IL248036A - Binder-drug conjugates (adcs) and their use - Google Patents

Binder-drug conjugates (adcs) and their use

Info

Publication number
IL248036A
IL248036A IL248036A IL24803616A IL248036A IL 248036 A IL248036 A IL 248036A IL 248036 A IL248036 A IL 248036A IL 24803616 A IL24803616 A IL 24803616A IL 248036 A IL248036 A IL 248036A
Authority
IL
Israel
Prior art keywords
adcs
binder
use
drug conjugates
conjugates
Prior art date
Application number
IL248036A
Other languages
Hebrew (he)
Original Assignee
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP11163470 priority Critical
Priority to EP11163472 priority
Priority to EP11163474 priority
Priority to EP11163467 priority
Priority to EP11168557 priority
Priority to EP11168556 priority
Priority to EP11168558 priority
Priority to EP11168559 priority
Priority to EP11193621 priority
Priority to EP11193609 priority
Priority to EP11193623 priority
Priority to EP11193618 priority
Priority to PCT/EP2012/057247 priority patent/WO2012143497A2/en
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of IL248036A publication Critical patent/IL248036A/en

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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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CA3027793A1 (en) 2012-10-26
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