IL253651D0 - 1,2,4-oxadiazole derivatives as immunomodulators - Google Patents

1,2,4-oxadiazole derivatives as immunomodulators

Info

Publication number
IL253651D0
IL253651D0 IL253651A IL25365117A IL253651D0 IL 253651 D0 IL253651 D0 IL 253651D0 IL 253651 A IL253651 A IL 253651A IL 25365117 A IL25365117 A IL 25365117A IL 253651 D0 IL253651 D0 IL 253651D0
Authority
IL
Israel
Prior art keywords
immunomodulators
oxadiazole derivatives
oxadiazole
derivatives
Prior art date
Application number
IL253651A
Other languages
Hebrew (he)
Other versions
IL253651A (en
Inventor
Govindan Nair Sasikumar Pottayil
Ramachandra Muralidhara
Setty Sudarshan Naremaddepalli Seetharamaiah
Original Assignee
Aurigene Discovery Tech Ltd
Govindan Nair Sasikumar Pottayil
Ramachandra Muralidhara
Setty Sudarshan Naremaddepalli Seetharamaiah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IN4011CH2013 priority Critical
Priority to PCT/IB2014/064279 priority patent/WO2015033299A1/en
Application filed by Aurigene Discovery Tech Ltd, Govindan Nair Sasikumar Pottayil, Ramachandra Muralidhara, Setty Sudarshan Naremaddepalli Seetharamaiah filed Critical Aurigene Discovery Tech Ltd
Publication of IL253651D0 publication Critical patent/IL253651D0/en
Publication of IL253651A publication Critical patent/IL253651A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00—Drug, bio-affecting and body treating compositions
    • Y10S514/885—Immune response affecting drug
IL253651A 2013-09-06 2017-07-25 1,2,4-oxadiazole derivatives as immunomodulators IL253651A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IN4011CH2013 2013-09-06
PCT/IB2014/064279 WO2015033299A1 (en) 2013-09-06 2014-09-05 1,2,4-oxadiazole derivatives as immunomodulators

Publications (2)

Publication Number Publication Date
IL253651D0 true IL253651D0 (en) 2017-09-28
IL253651A IL253651A (en) 2019-07-31

Family

ID=51830558

Family Applications (3)

Application Number Title Priority Date Filing Date
IL244314A IL244314A (en) 2013-09-06 2016-02-28 1,2,4-oxadiazole derivatives as immunomodulators
IL253651A IL253651A (en) 2013-09-06 2017-07-25 1,2,4-oxadiazole derivatives as immunomodulators
IL268035A IL268035A (en) 2013-09-06 2019-07-14 1,2,4 oxadiazole derivatives as immunomodulators

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL244314A IL244314A (en) 2013-09-06 2016-02-28 1,2,4-oxadiazole derivatives as immunomodulators

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL268035A IL268035A (en) 2013-09-06 2019-07-14 1,2,4 oxadiazole derivatives as immunomodulators

Country Status (26)

Country Link
US (6) US9233940B2 (en)
EP (2) EP3041827B1 (en)
JP (1) JP6521977B2 (en)
KR (1) KR20160081897A (en)
CN (2) CN108164474A (en)
AU (3) AU2014316682B2 (en)
BR (1) BR112016004889A2 (en)
CA (1) CA2922607A1 (en)
CU (1) CU24362B1 (en)
CY (1) CY1120899T1 (en)
DK (2) DK3041827T3 (en)
EA (1) EA030155B1 (en)
ES (2) ES2675027T3 (en)
HR (2) HRP20181052T1 (en)
HU (2) HUE048874T2 (en)
IL (3) IL244314A (en)
LT (2) LT3041827T (en)
MX (1) MX365218B (en)
PH (1) PH12016500406A1 (en)
PL (2) PL3041827T3 (en)
PT (2) PT3363790T (en)
RS (2) RS60317B1 (en)
SG (1) SG11201601682RA (en)
SI (2) SI3363790T1 (en)
TR (1) TR201809838T4 (en)
WO (1) WO2015033299A1 (en)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2928474B1 (en) 2012-12-07 2018-11-14 ChemoCentryx, Inc. Diazole lactams
US9687059B2 (en) 2013-08-23 2017-06-27 Preemadonna Inc. Nail decorating apparatus
PT3041828T (en) * 2013-09-06 2018-10-09 Aurigene Discovery Tech Ltd 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as immunomodulators
PT3363790T (en) 2013-09-06 2020-05-06 Aurigene Discovery Tech Ltd 1,2,4-oxadiazole derivatives as immunomodulators
KR20170123317A (en) * 2015-03-10 2017-11-07 오리진 디스커버리 테크놀로지스 리미티드 3-substituted -1,2,4-oxadiazoles and thiadiazole compounds as immunomodulators
SG11201706908PA (en) * 2015-03-10 2017-09-28 Aurigene Discovery Tech Ltd 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
WO2017046747A1 (en) 2015-09-15 2017-03-23 Acerta Pharma B.V. Therapeutic combinations of a cd19 inhibitor and a btk inhibitor
CR20180323A (en) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd DERIVATIVES OF INDOL N-SUBSTITUTES AS MODULATORS OF PGE2 RECEIVERS
DK3402503T3 (en) 2016-01-13 2020-12-21 Acerta Pharma Bv THERAPEUTIC COMBINATIONS OF AN ANTIFOLATE AND A BTK INHIBITOR
SG11201808626WA (en) 2016-04-07 2018-10-30 Chemocentryx Inc Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors
TW201808902A (en) * 2016-05-26 2018-03-16 美商英塞特公司 Heterocyclic compounds as immunomodulators
EP3474845A4 (en) 2016-06-27 2020-02-26 ChemoCentryx, Inc. Immunomodulator compounds
CA3029857A1 (en) 2016-07-05 2018-01-11 Guangzhou Maxinovel Pharmaceuticals Co., Ltd. Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof
EP3484866A1 (en) * 2016-07-14 2019-05-22 Incyte Corporation Heterocyclic compounds as immunomodulators
JP6655754B2 (en) 2016-07-28 2020-02-26 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Piperidine CXCR7 receptor modulator
WO2018047139A1 (en) * 2016-09-12 2018-03-15 Aurigene Discovery Technologies Limited Compounds as modulators of tigit signalling pathway
WO2018051254A1 (en) * 2016-09-14 2018-03-22 Aurigene Discovery Technologies Limited Cyclic substituted-1,2,4-oxadiazole compounds as immunomodulators
US20200016177A1 (en) 2016-09-22 2020-01-16 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for reprograming immune environment in a subject in need thereof
JP6811857B2 (en) 2016-10-14 2021-01-13 プレシジョン バイオサイエンシズ，インク． Genetically engineered meganuclease specific for the recognition sequence of the hepatitis B virus genome
CN110139856A (en) * 2016-10-20 2019-08-16 奥列基因发现技术有限公司 The double inhibitor of VISTA and PD-1 access
TW201831690A (en) 2016-10-31 2018-09-01 美商艾歐凡斯生物治療公司 Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
CA3045759A1 (en) * 2016-12-02 2018-06-07 Augusta University Research Institute, Inc. Compositions for modulating pd-1 signal transduction
AU2017382870A1 (en) 2016-12-22 2019-07-04 Incyte Corporation Benzooxazole derivatives as immunomodulators
CN110267953A (en) 2016-12-22 2019-09-20 因赛特公司 Imidazolidine simultaneously [4,5-C] pyridine derivate as PD-L1 internalization inducer
EP3558989A1 (en) 2016-12-22 2019-10-30 Incyte Corporation Triazolo[1,5-a]pyridine derivatives as immunomodulators
CN108395443A (en) * 2017-02-04 2018-08-14 广州丹康医药生物有限公司 Inhibit the cyclic compound and application thereof of programmed death receptors ligand 1
WO2018196768A1 (en) * 2017-04-26 2018-11-01 南京圣和药业股份有限公司 Heterocyclic compound serving as pd-l1 inhibitor
CN110621671A (en) 2017-05-18 2019-12-27 爱杜西亚药品有限公司 Benzofuran and benzothiophene derivatives as PGE2 receptor modulators
US20200179383A1 (en) 2017-05-18 2020-06-11 Idorsia Pharmaceuticals Ltd Phenyl derivatives as pge2 receptor modulators
CA3060394A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as pge2 receptor modulators
MX2019013639A (en) 2017-05-18 2020-01-21 Idorsia Pharmaceuticals Ltd N-substituted indole derivatives.
CN110621667A (en) 2017-05-18 2019-12-27 爱杜西亚药品有限公司 Pyrimidine derivatives
EP3658173A1 (en) 2017-07-25 2020-06-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for modulating monocytopoiesis
AU2018313744A1 (en) 2017-08-08 2020-02-20 Chemocentryx, Inc. Macrocyclic immunomodulators
WO2019034725A1 (en) 2017-08-17 2019-02-21 Idorsia Pharmaceuticals Ltd Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
WO2019061324A1 (en) * 2017-09-29 2019-04-04 Curis Inc. Crystal forms of immunomodulators
KR20200068659A (en) 2017-10-11 2020-06-15 오리진 디스커버리 테크놀로지스 리미티드 Crystalline form of 3-substituted 1,2,4-oxadiazole
EA202090746A1 (en) * 2017-11-03 2020-08-17 Ориджен Дискавери Текнолоджис Лимитед DOUBLE TIM-3 AND PD-1 PATH INHIBITORS
CA3077664A1 (en) 2017-11-06 2019-05-09 Genentech, Inc. Diagnostic and therapeutic methods for cancer
CN111386128A (en) 2017-11-06 2020-07-07 奥瑞基尼探索技术有限公司 Combination therapy for immunomodulation
CN109988144A (en) 2017-12-29 2019-07-09 广州再极医药科技有限公司 Aromatic ethylene or fragrant ethyl analog derivative, preparation method, intermediate, pharmaceutical composition and application
SG11202006490YA (en) 2018-01-10 2020-08-28 Idorsia Pharmaceuticals Ltd 2,4,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-5-one derivatives and related compounds as c5a receptor modulators for treating vasculitis and inflammatory diseases
AU2019206438A1 (en) * 2018-01-12 2020-07-02 Aurigene Discovery Technologies Limited 1,2,4-oxadiazole compounds as inhibitors of CD47 signalling pathways
EP3740493A1 (en) 2018-01-15 2020-11-25 Idorsia Pharmaceuticals Ltd Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
EP3740476A1 (en) 2018-01-19 2020-11-25 Idorsia Pharmaceuticals Ltd C5a receptor modulators
CA3087784A1 (en) 2018-01-19 2019-07-25 Idorsia Pharmaceuticals Ltd C5a receptor modulators
AU2019212888A1 (en) 2018-01-26 2020-09-10 Idorsia Pharmaceuticals Ltd Crystalline forms of the CXCR7 receptor antagonist (3s,4s)-1-Cyclopropylmethyl-4-{(5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl)-amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide
CN111712494A (en) 2018-02-13 2020-09-25 吉利德科学公司 PD-1/PD-L1 inhibitors
EP3755311A2 (en) 2018-02-22 2020-12-30 ChemoCentryx, Inc. Indane-amines as pd-l1 antagonists
CA3091142A1 (en) 2018-02-26 2019-08-29 Gilead Sciences, Inc. Substituted pyrrolizine compounds as hbv replication inhibitors
WO2019175113A1 (en) 2018-03-12 2019-09-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of caloric restriction mimetics for potentiating chemo-immunotherapy for the treatment of cancers
EP3768259A2 (en) * 2018-03-14 2021-01-27 Aurigene Discovery Technologies Limited Method of modulating tigit and pd-1 signalling pathways using 1,2,4-oxadiazole compounds
CN112135824A (en) 2018-03-30 2020-12-25 因赛特公司 Heterocyclic compounds as immunomodulators
US10870691B2 (en) 2018-04-05 2020-12-22 Gilead Sciences, Inc. Antibodies and fragments thereof that bind hepatitis B virus protein X
TW202010503A (en) 2018-04-06 2020-03-16 捷克科學院有機化學與生物化學研究所 3’3’－cyclic dinucleotides
TW202005654A (en) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 2'2'-cyclic dinucleotides
TW202005655A (en) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 2'3'-cyclic dinucleotides
US20190338263A1 (en) 2018-04-12 2019-11-07 Precision Biosciences, Inc. Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome
KR20200145834A (en) 2018-04-19 2020-12-30 길리애드 사이언시즈, 인코포레이티드 PD-1/PD-L1 inhibitor
US20190359645A1 (en) 2018-05-03 2019-11-28 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3'-cyclic dinucleotides comprising carbocyclic nucleotide
AU2019267824A1 (en) 2018-05-11 2021-01-07 Incyte Corporation Tetrahydro-imidazo(4,5-C)pyridine derivatives as PD-L1 immunomodulators
CA3103017A1 (en) 2018-06-23 2019-12-26 Genentech, Inc. Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor
TW202019911A (en) 2018-07-13 2020-06-01 美商基利科學股份有限公司 Pd-1/pd-l1 inhibitors
US20200171146A1 (en) 2018-07-18 2020-06-04 Genentech, Inc. Methods of treating lung cancer with a pd-1 axis binding antagonist, an antimetabolite, and a platinum agent
WO2020028097A1 (en) 2018-08-01 2020-02-06 Gilead Sciences, Inc. Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid
TW202031273A (en) 2018-08-31 2020-09-01 美商艾歐凡斯生物治療公司 Treatment of nsclc patients refractory for anti-pd-1 antibody
TW202024023A (en) 2018-09-03 2020-07-01 瑞士商赫孚孟拉羅股份公司 Therapeutic compounds and methods of use
WO2020048942A1 (en) 2018-09-04 2020-03-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for enhancing cytotoxic t lymphocyte-dependent immune responses
WO2020058372A1 (en) 2018-09-19 2020-03-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for the treatment of cancers resistant to immune checkpoint therapy
TW202028457A (en) 2018-09-20 2020-08-01 美商艾歐凡斯生物治療公司 Expansion of tils from cryopreserved tumor samples
WO2020070053A1 (en) 2018-10-01 2020-04-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of inhibitors of stress granule formation for targeting the regulation of immune responses
TW202033522A (en) 2018-10-31 2020-09-16 美商基利科學股份有限公司 Substituted 6-azabenzimidazole compounds
TW202031654A (en) 2018-10-31 2020-09-01 美商基利科學股份有限公司 Substituted 6-azabenzimidazole compounds
WO2020109355A1 (en) 2018-11-28 2020-06-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kit for assaying lytic potential of immune effector cells
WO2020115262A1 (en) 2018-12-07 2020-06-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of cd26 and cd39 as new phenotypic markers for assessing maturation of foxp3+ t cells and uses thereof for diagnostic purposes
WO2020127059A1 (en) 2018-12-17 2020-06-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of sulconazole as a furin inhibitor
WO2020141199A1 (en) 2019-01-03 2020-07-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for enhancing cd8+ t cell-dependent immune responses in subjects suffering from cancer
WO2020150152A1 (en) 2019-01-14 2020-07-23 Genentech, Inc. Methods of treating cancer with a pd-1 axis binding antagonist and an rna vaccine
WO2020148338A1 (en) 2019-01-15 2020-07-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Mutated interleukin-34 (il-34) polypeptides and uses thereof in therapy
WO2020169472A2 (en) 2019-02-18 2020-08-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of inducing phenotypic changes in macrophages
WO2020178769A1 (en) 2019-03-07 2020-09-10 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3'-cyclic dinucleotides and prodrugs thereof
WO2020178768A1 (en) 2019-03-07 2020-09-10 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
WO2020178770A1 (en) 2019-03-07 2020-09-10 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3'-cyclic dinucleotides and prodrugs thereof
WO2020201362A2 (en) 2019-04-02 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
WO2020208060A1 (en) 2019-04-09 2020-10-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of sk2 inhibitors in combination with immune checkpoint blockade therapy for the treatment of cancer
WO2020214652A1 (en) 2019-04-17 2020-10-22 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
WO2020212484A1 (en) 2019-04-17 2020-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of nlrp3 inflammasome mediated il-1beta dependent disorders
US20200345738A1 (en) 2019-04-17 2020-11-05 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
WO2020214995A1 (en) 2019-04-19 2020-10-22 Genentech, Inc. Anti-mertk antibodies and their methods of use
WO2020225077A1 (en) 2019-05-03 2020-11-12 Idorsia Pharmaceuticals Ltd Pyrimido[4,5-b]indol derivatives as pdhk1 inhibitors
WO2020237025A1 (en) 2019-05-23 2020-11-26 Gilead Sciences, Inc. Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
WO2020239558A1 (en) 2019-05-24 2020-12-03 Pfizer Inc. Combination therapies using cdk inhibitors
WO2021005101A1 (en) 2019-07-09 2021-01-14 Idorsia Pharmaceuticals Ltd Pharmaceutical composition comprising a tetrahydropyrazolopyrimidinone compound
WO2021005222A1 (en) 2019-07-11 2021-01-14 Idorsia Pharmaceuticals Ltd Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3227725A (en) 1962-04-17 1966-01-04 Union Carbide Corp Certain 3,5-disubstituted 1,2,4-oxadiazole compounds
TW201311B (en) 1991-06-17 1993-03-01 Hoffmann La Roche
CA2143246C (en) 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
US6809107B1 (en) * 1999-07-09 2004-10-26 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic pyrrolidines and piperidines, and related compositions and methods
IL147972D0 (en) 1999-08-23 2002-09-12 Dana Farber Cancer Inst Inc Ge Pd-1, a receptor for b7-4 and uses therefor
NZ528265A (en) 2001-04-02 2005-10-28 Wyeth Corp Screening of compounds which modulate PD-1 signalling by testing for compounds that modulate phosphorylation of SHP-2, ERK1 or ERK-2, and PKC-theta
US7794710B2 (en) 2001-04-20 2010-09-14 Mayo Foundation For Medical Education And Research Methods of enhancing T cell responsiveness
WO2003042402A2 (en) 2001-11-13 2003-05-22 Dana-Farber Cancer Institute, Inc. Agents that modulate immune cell activation and methods of use thereof
GB0204159D0 (en) 2002-02-22 2002-04-10 British Biotech Pharm Metalloproteinase inhibitors
EP2243493A1 (en) 2002-07-03 2010-10-27 Ono Pharmaceutical Co., Ltd. Immunopotentiative composition
BR0316880A (en) 2002-12-23 2005-10-25 Wyeth Corp Pd-1 Antibodies and Uses
US7569578B2 (en) 2003-12-05 2009-08-04 Bristol-Meyers Squibb Company Heterocyclic anti-migraine agents
US7585881B2 (en) 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
EP1593671A1 (en) 2004-03-05 2005-11-09 Graffinity Pharmaceuticals AG DPP-IV inhibitors
WO2006067532A1 (en) 2004-12-24 2006-06-29 Prosidion Ltd G-protein coupled receptor agonists
PT2161336E (en) 2005-05-09 2013-10-03 Ono Pharmaceutical Co Human monoclonal antibodies to programmed death 1(pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
EP1888512A2 (en) 2005-06-06 2008-02-20 Smithkline Beecham Corporation Chemical compounds
EP1971602A4 (en) 2005-12-20 2009-11-11 Merck & Co Inc Niacin receptor agonists, compositions containing such compounds and methods of treatment
WO2008011557A2 (en) 2006-07-20 2008-01-24 Borchardt Allen J Heteroaryl inhibitors of rho kinase
ES2655338T3 (en) 2006-09-25 2018-02-19 Ptc Therapeutics, Inc. Method of preparing crystalline forms of 3- [5- (2-fluorophenyl) - [1,2,4] -oxadiazol-3-yl] -benzoic acid
AU2008266951B2 (en) 2007-06-18 2013-12-12 Merck Sharp & Dohme B.V. Antibodies to human programmed death receptor PD-1
CN101842095B (en) 2007-07-02 2015-06-24 于明 Methods, composition, targets for combinational cancer treatments
US7868001B2 (en) 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors
CN102083828B (en) 2008-02-22 2013-11-13 Irm责任有限公司 Heterocyclic compounds and compositions as C-KIT and PDGFR kinase inhibitors
US20110275673A1 (en) 2008-09-19 2011-11-10 Yibin Xiang Inhibitors of sphingosine kinase 1
WO2010051447A1 (en) 2008-10-30 2010-05-06 Elixir Pharmaceuticals, Inc. Sulfonamide containing compounds and uses thereof
KR20180089573A (en) 2008-12-09 2018-08-08 제넨테크, 인크. Anti-pd-l1 antibodies and their use to enhance t-cell function
CN102918058B (en) 2009-11-24 2015-05-20 米迪缪尼有限公司 Targeted binding agents against B7-H1
US20130022629A1 (en) 2010-01-04 2013-01-24 Sharpe Arlene H Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof
WO2011137587A1 (en) 2010-05-06 2011-11-10 Hutchison Medipharma Limited Cytokine inhibitors
US8907053B2 (en) * 2010-06-25 2014-12-09 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
WO2012129564A2 (en) 2011-03-24 2012-09-27 H. Lee Moffitt Cancer Center And Research Institute, Inc. Proteasome chymotrypsin-like inhibition using pi-1833 analogs
US9096642B2 (en) 2011-06-08 2015-08-04 Aurigene Discovery Technologies Limited Therapeutic compounds for immunomodulation
EP2822957A1 (en) 2012-03-07 2015-01-14 Aurigene Discovery Technologies Limited Peptidomimetic compounds as immunomodulators
KR20140142736A (en) 2012-03-29 2014-12-12 오리진 디스커버리 테크놀로지스 리미티드 Immunomodulating cyclic compounds from the bc loop of human pd1
CN104994873B (en) 2012-10-04 2017-12-22 达纳－法伯癌症研究所公司 The anti-PD L1 antibody of human monoclonal and application method
JP6401704B2 (en) 2012-10-10 2018-10-10 サンガモ セラピューティクス， インコーポレイテッド Compounds that modify T cells and uses thereof
AR093984A1 (en) 2012-12-21 2015-07-01 Merck Sharp & Dohme ANTIBODIES THAT JOIN LEGEND 1 OF SCHEDULED DEATH (PD-L1) HUMAN
ES2614053T3 (en) 2013-01-09 2017-05-29 Gilead Sciences, Inc. 5-member heteroaryls and their use as antivirals
US9434719B2 (en) 2013-03-14 2016-09-06 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
WO2014147586A1 (en) 2013-03-22 2014-09-25 Novartis Ag 1-(2-(ethylamino)pyrimidin-4-yl)pyrrolidin-2-ones as inhibitors of mutant idh
PT3363790T (en) 2013-09-06 2020-05-06 Aurigene Discovery Tech Ltd 1,2,4-oxadiazole derivatives as immunomodulators
PT3041828T (en) 2013-09-06 2018-10-09 Aurigene Discovery Tech Ltd 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as immunomodulators
CN107090041B (en) 2013-09-13 2018-11-16 百济神州有限公司 Anti- PD1 antibody and its purposes as therapeutic agent and diagnosticum
WO2016073470A1 (en) 2014-11-04 2016-05-12 The University Of Kansas Lkb1-ampk activators for therapeutic use in polycystic kidney disease
SG11201706908PA (en) 2015-03-10 2017-09-28 Aurigene Discovery Tech Ltd 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators

Also Published As

Publication number Publication date
US9771338B2 (en) 2017-09-26
CA2922607A1 (en) 2015-03-12
SI3041827T1 (en) 2018-09-28
LT3041827T (en) 2018-07-25
US20170101386A1 (en) 2017-04-13
RS57508B1 (en) 2018-10-31
MX365218B (en) 2019-05-27
HRP20181052T1 (en) 2018-09-07
IL268035A (en) 2020-04-30
PT3363790T (en) 2020-05-06
PT3041827T (en) 2018-07-09
SG11201601682RA (en) 2016-04-28
US20190144402A1 (en) 2019-05-16
DK3041827T3 (en) 2018-07-16
MX2016002969A (en) 2016-10-07
US20150073042A1 (en) 2015-03-12
PH12016500406A1 (en) 2016-05-16
IL253651A (en) 2019-07-31
CN105814028A (en) 2016-07-27
KR20160081897A (en) 2016-07-08
PL3041827T3 (en) 2018-09-28
PH12016500406B1 (en) 2016-05-16
IL268035D0 (en) 2019-09-26
DK3363790T3 (en) 2020-04-27
WO2015033299A1 (en) 2015-03-12
RS60317B1 (en) 2020-07-31
CY1120899T1 (en) 2019-12-11
US10590093B2 (en) 2020-03-17
ES2675027T3 (en) 2018-07-05
JP2016532710A (en) 2016-10-20
US20200199086A1 (en) 2020-06-25
EA201600236A1 (en) 2016-08-31
ES2788848T3 (en) 2020-10-23
US9233940B2 (en) 2016-01-12
CN108164474A (en) 2018-06-15
CU20160029A7 (en) 2017-02-02
IL244314D0 (en) 2016-04-21
LT3363790T (en) 2020-05-11
HRP20200703T1 (en) 2020-09-04
AU2018271231A1 (en) 2018-12-13
US20180072689A1 (en) 2018-03-15
AU2020239615A1 (en) 2020-10-15
CU24362B1 (en) 2018-10-04
CN105814028B (en) 2018-02-16
EP3041827B1 (en) 2018-04-18
US20150073024A1 (en) 2015-03-12
EA030155B1 (en) 2018-06-29
TR201809838T4 (en) 2018-07-23
IL244314A (en) 2017-09-28
EP3363790A1 (en) 2018-08-22
AU2018271231B2 (en) 2020-06-25
SI3363790T1 (en) 2020-08-31
PL3363790T3 (en) 2020-07-27
AU2014316682A1 (en) 2016-04-28
JP6521977B2 (en) 2019-05-29
HUE038169T2 (en) 2018-09-28
EP3041827A1 (en) 2016-07-13
AU2014316682B2 (en) 2018-11-22
EP3363790B1 (en) 2020-02-19
HUE048874T2 (en) 2020-08-28
US10173989B2 (en) 2019-01-08
BR112016004889A2 (en) 2017-08-01

Similar Documents

Publication Publication Date Title
IL264409D0 (en) Bipyrazole derivatives as jak inhibitors
IL249518D0 (en) Trk-inhibiting compound
HK1223093A1 (en) Fungicidal compositions
HK1224312A1 (en) Novel compounds
IL240126D0 (en) Substituted5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones
HK1223366A1 (en) Compounds useful as immunomodulators
HK1222846A1 (en) Substituted benzylpyrazoles
HRP20181251T1 (en) 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as immunomodulators
HK1221717A1 (en) Substituted benzylpyrazoles
AP201508713A0 (en) Tetrahydropyrrolothiazine compounds
HK1215795A1 (en) Amatoxin derivatives
PL3065569T3 (en) Composition
GB201307577D0 (en) New compounds
GB201311888D0 (en) Novel compounds
HK1210609A1 (en) Fluoro-[1,3]oxazines as bace1 inhibitors bace1 -[13]
PL2978740T3 (en) Polyetheramines based on 1,3-dialcohols
GB201311910D0 (en) Novel Compounds
EP2889350A4 (en) Tacky-adhesive composition
HRP20181709T1 (en) Pyridinylimidazolones as herbicides
IL268035D0 (en) 1,2,4 oxadiazole derivatives as immunomodulators
GB201310542D0 (en) Compounds
EP2952278A4 (en) Drill
GB201309085D0 (en) Compounds
PL2996514T3 (en) Sliding arrangement
IL241355A (en) Pyrazole-amide compounds, compositions comprising same and uses yhereof

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed