IL261404D0 - Improved differentiation method - Google Patents

Improved differentiation method

Info

Publication number
IL261404D0
IL261404D0 IL261404A IL26140418A IL261404D0 IL 261404 D0 IL261404 D0 IL 261404D0 IL 261404 A IL261404 A IL 261404A IL 26140418 A IL26140418 A IL 26140418A IL 261404 D0 IL261404 D0 IL 261404D0
Authority
IL
Israel
Prior art keywords
improved differentiation
differentiation
improved
Prior art date
Application number
IL261404A
Other languages
Hebrew (he)
Original Assignee
Koninklijke Nederlandse Akademie Van Wetenschappen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB1603569.3A priority Critical patent/GB201603569D0/en
Priority to PCT/EP2017/054797 priority patent/WO2017149025A1/en
Application filed by Koninklijke Nederlandse Akademie Van Wetenschappen filed Critical Koninklijke Nederlandse Akademie Van Wetenschappen
Publication of IL261404D0 publication Critical patent/IL261404D0/en

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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/067Hepatocytes
    • C12N5/0672Stem cells; Progenitor cells; Precursor cells; Oval cells
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/067Hepatocytes
    • C12N5/0671Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/407Liver; Hepatocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999Small molecules not provided for elsewhere
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    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/14Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from hepatocytes
IL261404A 2016-03-01 2018-08-27 Improved differentiation method IL261404D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GBGB1603569.3A GB201603569D0 (en) 2016-03-01 2016-03-01 Improved differentiation method
PCT/EP2017/054797 WO2017149025A1 (en) 2016-03-01 2017-03-01 Improved differentiation method

Publications (1)

Publication Number Publication Date
IL261404D0 true IL261404D0 (en) 2018-10-31

Family

ID=55807141

Family Applications (1)

Application Number Title Priority Date Filing Date
IL261404A IL261404D0 (en) 2016-03-01 2018-08-27 Improved differentiation method

Country Status (10)

Country Link
US (1) US20210040454A1 (en)
EP (1) EP3423565A1 (en)
JP (1) JP2019514345A (en)
CN (1) CN109477070A (en)
AU (1) AU2017228002A1 (en)
CA (1) CA3015026A1 (en)
GB (1) GB201603569D0 (en)
IL (1) IL261404D0 (en)
SG (1) SG11201806988UA (en)
WO (1) WO2017149025A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
US10597633B2 (en) 2014-05-16 2020-03-24 Koninklijke Nederlandse Akademie Van Wetenschappen Culture method for organoids
CA2949834A1 (en) 2014-05-28 2015-12-03 James Macormack Wells Methods and systems for converting precursor cells into gastric tissues through directed differentiation
WO2019185017A1 (en) * 2018-03-30 2019-10-03 中国科学院上海生命科学研究院 Medium for hepatocyte culture and preparation of liver organs
CA3101021A1 (en) * 2018-05-31 2019-12-05 University Health Network Methods and compositions comprising tankyrase inhibitors for generating insulin producing cells
GB201819224D0 (en) * 2018-11-26 2019-01-09 Koninklijke Nederlandse Akademie Van Wetenschappen Hepatocyte expansion methods
KR20200065892A (en) * 2018-11-30 2020-06-09 오가노이드사이언스 주식회사 A composition for bio transplanting of organoid
KR102133693B1 (en) * 2018-12-28 2020-07-13 서울대학교병원 Method for differentiating salivary gland stem cell to salivary gland tissue and pharmaceutical composition for treating or preventing xerostomia
GB201906978D0 (en) 2019-05-17 2019-07-03 Koninklijke Nederlandse Akademie Van Wetenschappen Improved culture method using integrin agonist
CN111394314B (en) * 2020-04-22 2020-12-01 创芯国际生物科技(广州)有限公司 Culture medium and culture method for intestinal cancer organoid
CN111979183A (en) * 2020-08-10 2020-11-24 创芯国际生物科技(广州)有限公司 Drug hepatotoxicity evaluation method based on liver organoid model

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0953633A1 (en) * 1998-04-28 1999-11-03 Livercell L.L.C. Cell culturing method and medium for producing proliferated, normal, differentiated human liver cells
US9752124B2 (en) * 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
EP2956538B1 (en) * 2013-02-13 2018-11-14 Wake Forest University Health Sciences Bioengineered liver constructs and methods relating thereto

Also Published As

Publication number Publication date
AU2017228002A1 (en) 2018-08-30
CN109477070A (en) 2019-03-15
JP2019514345A (en) 2019-06-06
WO2017149025A1 (en) 2017-09-08
EP3423565A1 (en) 2019-01-09
US20210040454A1 (en) 2021-02-11
GB201603569D0 (en) 2016-04-13
CA3015026A1 (en) 2017-09-08
SG11201806988UA (en) 2018-09-27

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