IL47174A - Pgf2alpha-9,11-cyclic boronates and process for their preparation - Google Patents
Pgf2alpha-9,11-cyclic boronates and process for their preparationInfo
- Publication number
- IL47174A IL47174A IL47174A IL4717472A IL47174A IL 47174 A IL47174 A IL 47174A IL 47174 A IL47174 A IL 47174A IL 4717472 A IL4717472 A IL 4717472A IL 47174 A IL47174 A IL 47174A
- Authority
- IL
- Israel
- Prior art keywords
- phenyl
- alkyl
- formula
- cis
- trans
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 8
- 125000000217 alkyl group Chemical group 0.000 claims abstract 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 9
- 150000001875 compounds Chemical class 0.000 claims abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 6
- -1 CF 3 Inorganic materials 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 3
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical compound OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 claims 2
- QPKFVRWIISEVCW-UHFFFAOYSA-N 1-butane boronic acid Chemical compound CCCCB(O)O QPKFVRWIISEVCW-UHFFFAOYSA-N 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 239000012429 reaction media Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 3
- 150000003180 prostaglandins Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000005621 boronate group Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21447271A | 1971-12-30 | 1971-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL47174A true IL47174A (en) | 1976-03-31 |
Family
ID=22799199
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL40970A IL40970A (en) | 1971-12-30 | 1972-11-30 | Prostaglandin f2alpha 15-esters |
| IL47174A IL47174A (en) | 1971-12-30 | 1972-11-30 | Pgf2alpha-9,11-cyclic boronates and process for their preparation |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL40970A IL40970A (en) | 1971-12-30 | 1972-11-30 | Prostaglandin f2alpha 15-esters |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS4875548A (fr) |
| BE (1) | BE793534A (fr) |
| CA (1) | CA978940A (fr) |
| CH (1) | CH583191A5 (fr) |
| DE (1) | DE2262608A1 (fr) |
| DK (1) | DK135212B (fr) |
| ES (1) | ES410104A1 (fr) |
| FR (1) | FR2166194B1 (fr) |
| GB (2) | GB1389070A (fr) |
| HU (1) | HU166953B (fr) |
| IL (2) | IL40970A (fr) |
| NL (1) | NL7217579A (fr) |
| SE (1) | SE411899B (fr) |
| ZA (1) | ZA728737B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4001306A (en) * | 1971-12-30 | 1977-01-04 | The Upjohn Company | Prostaglandin F.sub.α 15-monoacrylates |
| CA2014038A1 (fr) * | 1989-05-25 | 1990-11-25 | Charles Gluchowski | 15-acyl prostaglandines reduisant la pression intraoculaire |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2166721A1 (de) * | 1970-09-11 | 1975-05-15 | Upjohn Co | Prostansaeurederivate und deren herstellung |
-
0
- BE BE793534D patent/BE793534A/fr unknown
-
1972
- 1972-11-24 CA CA157,431A patent/CA978940A/en not_active Expired
- 1972-11-28 GB GB3201074A patent/GB1389070A/en not_active Expired
- 1972-11-28 GB GB5494872A patent/GB1389069A/en not_active Expired
- 1972-11-30 IL IL40970A patent/IL40970A/en unknown
- 1972-11-30 IL IL47174A patent/IL47174A/en unknown
- 1972-12-11 ZA ZA728737A patent/ZA728737B/xx unknown
- 1972-12-11 JP JP47123522A patent/JPS4875548A/ja active Pending
- 1972-12-13 CH CH1813872A patent/CH583191A5/xx not_active IP Right Cessation
- 1972-12-21 DE DE2262608A patent/DE2262608A1/de active Pending
- 1972-12-22 NL NL7217579A patent/NL7217579A/xx not_active Application Discontinuation
- 1972-12-27 HU HUUO84A patent/HU166953B/hu unknown
- 1972-12-27 SE SE7216988A patent/SE411899B/xx unknown
- 1972-12-28 ES ES410104A patent/ES410104A1/es not_active Expired
- 1972-12-29 FR FR7246986A patent/FR2166194B1/fr not_active Expired
- 1972-12-29 DK DK655272AA patent/DK135212B/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES410104A1 (es) | 1975-12-16 |
| FR2166194B1 (fr) | 1977-01-28 |
| IL40970A0 (en) | 1973-01-30 |
| CH583191A5 (fr) | 1976-12-31 |
| NL7217579A (fr) | 1973-07-03 |
| CA978940A (en) | 1975-12-02 |
| DK135212C (fr) | 1977-09-05 |
| HU166953B (fr) | 1975-06-28 |
| DK135212B (da) | 1977-03-21 |
| GB1389069A (en) | 1975-04-03 |
| FR2166194A1 (fr) | 1973-08-10 |
| DE2262608A1 (de) | 1973-07-12 |
| BE793534A (fr) | 1973-06-29 |
| GB1389070A (en) | 1975-04-03 |
| ZA728737B (en) | 1973-09-26 |
| JPS4875548A (fr) | 1973-10-11 |
| SE411899B (sv) | 1980-02-11 |
| IL40970A (en) | 1976-03-31 |
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