IL246390D0 - Cortistatin analogues and syntheses and uses thereof - Google Patents

Cortistatin analogues and syntheses and uses thereof

Info

Publication number
IL246390D0
IL246390D0 IL246390A IL24639016A IL246390D0 IL 246390 D0 IL246390 D0 IL 246390D0 IL 246390 A IL246390 A IL 246390A IL 24639016 A IL24639016 A IL 24639016A IL 246390 D0 IL246390 D0 IL 246390D0
Authority
IL
Israel
Prior art keywords
syntheses
cortistatin analogues
cortistatin
analogues
Prior art date
Application number
IL246390A
Other languages
Hebrew (he)
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201361920674P priority Critical
Priority to US201461935240P priority
Priority to US201461993329P priority
Priority to PCT/US2014/072365 priority patent/WO2015100420A1/en
Application filed by Harvard College filed Critical Harvard College
Publication of IL246390D0 publication Critical patent/IL246390D0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
IL246390A 2013-12-24 2016-06-22 Cortistatin analogues and syntheses and uses thereof IL246390D0 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US201361920674P true 2013-12-24 2013-12-24
US201461935240P true 2014-02-03 2014-02-03
US201461993329P true 2014-05-15 2014-05-15
PCT/US2014/072365 WO2015100420A1 (en) 2013-12-24 2014-12-24 Cortistatin analogues and syntheses and uses thereof

Publications (1)

Publication Number Publication Date
IL246390D0 true IL246390D0 (en) 2016-08-31

Family

ID=52350382

Family Applications (1)

Application Number Title Priority Date Filing Date
IL246390A IL246390D0 (en) 2013-12-24 2016-06-22 Cortistatin analogues and syntheses and uses thereof

Country Status (28)

Country Link
US (3) US9994582B2 (en)
EP (2) EP3087080B1 (en)
JP (2) JP6494631B2 (en)
KR (1) KR20160101162A (en)
CN (2) CN110183461A (en)
AP (1) AP201609324A0 (en)
AU (2) AU2014369834B2 (en)
BR (1) BR112016014760A2 (en)
CA (1) CA2934819A1 (en)
CL (1) CL2016001631A1 (en)
CR (1) CR20160291A (en)
DO (1) DOP2016000158A (en)
EA (2) EA201891279A1 (en)
EC (1) ECSP16062174A (en)
ES (1) ES2709480T3 (en)
GT (1) GT201600135A (en)
IL (1) IL246390D0 (en)
MD (1) MD20160089A2 (en)
MX (1) MX361652B (en)
NI (1) NI201600089A (en)
PE (1) PE20161405A1 (en)
PH (1) PH12016501258A1 (en)
RU (1) RU2016126503A3 (en)
SG (2) SG11201605178WA (en)
SV (1) SV2016005234A (en)
TN (1) TN2016000240A1 (en)
WO (1) WO2015100420A1 (en)
ZA (1) ZA201603894B (en)

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EP3087080B1 (en) 2013-12-24 2018-11-28 President and Fellows of Harvard College Cortistatin analogues and syntheses and uses thereof
ES2735099T3 (en) 2014-02-03 2019-12-16 Vitae Pharmaceuticals Llc ROR-gamma dihydropyrrolopyridine inhibitors
EP3294298A4 (en) 2015-05-08 2018-10-17 President and Fellows of Harvard College Cortistatin analogues, syntheses, and uses thereof
JP2018516884A (en) * 2015-05-08 2018-06-28 プレジデント アンド フェローズ オブ ハーバード カレッジ Targeted selection of patients for treatment with cortisatin derivatives
EP3316889A4 (en) * 2015-07-01 2018-11-14 President and Fellows of Harvard College Cortistatin analogues and syntheses and uses thereof
DK3331876T3 (en) 2015-08-05 2021-01-11 Vitae Pharmaceuticals Llc MODULATORS OF ROR-GAMMA
EP3394038A4 (en) * 2015-12-23 2019-08-21 President and Fellows of Harvard College Targeted selection of patients for treatment with specific cortistatin derivatives
MX2018007804A (en) * 2015-12-23 2019-07-04 Harvard College Cortistatin analogs and uses thereof.
TW201734001A (en) 2016-01-29 2017-10-01 維它藥物公司 Modulators of ROR-gamma
MX2018009998A (en) * 2016-02-19 2018-12-10 Harvard College Cortistatin analogs.
US20190183881A1 (en) * 2016-08-03 2019-06-20 The Broad Institute, Inc. Use of cdk8 inhibitors to treat diseases of inflammation and autoimmunity
CN110234648A (en) 2017-01-30 2019-09-13 国立大学法人京都大学 The manufacturing method of new compound and regulatory T cells
CN107028956A (en) * 2017-03-06 2017-08-11 刘杰 A kind of pharmaceutical composition for treating menstrual period depression
SG11202000621VA (en) 2017-07-24 2020-02-27 Vitae Pharmaceuticals Llc Inhibitors of ror?
EP3691642A1 (en) 2017-10-02 2020-08-12 Boehringer Ingelheim International GmbH New [1,6]naphthyridine compounds and derivatives as cdk8/cdk19 inhibitors
WO2020160537A1 (en) * 2019-02-01 2020-08-06 University Of South Carolina Bicyclic pyridine compositions and methods of using the same for cancer therapy

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Also Published As

Publication number Publication date
BR112016014760A2 (en) 2017-12-12
EP3087080A1 (en) 2016-11-02
AU2014369834A1 (en) 2016-06-23
EA201691167A1 (en) 2016-11-30
RU2016126503A (en) 2018-01-30
MX361652B (en) 2018-12-13
CL2016001631A1 (en) 2017-02-24
SG11201605178WA (en) 2016-07-28
CN106103452A (en) 2016-11-09
US10273241B2 (en) 2019-04-30
ECSP16062174A (en) 2018-12-31
RU2016126503A3 (en) 2018-07-17
AU2019201888A1 (en) 2019-04-11
EP3087080B1 (en) 2018-11-28
ZA201603894B (en) 2018-08-29
MD20160089A2 (en) 2016-12-31
US20170029435A1 (en) 2017-02-02
CA2934819A1 (en) 2015-07-02
US20190185484A1 (en) 2019-06-20
PH12016501258A1 (en) 2016-08-15
US10508121B2 (en) 2019-12-17
US20180319814A1 (en) 2018-11-08
AP201609324A0 (en) 2016-07-31
GT201600135A (en) 2018-11-27
MX2016008436A (en) 2016-12-16
DOP2016000158A (en) 2016-10-16
SG10201808151RA (en) 2018-10-30
CN110183461A (en) 2019-08-30
CR20160291A (en) 2017-02-24
PE20161405A1 (en) 2017-01-18
JP2017509586A (en) 2017-04-06
AU2014369834B2 (en) 2018-12-20
KR20160101162A (en) 2016-08-24
JP2019108367A (en) 2019-07-04
EA201891279A1 (en) 2019-01-31
EA030907B1 (en) 2018-10-31
SV2016005234A (en) 2018-12-14
CN106103452B (en) 2019-05-21
EP3505521A1 (en) 2019-07-03
TN2016000240A1 (en) 2017-10-06
ES2709480T3 (en) 2019-04-16
NI201600089A (en) 2016-08-18
US9994582B2 (en) 2018-06-12
WO2015100420A1 (en) 2015-07-02
JP6494631B2 (en) 2019-04-03

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