IL267121B - Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease - Google Patents
Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of diseaseInfo
- Publication number
- IL267121B IL267121B IL267121A IL26712119A IL267121B IL 267121 B IL267121 B IL 267121B IL 267121 A IL267121 A IL 267121A IL 26712119 A IL26712119 A IL 26712119A IL 267121 B IL267121 B IL 267121B
- Authority
- IL
- Israel
- Prior art keywords
- dlk
- bicyclo
- pentane
- kinase
- inhibitors
- Prior art date
Links
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 title 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- MKCBRYIXFFGIKN-UHFFFAOYSA-N bicyclo[1.1.1]pentane Chemical compound C1C2CC1C2 MKCBRYIXFFGIKN-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662431504P | 2016-12-08 | 2016-12-08 | |
| PCT/US2017/065385 WO2018107072A1 (en) | 2016-12-08 | 2017-12-08 | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL267121A IL267121A (en) | 2019-08-29 |
| IL267121B true IL267121B (en) | 2021-12-01 |
Family
ID=62492159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL267121A IL267121B (en) | 2016-12-08 | 2019-06-05 | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10093664B2 (en) |
| EP (1) | EP3551610B1 (en) |
| JP (1) | JP7128816B2 (en) |
| KR (1) | KR20190087622A (en) |
| CN (1) | CN110191878B (en) |
| AU (1) | AU2017371084B2 (en) |
| BR (1) | BR112019011801A2 (en) |
| CA (1) | CA3045947A1 (en) |
| CL (1) | CL2019001539A1 (en) |
| CO (1) | CO2019006785A2 (en) |
| EA (1) | EA201991375A1 (en) |
| EC (1) | ECSP19048477A (en) |
| ES (1) | ES2895257T3 (en) |
| IL (1) | IL267121B (en) |
| MX (1) | MX386838B (en) |
| WO (1) | WO2018107072A1 (en) |
| ZA (1) | ZA201904402B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019011801A2 (en) | 2016-12-08 | 2019-10-29 | Univ Texas | compound, pharmaceutical composition and dlk inhibition method, method of treating a dlk-mediated disease, method of treating cancer and reducing the development of a chemotherapy-induced neurological disorder and method for achieving an effect in a patient |
| CR20200054A (en) | 2017-08-09 | 2020-03-21 | Denali Therapeutics Inc | Compounds, compositions and methods |
| HUE062446T2 (en) | 2017-09-01 | 2023-11-28 | Denali Therapeutics Inc | Compounds, compositions and methods |
| US20190382396A1 (en) * | 2018-06-13 | 2019-12-19 | Board Of Regents, The University Of Texas System | Salts of bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease |
| GB201811165D0 (en) * | 2018-07-06 | 2018-08-29 | Metrion Biosciences Ltd | Novel compounds |
| SG11202101060WA (en) * | 2018-08-01 | 2021-02-25 | Agency Science Tech & Res | Bicyclic compounds as kinase modulators, methods and uses thereof |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF |
| CN113164508B (en) | 2018-12-19 | 2025-07-08 | 达萨玛治疗公司 | SARM1 inhibitors in combination with neuroprotective agents |
| MA54959A (en) | 2019-02-13 | 2021-12-22 | Denali Therapeutics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| EP3923935A4 (en) | 2019-02-13 | 2022-10-26 | Denali Therapeutics Inc. | COMPOUNDS, COMPOSITIONS AND METHODS |
| IL291665B2 (en) * | 2019-09-27 | 2025-07-01 | Univ Texas | Inhibitors of receptor interaction with protein kinase I for the treatment of disease |
| US11560366B2 (en) * | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
| CA3193736A1 (en) * | 2020-09-02 | 2022-03-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Lzk-targeting degraders and methods of use |
| CA3229861A1 (en) * | 2021-09-01 | 2023-03-09 | John F. BROGNARD | Mixed lineage kinase inhibitors and methods of use |
| CN115974795A (en) * | 2022-12-26 | 2023-04-18 | 杭州师范大学 | A kind of disubstituted bicyclo[1.1.1]pentane containing perfluoroalkyl and N heterocycle and its synthesis method |
| WO2025021997A1 (en) | 2023-07-27 | 2025-01-30 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | New map4k1 inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006524702A (en) | 2003-04-25 | 2006-11-02 | カイロン コーポレイション | Pyridyl-substituted ketolide antibody |
| TW200944520A (en) | 2008-01-29 | 2009-11-01 | Glaxo Group Ltd | Spiro compounds as NPY Y5 receptor antagonists |
| EP2651930B1 (en) | 2010-12-16 | 2015-10-28 | Boehringer Ingelheim International GmbH | Biarylamide inhibitors of leukotriene production |
| BR112014026176A2 (en) | 2012-05-22 | 2017-06-27 | Hoffmann La Roche | substituted dipyridylamines and their uses |
| MX2015009270A (en) * | 2013-01-18 | 2015-10-30 | Hoffmann La Roche | 3-substituted pyrazoles and use as dlk inhibitors. |
| CN104119340A (en) | 2013-01-22 | 2014-10-29 | 韩冰 | Protease inhibitors, preparation method and application thereof |
| PE20161063A1 (en) | 2013-05-01 | 2016-10-22 | Hoffmann La Roche | BIHETEROARIL COMPOUNDS AND USES OF THEM |
| WO2014177524A1 (en) | 2013-05-01 | 2014-11-06 | F. Hoffmann-La Roche Ag | C-linked heterocycloalkyl substituted pyrimidines and their uses |
| MX2016008110A (en) | 2013-12-20 | 2016-08-19 | Hoffmann La Roche | Pyrazole derivatives and uses thereof as inhibitors of dlk. |
| CN113336653A (en) * | 2014-03-07 | 2021-09-03 | 里科瑞尔姆Ip控股有限责任公司 | Propalane derivatives and synthesis |
| US9307840B2 (en) | 2014-07-01 | 2016-04-12 | Carlos Arturo Restrepo | Foldable and portable lounge chair having an integrated lockable storage compartment |
| PE20171789A1 (en) * | 2015-03-02 | 2017-12-28 | Bristol Myers Squibb Co | INHIBITORS OF THE TRANSFORMATION GROWTH FACTOR BETA (TGF-BETA) |
| ES2788160T3 (en) * | 2015-04-03 | 2020-10-20 | Recurium Ip Holdings Llc | Spirocyclic compounds |
| BR112019004243A2 (en) | 2016-08-29 | 2019-06-04 | Univ Texas | compound, pharmaceutical composition, method for inhibiting double leucine zipper kinase, method for treating a double leucine zipper kinase mediated disease and method for obtaining an effect on a patient |
| BR112019011801A2 (en) | 2016-12-08 | 2019-10-29 | Univ Texas | compound, pharmaceutical composition and dlk inhibition method, method of treating a dlk-mediated disease, method of treating cancer and reducing the development of a chemotherapy-induced neurological disorder and method for achieving an effect in a patient |
| US11560366B2 (en) * | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
-
2017
- 2017-12-08 BR BR112019011801-2A patent/BR112019011801A2/en not_active IP Right Cessation
- 2017-12-08 ES ES17879488T patent/ES2895257T3/en active Active
- 2017-12-08 JP JP2019530500A patent/JP7128816B2/en active Active
- 2017-12-08 EA EA201991375A patent/EA201991375A1/en unknown
- 2017-12-08 CA CA3045947A patent/CA3045947A1/en active Pending
- 2017-12-08 CN CN201780082917.2A patent/CN110191878B/en not_active Expired - Fee Related
- 2017-12-08 US US15/836,442 patent/US10093664B2/en active Active
- 2017-12-08 WO PCT/US2017/065385 patent/WO2018107072A1/en not_active Ceased
- 2017-12-08 KR KR1020197019246A patent/KR20190087622A/en not_active Abandoned
- 2017-12-08 AU AU2017371084A patent/AU2017371084B2/en not_active Ceased
- 2017-12-08 EP EP17879488.9A patent/EP3551610B1/en active Active
- 2017-12-08 MX MX2019006645A patent/MX386838B/en unknown
-
2018
- 2018-09-04 US US16/121,198 patent/US10428057B2/en active Active
-
2019
- 2019-06-05 IL IL267121A patent/IL267121B/en unknown
- 2019-06-05 CL CL2019001539A patent/CL2019001539A1/en unknown
- 2019-06-26 CO CONC2019/0006785A patent/CO2019006785A2/en unknown
- 2019-07-04 ZA ZA2019/04402A patent/ZA201904402B/en unknown
- 2019-07-08 EC ECSENADI201948477A patent/ECSP19048477A/en unknown
-
2022
- 2022-03-10 US US17/654,301 patent/US20220267311A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP7128816B2 (en) | 2022-08-31 |
| ES2895257T3 (en) | 2022-02-18 |
| BR112019011801A2 (en) | 2019-10-29 |
| EP3551610A1 (en) | 2019-10-16 |
| US10093664B2 (en) | 2018-10-09 |
| EA201991375A1 (en) | 2020-01-20 |
| EP3551610A4 (en) | 2020-04-22 |
| AU2017371084A1 (en) | 2019-06-20 |
| MX2019006645A (en) | 2019-08-26 |
| CN110191878A (en) | 2019-08-30 |
| MX386838B (en) | 2025-03-19 |
| CL2019001539A1 (en) | 2019-08-23 |
| ZA201904402B (en) | 2020-12-23 |
| JP2020502092A (en) | 2020-01-23 |
| US20190092764A1 (en) | 2019-03-28 |
| US10428057B2 (en) | 2019-10-01 |
| CN110191878B (en) | 2023-05-26 |
| US20220267311A1 (en) | 2022-08-25 |
| CA3045947A1 (en) | 2018-06-14 |
| AU2017371084B2 (en) | 2022-04-28 |
| KR20190087622A (en) | 2019-07-24 |
| WO2018107072A1 (en) | 2018-06-14 |
| IL267121A (en) | 2019-08-29 |
| US20180186781A1 (en) | 2018-07-05 |
| ECSP19048477A (en) | 2019-07-31 |
| CO2019006785A2 (en) | 2019-07-10 |
| EP3551610B1 (en) | 2021-08-11 |
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