IL255459D0 - Triazole agonists of the apj receptor - Google Patents

Triazole agonists of the apj receptor

Info

Publication number
IL255459D0
IL255459D0 IL255459A IL25545917A IL255459D0 IL 255459 D0 IL255459 D0 IL 255459D0 IL 255459 A IL255459 A IL 255459A IL 25545917 A IL25545917 A IL 25545917A IL 255459 D0 IL255459 D0 IL 255459D0
Authority
IL
Israel
Prior art keywords
triazole
agonists
apj receptor
apj
receptor
Prior art date
Application number
IL255459A
Other languages
Hebrew (he)
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201562164106P priority Critical
Priority to PCT/US2016/033088 priority patent/WO2016187308A1/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of IL255459D0 publication Critical patent/IL255459D0/en

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    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1143120A (en) * 1997-07-28 1999-02-16 Ishikawajima Harima Heavy Ind Co Ltd After treatment device of container
US9573936B2 (en) * 2015-05-20 2017-02-21 Amgen Inc. Triazole agonists of the APJ receptor
AU2016270903A1 (en) 2015-06-03 2018-01-18 Bristol-Myers Squibb Company 4-hydroxy-3-(heteroaryl)pyridine-2-one APJ agonists for use in the treatment of cardiovascular disorders
CA3001974A1 (en) 2015-10-14 2017-04-20 Bristol-Myers Squibb Company 2,4-dihydroxy-nicotinamides as apj agonists
EA201892123A1 (en) 2016-03-24 2019-02-28 Бристол-Маерс Сквибб Компани 6-hydroxy-4-oxo-1,4-dihydropyrimidin-5-carboxamide as apj agonists
EP3452466A1 (en) 2016-05-03 2019-03-13 Amgen Inc. Heterocyclic triazole compounds as agonists of the apj receptor
WO2018093579A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Triazole phenyl compounds as agonists of the apj receptor
WO2018097944A1 (en) 2016-11-16 2018-05-31 Amgen Inc. Triazole furan compounds as agonists of the apj receptor
EP3541805A1 (en) 2016-11-16 2019-09-25 Amgen Inc. Heteroaryl-substituted triazoles as apj receptor agonists
EP3541804A1 (en) 2016-11-16 2019-09-25 Amgen Inc. Cycloalkyl substituted triazole compounds as agonists of the apj receptor
US20190300507A1 (en) 2016-11-16 2019-10-03 Amgen Inc. Triazole pyridyl compounds as agonists of the apj receptor
WO2018093576A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Alkyl substituted triazole compounds as agonists of the apj receptor
WO2019034696A1 (en) * 2017-08-15 2019-02-21 Inflazome Limited Novel sulfonamide carboxamide compounds
WO2019089335A1 (en) 2017-11-03 2019-05-09 Amgen Inc. Fused triazole agonists of the apj receptor
WO2019169193A1 (en) 2018-03-01 2019-09-06 Annapurna Bio Inc. Compounds and compositions for treating conditions associated with apj receptor activity
WO2019213006A1 (en) 2018-05-01 2019-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the apj receptor

Family Cites Families (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4160452A (en) 1977-04-07 1979-07-10 Alza Corporation Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US4681943A (en) * 1984-11-30 1987-07-21 The Dow Chemical Company 1-acyl-1-(2-pyridinyl)semicarbazides
JPS62149673A (en) * 1985-09-05 1987-07-03 Sumitomo Chem Co Ltd Pyridine derivative, production thereof and plant blight controlling agent containing said derivative as active component
DE3825867A1 (en) 1988-03-04 1989-09-14 Bayer Ag Heterocyclic substituted sulfonylaminoazole and their use as herbicides
EP0409332A3 (en) 1989-07-19 1991-08-07 Merck & Co. Inc. Substituted triazoles as angiotensin ii antagonists
DE3928605A1 (en) 1989-08-30 1991-03-07 Bayer Ag substituted sulfonylaminoazole
JP2726563B2 (en) 1990-02-13 1998-03-11 メルク・エンド・カムパニー・インコーポレーテツド Triazole angiotensin ▲ ii ▼ antagonists comprising substituted benzyl element
JPH0511439A (en) 1990-09-13 1993-01-22 Fuji Photo Film Co Ltd Photopolymerizable composition
DE4035141A1 (en) 1990-11-06 1992-05-07 Bayer Ag substituted sulfonylaminotriazolylpyrimidine
SK278998B6 (en) 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Imidazole, triazole and tetrazole derivatives, method of producing same, their use and pharmaceutical compositons on their base
SE9103397D0 (en) 1991-11-18 1991-11-18 Kabi Pharmacia Ab New substituted salicylic acids
JP3217846B2 (en) * 1992-03-04 2001-10-15 イハラケミカル工業株式会社 Triazole derivatives and insecticides
JP3309982B2 (en) 1992-03-13 2002-07-29 メルク シヤープ エンド ドーム リミテツド Imidazole, triazole and tetrazole derivatives
US5411839A (en) 1993-01-15 1995-05-02 Eastman Kodak Company Image formation in color reversal materials using strong inhibitors
KR100441334B1 (en) 1995-02-03 2004-10-20 파마시아 앤드 업존 캄파니 Hetero-aromatic rings substituted phenyloxazolidinone antimicrobials
US5563026A (en) 1995-04-28 1996-10-08 Eastman Kodak Company Color negative element having improved green record printer compatibility
DE19725450A1 (en) 1997-06-16 1998-12-17 Hoechst Schering Agrevo Gmbh 4-haloalkyl-3-heterocyclylpyridine and 4-haloalkyl-5-heterocyclylpyrimidine, processes for their preparation, compositions containing them and their use as pesticides
JP3788676B2 (en) 1997-11-11 2006-06-21 富士写真フイルム株式会社 Organic electroluminescent device material and organic electroluminescent device using the same
AU757197B2 (en) 1998-02-13 2003-02-06 Pharmacia & Upjohn Company Substituted aminophenyl isoxazoline derivatives useful as antimicrobials
AU3180999A (en) 1998-02-25 1999-09-15 Pharmacia & Upjohn Company Substituted aminomethyl isoxazoline derivatives useful as antimicrobials
CA2384101A1 (en) 1999-09-10 2001-03-15 Merck & Co., Inc. Tyrosine kinase inhibitors
EP1265921B1 (en) 2000-03-16 2007-05-23 Genesoft, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
CN1419563A (en) 2000-03-23 2003-05-21 武田药品工业株式会社 Peptide derivative
PL359340A1 (en) 2000-05-19 2004-08-23 Triazole derivatives
AU2002232919A1 (en) 2000-12-29 2002-07-16 Alteon, Inc. Method for treating fibrotic diseases or other indications
WO2002053160A1 (en) 2000-12-29 2002-07-11 Alteon, Inc. Method for treating glaucoma ivb
US6727364B2 (en) 2001-04-30 2004-04-27 The Procter & Gamble Company Triazole compounds useful in treating diseases associated with unwanted cytokine activity
US6787555B2 (en) 2001-04-30 2004-09-07 The Procter & Gamble Company Triazole compounds useful in treating diseases associated with unwanted cytokine activity
US6790846B2 (en) 2001-05-24 2004-09-14 The Procter & Gamble Company Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity
JP2003005356A (en) 2001-06-20 2003-01-08 Fuji Photo Film Co Ltd Negative type resist composition for electron beam or x-ray
DE10138569A1 (en) 2001-08-06 2003-04-30 Bayer Ag Regulation of the APJ receptor
JP2003321456A (en) 2002-04-30 2003-11-11 Fuji Photo Film Co Ltd Method for producing 5-amino-4-nitrogen-containing aromatic heterocyclic substituted pyrazol
US20060135556A1 (en) 2002-08-23 2006-06-22 Jean-Luc Girardet Non-nucleoside reverse transcriptase inhibitors
US7084145B2 (en) 2002-10-25 2006-08-01 Pfizer Inc. Triazole compounds useful in therapy
EP1581222A2 (en) 2003-01-02 2005-10-05 Millennium Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR INHIBITING TGF-&bgr;
US7169797B2 (en) 2003-02-14 2007-01-30 Abbott Laboratories Protein-tyrosine phosphatase inhibitors and uses thereof
US20040167188A1 (en) 2003-02-14 2004-08-26 Zhili Xin Protein-tyrosine phosphatase inhibitors and uses thereof
JP2007524374A (en) 2003-02-28 2007-08-30 プレキシコン,インコーポレーテッド PYK2 crystal structure and use
US20090048301A1 (en) 2003-07-09 2009-02-19 Imclone Systems Incorporated Heterocyclic compounds and their use as anticancer agents
EP1664052B1 (en) 2003-08-15 2009-02-18 AstraZeneca AB Fused heterocycles as inhibitors of glutamate racemase (muri)
WO2005039569A1 (en) 2003-10-18 2005-05-06 Bayer Healthcare Ag 5-substituted 2-(phenylmethyl) thio-4-phenyl-4h-1,2,4-triazole derivatives and related compounds as gaba-agonists for the treatment of urinary incontinence and related diseases
JP2005170939A (en) 2003-11-20 2005-06-30 Takeda Chem Ind Ltd Prophylactic/therapeutic agent for diabetes
WO2005073193A1 (en) 2004-01-23 2005-08-11 Amgen Inc. Vanilloid receptor ligands and their use in treatments
US7297168B2 (en) 2004-02-02 2007-11-20 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
DE102004008141A1 (en) 2004-02-19 2005-09-01 Abbott Gmbh & Co. Kg Guanidine compounds and their use as binding partners for 5-HT5 receptors
AU2005230867A1 (en) 2004-03-26 2005-10-20 Amphora Discovery Corporation Certain triazole-based compounds, compositions, and uses thereof
US20080153869A1 (en) 2004-06-14 2008-06-26 Bressi Jerome C Kinase Inhibitors
US7399317B2 (en) 2004-08-26 2008-07-15 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
MX2007003161A (en) 2004-09-16 2007-05-16 Astellas Pharma Inc Triazole derivative or salt thereof.
CA2586612C (en) 2004-11-18 2016-10-11 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
US20060156480A1 (en) 2005-01-14 2006-07-20 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
WO2006080533A1 (en) 2005-01-31 2006-08-03 Mochida Pharmaceutical Co., Ltd. 3-amino-1,2,4-triazole derivative
KR20070112400A (en) 2005-03-09 2007-11-23 니폰 가야꾸 가부시끼가이샤 Novel hsp90 inhibitor
US8399464B2 (en) 2005-03-09 2013-03-19 Nippon Kayaku Kabushiki Kaisha HSP90 inhibitor
US20080214622A1 (en) 2005-03-21 2008-09-04 Alan Daniel Brown Substituted Triazole Derivatives As Oxytocin Antagonists
CA2603701A1 (en) 2005-04-06 2006-10-19 Banyu Pharmaceutical Co., Ltd. 1,4-substituted piperazine derivative
JPWO2007007688A1 (en) 2005-07-08 2009-01-29 持田製薬株式会社 3,5-diamino-1,2,4-triazole derivative
US7615569B2 (en) 2005-08-16 2009-11-10 Icagen, Inc. Inhibitors of ion channels
WO2007022947A2 (en) 2005-08-21 2007-03-01 Abbott Gmbh & Co. Kg 5-ring heteroaromatic compounds and their use as binding partners for 5-ht5 receptors
CN101426766B (en) 2006-04-19 2014-03-26 默克雪兰诺有限公司 Novel heteroaryl-substituted arylaminopyridine derivatives as MEK inhibitors
TW200806637A (en) 2006-05-25 2008-02-01 Synta Pharmaceuticals Corp Synthesis of triazole compounds that modulate HSP90 activity
WO2007139955A2 (en) 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
TW200800260A (en) 2006-05-25 2008-01-01 Synta Pharmaceuticals Corp Method for treating proliferative disorders associated with protooncogene products
EP2026797A2 (en) 2006-05-25 2009-02-25 Synta Pharmaceuticals Corporation Method for treating non-hodgkin's lymphoma
PL2035396T3 (en) 2006-05-25 2014-10-31 Synta Pharmaceuticals Corp Triazole compounds that modulate hsp90 activity
AU2012200157B2 (en) 2006-05-25 2014-08-21 Synta Pharmaceuticals Corp. Method for treating proliferative disorders associated with protooncogene products
ES2431466T3 (en) 2006-06-30 2013-11-26 Sunesis Pharmaceuticals, Inc. Pyridinonyl pdk1 inhibitors
US7718683B2 (en) 2006-07-14 2010-05-18 Chemocentryx, Inc. Triazolyl phenyl benzenesulfonamides
AT496905T (en) 2006-07-14 2011-02-15 Chemocentryx Inc Triazolyl-pyridyl-benzolsulfonamides as ccr2 or ccr9 modulators for the treatment of atherosclerosis
CA2659425C (en) 2006-08-17 2017-06-20 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
WO2008051416A2 (en) 2006-10-19 2008-05-02 Synta Pharmaceuticals Corp. Compounds that inhibit the activity of hsp90 for treating infections
WO2008057246A2 (en) 2006-10-26 2008-05-15 Synta Pharmaceuticals Corp. Method for treating inflammatory disorders
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
WO2008097640A2 (en) 2007-02-08 2008-08-14 Synta Pharmaceuticals Corp. Triazole compounds that are useful in the treatment of proliferative disorders, such as cancer
US7909187B2 (en) 2007-02-20 2011-03-22 Lonzell Montgomery Modular baby bottle system
WO2008112199A1 (en) 2007-03-12 2008-09-18 Synta Pharmaceuticals Corp. Method for inhibiting topoisomerase ii
US8648104B2 (en) 2007-05-25 2014-02-11 Synta Pharmaceuticals Corp. Method for treating proliferative disorders associated with mutations in c-Met
CA2693162C (en) 2007-07-17 2017-05-16 Acea Biosciences Inc. Heterocyclic compounds and uses as anticancer agents
CN101801983B (en) 2007-08-13 2014-01-29 辛塔制药公司 Triazole compounds that modulate HSP90 activity
TW200922564A (en) 2007-09-10 2009-06-01 Curis Inc CDK inhibitors containing a zinc binding moiety
WO2009075890A2 (en) 2007-12-12 2009-06-18 Synta Pharmaceuticals Corp. Method for synthesis of triazole compounds that modulate hsp90 activity
CA2710194C (en) 2007-12-19 2014-04-22 Amgen Inc. Inhibitors of p13 kinase
DE102008013587A1 (en) 2008-03-11 2009-09-17 Bayer Schering Pharma Aktiengesellschaft Heteroaryl-substituted dicyanopyridines and their use
EP2103602A1 (en) 2008-03-17 2009-09-23 AEterna Zentaris GmbH Novel 1,2,4-triazole derivatives and process of manufacturing thereof
US9029376B2 (en) 2008-06-03 2015-05-12 Siga Technologies, Inc. Small molecule inhibitors for the treatment or prevention of dengue virus infection
MX2010014565A (en) 2008-07-01 2011-03-04 Genentech Inc Isoindolone derivatives as mek kinase inhibitors and methods of use.
US8841462B2 (en) 2008-07-01 2014-09-23 Robert A. Heald Bicyclic heterocycles as MEK kinase inhibitors
US20100031237A1 (en) 2008-08-01 2010-02-04 International Business Machines Corporation Methods for Detecting Inter-Module Dependencies
TW201011003A (en) 2008-08-08 2010-03-16 Synta Pharmaceuticals Corp Triazole compounds that modulate HSP90 activity
DE102008038221A1 (en) 2008-08-18 2010-02-25 Merck Patent Gmbh 7-azaindole derivatives
US9339480B2 (en) 2008-11-26 2016-05-17 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of obesity and diabetes
DE102008059702A1 (en) 2008-12-01 2010-06-02 Byk-Chemie Gmbh Process for the preparation of rheologically active urea urethanes in organic salts
WO2010139966A1 (en) 2009-06-05 2010-12-09 Oslo University Hospital Hf Azole derivatives as wtn pathway inhibitors
KR101460095B1 (en) 2009-06-08 2014-11-10 캘리포니아 캐피탈 에쿼티, 엘엘씨 Triazine derivatives and their therapeutical applications
TW201120027A (en) 2009-12-11 2011-06-16 Exelixis Inc TGR5 agonists
CN110269856A (en) 2010-03-30 2019-09-24 维颂公司 Inhibitor of the polysubstituted aromatic compounds as fibrin ferment
WO2011133521A2 (en) 2010-04-19 2011-10-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a vegf inhibitor
WO2011133520A1 (en) 2010-04-19 2011-10-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
US20130172333A1 (en) 2010-05-20 2013-07-04 Synta Pharmaceuticals Corp. Formulation and dosing of hsp90 inhibitory compounds
WO2011150286A2 (en) 2010-05-26 2011-12-01 Satiogen Pharmaceuticals,Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
WO2012007500A2 (en) 2010-07-15 2012-01-19 Bayer Cropscience Ag New heterocyclic compounds as pesticides
WO2012021778A2 (en) 2010-08-12 2012-02-16 The Regents Of The University Of California Methods for blocking cell proliferation and treating diseases and conditions responsive to cell growth inhibition
JP5517890B2 (en) * 2010-11-15 2014-06-11 サンデン株式会社 Showcase and lighting module
WO2012076898A1 (en) * 2010-12-08 2012-06-14 Golding, Louise Triazole derivatives as wnt signaling pathway inhibitors
WO2012116247A1 (en) 2011-02-25 2012-08-30 Synta Pharmaceuticals Corp. Hsp90 inhibitory compounds in treating jak/stat signaling-mediated cancers
JP2014521699A (en) 2011-08-04 2014-08-28 ルメナ ファーマシューティカルズ,インク. Bile acid recycling inhibitors for the treatment of pancreatitis
WO2013032939A1 (en) 2011-08-26 2013-03-07 Metabolex, Inc. Bicyclic agonists of gpr131 and uses thereof
US20130108573A1 (en) 2011-10-28 2013-05-02 Lumena Pharmaceuticals, Inc. Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease
DK2771003T3 (en) 2011-10-28 2017-07-17 Lumena Pharmaceuticals Llc Bile acid recycling inhibitors for the treatment of pediatric cholestatic liver disease
CA2853806A1 (en) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with platinum-containing agents
JP2014532712A (en) 2011-11-02 2014-12-08 シンタ ファーマシューティカルズ コーポレーション Cancer therapy using a combination of a topoisomerase I inhibitor and an HSP90 inhibitor
US9402831B2 (en) 2011-11-14 2016-08-02 Synta Pharmaceutical Corp. Combination therapy of HSP90 inhibitors with BRAF inhibitors
CA2860740A1 (en) 2012-01-09 2013-07-18 Anchor Therapeutics, Inc. Apj receptor compounds
CN104169275B (en) 2012-01-13 2017-06-09 百时美施贵宝公司 The pyridine compounds of the triazole substitution as kinase inhibitor
US8673848B2 (en) 2012-01-27 2014-03-18 Novartis Ag Synthetic apelin mimetics for the treatment of heart failure
WO2013148857A1 (en) 2012-03-28 2013-10-03 Synta Pharmaceuticals Corp. Triazole derivatives as hsp90 inhibitors
AU2013271731A1 (en) 2012-06-07 2014-12-18 Georgia State University Research Foundation, Inc. SecA inhibitors and methods of making and using thereof
US20140005181A1 (en) * 2012-06-21 2014-01-02 Sanford-Burnham Medical Research Institute Small molecule antagonists of the apelin receptor for the treatment of disease
RU2015114772A (en) 2012-09-21 2016-11-10 Санофи Amenide derivatives of benzoimidazole-carboxylic acid as apj receptor modulators
US20160067347A1 (en) 2012-12-20 2016-03-10 Amgen Inc. Apj receptor agonists and uses thereof
CA2904660A1 (en) 2013-03-15 2014-09-25 Shifa Biomedical Corporation Anti-proprotein convertase subtilisin kexin type 9 (anti-pcsk9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases
UY35517A (en) 2013-04-04 2014-10-31 Mabxience S A A method for increasing the formation of pyroglutamic acid of a protein
AU2014273962B2 (en) 2013-05-30 2019-07-25 Washington University Compounds and methods for treating bacterial infections
JP2017516490A (en) 2014-03-20 2017-06-22 セントル ナショナル デ ラ ルシュルシュ サイエンティフィーク(シーエヌアールエス) Use of compounds that inhibit apelin / APJ / GP130 signaling for the treatment of cancer
JP2017515468A (en) 2014-04-24 2017-06-15 ナンヤン テクノロジカル ユニヴァーシティー ASX-specific protein ligase
WO2015184011A2 (en) * 2014-05-28 2015-12-03 Sanford-Burnham Medical Research Institute Agonists of the apelin receptor and methods of use thereof
CN106459004A (en) 2014-06-06 2017-02-22 研究三角协会 Pyrazole amide derivative
US20160058705A1 (en) 2014-08-28 2016-03-03 Jayakumar Rajadas Compositions and methods for treating cardiovascular and pulmonary diseases and disorders with apelin
US9573936B2 (en) * 2015-05-20 2017-02-21 Amgen Inc. Triazole agonists of the APJ receptor
AU2016270903A1 (en) 2015-06-03 2018-01-18 Bristol-Myers Squibb Company 4-hydroxy-3-(heteroaryl)pyridine-2-one APJ agonists for use in the treatment of cardiovascular disorders
EP3115826A1 (en) 2015-07-06 2017-01-11 Trumpf Laser Marking Systems AG Device for deflecting a laser beam
WO2017010058A1 (en) 2015-07-14 2017-01-19 パナソニックIpマネジメント株式会社 Identification medium recognition device and identification medium recognition method
CA3001974A1 (en) 2015-10-14 2017-04-20 Bristol-Myers Squibb Company 2,4-dihydroxy-nicotinamides as apj agonists
EP3380970A4 (en) 2015-11-24 2019-05-08 Sanford Burnham Prebys Medical Discovery Institute Novel azole derivatives as apelin receptor agonist
MX2018006217A (en) 2015-12-04 2018-08-01 Squibb Bristol Myers Co Apelin receptor agonists and methods of use.
CN108602806A (en) 2015-12-09 2018-09-28 研究三角协会 Improved Ai Palin peptides receptor (APJ) agonist and application thereof
EP3452466A1 (en) * 2016-05-03 2019-03-13 Amgen Inc. Heterocyclic triazole compounds as agonists of the apj receptor

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PE5292018A1 (en) 2018-03-19
CL2017002922A1 (en) 2018-03-16
US20170281625A1 (en) 2017-10-05
UY36684A (en) 2016-12-30
US20170042897A1 (en) 2017-02-16
US20190100510A1 (en) 2019-04-04
US10058550B2 (en) 2018-08-28
US20160340336A1 (en) 2016-11-24
US9656997B2 (en) 2017-05-23
US9868721B2 (en) 2018-01-16
EA201792536A1 (en) 2018-10-31
TW201706248A (en) 2017-02-16
US9845310B2 (en) 2017-12-19
TWI606039B (en) 2017-11-21

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