IL32836D0 - Benzothiazine l,l-dioxides and their preparation - Google Patents

Benzothiazine l,l-dioxides and their preparation

Info

Publication number
IL32836D0
IL32836D0 IL3283669A IL3283669A IL32836D0 IL 32836 D0 IL32836 D0 IL 32836D0 IL 3283669 A IL3283669 A IL 3283669A IL 3283669 A IL3283669 A IL 3283669A IL 32836 D0 IL32836 D0 IL 32836D0
Authority
IL
Israel
Prior art keywords
benzothiazine
dioxides
Prior art date
Application number
IL3283669A
Other versions
IL32836A (en
Original Assignee
Pfizer & Co C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US76759468A priority Critical
Application filed by Pfizer & Co C filed Critical Pfizer & Co C
Publication of IL32836D0 publication Critical patent/IL32836D0/en
Publication of IL32836A publication Critical patent/IL32836A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/021,2-Thiazines; Hydrogenated 1,2-thiazines
IL3283669A 1968-08-27 1969-08-15 Benzothiazine 1,1-dioxides and their preparation IL32836A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US76759468A true 1968-08-27 1968-08-27

Publications (2)

Publication Number Publication Date
IL32836D0 true IL32836D0 (en) 1969-11-12
IL32836A IL32836A (en) 1972-08-30

Family

ID=25079964

Family Applications (1)

Application Number Title Priority Date Filing Date
IL3283669A IL32836A (en) 1968-08-27 1969-08-15 Benzothiazine 1,1-dioxides and their preparation

Country Status (18)

Country Link
US (1) US3591584A (en)
JP (2) JPS50677B1 (en)
AT (2) AT298503B (en)
BE (1) BE737962A (en)
BR (1) BR6911817D0 (en)
CH (1) CH520705A (en)
DE (2) DE1943265C3 (en)
DK (1) DK145297C (en)
ES (1) ES370861A1 (en)
FI (1) FI51189C (en)
FR (1) FR2016455B1 (en)
GB (1) GB1257180A (en)
IL (1) IL32836A (en)
MY (1) MY7300310A (en)
NL (1) NL157013B (en)
NO (1) NO129746B (en)
PH (1) PH10029A (en)
SE (2) SE373854B (en)

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US3862319A (en) * 1971-02-09 1975-01-21 Pfizer Benzothiazine dioxides as anti-thromobotic agents
US3787324A (en) * 1971-03-01 1974-01-22 Warner Lambert Co 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
DK153148C (en) * 1971-03-01 1988-10-31 Warner Lambert Co Method of analogue for the preparation of 4-hydroxy-3- (3-isoxazolcarbamyl) -2h-1,2-benzothiazine-1,1-d ioxides or alkalimetal, earthalkalimetal or aminal salts
US3769292A (en) * 1972-04-28 1973-10-30 Warner Lambert Co N-(pyridyl)2h 1-benzothiopyran-3-carboxamide-4-hydroxy 1,1-dioxides
US3927002A (en) * 1973-04-23 1975-12-16 Pfizer N-(pyridyl)-N{40 -alkyl-N{40 -(2-alkoxycarbonylbenzenesulfonyl)-glycineamides and derivatives
US3853862A (en) * 1973-04-23 1974-12-10 Pfizer Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides
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US3891637A (en) * 1974-10-01 1975-06-24 Pfizer Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides
DE2539112C2 (en) * 1975-09-03 1983-12-15 Dr. Karl Thomae Gmbh, 7950 Biberach, De
SE421792B (en) * 1976-01-12 1982-02-01 Pfizer PROCEDURE FOR PREPARING N- (2-PYRIDYL) -4-HYDROXY-2-METHYL-2H-1,2-BENZO-THIAZINE-3-CARBOXAMIDE-1,1-DIOXIDE
MC1135A1 (en) * 1976-02-23 1977-11-18 Hoffmann La Roche Thiazine derivatives
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JPS5342370U (en) * 1976-09-16 1978-04-12
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DE2756113A1 (en) * 1977-12-16 1979-06-21 Thomae Gmbh Dr K NEW 4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE-1,1-DIOXIDES, THE PROCESS FOR THEIR MANUFACTURING AND THE MEDICINAL PRODUCTS CONTAINING THESE
US4213980A (en) * 1978-01-30 1980-07-22 Ciba-Geigy Corporation Azathianaphthalenes
GB2078738B (en) * 1980-06-27 1983-11-30 Mitsui Toatsu Chemicals Benzothiazine derivatives
JPS6318591B2 (en) * 1980-06-27 1988-04-19 Mitsui Toatsu Chemicals
US4289879A (en) * 1980-09-29 1981-09-15 Pfizer Inc. Synthetic method and intermediate for piroxicam
US4309427A (en) * 1981-01-15 1982-01-05 Pfizer Inc. Benzothiazine dioxide derivatives
JPS57140785A (en) * 1981-02-24 1982-08-31 Mitsui Toatsu Chem Inc Benzothiazine derivative, its preparation, and pharmaceutical composition containing the same
US4474955A (en) * 1981-06-17 1984-10-02 Vincenzo Iannella Process for preparing 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-[N-(2-pyridinyl)carboxamide]-1,1-dioxide, and its phosphoric ester
GT198276334A (en) * 1981-08-03 1984-01-10 Procedure and intermediates for the production of benzothiazine carboxamides.
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CA1197244A (en) * 1982-04-16 1985-11-26 Medichem, S.A. Process for the preparation of 4-hydroxy-2-methyl-2h- 1,2-benzothiazine-3-carboxamide-1,1-dioxides
SU1306476A3 (en) * 1982-06-17 1987-04-23 Пфайзер,Инк (Фирма) Method for producing 2-methyl-3-n-(2-pyridyl)-carbamoyl-3,4-dihydro-2h-1,2-benzthiazine-1,1-dioxide
DE3374865D1 (en) * 1982-07-07 1988-01-21 Siegfried Ag Process for preparing 4-hydroxy-2-methyl-n-2-pyridyl-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide
JPH0338250B2 (en) * 1982-07-13 1991-06-10 Fuaizaa Seiyaku Kk
US4483982A (en) * 1982-09-02 1984-11-20 Pfizer Inc. Processes for preparing piroxicam and intermediates leading thereto
DE3237473A1 (en) * 1982-10-09 1984-04-12 Thomae Gmbh Dr K NEW 4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE-1,1-DIOXIDE, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
IT1153293B (en) * 1982-10-22 1987-01-14 Francia Famaceutici S R L Derivatives of 4-hydroxy-2-methyl-2h-1, 2-benzothiazine-3-carboxamide 1, 1-dioxide and process for their preparation
JPS59193879A (en) * 1983-03-31 1984-11-02 Fujisawa Pharmaceut Co Ltd Tropone derivative
JPS59179683U (en) * 1983-05-19 1984-11-30
GR80576B (en) * 1983-10-17 1984-11-29 Fujisawa Pharmaceutical Co Thiazine derivatives, process for preparation thereof and pharmaceutical composition comprising the same
US4551452A (en) * 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
US4656265A (en) * 1984-06-21 1987-04-07 Pfizer Inc. Cyclic prodrugs of antiinflammatory oxicams
DE3437232A1 (en) * 1984-10-10 1986-04-17 Mack Chem Pharm STABILIZED INJECTION SOLUTIONS FROM PIROXICAM
US4582831A (en) * 1984-11-16 1986-04-15 Pfizer Inc. Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide compound, composition, and method of use therefor
CH663899A5 (en) * 1985-03-20 1988-01-29 Nestle Sa Process for the preparation of a composition based on a finely divided low hydrosolubility active ingredient.
US4623486A (en) * 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
US4610982A (en) * 1985-06-03 1986-09-09 Pfizer Inc. Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
US4761424A (en) * 1985-10-01 1988-08-02 Warner-Lambert Company Enolamides, pharmaceutical compositions and methods for treating inflammation
HU199833B (en) * 1986-05-16 1990-03-28 Pfizer Process for producing benzothiazine dioxide derivatives
AT66477T (en) * 1986-08-29 1991-09-15 Pfizer 2-GUANIDINO-4-ARYL-THIAZOLE FOR THE TREATMENT OF PEPTIC Ulcers.
US5196410A (en) * 1986-10-31 1993-03-23 Pfizer Inc. Transdermal flux enhancing compositions
MX174093B (en) * 1987-06-10 1994-04-21 Pfizer 1,1-3,4-DIHYDRO-2-ALKYL-3-OXO-N-ARYL-2H [1] BENZOTIENO [3,2-e] -1,2-THIAZINO-4-CARBOXIAMIDE
WO1989003682A1 (en) * 1987-10-26 1989-05-05 Pfizer Inc. Benzothiazine dioxide derivatives
JPH0629271B2 (en) * 1988-03-09 1994-04-20 株式会社日本ハイポックス Benzothiazine-1,1-dioxide derivative and pharmaceutical composition containing the same
HU200926B (en) * 1988-10-28 1990-09-28 Egyt Gyogyszervegyeszeti Gyar Pharmaceutical composition comprising piroxicam and lactose for use in making tablets or capsules
JPH0717589B2 (en) * 1990-01-22 1995-03-01 ファイザー製薬株式会社 Novel 1,3-dicarbonyl compound and composition thereof
JP2988739B2 (en) * 1990-04-16 1999-12-13 協和醗酵工業株式会社 1,8-naphthyridin-2-one derivatives
DE4141218A1 (en) * 1991-12-13 1993-06-17 Luitpold Werk Chem Pharm THIADIAZINCARBONE ACIDAMIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENTS
JP2964195B2 (en) * 1992-04-28 1999-10-18 エスエス製薬株式会社 Piroxicam tablets and method for producing the same
US5362758A (en) * 1992-09-18 1994-11-08 Pfizer Inc. Ophthalmic piroxicam solution
US5420124A (en) * 1994-01-12 1995-05-30 Kim; Young S. Stable, painless piroxicam potassium injectable composition
US5436241A (en) * 1994-01-14 1995-07-25 Bristol-Myers Squibb Company Topical anti-inflammatory compositions containing piroxicam
US5741798A (en) * 1996-06-03 1998-04-21 Boehringer Ingelheim Pharmaceuticals, Inc. 2-benzyl-4-sulfonyl-4H-isoquinolin-1,3-diones and their use as antiinflammatory agents
US5952328A (en) * 1997-11-12 1999-09-14 Cephalon, Inc. Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
US6297260B1 (en) 1998-10-30 2001-10-02 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
IT1308633B1 (en) 1999-03-02 2002-01-09 Nicox Sa Nitroxy derivatives.
IT1318674B1 (en) * 2000-08-08 2003-08-27 Nicox Sa Make us for incontinence.
IT1318673B1 (en) * 2000-08-08 2003-08-27 Nicox Sa Drugs for sexual dysfunction.
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
ITMI20020773A1 (en) * 2002-04-11 2003-10-13 Nicox Sa Medicines for the treatment of arthritis
BRPI0413349A (en) * 2003-08-06 2006-10-10 Pfizer Prod Inc oxazole compounds for the treatment of neurodegenerative diseases
US20060047171A1 (en) * 2003-12-22 2006-03-02 Harold Meckler Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof
US20050222227A1 (en) * 2004-04-01 2005-10-06 Pfizer Inc Oxazole-amine compounds for the treatment of neurodegenerative disorders
CA2657606A1 (en) 2006-03-08 2007-09-13 Cortria Corporation Combination therapy with non-selective cox inhibitors to prevent cox-related gastric injuries
FR2942797B1 (en) * 2009-03-03 2011-04-29 Pf Medicament Benzothiazine derivatives, their preparation and their application as medicaments
CN101665472B (en) * 2009-06-15 2011-08-24 威海迪素制药有限公司 Preparation method of 2-methyl-3. 4-dihydro-4-oxo-2H-1. 2-benzothiazine-3-carboxylic ethyl ester-1, 1-dioxide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1302858B (en) * 1962-09-21 1972-05-04

Also Published As

Publication number Publication date
GB1257180A (en) 1971-12-15
NO129746B (en) 1974-05-20
DE1943265A1 (en) 1970-08-13
MY7300310A (en) 1973-12-31
AT294113B (en) 1971-11-10
FR2016455A1 (en) 1970-05-08
SE402459B (en) 1978-07-03
ES370861A1 (en) 1971-07-01
FI51189B (en) 1976-08-02
FR2016455B1 (en) 1974-02-01
JPS5142114B1 (en) 1976-11-13
US3591584A (en) 1971-07-06
DK145297B (en) 1982-10-25
DE1967325C2 (en) 1982-03-18
FI51189C (en) 1976-11-10
JPS50677B1 (en) 1975-01-10
NL157013B (en) 1978-06-15
DE1943265B2 (en) 1981-05-14
NL6912981A (en) 1970-03-03
DK145297C (en) 1983-03-14
CH520705A (en) 1972-03-31
AT298503B (en) 1972-05-10
BR6911817D0 (en) 1973-02-13
IL32836A (en) 1972-08-30
BE737962A (en) 1970-02-26
PH10029A (en) 1976-07-13
DE1943265C3 (en) 1982-02-04
SE373854B (en) 1975-02-17
DE1967325B2 (en) 1981-08-13

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