IL244498D0 - Micromirs - Google Patents

Micromirs

Info

Publication number
IL244498D0
IL244498D0 IL244498A IL24449816A IL244498D0 IL 244498 D0 IL244498 D0 IL 244498D0 IL 244498 A IL244498 A IL 244498A IL 24449816 A IL24449816 A IL 24449816A IL 244498 D0 IL244498 D0 IL 244498D0
Authority
IL
Israel
Prior art keywords
micromirs
Prior art date
Application number
IL244498A
Other languages
Hebrew (he)
Original Assignee
Roche Innovation Ct Copenhagen As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US97749707P priority Critical
Priority to US97921707P priority
Priority to US2806208P priority
Priority to EP08104780 priority
Priority to PCT/DK2008/000344 priority patent/WO2009043353A2/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40526747&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL244498(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Innovation Ct Copenhagen As filed Critical Roche Innovation Ct Copenhagen As
Publication of IL244498D0 publication Critical patent/IL244498D0/en

Links

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111General methods applicable to biologically active non-coding nucleic acids
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/113Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • C12N2310/141MicroRNAs, miRNAs
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
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    • C12N2310/3222'-R Modification
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/323Chemical structure of the sugar modified ring structure
    • C12N2310/3231Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/33Chemical structure of the base
    • C12N2310/334Modified C
    • C12N2310/33415-Methylcytosine
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/34Spatial arrangement of the modifications
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
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    • C12N2310/30Chemical structure
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    • C12N2310/3513Protein; Peptide
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/352Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525MOE, methoxyethoxy
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/353Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533Halogen
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    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/31Combination therapy
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y02A50/46Medical treatment of waterborne diseases characterized by the agent
    • Y02A50/462The waterborne disease being caused by a virus
    • Y02A50/465The waterborne disease being caused by a virus the virus being the poliovirus, i.e. Poliomyelitis or Polio
IL244498A 2007-10-04 2016-03-08 Micromirs IL244498D0 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US97749707P true 2007-10-04 2007-10-04
US97921707P true 2007-10-11 2007-10-11
US2806208P true 2008-02-12 2008-02-12
EP08104780 2008-07-17
PCT/DK2008/000344 WO2009043353A2 (en) 2007-10-04 2008-10-03 Micromirs

Publications (1)

Publication Number Publication Date
IL244498D0 true IL244498D0 (en) 2016-04-21

Family

ID=40526747

Family Applications (2)

Application Number Title Priority Date Filing Date
IL204254A IL204254A (en) 2007-10-04 2010-03-02 Oligomers comprising locked nucleic acid units, pharmaceutical compositions comprising them and use of same
IL244498A IL244498D0 (en) 2007-10-04 2016-03-08 Micromirs

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL204254A IL204254A (en) 2007-10-04 2010-03-02 Oligomers comprising locked nucleic acid units, pharmaceutical compositions comprising them and use of same

Country Status (17)

Country Link
US (5) US8906871B2 (en)
EP (5) EP2623599B1 (en)
JP (2) JP6035010B2 (en)
KR (1) KR101889518B1 (en)
CN (1) CN101821391B (en)
AU (1) AU2008306327B2 (en)
CA (1) CA2701547C (en)
DK (2) DK2623599T3 (en)
EA (1) EA019939B1 (en)
ES (3) ES2406686T3 (en)
IL (2) IL204254A (en)
MX (1) MX2010003299A (en)
MY (1) MY156951A (en)
NZ (1) NZ583677A (en)
PL (1) PL2623598T3 (en)
WO (2) WO2009043353A2 (en)
ZA (1) ZA201002040B (en)

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2533701A1 (en) 2003-07-31 2005-02-17 Isis Pharmaceuticals, Inc. Oligomeric compounds and compositions for use in modulation of small non-coding rnas
CA2912903A1 (en) 2004-05-04 2005-11-17 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of mir-122 in hepatitis c virus infected subjects and cells
EP2487259B1 (en) 2006-01-05 2015-07-01 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
WO2007109236A2 (en) 2006-03-20 2007-09-27 The Ohio State University Research Foundation Microrna fingerprints during human megakaryocytopoiesis
SG10201406016SA (en) * 2006-04-03 2014-11-27 Stella Aps Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
JP5198430B2 (en) 2006-04-03 2013-05-15 サンタリス ファーマ アー/エスSantaris Pharma A/S Pharmaceutical composition comprising antimiRNA antisense oligonucleotide
WO2008061537A2 (en) * 2006-11-23 2008-05-29 Querdenker Aps Oligonucleotides for modulating target rna activity
US8697672B2 (en) * 2007-05-16 2014-04-15 California Institute Of Technology Microrna inhibition for the treatment of inflammation and myeloproliferative disorders
US8691965B2 (en) * 2007-06-14 2014-04-08 Mirx Therapeutics Aps Oligonucleotides for modulating target RNA activity
KR20100057022A (en) 2007-07-31 2010-05-28 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 Micro-rnas that control myosin expression and myofiber identity
EP2182969B1 (en) 2007-07-31 2016-11-16 The Board of Regents of The University of Texas System A micro-rna family that modulates fibrosis and uses thereof
US8465918B2 (en) 2007-08-03 2013-06-18 The Ohio State University Research Foundation Ultraconserved regions encoding ncRNAs
ES2406686T3 (en) * 2007-10-04 2013-06-07 Santaris Pharma A/S Micromirs
JP5535076B2 (en) 2007-10-29 2014-07-02 レグルス・セラピューティクス・インコーポレイテッドRegulus Therapeutics Inc. Targeted microRNA for treating liver cancer
JP5654352B2 (en) 2007-11-09 2015-01-14 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム Regulation of cardiomyocyte survival and cardiac repair by miR-15 family of microRNAs
WO2009091972A2 (en) * 2008-01-18 2009-07-23 Alnylam Pharmaceuticals, Inc. Chemically modified oligonucleotides and small molecules for use in reducing micro rna activity levels and uses thereof
WO2009108860A2 (en) * 2008-02-28 2009-09-03 The Ohio University Rasearch Foundation Microrna-based methods and compositions for the diagnosis, pronosis and treatment of prostate related disorders
JP5662166B2 (en) * 2008-02-28 2015-01-28 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションThe Ohio State University Research Foundation MicroRNA-based methods and compositions for diagnosis, prognosis and treatment of gastric cancer
WO2009109665A1 (en) * 2008-03-07 2009-09-11 Santaris Pharma A/S Pharmaceutical compositions for treatment of microrna related diseases
WO2009117418A2 (en) 2008-03-17 2009-09-24 The Board Of Regents Of The University Of Texas System Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration
WO2009124295A2 (en) * 2008-04-04 2009-10-08 Isis Pharmaceuticals, Inc. Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
WO2010012667A1 (en) 2008-08-01 2010-02-04 Santaris Pharma A/S Micro-rna mediated modulation of colony stimulating factors
US9068232B2 (en) * 2008-08-06 2015-06-30 Rosetta Genomics Ltd. Gene expression signature for classification of kidney tumors
WO2010033247A2 (en) * 2008-09-22 2010-03-25 Rxi Pharmaceuticals Corporation Reduced size self-delivering rnai compounds
EP2384197B1 (en) * 2008-12-31 2016-04-06 Roche Innovation Center Copenhagen A/S Use of lna apob antisense oligomers for the treatment of acute coronary syndromes
WO2010091204A1 (en) 2009-02-04 2010-08-12 Board Of Regents, The University Of Texas System Dual targeting of mir-208 and mir-499 in the treatment of cardiac disorders
JP5755569B2 (en) * 2009-02-25 2015-07-29 セファイド How to detect lung cancer
WO2010122538A1 (en) 2009-04-24 2010-10-28 Santaris Pharma A/S Pharmaceutical compositions for treatment of hcv patients that are non-responders to interferon
US8592388B2 (en) 2009-05-20 2013-11-26 Eth Zurich Targeting MicroRNAs for metabolic disorders
WO2010135714A2 (en) * 2009-05-22 2010-11-25 The Methodist Hospital Research Institute Methods for modulating adipocyte expression using microrna compositions
US20120148664A1 (en) * 2009-06-08 2012-06-14 Miragen Therapeutics Chemical modifications motifs for mirna inhibitors and mimetics
WO2011017089A1 (en) * 2009-07-27 2011-02-10 The Regents Of The University Of Colorado, A Body Corporate Mirna inhibition of six1 expression
WO2011016714A1 (en) * 2009-08-06 2011-02-10 Umc Utrecht Holding B.V. Means and methods for counteracting, delaying and/or preventing adverse energy metabolism switches in heart disease
WO2011021177A2 (en) 2009-08-19 2011-02-24 Rosetta Genomics Ltd. Compositions and methods for prognosis and treatment of prostate cancer
EP2476758A4 (en) * 2009-09-07 2013-04-03 Yoshiki Murakami Method for prediction of therapeutic effect on chronic hepatitis c
JP6143041B2 (en) * 2009-09-30 2017-06-07 公益財団法人ヒューマンサイエンス振興財団 Colon cancer test kit
US9364495B2 (en) 2009-10-20 2016-06-14 Roche Innovation Center Copenhagen A/S Oral delivery of therapeutically effective LNA oligonucleotides
JP2013510576A (en) * 2009-11-11 2013-03-28 サンフォード−バーンハム メディカル リサーチ インスティテュート Methods and compositions for generation and regulation of iPS cells
CN101798594A (en) * 2009-11-13 2010-08-11 北京命码生科科技有限公司 Marker, detection method, biological chip and test box for detecting milk quality
CN102803511A (en) 2009-11-23 2012-11-28 俄亥俄州立大学 Materials and methods useful for affecting tumor cell growth, migration and invasion
FR2953220B1 (en) * 2009-12-01 2012-11-23 Oreal Microarn signature of epidermic differentiation and uses
WO2011069100A2 (en) * 2009-12-04 2011-06-09 Duke University Microrna and use thereof in identification of b cell malignancies
US20110171323A1 (en) * 2010-01-09 2011-07-14 The Translational Genomics Research Institute Methods and kits to predict prognostic and therapeutic outcome in small cell lung cancer
US8841269B2 (en) * 2010-02-23 2014-09-23 Creighton University Polynucleotides for use in treating and diagnosing cancers
WO2011106104A2 (en) * 2010-02-26 2011-09-01 Memorial Sloan-Kettering Cancer Center Methods and compositions for the detection and treatment of cancer involving mirnas and mirna inhibitors and targets
US8906875B2 (en) 2010-03-12 2014-12-09 The Brigham And Women's Hospital, Inc. Methods of treating vascular inflammatory disorders
EP2865765B1 (en) * 2010-04-20 2016-08-17 Hummingbird Diagnostics GmbH Complex miRNA sets as novel biomarkers for an acute coronary syndrome
WO2011146937A1 (en) * 2010-05-21 2011-11-24 The Translational Genomics Research Institute Methods and kits useful in diagnosing nsclc
JP6109069B2 (en) * 2010-06-04 2017-04-05 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム Metabolic regulation by miR-378
WO2011163214A2 (en) * 2010-06-21 2011-12-29 Diogenix, Inc. Microrna profiles for evaluating multiple sclerosis
EP3369817A1 (en) 2010-07-06 2018-09-05 InteRNA Technologies B.V. Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma , or in diseases or conditions with activated braf pathway
CN102002494B (en) * 2010-07-08 2012-12-12 浙江理工大学 microRNA biomarker and application thereof
GB201012418D0 (en) 2010-07-23 2010-09-08 Santaris Pharma As Process
US8815826B2 (en) 2010-07-23 2014-08-26 Regulus Therapeutics, Inc. Targeting microRNAs for the treatment of fibrosis
EP2608812B1 (en) 2010-08-25 2018-08-15 The General Hospital Corporation Nucleic acids targeting mir-33 micrornas for regulating lipid metabolism
CN102399852A (en) * 2010-09-08 2012-04-04 上海市公共卫生临床中心 Blood plasma miRNA spectrum and detection kit used for predicting chronic hepatitis b curative effect of interferon
AU2011326032B2 (en) 2010-11-12 2016-10-06 The Ohio State University Research Foundation Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer
ES2633565T3 (en) 2010-11-12 2017-09-22 The General Hospital Corporation Non-coding RNAs associated with polycomb
US9920317B2 (en) 2010-11-12 2018-03-20 The General Hospital Corporation Polycomb-associated non-coding RNAs
EA201370139A1 (en) 2010-12-15 2013-10-30 Мираген Терапеутикс Micro-rna inhibitors containing closed nucleotides
EP2474617A1 (en) 2011-01-11 2012-07-11 InteRNA Technologies BV Mir for treating neo-angiogenesis
US9045749B2 (en) 2011-01-14 2015-06-02 The General Hospital Corporation Methods targeting miR-128 for regulating cholesterol/lipid metabolism
US20120244530A1 (en) * 2011-01-26 2012-09-27 Cepheid Methods of detecting lung cancer
CN102643811B (en) * 2011-02-18 2015-12-09 中国科学院上海药物研究所 The antisense oligonucleotide of people miR-1229 and application thereof
CN102643809B (en) * 2011-02-18 2016-01-20 中国科学院上海药物研究所 The antisense oligonucleotide of people miR-1274b and application thereof
CN102643813B (en) * 2011-02-18 2015-07-29 中国科学院上海药物研究所 The antisense oligonucleotide of people miR-504 and application thereof
CN102643814B (en) * 2011-02-18 2015-06-17 中国科学院上海药物研究所 Antisense oligonucleotide for human miR-431 and application thereof
CN102643806B (en) * 2011-02-18 2016-08-03 中国科学院上海药物研究所 The antisense oligonucleotide of people miR-1913 and application thereof
CN102643808B (en) * 2011-02-18 2016-01-20 中国科学院上海药物研究所 The antisense oligonucleotide of people miR-1539 and application thereof
CN102643810B (en) * 2011-02-18 2015-12-16 中国科学院上海药物研究所 The antisense oligonucleotide of people miR-299-5p and application thereof
EP2725902A4 (en) * 2011-04-06 2015-06-24 Univ Princeton Anti-viral combination therapy
WO2012145374A1 (en) 2011-04-19 2012-10-26 Regulus Therapeutics Inc. TARGETING miR-378 FAMILY MEMBERS FOR THE TREATMENT OF METABOLIC DISORDERS
TW201811812A (en) * 2011-04-25 2018-04-01 美商瑞格勒斯治療學公司 MicroRNA compounds and methods for modulating MIR-21 activity
WO2012149557A1 (en) * 2011-04-28 2012-11-01 New York University miR-33 INHIBITORS AND USES THEREOF TO DECREASE INFLAMMATION
KR101800243B1 (en) 2011-06-22 2017-12-20 (주)아모레퍼시픽 Composition for regulating expression of pigmentation-related genes containing microRNA
JP2014522814A (en) * 2011-06-23 2014-09-08 ステラ・アンパルトセルスカブStella Aps HCV combination therapy
US20140194491A1 (en) * 2011-06-24 2014-07-10 Syddansk Universitet Modulation of microrna-138 for the treatment of bone loss
EP2726610A1 (en) * 2011-06-30 2014-05-07 Stella ApS Hcv combination therapy
US20140213632A1 (en) * 2011-06-30 2014-07-31 Stella Aps HCV Combination Therapy
CN102851282B (en) * 2011-06-30 2014-10-08 上海市肿瘤研究所 MicroRNA markers for discriminating constitutional lung cancer tissue and paracancerous tissue
WO2013013165A2 (en) * 2011-07-21 2013-01-24 The Trustees Of The University Of Pennsylvania Use of lna compounds for therapeutic inhibition of mir-21 in systemic lupus erythematosus
JP5995849B2 (en) * 2011-08-29 2016-09-21 学校法人 新潟科学技術学園 新潟薬科大学 Heptamer-type small guide nucleic acid induces apoptosis of human leukemia cells
EP2755663A4 (en) * 2011-09-13 2015-10-07 Ottawa Hospital Res Inst Microrna inhibitors
AU2012308320C1 (en) 2011-09-14 2018-08-23 Translate Bio Ma, Inc. Multimeric oligonucleotide compounds
CA2850223A1 (en) 2011-10-06 2013-04-11 Eva Van Rooij Control of whole body energy homeostasis by microrna regulation
JP6234370B2 (en) 2011-10-11 2017-11-22 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. MicroRNAs in neurodegenerative disorders
CA2852066A1 (en) 2011-10-14 2013-04-18 The Ohio State University Methods and materials related to ovarian cancer
JP2014533099A (en) 2011-11-07 2014-12-11 ステラ・アンパルトセルスカブStella Aps Predictive method for checking the efficacy of microRNA-122 inhibitors in HCV + patients
WO2013068348A1 (en) 2011-11-07 2013-05-16 Santaris Pharma A/S Lna oligomers for improvement in hepatic function
WO2013082499A1 (en) * 2011-11-30 2013-06-06 Cedars-Sinai Medical Center Targeting micrornas mir-409-5p, mir-379 and mir-154* to treat prostate cancer bone metastasis and drug resistant lung cancer
US9745578B2 (en) 2011-11-30 2017-08-29 Cedars-Sinai Medical Center Targeting microRNA miR-409-3P to treat prostate cancer
JP2015501645A (en) * 2011-12-10 2015-01-19 オハイオ・ステイト・イノベーション・ファウンデーション MiRNAs and related compositions and methods useful for reducing tumor development and chemotherapy resistance in lung cancer
CN104619353A (en) 2011-12-13 2015-05-13 俄亥俄州国家创新基金会 Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
WO2013088338A1 (en) * 2011-12-15 2013-06-20 Oncostamen S.R.L. Micrornas and uses therof
US10519506B2 (en) * 2011-12-22 2019-12-31 Baylor Research Institute Identification of metastasis-specific miRNA and hypomethylation signatures in human colorectal cancer
JP2015511121A (en) 2012-01-20 2015-04-16 ジ・オハイオ・ステート・ユニバーシティ Breast cancer biomarker signature for invasiveness and prognosis
WO2013134403A1 (en) * 2012-03-06 2013-09-12 The Washington University Method of treating neurodegenerative diseases with microrna regulators
EP2841579B1 (en) * 2012-04-25 2018-10-10 Regulus Therapeutics Inc. Microrna compounds and methods for modulating mir-21 activity
WO2013170146A1 (en) 2012-05-10 2013-11-14 Uab Research Foundation Methods and compositions for modulating mir-204 activity
AU2013262699A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating ATP2A2 expression
US20150152410A1 (en) * 2012-05-16 2015-06-04 Rana Therapeutics, Inc. Compositions and methods for modulating mecp2 expression
WO2013173652A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics, Inc. Compositions and methods for modulating gene expression
US10059941B2 (en) 2012-05-16 2018-08-28 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
EP2850185A4 (en) 2012-05-16 2015-12-30 Rana Therapeutics Inc Compositions and methods for modulating utrn expression
EP2850188A4 (en) 2012-05-16 2016-01-20 Rana Therapeutics Inc Compositions and methods for modulating hemoglobin gene family expression
KR101928418B1 (en) 2012-06-21 2018-12-12 미라젠 세러퓨틱스 인코포레이티드 Oligonucleotide-Based Inhibitors Comprising Locked Nucleic Acid Motif
US9163235B2 (en) * 2012-06-21 2015-10-20 MiRagen Therapeutics, Inc. Inhibitors of the miR-15 family of micro-RNAs
JP6320382B2 (en) * 2012-08-13 2018-05-09 ザ ロックフェラー ユニヴァーシティ Melanoma treatment and diagnosis
CN103627704A (en) * 2012-08-30 2014-03-12 苏州博泰安生物科技有限公司 Prostatic cancer molecular marker miR-19a and applications thereof
JP2015529469A (en) 2012-09-14 2015-10-08 ラナ セラピューティクス インコーポレイテッド Multimeric oligonucleotide compounds
CA2885605A1 (en) 2012-10-09 2014-04-17 Regulus Therapeutics Inc. Methods for treatment of alport syndrome
WO2014059126A1 (en) * 2012-10-10 2014-04-17 Beth Israel Deaconess Medical Center, Inc. Biomarkers and treatments for heart failure
US9267139B2 (en) 2012-10-11 2016-02-23 Georgia Regents Research Institute, Inc. Compositions and methods for treating musculoskeletal diseases and disorders
US9944991B2 (en) 2012-11-02 2018-04-17 Dana-Farber Cancer Institute, Inc. Compositions and methods for diagnosis, prognosis and treatment of hematological malignancies
AU2014211406B2 (en) 2013-01-30 2019-07-18 Roche Innovation Center Copenhagen A/S LNA oligonucleotide carbohydrate conjugates
EA201592215A1 (en) 2013-06-27 2016-05-31 Рош Инновейшен Сентер Копенгаген А/С Antisminal oligomers and their conjugates aimed at proprotein convertasy subtilysine / kexin type 9 (pcsk9)
WO2014078749A1 (en) * 2012-11-15 2014-05-22 The Regents Of The University Of California Splice modulating oligonucleotides that inhibit cancer
WO2014118272A1 (en) 2013-01-30 2014-08-07 Santaris Pharma A/S Antimir-122 oligonucleotide carbohydrate conjugates
BR112015011112A2 (en) 2012-11-15 2018-11-06 Roche Innovation Ct Copenhagen As oligomeric compound, oligomer, pharmaceutical composition, use of the oligomeric compound, method of synthesis of an oligomeric compound and method of treating a disease.
WO2014075822A1 (en) 2012-11-16 2014-05-22 Siemens Aktiengesellschaft New diagnostic mirna markers for parkinson disease
EP2733219B1 (en) 2012-11-16 2017-09-20 Siemens Aktiengesellschaft Diagnostic miRNA markers for Alzheimer
EP2733220B1 (en) * 2012-11-16 2017-10-18 Siemens Aktiengesellschaft Novel miRNA as a diagnostic marker for Alzheimer's Disease
EP2943570B1 (en) 2013-01-14 2018-01-03 Pierfrancesco Tassone Inhibitors of mirnas 221 and 222 for anti-tumor activity in multiple myeloma
PL2759595T3 (en) * 2013-01-24 2017-09-29 Pierre Fabre Médicament S.A.S. Composition comprising an encapsulated antagomir
US20160145612A1 (en) * 2013-03-06 2016-05-26 Royal College Of Surgeons In Ireland Diagnosis and treatment of metabolic disorders
KR101465319B1 (en) * 2013-03-08 2014-11-28 서울대학교산학협력단 MicroRNA decay element and its use
CA2902623A1 (en) * 2013-03-15 2014-09-25 MiRagen Therapeutics, Inc. Locked nucleic acid inhibitor of mir-145 and uses thereof
US20140274780A1 (en) * 2013-03-15 2014-09-18 PSertain Technologies Methods of improving survival in cancer
EP2992096A1 (en) 2013-05-01 2016-03-09 Regulus Therapeutics Inc Compounds and methods for enhanced cellular uptake
EP2992095B1 (en) * 2013-05-01 2019-01-09 Regulus Therapeutics Inc. Microrna compounds and methods for modulating mir-122
CN103290010B (en) * 2013-05-16 2015-09-16 南京市妇幼保健院 The maternal serum relevant to fetal congenital heart disease/blood plasma miRNA mark mir-375 and application thereof
EP3007706A4 (en) * 2013-06-12 2017-05-17 New York University Anti-mir-27b and anti-mir-148a oligonucleotides as therapeutic tools for treating dyslipidemias and cardiovascular diseases
US9976140B2 (en) * 2013-06-14 2018-05-22 Joslin Diabetes Center, Inc. Microrna and uses in brown fat differentiation
EP3013958B1 (en) * 2013-06-25 2019-12-25 The United States of America, as represented by the Secretary, Department of Health and Human Services Glucan-encapsulated sirna for treating type 2 diabetes mellitus
EP3643320A1 (en) * 2013-07-08 2020-04-29 International Dehydrated Foods, Inc. Compositions prepared from poultry and methods of their use
CN104342439B (en) * 2013-07-23 2017-06-23 中国科学院遗传与发育生物学研究所 MiR 7 and its application
JP2016534035A (en) 2013-10-04 2016-11-04 ラナ セラピューティクス インコーポレイテッド Compositions and methods for treating amyotrophic lateral sclerosis
US9994846B2 (en) 2013-10-25 2018-06-12 Regulus Therapeutics Inc. MicroRNA compounds and methods for modulating miR-21 activity
US10392617B2 (en) * 2014-01-08 2019-08-27 Hadasit Medical Research Services And Development Ltd. miR-122* as an active micro-RNA, compositions comprising the same and uses thereof
CN104774914B (en) * 2014-01-09 2018-01-09 复旦大学附属儿科医院 The microRNA serum marks analyte detection and its application of Biliary atresia and silt courage type INFANT HEPATITIS SYNDROME
WO2015106164A1 (en) 2014-01-10 2015-07-16 Rgenix, Inc. Lxr agonists and uses thereof
CN104974987B (en) * 2014-04-04 2018-06-19 宁夏医科大学 Purposes of the small molecule RNA-1247-5p as novel tumor treatment molecular target
CN103937888B (en) * 2014-04-14 2016-08-17 上海交通大学 Differentiate screening and the application of the blood plasma microRNA mark of gastric cancer
CN103940998B (en) * 2014-05-04 2016-04-20 山东大学 The application of the early diagnosis marker that serum microRNA shifts as hepatocellular carcinoma
WO2015200697A1 (en) 2014-06-25 2015-12-30 The General Hospital Corporation Targeting human satellite ii (hsatii)
US10472626B2 (en) * 2014-07-31 2019-11-12 Agency For Science, Technology And Research Modified antimir-138 oligonucleotides
WO2016022536A2 (en) * 2014-08-04 2016-02-11 MiRagen Therapeutics, Inc. Inhibitors of myh7b and uses thereof
CA2953883A1 (en) 2014-08-07 2016-02-11 Regulus Therapeutics Inc. Targeting micrornas for metabolic disorders
WO2016077574A1 (en) * 2014-11-12 2016-05-19 The General Hospital Corporation INHIBITORS OF MICRORNAs miR-155, miR-103, miR-105 and miR-107 THAT REGULATE PRODUCTION OF ATRIAL NATRIURETIC PEPTIDE (ANP) AS THERAPEUTICS AND USES THEREOF
WO2017067970A1 (en) 2015-10-22 2017-04-27 Roche Innovation Center Copenhagen A/S In vitro toxicity screening assay
EP3221452A4 (en) * 2014-11-21 2018-11-21 Caris Science, Inc. Oligonucleotide probes and uses thereof
AU2015364508A1 (en) * 2014-12-18 2017-07-06 Alnylam Pharmaceuticals, Inc. ReversirTM compounds
EA201791644A1 (en) 2015-01-20 2018-01-31 Мираджен Терапьютикс, Инк. Mir-92 inhibitors and their application
US10487324B2 (en) 2015-02-25 2019-11-26 Washington University Methods to detect motor neuron disease comprising micro-RNAs
WO2016145008A2 (en) * 2015-03-09 2016-09-15 University Of Kentucky Research Foundation Mirna for treatment of breast cancer
WO2016160882A1 (en) * 2015-04-01 2016-10-06 Baylor Research Institute Methods for diagnosing and treating colorectal cancer using mirna549a
JP2018517704A (en) * 2015-06-05 2018-07-05 ミラゲン セラピューティクス, インコーポレイテッド MiR-155 inhibitor for treating amyotrophic lateral sclerosis (ALS)
RU2718534C2 (en) 2015-06-05 2020-04-08 Мираджен Терапьютикс, Инк. Mir-155 inhibitors for treatment of cutaneous t-cell lymphoma (ctcl)
EP3314250A4 (en) 2015-06-26 2018-12-05 Beth Israel Deaconess Medical Center, Inc. Cancer therapy targeting tetraspanin 33 (tspan33) in myeloid derived suppressor cells
KR20180039162A (en) 2015-08-20 2018-04-17 아소시아시온 센트로 데 인베스티가시온 코오페라티바 엔 비오시엔시아스-시스 비오구네 Methods and compositions for treating liver diseases and conditions
EP3341479B1 (en) 2015-08-24 2019-12-18 Roche Innovation Center Copenhagen A/S Lna-g process
US10577388B2 (en) 2015-10-02 2020-03-03 Roche Innovation Center Copenhagen A/S Oligonucleotide conjugation process
WO2017087708A1 (en) 2015-11-19 2017-05-26 The Brigham And Women's Hospital, Inc. Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
CN108779139A (en) 2016-03-18 2018-11-09 罗氏创新中心哥本哈根有限公司 The L-LNA- guanosine monomers of acyl group protection
WO2017192959A2 (en) * 2016-05-05 2017-11-09 The Research Foundation For The State University Of New York Therapeutically modulating apob and apoai
EP3254683A1 (en) 2016-06-06 2017-12-13 Medizinische Hochschule Hannover Medicament for the treatment of acute liver failure
US20200109451A1 (en) 2016-06-17 2020-04-09 Hoffmann-La Roche Inc. In vitro nephrotoxicity screening assay
JP2019527038A (en) 2016-06-17 2019-09-26 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft In vitro nephrotoxicity screening assay
AU2017370560A1 (en) * 2016-12-05 2019-06-06 Regulus Therapeutics Inc. Modified oligonucleotides for treatment of polycystic kidney disease
WO2018177825A1 (en) 2017-03-29 2018-10-04 Roche Innovation Center Copenhagen A/S Orthogonal protecting groups for the preparation of stereodefined phosphorothioate oligonucleotides
EP3601310A1 (en) 2017-03-29 2020-02-05 Roche Innovation Center Copenhagen A/S Unylinker rapid cleavage
WO2018195486A1 (en) 2017-04-21 2018-10-25 The Broad Institute, Inc. Targeted delivery to beta cells
US20200148714A1 (en) 2017-06-28 2020-05-14 Roche Innovation Center Copenhagen A/S Multiple coupling & oxidation method
KR101871920B1 (en) 2017-08-04 2018-07-02 (주)아모레퍼시픽 Composition containing microRNA
CN111226114A (en) 2017-10-13 2020-06-02 罗氏创新中心哥本哈根有限公司 Method for identifying improved variants of antisense oligonucleotides using a subset of sterically defined oligonucleotides
TW201934750A (en) 2017-12-22 2019-09-01 丹麥商羅氏創新中心哥本哈根有限公司 GAPMER oligonucleotides comprising a phosphorodithioate internucleoside linkage
WO2019122279A1 (en) 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorodithioate internucleoside linkage
WO2019122277A1 (en) 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Novel thiophosphoramidites
WO2019219723A1 (en) 2018-05-18 2019-11-21 F. Hoffmann-La Roche Ag Pharmaceutical compositions for treatment of microrna related diseases
WO2020025527A1 (en) 2018-07-31 2020-02-06 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
WO2020025563A1 (en) 2018-07-31 2020-02-06 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
WO2020038968A1 (en) 2018-08-23 2020-02-27 Roche Innovation Center Copenhagen A/S Microrna-134 biomarker
EP3620519A1 (en) 2018-09-04 2020-03-11 F. Hoffmann-La Roche AG Use of isolated milk extracellular vesicles for delivering oligonucleotides orally
WO2020051398A1 (en) * 2018-09-06 2020-03-12 Aptamir Therapeutics, Inc. Metabolic benefits of short mir-22 mirna antagomir therapies

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2806208A (en) 1951-09-29 1957-09-10 Columbia Broadcasting Syst Inc Vacuum tube voltmeter
US4914210A (en) 1987-10-02 1990-04-03 Cetus Corporation Oligonucleotide functionalizing reagents
US4962029A (en) 1987-10-02 1990-10-09 Cetus Corporation Covalent oligonucleotide-horseradish peroxidase conjugate
US4920115A (en) 1988-12-28 1990-04-24 Virginia Commonwealth University Method of lowering LDL cholesterol in blood
EP1383782A1 (en) 2001-03-26 2004-01-28 Lawrence Blatt Oligonucleotide mediated inhibition of hepatitis b virus and hepatitis c virus replication
JPH06311885A (en) 1992-08-25 1994-11-08 Mitsubishi Kasei Corp Anti-sense compound complementary with gene of hepatitis c virus
AU680435B2 (en) 1992-09-10 1997-07-31 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of hepatitis C virus-associated diseases
US6433159B1 (en) 1992-09-10 2002-08-13 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of Hepatitis C virus associated diseases
US6423489B1 (en) 1992-09-10 2002-07-23 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of Hepatitis C virus-associated diseases
EP0759979A4 (en) 1994-05-10 1999-10-20 Gen Hospital Corp Antisense inhibition of hepatitis c virus
US5919795A (en) 1995-06-07 1999-07-06 Pfizer Inc. Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and their use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion
IL129744D0 (en) 1996-11-27 2000-02-29 Pfizer Apo b-secretion/mtp inhibitory amides
HU0001395A3 (en) 1997-03-05 2001-09-28 Univ Washington Seattle Novel screening methods to identify agents that selectively inhibit hepatitis c virus replication
AU9063398A (en) 1997-09-12 1999-04-05 Exiqon A/S Oligonucleotide analogues
AU2507199A (en) * 1998-02-20 1999-09-06 Decoma International Corp. Mold clamp
CA2368135C (en) 1999-03-18 2010-06-08 Exiqon A/S Xylo-lna analogues
AT332909T (en) 1999-03-24 2006-08-15 Exiqon As Improved synthesis for 2.2.1.obicyclo nucleosides
KR100782896B1 (en) 1999-05-04 2007-12-06 엑시콘 에이/에스 L-Ribo-LNA analogues
US6617442B1 (en) 1999-09-30 2003-09-09 Isis Pharmaceuticals, Inc. Human Rnase H1 and oligonucleotide compositions thereof
IL148916D0 (en) 1999-10-04 2002-09-12 Exiqon As Design of high affinity rnase h recruiting oligonucleotide
IL139450D0 (en) 1999-11-10 2001-11-25 Pfizer Prod Inc Methods of administering apo b-secretion/mtp inhibitors
WO2002008875A2 (en) 2000-07-25 2002-01-31 Authentisure, Inc. Unified trust model providing secure identification, authentication and validation of physical products and entities, and processing, storage, and exchange of information
DE60119562T2 (en) 2000-10-04 2007-05-10 Santaris Pharma A/S Improved synthesis of purin-blocked nucleic acid analogue
AU2002250236A1 (en) * 2001-03-02 2002-09-19 Medimmune, Inc. Cd2 antagonists for treatment of autoimmune or inflammatory disease
GB2397062B (en) 2002-02-20 2005-06-15 Sirna Therapeutics Inc RNA interference mediated inhibition of hepatitis c virus (HCV) gene expression using short interfering nucleic acid (siNA)
WO2002094250A2 (en) 2001-05-18 2002-11-28 Cureon A/S Therapeutic uses of lna-modified oligonucleotides in infectious diseases
DK1409497T3 (en) 2001-07-12 2005-05-30 Santaris Pharma As Process for Preparation of LNA Phosphoramidites
US7407943B2 (en) 2001-08-01 2008-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein B expression
WO2003029459A2 (en) 2001-09-28 2003-04-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Micro-rna molecules
US7459461B2 (en) * 2001-10-19 2008-12-02 Ortho-Mcneil Pharmaceutical, Inc. Phosphonic acid compounds as inhibitors of serine proteases
EP1501848B1 (en) 2002-05-08 2007-08-08 Santaris Pharma A/S Synthesis of locked nucleic acid derivatives
CA2505801A1 (en) 2002-11-13 2004-05-27 Rosanne Crooke Antisense modulation of apolipoprotein b expression
EG25699A (en) * 2002-08-12 2012-05-22 Janssen Pharmaceutica Nv N-aryl piperidine substituted biphenylcarboxamides
US7183302B2 (en) * 2002-08-12 2007-02-27 Bristol-Myers Squibb Company Iminothiazolidinones as inhibitors of HCV replication
DK2284269T3 (en) 2002-11-18 2017-10-23 Roche Innovation Ct Copenhagen As Antisense design
US8124582B2 (en) 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
FR2848572B1 (en) * 2002-12-12 2005-12-09 Univ Joseph Fourier Inhibitor molecules of protein synthesis of hepatitis c virus and method for screening these inhibitory molecules
AU2004209598B2 (en) 2003-02-10 2009-08-06 Enzon Pharmaceuticals, Inc. Oligomeric compounds for the modulation of survivin expression
CA2515586A1 (en) 2003-02-10 2004-09-10 National Institute Of Advanced Industrial Science And Technology Regulation of gene expression by dna interference
US7087229B2 (en) 2003-05-30 2006-08-08 Enzon Pharmaceuticals, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
CA2533701A1 (en) 2003-07-31 2005-02-17 Isis Pharmaceuticals, Inc. Oligomeric compounds and compositions for use in modulation of small non-coding rnas
AU2004263124B2 (en) 2003-08-07 2009-01-15 Avi Biopharma, Inc. Sense antiviral compound and method for treating ssRNA viral infection
US20050142581A1 (en) 2003-09-04 2005-06-30 Griffey Richard H. Microrna as ligands and target molecules
EP1793674B1 (en) 2003-11-26 2018-05-30 University of Massachusetts Sequence-specific inhibtion of small rna function
SG149001A1 (en) 2003-12-09 2009-01-29 Janssen Pharmaceutica Nv N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b
KR20070006709A (en) 2003-12-23 2007-01-11 산타리스 팔마 에이/에스 Oligomeric compounds for the modulation of bcl-2
WO2005078139A2 (en) 2004-02-09 2005-08-25 Thomas Jefferson University DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES
US20050182005A1 (en) 2004-02-13 2005-08-18 Tuschl Thomas H. Anti-microRNA oligonucleotide molecules
AU2005214904B2 (en) 2004-02-13 2011-07-21 Rockefeller University Anti-microRNA oligonucleotide molecules
DE102004015101B4 (en) 2004-03-27 2012-04-26 Eastman Kodak Co. Method and sensor device for controlling an endless, seam-containing transport medium for a printing press
CA2562390C (en) 2004-04-07 2014-12-02 Exiqon A/S Novel methods for quantification of micrornas and small interfering rnas
US7365058B2 (en) * 2004-04-13 2008-04-29 The Rockefeller University MicroRNA and methods for inhibiting same
US7811759B2 (en) 2004-04-20 2010-10-12 Jian Han Method for detecting ncRNA
CA2912903A1 (en) 2004-05-04 2005-11-17 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of mir-122 in hepatitis c virus infected subjects and cells
CA2574088C (en) 2004-07-21 2013-09-17 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising a modified or non-natural nucleobase
US20080213891A1 (en) 2004-07-21 2008-09-04 Alnylam Pharmaceuticals, Inc. RNAi Agents Comprising Universal Nucleobases
FR2873694B1 (en) 2004-07-27 2006-12-08 Merck Sante Soc Par Actions Si New aza-indoles inhibitors of mtp and apob
EP1913011B1 (en) 2004-08-04 2016-11-02 Alnylam Pharmaceuticals Inc. Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase
EP2990410A1 (en) 2004-08-10 2016-03-02 Alnylam Pharmaceuticals Inc. Chemically modified oligonucleotides
ES2663810T3 (en) 2004-08-10 2018-04-17 Kastle Therapeutics, Llc Methods to modulate the levels of lipoproteins and cholesterol in humans
WO2006027776A1 (en) 2004-09-07 2006-03-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Agents, compositions and methods for treating pathologies in which regulating an ache-associated biological pathway is beneficial
NZ583290A (en) 2004-09-24 2011-05-27 Alnylam Pharmaceuticals Inc Rnai modulation of apob and uses thereof
PL2302055T3 (en) 2004-11-12 2015-02-27 Asuragen Inc Methods and compositions involving miRNA and miRNA inhibitor molecules
WO2006053430A1 (en) 2004-11-17 2006-05-26 Protiva Biotherapeutics, Inc. Sirna silencing of apolipoprotein b
US20060185027A1 (en) 2004-12-23 2006-08-17 David Bartel Systems and methods for identifying miRNA targets and for altering miRNA and target expression
US20070099196A1 (en) 2004-12-29 2007-05-03 Sakari Kauppinen Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mRNAs
US20070065840A1 (en) * 2005-03-23 2007-03-22 Irena Naguibneva Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAS and their target mRNAS
US8980915B2 (en) 2005-04-19 2015-03-17 Surface Logix, Inc. Inhibitors of microsomal triglyceride transfer protein and apo-B secretion
US20060265771A1 (en) 2005-05-17 2006-11-23 Lewis David L Monitoring microrna expression and function
EP1904111A4 (en) 2005-06-03 2009-08-19 Univ Johns Hopkins Compositions and methods for decreasing microrna expression for the treatment of neoplasia
US20070213292A1 (en) 2005-08-10 2007-09-13 The Rockefeller University Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
AU2006279906B2 (en) 2005-08-10 2012-05-10 Alnylam Pharmaceuticals, Inc. Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
EP2338992A3 (en) 2005-08-29 2011-10-12 Regulus Therapeutics, Inc Antisense compounds having enhanced anti-microRNA activity
AT494372T (en) 2005-08-29 2011-01-15 Regulus Therapeutics Inc Process for mir-122a modulation
WO2007031091A2 (en) 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
JP2009507499A (en) 2005-09-15 2009-02-26 サンタリス ファーマ アー/エスSantaris Pharma A/S RNA antagonist compounds for suppression of APO-B100 expression
AU2007211082B2 (en) 2006-01-27 2012-09-27 Isis Pharmaceuticals, Inc. Oligomeric compounds and compositions for the use in modulation of microRNAs
US8586554B2 (en) 2006-05-05 2013-11-19 Isis Pharmaceuticals, Inc. Compounds and methods for modulating expression of PTP1B
SG10201406016SA (en) 2006-04-03 2014-11-27 Stella Aps Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
JP5198430B2 (en) 2006-04-03 2013-05-15 サンタリス ファーマ アー/エスSantaris Pharma A/S Pharmaceutical composition comprising antimiRNA antisense oligonucleotide
CA2651453C (en) 2006-05-11 2014-10-14 Isis Pharmaceuticals, Inc. 5'-modified bicyclic nucleic acid analogs
US7694029B2 (en) 2006-08-02 2010-04-06 International Business Machines Corporation Detecting miscabling in a storage area network
US20080199961A1 (en) 2006-08-25 2008-08-21 Avi Biopharma, Inc. ANTISENSE COMPOSITION AND METHOD FOR INHIBITION OF miRNA BIOGENESIS
KR20090054438A (en) 2006-09-15 2009-05-29 엔존 파마슈티컬즈, 인코포레이티드 Polymeric conjugates containing positively-charged moieties
WO2008034122A2 (en) 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Hindered ester-based biodegradable linkers for oligonucleotide delivery
US8580756B2 (en) 2007-03-22 2013-11-12 Santaris Pharma A/S Short oligomer antagonist compounds for the modulation of target mRNA
EP2090665A2 (en) 2006-10-20 2009-08-19 Exiqon A/S Novel human microRNAs associated with cancer
WO2008057234A2 (en) 2006-10-24 2008-05-15 The Board Of Trustees Of The Leland Stanford Junior University Modulation of t cell signaling threshold and t cell sensitivity to antigens
US9398493B2 (en) 2006-10-30 2016-07-19 Nokia Technologies Oy Method, apparatus, and system providing operator controlled mobility for user equipment
WO2008061537A2 (en) * 2006-11-23 2008-05-29 Querdenker Aps Oligonucleotides for modulating target rna activity
WO2008074328A2 (en) 2006-12-21 2008-06-26 Exiqon A/S Microrna target site blocking oligos and uses thereof
WO2008124384A2 (en) 2007-04-03 2008-10-16 Aegerion Pharmaceuticals, Inc. Combinations of mtp inhibitors with cholesterol absorption inhibitors or interferon for treating hepatitis c
WO2008150729A2 (en) 2007-05-30 2008-12-11 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
EP2173760B2 (en) 2007-06-08 2015-11-04 Isis Pharmaceuticals, Inc. Carbocyclic bicyclic nucleic acid analogs
US8691965B2 (en) 2007-06-14 2014-04-08 Mirx Therapeutics Aps Oligonucleotides for modulating target RNA activity
US20090082297A1 (en) 2007-06-25 2009-03-26 Lioy Daniel T Compositions and Methods for Regulating Gene Expression
WO2009032083A1 (en) 2007-08-29 2009-03-12 President And Fellows Of Harvard College Methods of increasing gene expression through rna protection
ES2406686T3 (en) 2007-10-04 2013-06-07 Santaris Pharma A/S Micromirs
WO2009109665A1 (en) 2008-03-07 2009-09-11 Santaris Pharma A/S Pharmaceutical compositions for treatment of microrna related diseases
WO2010000665A1 (en) 2008-06-30 2010-01-07 Santaris Pharma A/S Antidote oligomers
WO2010013999A1 (en) 2008-08-01 2010-02-04 Twister B.V. Cyclonic separator with a volute outlet duct
WO2010012667A1 (en) 2008-08-01 2010-02-04 Santaris Pharma A/S Micro-rna mediated modulation of colony stimulating factors
WO2010122538A1 (en) * 2009-04-24 2010-10-28 Santaris Pharma A/S Pharmaceutical compositions for treatment of hcv patients that are non-responders to interferon
US8942209B2 (en) 2009-08-12 2015-01-27 Qualcomm Incorporated Systems and methods for supporting an enhanced serving cell change when moving among different cell types
US9364495B2 (en) 2009-10-20 2016-06-14 Roche Innovation Center Copenhagen A/S Oral delivery of therapeutically effective LNA oligonucleotides

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