IL286180A - Heteroaromatic and heterobicyclic aromatic derivatives for the treatment of ferroptosis-related disorders - Google Patents

Heteroaromatic and heterobicyclic aromatic derivatives for the treatment of ferroptosis-related disorders

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Publication number
IL286180A
IL286180A IL286180A IL28618021A IL286180A IL 286180 A IL286180 A IL 286180A IL 286180 A IL286180 A IL 286180A IL 28618021 A IL28618021 A IL 28618021A IL 286180 A IL286180 A IL 286180A
Authority
IL
Israel
Prior art keywords
ferroptosis
heteroaromatic
treatment
related disorders
aromatic derivatives
Prior art date
Application number
IL286180A
Other languages
Hebrew (he)
Inventor
John Warner
Carmen Baldino
Laura Muollo
John Lee
Srinivasa Cheruku
Rowan Walker
James Siedlecki
John Proudfoot
Shawn Johnstone
Mehdi Numa
Craig Rosenfeld
Original Assignee
Collaborative Medicinal Dev Llc
John Warner
Carmen Baldino
Laura Muollo
John Lee
Srinivasa Cheruku
Rowan Walker
James Siedlecki
John Proudfoot
Shawn Johnstone
Mehdi Numa
Craig Rosenfeld
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Collaborative Medicinal Dev Llc, John Warner, Carmen Baldino, Laura Muollo, John Lee, Srinivasa Cheruku, Rowan Walker, James Siedlecki, John Proudfoot, Shawn Johnstone, Mehdi Numa, Craig Rosenfeld filed Critical Collaborative Medicinal Dev Llc
Publication of IL286180A publication Critical patent/IL286180A/en

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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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IL286180A 2019-03-11 2021-09-05 Heteroaromatic and heterobicyclic aromatic derivatives for the treatment of ferroptosis-related disorders IL286180A (en)

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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022020150A1 (en) * 2020-07-21 2022-01-27 Collaborative Medicinal Development, Llc Methods of extending lifespan by administering ferroptosis inhibitors
EP4269392A4 (en) 2020-12-25 2025-01-29 Toray Industries, Inc. Tetrahydroquinoline derivative and medicinal use thereof
US20240116923A1 (en) * 2021-01-25 2024-04-11 Seabelife Use of indole, 6- and 7-azaindole derivatives as inhibitors of ferroptosis regulated cell death
WO2023280296A1 (en) * 2021-07-09 2023-01-12 Sironax Ltd. Ferroptosis modulators, preparations, and uses thereof
IL310387A (en) * 2021-08-09 2024-03-01 Sironax Ltd Ferroptosis modulators, preparations, and uses thereof
US11541116B1 (en) 2022-01-07 2023-01-03 Kojin Therapeutics, Inc. Methods and compositions for inducing ferroptosis in vivo
JPWO2023249107A1 (en) * 2022-06-24 2023-12-28
WO2023249105A1 (en) * 2022-06-24 2023-12-28 東レ株式会社 Therapeutic agent or preventive agent for drug-induced myocardial disorders
EP4545079A4 (en) * 2022-06-24 2026-06-03 Toray Industries THERAPEUTIC OR PROPHYLACTIC FOR AMYOTROPHIC LATERAL SCLEROSIS
JPWO2024204437A1 (en) 2023-03-29 2024-10-03

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB573958A (en) * 1943-03-01 1945-12-14 May & Baker Ltd Improvements in or relating to the production of new therapeutically valuable quinoline derivatives
US3657744A (en) 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5350395A (en) 1986-04-15 1994-09-27 Yock Paul G Angioplasty apparatus facilitating rapid exchanges
US5040548A (en) 1989-06-01 1991-08-20 Yock Paul G Angioplasty mehtod
US5061273A (en) 1989-06-01 1991-10-29 Yock Paul G Angioplasty apparatus facilitating rapid exchanges
US4748982A (en) 1987-01-06 1988-06-07 Advanced Cardiovascular Systems, Inc. Reinforced balloon dilatation catheter with slitted exchange sleeve and method
US5001139A (en) 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US4992445A (en) 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
CA1322628C (en) 1988-10-04 1993-10-05 Richard A. Schatz Expandable intraluminal graft
JP2899757B2 (en) * 1989-06-26 1999-06-02 持田製薬株式会社 Dihydroimidazoquinolinone oxime sulfonic acid derivative
US6344053B1 (en) 1993-12-22 2002-02-05 Medtronic Ave, Inc. Endovascular support device and method
US5292331A (en) 1989-08-24 1994-03-08 Applied Vascular Engineering, Inc. Endovascular support device
US5674278A (en) 1989-08-24 1997-10-07 Arterial Vascular Engineering, Inc. Endovascular support device
FR2747678B1 (en) * 1996-04-22 1998-05-22 Synthelabo COMPOUNDS DERIVED FROM IMIDAZOBENZOXAZINE, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES
US5939431A (en) * 1996-06-20 1999-08-17 Schering Corporation Naphthyridines which affect IL-4 and G-CSF
EP1719761A4 (en) * 2004-02-23 2007-10-10 Dainippon Sumitomo Pharma Co NEW HETEROCYCLIC COMPOUND
WO2006113432A2 (en) * 2005-04-14 2006-10-26 Smithkline Beecham Corporation Compounds, compositions and methods
MX2008001152A (en) * 2005-08-05 2008-04-02 Astrazeneca Ab Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators.
CN101479269A (en) * 2006-06-23 2009-07-08 阿斯利康(瑞典)有限公司 Pteridine derivatives and their use as cathespin inhibitors
WO2009022185A2 (en) * 2007-08-16 2009-02-19 Astrazeneca Ab 6, 6-fused heterocycles, their pharmaceutical compositions and methos of use
WO2011078143A1 (en) * 2009-12-22 2011-06-30 塩野義製薬株式会社 Pyrimidine derivatives and pharmaceutical composition containing same
CN103391939B (en) * 2010-12-03 2016-03-09 Epizyme股份有限公司 As the purine be substituted and the 7-azapurine compound of epigenetic enzyme conditioning agent
US9580398B2 (en) * 2012-04-02 2017-02-28 The Trustees Of Columbia University In The City Of New York Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
GB201220157D0 (en) * 2012-11-08 2012-12-26 Selvita Sa Substitute tricyclic benzimidazoles as kinase inhibitors
EP3076962A4 (en) * 2013-12-02 2017-10-18 The Trustees of Columbia University in the City of New York Modulating ferroptosis and treating excitotoxic disorders
US9828363B2 (en) * 2014-01-20 2017-11-28 Cleave Biosciences, Inc. Fused pyrimidines as inhibitors of P97 complex
GB201420235D0 (en) * 2014-11-14 2014-12-31 Vib Vzw And Universiteit Antwerpen And Universiteit Gent Compounds for inhibiting cell death
HK1256753A1 (en) * 2015-08-11 2019-10-04 Neomed Institute Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals
US10065970B2 (en) * 2015-09-08 2018-09-04 Genentech, Inc. Tricyclic PI3K inhibitor compounds and methods of use
RU2764243C2 (en) * 2017-09-22 2022-01-14 ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи Heterocyclic compounds as pad inhibitors
WO2019106434A1 (en) * 2017-12-01 2019-06-06 Collaborative Medicinal Development Pty. Ltd. Heterobicyclic aromatic derivatives for the treatment of ferroptosis-related disorders
GB201801943D0 (en) * 2018-02-07 2018-03-21 Vib Vzw Compounds for inhibiting cell death
EP3806841A1 (en) * 2018-06-15 2021-04-21 Flagship Pioneering Innovations V, Inc. Decreasing immune activity through modulation of postcellular signaling factors
EP3887351A4 (en) * 2018-11-27 2022-11-02 The Trustees of Columbia University in the City of New York COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING FERROPTOSE AND TREATING EXCITOTOXIC DISORDERS
WO2022020150A1 (en) * 2020-07-21 2022-01-27 Collaborative Medicinal Development, Llc Methods of extending lifespan by administering ferroptosis inhibitors

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