IL263389D0 - Method for producing substituted 5-fluoro-1h-pyrazolopyridines - Google Patents

Method for producing substituted 5-fluoro-1h-pyrazolopyridines

Info

Publication number
IL263389D0
IL263389D0 IL263389A IL26338918A IL263389D0 IL 263389 D0 IL263389 D0 IL 263389D0 IL 263389 A IL263389 A IL 263389A IL 26338918 A IL26338918 A IL 26338918A IL 263389 D0 IL263389 D0 IL 263389D0
Authority
IL
Israel
Prior art keywords
pyrazolopyridines
fluoro
producing substituted
substituted
producing
Prior art date
Application number
IL263389A
Other languages
Hebrew (he)
Original Assignee
Adverio Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP11190789 priority Critical
Priority to EP11192301 priority
Priority to PCT/EP2012/073276 priority patent/WO2013076168A1/en
Application filed by Adverio Pharma Gmbh filed Critical Adverio Pharma Gmbh
Publication of IL263389D0 publication Critical patent/IL263389D0/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulfur atoms
    • C07D295/104Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulfur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/02Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
    • C07C317/04Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023Preparation; Separation; Stabilisation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/037Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements with quaternary ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
IL263389A 2011-11-25 2018-11-29 Method for producing substituted 5-fluoro-1h-pyrazolopyridines IL263389D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP11190789 2011-11-25
EP11192301 2011-12-07
PCT/EP2012/073276 WO2013076168A1 (en) 2011-11-25 2012-11-21 Method for producing substituted 5-fluoro-1h-pyrazolopyridines

Publications (1)

Publication Number Publication Date
IL263389D0 true IL263389D0 (en) 2018-12-31

Family

ID=47222101

Family Applications (3)

Application Number Title Priority Date Filing Date
IL232585A IL232585D0 (en) 2011-11-25 2014-05-13 Method for producing substituted 5-fluoro-1h-pyrazolopyridines
IL246265A IL246265A (en) 2011-11-25 2016-06-16 Process for preparing intermediates for the preparation of 5-fluoro-1h-pyrazolopyridines and some such compounds
IL263389A IL263389D0 (en) 2011-11-25 2018-11-29 Method for producing substituted 5-fluoro-1h-pyrazolopyridines

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL232585A IL232585D0 (en) 2011-11-25 2014-05-13 Method for producing substituted 5-fluoro-1h-pyrazolopyridines
IL246265A IL246265A (en) 2011-11-25 2016-06-16 Process for preparing intermediates for the preparation of 5-fluoro-1h-pyrazolopyridines and some such compounds

Country Status (40)

Country Link
US (7) US8802847B2 (en)
EP (3) EP2896617B1 (en)
JP (4) JP6189315B2 (en)
KR (3) KR101993022B1 (en)
CN (3) CN106905314A (en)
AP (4) AP3898A (en)
AR (1) AR088983A1 (en)
AU (3) AU2012342547C1 (en)
BR (1) BR112014012414A8 (en)
CA (2) CA2856706C (en)
CL (2) CL2014001339A1 (en)
CO (1) CO6960555A2 (en)
CR (2) CR20190057A (en)
CU (3) CU24354B1 (en)
DK (2) DK2782914T3 (en)
DO (2) DOP2014000112A (en)
EA (4) EA031602B1 (en)
EC (1) ECSP14001627A (en)
ES (2) ES2694158T3 (en)
GT (1) GT201400101A (en)
HK (2) HK1203951A1 (en)
HR (2) HRP20161501T1 (en)
HU (2) HUE041592T2 (en)
IL (3) IL232585D0 (en)
LT (2) LT2782914T (en)
MX (1) MX357481B (en)
NZ (3) NZ721592A (en)
PE (3) PE20190180A1 (en)
PH (2) PH12014501160B1 (en)
PL (2) PL2896617T3 (en)
PT (2) PT2782914T (en)
RS (2) RS57945B1 (en)
SG (3) SG10201604196VA (en)
SI (2) SI2896617T1 (en)
TR (1) TR201816203T4 (en)
TW (5) TWI631123B (en)
UA (3) UA120278C2 (en)
UY (1) UY34467A (en)
WO (1) WO2013076168A1 (en)
ZA (2) ZA201403613B (en)

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JP6340391B2 (en) 2018-06-06
AR088983A1 (en) 2014-07-23
US10364229B2 (en) 2019-07-30
HK1223613A1 (en) 2017-08-04
DOP2014000112A (en) 2014-07-15
ECSP14001627A (en) 2015-11-30
CL2016000344A1 (en) 2017-02-10
AU2019202123B2 (en) 2020-09-24
PH12015501494B1 (en) 2015-09-07
EA031602B1 (en) 2019-01-31
AU2012342547C1 (en) 2019-02-21
HRP20181818T1 (en) 2019-01-11
AU2012342547B2 (en) 2017-08-17
CA3040720A1 (en) 2013-05-30
PE20142359A1 (en) 2015-01-09
AU2019202123A1 (en) 2019-04-18
PL2896617T3 (en) 2017-07-31
LT2896617T (en) 2016-12-12
AP2015008243A0 (en) 2015-01-31
US20190177287A1 (en) 2019-06-13
CU24257B1 (en) 2017-05-10
AP2014007705A0 (en) 2014-06-30
EA030018B1 (en) 2018-06-29
TWI665198B (en) 2019-07-11
UY34467A (en) 2013-06-28
PE20190180A1 (en) 2019-02-01
AU2017254916B2 (en) 2019-02-28
UA116623C2 (en) 2018-04-25
US20160009671A1 (en) 2016-01-14
US20190177288A1 (en) 2019-06-13
HRP20161501T1 (en) 2016-12-16
CA2856706A1 (en) 2013-05-30
US9845300B2 (en) 2017-12-19
PL2782914T3 (en) 2019-01-31
EP3421470B1 (en) 2021-01-20
EA201690520A1 (en) 2016-07-29
AU2012342547A1 (en) 2014-06-05
CA2856706C (en) 2020-06-16
JP2018058860A (en) 2018-04-12
US9150573B2 (en) 2015-10-06
HK1203951A1 (en) 2015-11-06
CU20140055A7 (en) 2014-10-02
TW201708219A (en) 2017-03-01
TR201816203T4 (en) 2018-11-21
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