IL272652B - A pentacyclic compound, the pharmaceutical compounds that make it up and their use for the treatment of Alzheimer's disease - Google Patents
A pentacyclic compound, the pharmaceutical compounds that make it up and their use for the treatment of Alzheimer's diseaseInfo
- Publication number
- IL272652B IL272652B IL272652A IL27265220A IL272652B IL 272652 B IL272652 B IL 272652B IL 272652 A IL272652 A IL 272652A IL 27265220 A IL27265220 A IL 27265220A IL 272652 B IL272652 B IL 272652B
- Authority
- IL
- Israel
- Prior art keywords
- thieno
- pharmaceutically acceptable
- acceptable salt
- pyrimido
- diazepine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017172169 | 2017-09-07 | ||
| PCT/JP2018/032797 WO2019049869A1 (ja) | 2017-09-07 | 2018-09-05 | 五環式化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL272652A IL272652A (en) | 2020-03-31 |
| IL272652B true IL272652B (en) | 2022-09-01 |
Family
ID=65517037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL272652A IL272652B (en) | 2017-09-07 | 2018-09-05 | A pentacyclic compound, the pharmaceutical compounds that make it up and their use for the treatment of Alzheimer's disease |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US10239889B1 (ar) |
| EP (1) | EP3680243B1 (ar) |
| JP (1) | JP6557441B1 (ar) |
| KR (1) | KR102307738B1 (ar) |
| CN (1) | CN111051316B (ar) |
| AR (1) | AR112788A1 (ar) |
| AU (1) | AU2018330578B2 (ar) |
| CA (1) | CA3072740A1 (ar) |
| CL (1) | CL2020000376A1 (ar) |
| CO (1) | CO2020001471A2 (ar) |
| CY (1) | CY1125355T1 (ar) |
| DK (1) | DK3680243T3 (ar) |
| ES (1) | ES2903172T3 (ar) |
| HR (1) | HRP20220019T1 (ar) |
| HU (1) | HUE056791T2 (ar) |
| IL (1) | IL272652B (ar) |
| JO (1) | JOP20200030B1 (ar) |
| LT (1) | LT3680243T (ar) |
| MA (1) | MA50093B1 (ar) |
| MD (1) | MD3680243T2 (ar) |
| MX (1) | MX2020001786A (ar) |
| PE (1) | PE20200860A1 (ar) |
| PH (1) | PH12020500341A1 (ar) |
| PL (1) | PL3680243T3 (ar) |
| PT (1) | PT3680243T (ar) |
| RS (1) | RS62796B1 (ar) |
| RU (1) | RU2754557C1 (ar) |
| SG (1) | SG11202001240XA (ar) |
| SI (1) | SI3680243T1 (ar) |
| SM (1) | SMT202200004T1 (ar) |
| TW (1) | TWI707859B (ar) |
| UA (1) | UA125940C2 (ar) |
| WO (1) | WO2019049869A1 (ar) |
| ZA (2) | ZA202000970B (ar) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109467538A (zh) | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| MX2020002611A (es) | 2017-09-07 | 2020-07-13 | Univ Res Inst Inc Augusta | Activador especifico de akt3 y usos del mismo. |
| EA202191966A1 (ru) | 2019-03-05 | 2021-12-08 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Пентациклическое гетероциклическое соединение |
| BR112021015979A2 (pt) * | 2019-03-05 | 2021-10-05 | Eisai R&D Management Co., Ltd. | Sal de composto pentacíclico e cristal do mesmo |
| US20230101747A1 (en) * | 2019-12-06 | 2023-03-30 | Schrödinger, Inc. | Cyclic compounds and methods of using same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4187306A (en) * | 1977-07-26 | 1980-02-05 | Bayer Aktiengesellschaft | Benzodiazepine-diones, a process for their production and their use as medicaments |
| DD258234A1 (de) * | 1987-03-05 | 1988-07-13 | Univ Leipzig | Verfahren zur herstellung von pyrido/3',2':4,5/thieno/2,3-e/imidazo-/1,2-c/pyrimidinen sowie strukturanaloger -pyrimido/1,2-c/pyrimidine bzw. -1,3-diazepino/1,2-c/pyrimidine |
| RU2117670C1 (ru) * | 1988-10-31 | 1998-08-20 | Эйсай Ко., Лтд. | Производные триазоло[1,4]диазепина и способы их получения |
| TW197442B (ar) * | 1990-02-08 | 1993-01-01 | Pfizer | |
| KR100203456B1 (ko) * | 1995-06-20 | 1999-06-15 | 한승수 | 디하이드로에보디아민-에이치씨1를 유효성분으로 함유하는 알츠하이머병에 의한 치매 치료제 |
| FR2779652B1 (fr) * | 1998-06-15 | 2001-06-08 | Sod Conseils Rech Applic | Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique |
| AU2005299031B2 (en) * | 2004-10-20 | 2011-11-10 | F. Hoffmann-La Roche Ag | Halogen substituted benzodiazepine derivatives |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
-
2018
- 2018-09-05 SG SG11202001240XA patent/SG11202001240XA/en unknown
- 2018-09-05 ES ES18853415T patent/ES2903172T3/es active Active
- 2018-09-05 IL IL272652A patent/IL272652B/en unknown
- 2018-09-05 PL PL18853415T patent/PL3680243T3/pl unknown
- 2018-09-05 SI SI201830467T patent/SI3680243T1/sl unknown
- 2018-09-05 AU AU2018330578A patent/AU2018330578B2/en active Active
- 2018-09-05 RU RU2020106798A patent/RU2754557C1/ru active
- 2018-09-05 US US16/122,116 patent/US10239889B1/en active Active
- 2018-09-05 PE PE2020000228A patent/PE20200860A1/es unknown
- 2018-09-05 TW TW107131095A patent/TWI707859B/zh active
- 2018-09-05 MD MDE20200725T patent/MD3680243T2/ro unknown
- 2018-09-05 LT LTEPPCT/JP2018/032797T patent/LT3680243T/lt unknown
- 2018-09-05 HR HRP20220019TT patent/HRP20220019T1/hr unknown
- 2018-09-05 HU HUE18853415A patent/HUE056791T2/hu unknown
- 2018-09-05 MX MX2020001786A patent/MX2020001786A/es unknown
- 2018-09-05 MA MA50093A patent/MA50093B1/fr unknown
- 2018-09-05 JP JP2019516726A patent/JP6557441B1/ja active Active
- 2018-09-05 DK DK18853415.0T patent/DK3680243T3/da active
- 2018-09-05 WO PCT/JP2018/032797 patent/WO2019049869A1/ja not_active Ceased
- 2018-09-05 AR ARP180102517A patent/AR112788A1/es active IP Right Grant
- 2018-09-05 EP EP18853415.0A patent/EP3680243B1/en active Active
- 2018-09-05 CN CN201880053052.1A patent/CN111051316B/zh active Active
- 2018-09-05 SM SM20220004T patent/SMT202200004T1/it unknown
- 2018-09-05 KR KR1020207004232A patent/KR102307738B1/ko active Active
- 2018-09-05 RS RS20220015A patent/RS62796B1/sr unknown
- 2018-09-05 JO JOJO/P/2020/0030A patent/JOP20200030B1/ar active
- 2018-09-05 CA CA3072740A patent/CA3072740A1/en active Pending
- 2018-09-05 UA UAA202000934A patent/UA125940C2/uk unknown
- 2018-09-05 PT PT188534150T patent/PT3680243T/pt unknown
-
2020
- 2020-02-11 CO CONC2020/0001471A patent/CO2020001471A2/es unknown
- 2020-02-13 CL CL2020000376A patent/CL2020000376A1/es unknown
- 2020-02-14 PH PH12020500341A patent/PH12020500341A1/en unknown
- 2020-02-14 ZA ZA2020/00970A patent/ZA202000970B/en unknown
- 2020-12-11 ZA ZA2020/07737A patent/ZA202007737B/en unknown
-
2022
- 2022-01-10 CY CY20221100025T patent/CY1125355T1/el unknown
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