IL240903D0 - Tetrahydropyrrolothiazine compounds - Google Patents

Tetrahydropyrrolothiazine compounds

Info

Publication number
IL240903D0
IL240903D0 IL240903A IL24090315A IL240903D0 IL 240903 D0 IL240903 D0 IL 240903D0 IL 240903 A IL240903 A IL 240903A IL 24090315 A IL24090315 A IL 24090315A IL 240903 D0 IL240903 D0 IL 240903D0
Authority
IL
Israel
Prior art keywords
tetrahydropyrrolothiazine compounds
tetrahydropyrrolothiazine
compounds
Prior art date
Application number
IL240903A
Other languages
Hebrew (he)
Other versions
IL240903A (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201361776819P priority Critical
Priority to PCT/US2014/020070 priority patent/WO2014143579A1/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL240903D0 publication Critical patent/IL240903D0/en
Publication of IL240903A publication Critical patent/IL240903A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
IL240903A 2013-03-12 2015-08-27 Tetrahydropyrrolothiazine compounds IL240903A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US201361776819P true 2013-03-12 2013-03-12
PCT/US2014/020070 WO2014143579A1 (en) 2013-03-12 2014-03-04 Tetrahydropyrrolothiazine compounds

Publications (2)

Publication Number Publication Date
IL240903D0 true IL240903D0 (en) 2015-10-29
IL240903A IL240903A (en) 2018-12-31

Family

ID=50382615

Family Applications (1)

Application Number Title Priority Date Filing Date
IL240903A IL240903A (en) 2013-03-12 2015-08-27 Tetrahydropyrrolothiazine compounds

Country Status (37)

Country Link
US (3) US8841293B1 (en)
EP (1) EP2970336B1 (en)
JP (1) JP6095844B2 (en)
KR (1) KR101688761B1 (en)
CN (1) CN105026404B (en)
AP (1) AP201508713A0 (en)
AR (1) AR094918A1 (en)
BR (1) BR112015018738A8 (en)
CA (1) CA2898500C (en)
CL (1) CL2015002529A1 (en)
CR (1) CR20150418A (en)
CY (1) CY1119585T1 (en)
DK (1) DK2970336T3 (en)
EA (1) EA026006B1 (en)
ES (1) ES2653421T3 (en)
HK (1) HK1212694A1 (en)
HR (1) HRP20171851T1 (en)
HU (1) HUE037487T2 (en)
IL (1) IL240903A (en)
JO (1) JO3317B1 (en)
LT (1) LT2970336T (en)
MA (1) MA38390A1 (en)
ME (1) ME02910B (en)
MX (1) MX2015012628A (en)
NO (1) NO3039297T3 (en)
NZ (1) NZ712207A (en)
PE (1) PE20151542A1 (en)
PH (1) PH12015502031B1 (en)
PL (1) PL2970336T3 (en)
PT (1) PT2970336T (en)
RS (1) RS56645B1 (en)
SG (1) SG11201507499XA (en)
SI (1) SI2970336T1 (en)
TN (1) TN2015000340A1 (en)
TW (1) TWI593692B (en)
UA (1) UA112941C2 (en)
WO (1) WO2014143579A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2912041T (en) 2012-10-26 2017-03-10 Eli Lilly And Company Tetrahydropyrrolothiazine derivatives as bace inhibitors
TW201622729A (en) 2014-03-14 2016-07-01 美國禮來大藥廠 Aminothiazine compounds
LT3122750T (en) 2014-03-26 2019-11-11 Hoffmann La Roche Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
TWI570127B (en) * 2014-09-15 2017-02-11 美國禮來大藥廠 Crystalline n-[3- [(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7- tetrahydropyrrolo [3,4-d] [ 1 ,3]thiazin-7a-yl] -4-fluoro-phenyl] -5 -methoxy- pyrazine-2-carboxamide, and use and pharmaceutical composition thereof
TWI599358B (en) 2014-09-16 2017-09-21 美國禮來大藥廠 Combination therapy
AR103406A1 (en) 2015-01-30 2017-05-10 Lilly Co Eli Tosylate salt
AR103680A1 (en) 2015-02-23 2017-05-24 Lilly Co Eli selective inhibitors BACE1
AR104241A1 (en) 2015-04-29 2017-07-05 Lilly Co Eli Thiazine derivatives as inhibitors selective tetrahydrofuro BACE1
TW201740954A (en) 2016-03-16 2017-12-01 美國禮來大藥廠 Combination therapy
TW201811363A (en) 2016-07-01 2018-04-01 美商美國禮來大藥廠 Anti-N3pGlu amyloid beta peptide antibodies and uses thereof
CA3047285A1 (en) 2016-12-15 2018-06-21 Amgen Inc. Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
AU2003219955A1 (en) * 2002-03-22 2003-10-13 Eli Lilly And Company Isoquinoline-3-carboxylic acid derivatives as excitatory amino acid receptor antagonists
BRPI0612072A2 (en) * 2005-06-14 2010-10-19 Schering Corp aspartyl protease inhibitors
EP2612854B1 (en) 2005-10-25 2015-04-29 Shionogi&Co., Ltd. Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors
EP2151435A4 (en) 2007-04-24 2011-09-14 Shionogi & Co Pharmaceutical composition for treatment of alzheimer's disease
DK2233474T3 (en) * 2008-01-18 2015-10-19 Eisai R&D Man Co Ltd Concentrated aminodihydrothiazinderivat
US8541427B2 (en) * 2008-04-22 2013-09-24 Merck, Sharp & Dohme, Corp. Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use
TWI431004B (en) * 2008-05-02 2014-03-21 Lilly Co Eli Bace inhibitors
EP2305672B1 (en) 2008-06-13 2019-03-27 Shionogi & Co., Ltd. SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING ß-SECRETASE-INHIBITING ACTIVITY
AU2009300836B2 (en) 2008-09-30 2014-02-27 Eisai R&D Management Co., Ltd. Novel fused aminodihydrothiazine derivative
AR077277A1 (en) 2009-07-09 2011-08-17 Lilly Co Eli Compounds bicyclo (1,3) thiazine-2-amine that comprises pharmaceutical formulation and its use for the manufacture of a medicament useful for the treatment of Alzheimer's disease
WO2011071109A1 (en) 2009-12-11 2011-06-16 塩野義製薬株式会社 Fused heterocyclic compound having amino group
GB201100181D0 (en) 2011-01-06 2011-02-23 Eisai Ltd Fused aminodihydrothiazine derivatives
GB201101140D0 (en) * 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
GB201101139D0 (en) 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
WO2012138590A1 (en) 2011-04-07 2012-10-11 Merck Sharp & Dohme Corp. Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
TW201302763A (en) 2011-05-24 2013-01-16 Squibb Bristol Myers Co Compounds for the reduction of beta-amyloid production
JO3143B1 (en) * 2012-04-03 2017-09-20 Lilly Co Eli Tetrahydropyrrolothiazine compounds

Also Published As

Publication number Publication date
CN105026404B (en) 2016-11-23
JP2016512252A (en) 2016-04-25
LT2970336T (en) 2018-01-10
CY1119585T1 (en) 2018-03-07
EA201591491A1 (en) 2016-01-29
AU2014228351A1 (en) 2015-09-17
TN2015000340A1 (en) 2017-01-03
EP2970336B1 (en) 2017-10-04
NZ712207A (en) 2019-09-27
EP2970336A1 (en) 2016-01-20
ME02910B (en) 2018-04-20
HK1212694A1 (en) 2016-06-17
AR094918A1 (en) 2015-09-09
ES2653421T3 (en) 2018-02-07
US20150157641A1 (en) 2015-06-11
PL2970336T3 (en) 2018-03-30
PH12015502031B1 (en) 2016-01-18
HRP20171851T1 (en) 2018-01-12
SG11201507499XA (en) 2015-10-29
JP6095844B2 (en) 2017-03-15
JO3317B1 (en) 2019-03-13
PE20151542A1 (en) 2015-10-28
BR112015018738A8 (en) 2018-01-23
US20140350245A1 (en) 2014-11-27
SI2970336T1 (en) 2017-11-30
TWI593692B (en) 2017-08-01
CA2898500A1 (en) 2014-09-18
TW201520217A (en) 2015-06-01
CL2015002529A1 (en) 2016-03-28
US20140275044A1 (en) 2014-09-18
BR112015018738A2 (en) 2017-07-18
NO3039297T3 (en) 2018-03-10
WO2014143579A1 (en) 2014-09-18
PT2970336T (en) 2017-12-21
HUE037487T2 (en) 2018-08-28
CA2898500C (en) 2017-11-14
EA026006B1 (en) 2017-02-28
US8841293B1 (en) 2014-09-23
UA112941C2 (en) 2016-11-10
CR20150418A (en) 2015-09-16
KR20150119070A (en) 2015-10-23
CN105026404A (en) 2015-11-04
PH12015502031A1 (en) 2016-01-18
RS56645B1 (en) 2018-03-30
KR101688761B1 (en) 2016-12-21
US8987254B2 (en) 2015-03-24
DK2970336T3 (en) 2017-11-13
IL240903A (en) 2018-12-31
MX2015012628A (en) 2016-07-07
MA38390A1 (en) 2018-08-31
AP201508713A0 (en) 2015-09-30

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