416609T3 (en) 1997-06-30
AT147383T (en) 1997-01-15
CA2024672C (en) 2002-02-26
JP2923014B2 (en) 1999-07-26
PT95231B (en) 1997-06-30
JPH03148272A (en) 1991-06-25
AU6220190A (en) 1991-03-14
CA2024672A1 (en) 1991-03-08

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