IL238408D0 - Aptamers and uses thereof - Google Patents

Aptamers and uses thereof

Info

Publication number
IL238408D0
IL238408D0 IL238408A IL23840815A IL238408D0 IL 238408 D0 IL238408 D0 IL 238408D0 IL 238408 A IL238408 A IL 238408A IL 23840815 A IL23840815 A IL 23840815A IL 238408 D0 IL238408 D0 IL 238408D0
Authority
IL
Israel
Prior art keywords
aptamers
uses
Prior art date
Application number
IL238408A
Other languages
Hebrew (he)
Other versions
IL238408A (en
Original Assignee
Caris Life Sciences Switzerland Holdings S A R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201261717566P priority Critical
Priority to US201261731419P priority
Priority to US201261735915P priority
Priority to US201361748437P priority
Priority to US201361749773P priority
Priority to US201361750331P priority
Priority to US201361754471P priority
Priority to US201361767131P priority
Priority to US201361769064P priority
Priority to US201361805365P priority
Priority to US201361808144P priority
Priority to US201361820419P priority
Priority to US201361826957P priority
Priority to US201361838762P priority
Priority to US201361843256P priority
Priority to US201361862809P priority
Priority to US201361863828P priority
Priority to US201361866014P priority
Priority to US201361867978P priority
Priority to US201361871107P priority
Priority to US201361874621P priority
Priority to PCT/IB2013/003092 priority patent/WO2014068408A2/en
Application filed by Caris Life Sciences Switzerland Holdings S A R L filed Critical Caris Life Sciences Switzerland Holdings S A R L
Publication of IL238408D0 publication Critical patent/IL238408D0/en
Publication of IL238408A publication Critical patent/IL238408A/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/344Position-specific modifications, e.g. on every purine, at the 3'-end
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/10Applications; Uses in screening processes
    • C12N2320/13Applications; Uses in screening processes in a process of directed evolution, e.g. SELEX, acquiring a new function
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/50Determining the risk of developing a disease
IL238408A 2012-10-23 2015-04-21 Method of detecting a microvesicle population in a biological sample IL238408A (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
US201261717566P true 2012-10-23 2012-10-23
US201261731419P true 2012-11-29 2012-11-29
US201261735915P true 2012-12-11 2012-12-11
US201361748437P true 2013-01-02 2013-01-02
US201361749773P true 2013-01-07 2013-01-07
US201361750331P true 2013-01-08 2013-01-08
US201361754471P true 2013-01-18 2013-01-18
US201361767131P true 2013-02-20 2013-02-20
US201361769064P true 2013-02-25 2013-02-25
US201361805365P true 2013-03-26 2013-03-26
US201361808144P true 2013-04-03 2013-04-03
US201361820419P true 2013-05-07 2013-05-07
US201361826957P true 2013-05-23 2013-05-23
US201361838762P true 2013-06-24 2013-06-24
US201361843256P true 2013-07-05 2013-07-05
US201361862809P true 2013-08-06 2013-08-06
US201361863828P true 2013-08-08 2013-08-08
US201361866014P true 2013-08-14 2013-08-14
US201361867978P true 2013-08-20 2013-08-20
US201361871107P true 2013-08-28 2013-08-28
US201361874621P true 2013-09-06 2013-09-06
PCT/IB2013/003092 WO2014068408A2 (en) 2012-10-23 2013-10-23 Aptamers and uses thereof

Publications (2)

Publication Number Publication Date
IL238408D0 true IL238408D0 (en) 2015-06-30
IL238408A IL238408A (en) 2019-09-26

Family

ID=50343809

Family Applications (2)

Application Number Title Priority Date Filing Date
IL238408A IL238408A (en) 2012-10-23 2015-04-21 Method of detecting a microvesicle population in a biological sample
IL26904519A IL269045D0 (en) 2012-10-23 2019-09-01 Aptamers and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL26904519A IL269045D0 (en) 2012-10-23 2019-09-01 Aptamers and uses thereof

Country Status (9)

Country Link
US (1) US9958448B2 (en)
EP (1) EP2912182A2 (en)
JP (2) JP6404822B2 (en)
KR (1) KR20150090072A (en)
CN (1) CN105452466A (en)
AU (2) AU2013340414B2 (en)
CA (1) CA2928520A1 (en)
IL (2) IL238408A (en)
WO (1) WO2014068408A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013340414B2 (en) 2012-10-23 2019-05-02 Caris Science, Inc. Aptamers and uses thereof
CA2895847C (en) 2012-12-19 2019-01-08 Caris Science, Inc. Compositions and methods for aptamer screening
US9909123B2 (en) * 2013-03-15 2018-03-06 Techulon Inc. Antisense molecules for treatment of Staphylococcus aureus infection
JP6128621B2 (en) * 2013-12-04 2017-05-17 国立研究開発法人産業技術総合研究所 Nucleic acid aptamers for microvesicles
US9605266B2 (en) 2014-07-16 2017-03-28 City Of Hope Cell-specific internalizing RNA aptamers against human CCR5 and uses therefore
US10385343B2 (en) 2014-08-29 2019-08-20 Children's Medical Center Corporation Methods and compositions for the treatment of cancer
EP3299816A4 (en) * 2015-05-20 2018-10-03 JSR Corporation Separation method, detection method, signal measurement method, disease determination method, drug efficacy assessment method, kit, liquid composition, and specimen diluent
US20180037892A1 (en) * 2015-02-11 2018-02-08 Deakin University Epcam aptamers and conjugates thereof
US20180073027A1 (en) * 2015-04-10 2018-03-15 The Methodist Hospital System CD117 Ligand-Drug Conjugates For Targeted Cancer Therapy
US10253314B2 (en) * 2015-04-13 2019-04-09 Research Foundation Of The City University Of New York Ligand-guided-selection method for screening antigen-specific ligands
WO2016201129A1 (en) * 2015-06-09 2016-12-15 President And Fellows Of Harvard College Compositions and methods for enrichment of cells
US20180171337A1 (en) * 2015-06-29 2018-06-21 Caris Science, Inc. Therapeutic oligonucleotides
CN106053853A (en) * 2015-11-29 2016-10-26 卢美珍 Kit for detecting human brain diseases
DE102016100039A1 (en) * 2016-01-04 2017-07-06 Universitätsklinikum Hamburg-Eppendorf (UKE) α6 integrin-binding DNA aptamer
EP3405575A4 (en) * 2016-01-20 2019-06-26 Vitrisa Therapeutics, Inc. Methods for improved aptamer selection
WO2017143150A1 (en) * 2016-02-19 2017-08-24 City Of Hope Bi-specific aptamer
JP2019205353A (en) * 2016-09-27 2019-12-05 Jsr株式会社 Nucleic acid analysis method
WO2018126043A1 (en) * 2016-12-30 2018-07-05 Arizona Board Of Regents On Behalf Of Arizona State University Nanoplasmonic quantification of tumor-derived extracellular vesicles in plasma microsamples
CN106636107B (en) * 2017-01-20 2018-07-31 江苏集萃药康生物科技有限公司 A kind of aptamer and kit of laryngeal cancer cell

Family Cites Families (226)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US794764A (en) 1905-02-13 1905-07-18 Peter M Wolf Pump-platform.
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4551435A (en) 1983-08-24 1985-11-05 Immunicon, Inc. Selective removal of immunospecifically recognizable substances from solution
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202B1 (en) 1985-03-28 1990-11-27 Cetus Corp
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US4925788A (en) 1986-10-24 1990-05-15 Immunicon Corporation Immunoassay system and procedure based on precipitin-like interaction between immune complex and Clq or other non-immunospecific factor
US5158871A (en) 1988-02-12 1992-10-27 University Of Connecticut Method of using magnetic particles for isolating, collecting and assaying diagnostic ligates
US5108933A (en) 1988-09-16 1992-04-28 Immunicon Corporation Manipulation of colloids for facilitating magnetic separations
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
SE470347B (en) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Microstructure fluid flow system and method for manufacturing such systems
US5756287A (en) 1990-06-11 1998-05-26 Nexstar Pharmaceuticals, Inc. High affinity HIV integrase inhibitors
US5789157A (en) 1990-06-11 1998-08-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue selex
US5864026A (en) 1990-06-11 1999-01-26 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue selex
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5650275A (en) 1990-06-11 1997-07-22 Nexstar Pharmacueticals Inc Target detection method using spectroscopically detectable nucleic acid ligands
US5712375A (en) 1990-06-11 1998-01-27 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue selex
US6716580B2 (en) 1990-06-11 2004-04-06 Somalogic, Inc. Method for the automated generation of nucleic acid ligands
AT274520T (en) 1995-05-03 2004-09-15 Gilead Sciences Inc Systematic evoultion of ligands through exponential enrichment: tissue selex
US6013443A (en) 1995-05-03 2000-01-11 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue SELEX
US5707796A (en) 1990-06-11 1998-01-13 Nexstar Pharmaceuticals, Inc. Method for selecting nucleic acids on the basis of structure
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US5763566A (en) 1990-06-11 1998-06-09 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue SELEX
US5853984A (en) 1990-06-11 1998-12-29 Nexstar Pharmaceuticals, Inc. Use of nucleic acid ligands in flow cytometry
ES2259188T3 (en) 1996-10-25 2006-09-16 Gilead Sciences, Inc. Nucleic acid binding complexes of vascular endotelial growth factor (vegf).
US5789163A (en) 1990-06-11 1998-08-04 Nexstar Pharmaceuticals, Inc. Enzyme linked oligonucleotide assays (ELONAS)
US6051698A (en) 1997-06-06 2000-04-18 Janjic; Nebojsa Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5580737A (en) 1990-06-11 1996-12-03 Nexstar Pharmaceuticals, Inc. High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
US6569620B1 (en) 1990-06-11 2003-05-27 Somalogic, Inc. Method for the automated generation of nucleic acid ligands
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5637459A (en) 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US6011020A (en) 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US5648214A (en) 1990-06-11 1997-07-15 University Research Corporation High-affinity oligonucleotide ligands to the tachykinin substance P
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5763177A (en) 1990-06-11 1998-06-09 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
AT160821T (en) 1990-06-11 1997-12-15 Nexstar Pharmaceuticals Inc Nucleic acid ligands
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US5817635A (en) 1993-08-09 1998-10-06 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Modified ribozymes
ES2061416T3 (en) 1990-10-12 1997-03-01 Max Planck Gesellschaft Modified ribozymes.
IE920151A1 (en) 1991-01-18 1992-07-29 Univ New York A novel expression-cloning method for identifying target¹proteins for receptor tyrosine kinases and novel human grb¹proteins
US5186827A (en) 1991-03-25 1993-02-16 Immunicon Corporation Apparatus for magnetic separation featuring external magnetic means
US6864048B2 (en) 1993-04-28 2005-03-08 Affymetrix, Inc. Factorial chemical libraries
US5736330A (en) 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
US6426335B1 (en) 1997-10-17 2002-07-30 Gilead Sciences, Inc. Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US5861254A (en) 1997-01-31 1999-01-19 Nexstar Pharmaceuticals, Inc. Flow cell SELEX
US6660714B1 (en) 1997-04-16 2003-12-09 Sloan Kettering Institute For Cancer Research α-O-linked glycoconjugates, methods of preparation and uses thereof
WO1999005255A1 (en) 1997-07-23 1999-02-04 Northeastern University Methods for enhancing or reducing preimplantation embryo survival rates
AU1080999A (en) 1997-10-14 1999-05-03 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same
US20070166741A1 (en) 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
US6242246B1 (en) 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US6719868B1 (en) 1998-03-23 2004-04-13 President And Fellows Of Harvard College Methods for fabricating microfluidic structures
US6180348B1 (en) 1998-04-20 2001-01-30 Weihua Li Method of isolating target specific oligonucleotide ligands
US6986902B1 (en) 1998-04-28 2006-01-17 Inex Pharmaceuticals Corporation Polyanionic polymers which enhance fusogenicity
US6287765B1 (en) 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US6423493B1 (en) 1998-10-26 2002-07-23 Board Of Regents The University Of Texas System Combinatorial selection of oligonucleotide aptamers
US8975026B2 (en) 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7855054B2 (en) 2007-01-16 2010-12-21 Somalogic, Inc. Multiplexed analyses of test samples
US6623526B1 (en) 1999-01-08 2003-09-23 Corin Limited Knee prosthesis
US6329145B1 (en) 1999-02-09 2001-12-11 Gilead Science, Inc. Determining non-nucleic acid molecule binding to target by competition with nucleic acid ligand
US6379698B1 (en) 1999-04-06 2002-04-30 Isis Pharmaceuticals, Inc. Fusogenic lipids and vesicles
US7074586B1 (en) 1999-06-17 2006-07-11 Source Precision Medicine, Inc. Quantitative assay for low abundance molecules
US6811668B1 (en) 1999-06-22 2004-11-02 Caliper Life Sciences, Inc. Apparatus for the operation of a microfluidic device
US6929030B2 (en) 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7144616B1 (en) 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
DE60031540T2 (en) 1999-06-28 2007-05-16 California Institute Of Technology, Pasadena Micromechanical pump and valve systems
US6899137B2 (en) 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US7195670B2 (en) 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
AUPQ147799A0 (en) 1999-07-07 1999-07-29 Medvet Science Pty. Ltd. Mesenchymal precursor cell
US6387620B1 (en) 1999-07-28 2002-05-14 Gilead Sciences, Inc. Transcription-free selex
US6506887B1 (en) 1999-07-29 2003-01-14 Somalogic, Incorporated Conditional-selex
US6790328B2 (en) 2000-01-12 2004-09-14 Ut-Battelle, Llc Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
US7452713B2 (en) 2000-02-29 2008-11-18 Stmicroelectronics S.R.L. Process for manufacturing a microfluidic device with buried channels
WO2001078087A2 (en) 2000-04-06 2001-10-18 Luminex Corporation Magnetically-responsive microspheres
US6645432B1 (en) 2000-05-25 2003-11-11 President & Fellows Of Harvard College Microfluidic systems including three-dimensionally arrayed channel networks
JP2004507731A (en) 2000-08-23 2004-03-11 イメゴ アーベー Microfluidic device and method for capturing a sample in a recess with a lid that can be opened and closed
US20020048534A1 (en) 2000-08-24 2002-04-25 David Storek Sample preparing arrangement and a method relating to such an arrangement
JP2004527220A (en) 2000-09-13 2004-09-09 アルケミックス コーポレイション Target activated nucleic acid biosensor and method of using same
US6376190B1 (en) 2000-09-22 2002-04-23 Somalogic, Inc. Modified SELEX processes without purified protein
US7312325B2 (en) 2000-09-26 2007-12-25 Duke University RNA aptamers and methods for identifying the same
KR20040036676A (en) 2000-10-27 2004-04-30 리서치 디벨럽먼트 파운데이션 In vitro selection of signaling aptamers
US7083958B2 (en) 2000-11-20 2006-08-01 The Board Of Trustees Of The University Of Illinois Membrane scaffold proteins
EP1340094A2 (en) 2000-12-01 2003-09-03 Protasis Corporation Microfluidic device with multiple microcoil nmr detectors
US7467928B2 (en) 2002-12-12 2008-12-23 Board Of Trustees Of The University Of Arkansas Microfluidic device utilizing magnetohydrodynamics and method for fabrication thereof
DE10109898A1 (en) 2001-02-21 2002-09-05 Novosom Gmbh Lipids variable charge
US7858117B2 (en) 2002-02-21 2010-12-28 Novosom Ag Amphoteric liposomes and their use
DE10109897A1 (en) 2001-02-21 2002-11-07 Novosom Ag Optional cationic liposomes and the use of this
US7189368B2 (en) 2001-09-17 2007-03-13 Gyros Patent Ab Functional unit enabling controlled flow in a microfluidic device
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US6802342B2 (en) 2001-04-06 2004-10-12 Fluidigm Corporation Microfabricated fluidic circuit elements and applications
AU2002314957A1 (en) 2001-06-06 2002-12-16 Proteologics, Inc. Methods and compositions related to tagging of membrane surface proteins
US7390463B2 (en) 2001-09-07 2008-06-24 Corning Incorporated Microcolumn-based, high-throughput microfluidic device
CA2463693C (en) 2001-10-16 2012-08-28 Kiwi Ingenuity Limited Sensitivity controls for blood serology prepared from modified cells
US7253003B2 (en) 2001-10-19 2007-08-07 Wisconsin Alumni Research Foundation Method for monitoring the environment within a microfluidic device
US7189580B2 (en) 2001-10-19 2007-03-13 Wisconsin Alumni Research Foundation Method of pumping fluid through a microfluidic device
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US7118910B2 (en) 2001-11-30 2006-10-10 Fluidigm Corporation Microfluidic device and methods of using same
US7258837B2 (en) 2001-12-05 2007-08-21 University Of Washington Microfluidic device and surface decoration process for solid phase affinity binding assays
US7238255B2 (en) 2001-12-31 2007-07-03 Gyros Patent Ab Microfluidic device and its manufacture
JP2005517456A (en) 2002-02-15 2005-06-16 ソマロジック・インコーポレーテッドSomaLogic, Inc. Methods and reagents for detecting target binding by nucleic acid ligands
US6958119B2 (en) 2002-02-26 2005-10-25 Agilent Technologies, Inc. Mobile phase gradient generation microfluidic device
US20030219801A1 (en) 2002-03-06 2003-11-27 Affymetrix, Inc. Aptamer base technique for ligand identification
US7195986B1 (en) 2002-03-08 2007-03-27 Caliper Life Sciences, Inc. Microfluidic device with controlled substrate conductivity
NZ518163A (en) 2002-04-05 2005-04-29 Kiwi Ingenuity Ltd Embryo modified with a glycolipid to enhance implantation into the endometrium
WO2003087842A1 (en) 2002-04-18 2003-10-23 Esbatech Ag Method for the identification of modulators of a secretase activity
GB2388189B (en) 2002-04-29 2006-01-11 Robert Jeffrey Geddes Carr Optical detection and analysis of particles
US7189581B2 (en) 2002-04-30 2007-03-13 Wisconsin Alumni Research Foundation Method of obtaining a sample concentration of a solution in a microfluidic device
EP1997772A3 (en) 2002-05-16 2011-01-26 Micronit Microfluidics B.V. Method of fabrication of a microfluidic device
US7288368B2 (en) 2002-06-17 2007-10-30 Stephen Eliot Zweig Membrane receptor reagent and assay
AU2003251935A1 (en) 2002-07-15 2004-02-02 James Madison University Hybrid polymers for functional tuning of microfluidic device surfaces
AU2003256806A1 (en) 2002-07-24 2004-02-09 Ciphergen Biosystems, Inc. Protein interaction difference mapping
US7452509B2 (en) 2002-07-26 2008-11-18 Applied Biosystems Inc. Microfluidic device including displaceable material trap, and system
US7201881B2 (en) 2002-07-26 2007-04-10 Applera Corporation Actuator for deformable valves in a microfluidic device, and method
US7135147B2 (en) 2002-07-26 2006-11-14 Applera Corporation Closing blade for deformable valve in a microfluidic device and method
KR100480338B1 (en) 2002-08-08 2005-03-30 한국전자통신연구원 Microfluidic devices for the controlled movements of solution
TW536524B (en) 2002-09-17 2003-06-11 Fan-Gen Tzeng Network-type micro-channel device for micro-fluid
US7118661B2 (en) 2002-09-30 2006-10-10 The Regents Of The University Of California Nanolaminate microfluidic device for mobility selection of particles
US7419822B2 (en) 2002-10-04 2008-09-02 Noo Li Jeon Microfluidic device for enabling fluidic isolation among interconnected compartments within the apparatus and methods relating to same
CA2749227A1 (en) 2002-10-16 2005-01-13 Board Of Regents Of The University Of Texas System Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries
US20050037394A1 (en) 2002-12-03 2005-02-17 Keefe Anthony D. Method for in vitro selection of 2'-substituted nucleic acids
CA2506748A1 (en) 2002-12-03 2004-06-17 Archemix Corporation Method for in vitro selection of 2'-substituted nucleic acids
FR2848125B1 (en) 2002-12-04 2006-06-09 Commissariat Energie Atomique Microfluidic device in which the liquid / fluid interface is stabilized
US7125711B2 (en) 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US7338637B2 (en) 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices
US7413709B2 (en) 2003-02-12 2008-08-19 Agilent Technologies, Inc. PAEK-based microfluidic device with integrated electrospray emitter
JP3856763B2 (en) 2003-03-11 2006-12-13 財団法人川村理化学研究所 Manufacturing method of microfluidic device
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US7666361B2 (en) 2003-04-03 2010-02-23 Fluidigm Corporation Microfluidic devices and methods of using same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US7422725B2 (en) 2003-05-01 2008-09-09 Enplas Corporation Sample handling unit applicable to microchip, and microfluidic device having microchips
US7544506B2 (en) 2003-06-06 2009-06-09 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
US7329742B2 (en) 2003-09-04 2008-02-12 The Regents Of The University Of California Aptamers and methods for their in vitro selection and uses thereof
FR2862007B1 (en) 2003-11-12 2005-12-23 Commissariat Energie Atomique Microfluidic device with an electronebulating nose.
JP5543052B2 (en) 2003-11-22 2014-07-09 株式会社テクノメディカ Target molecule detection method using aptamer
US7329391B2 (en) 2003-12-08 2008-02-12 Applera Corporation Microfluidic device and material manipulating method using same
EP1547688A1 (en) 2003-12-23 2005-06-29 SGS-THOMSON MICROELECTRONICS S.r.l. Microfluidic device and method of locally concentrating electrically charged substances in a microfluidic device
US7099778B2 (en) 2003-12-30 2006-08-29 Caliper Life Sciences, Inc. Method for determining diffusivity and molecular weight in a microfluidic device
US7351380B2 (en) 2004-01-08 2008-04-01 Sandia Corporation Microfluidic structures and methods for integrating a functional component into a microfluidic device
US7611863B2 (en) 2004-01-08 2009-11-03 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Selective staining of biomembranes using voltage-sensitive dyes
EP1709203A2 (en) 2004-01-23 2006-10-11 Lingvitae AS Improving polynucleotide ligation reactions
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
SG152261A1 (en) 2004-01-25 2009-05-29 Fluidigm Corp Crystal forming devices and systems and methods for making and using the same
CA2560781C (en) 2004-03-22 2011-10-11 Kode Biotech Limited Synthetic membrane anchors
US7402229B2 (en) 2004-03-31 2008-07-22 Intel Corporation Fabrication and use of semipermeable membranes and gels for the control of electrolysis in a microfluidic device
US7575722B2 (en) 2004-04-02 2009-08-18 Eksigent Technologies, Inc. Microfluidic device
US7419639B2 (en) 2004-05-12 2008-09-02 The Board Of Trustees Of The Leland Stanford Junior University Multilayer microfluidic device
JP4911722B2 (en) 2004-06-07 2012-04-04 フルイディグム コーポレイション Optical lens system and method for microfluidic devices
US7514400B2 (en) 2004-10-06 2009-04-07 The Penn State Research Foundation Synthetic mimics of mammalian cell surface receptors: method and compositions
WO2006055722A1 (en) 2004-11-17 2006-05-26 Luminex Corporation Device and method for managing data from a flow analyzer
US7488596B2 (en) 2004-12-17 2009-02-10 Samsung Electronics Co., Ltd. Microfluidic device comprising electrolysis device for cell lysis and method for electrochemically lysing cells using the same
EP2233581A1 (en) 2005-02-01 2010-09-29 AB Advanced Genetic Analysis Corporation Nucleic acid sequencing by performing successive cycles of duplex extension
CA2603759A1 (en) 2005-04-12 2006-11-02 Caliper Life Sciences, Inc. Compact optical detection system for a microfluidic device
US9777314B2 (en) 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples
KR100590581B1 (en) 2005-05-10 2006-06-09 삼성전자주식회사 Microfluidic device and method of preparing the same
CA2609328A1 (en) 2005-05-26 2006-11-30 The Trustees Of Boston University Quantification of nucleic acids and proteins using oligonucleotide mass tags
JP4992201B2 (en) 2005-06-07 2012-08-08 富士ゼロックス株式会社 Microfluidic control method, microfluidic device and manufacturing method thereof
JP4706019B2 (en) 2005-07-08 2011-06-22 国立大学法人東京農工大学 Aptamer identification method
US20100254901A1 (en) 2005-07-28 2010-10-07 Smith Cassandra L Compositions comprising nucleic acid aptamers
JPWO2007032359A1 (en) 2005-09-12 2009-03-19 国立大学法人東京農工大学 Target molecule detection method using aptamer-probe complex
EP1931803A2 (en) 2005-09-15 2008-06-18 Duke University Focused libraries, functional profiling, laser selex and deselex
TWI274040B (en) 2005-12-23 2007-02-21 Ind Tech Res Inst Microfluidic device and method of manufacturing the same
US7568399B2 (en) 2006-01-05 2009-08-04 Integrated Sensing Systems, Inc. Microfluidic device
US7581429B2 (en) 2006-01-06 2009-09-01 Integrated Sensing Systems, Inc. Microfluidic device and method of operation
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
JP5201573B2 (en) 2006-01-24 2013-06-05 株式会社テクノメディカ Method and apparatus for measuring a test substance in a sample
US8124015B2 (en) 2006-02-03 2012-02-28 Institute For Systems Biology Multiplexed, microfluidic molecular assay device and assay method
SG170802A1 (en) 2006-03-31 2011-05-30 Solexa Inc Systems and devices for sequence by synthesis analysis
JP2009538123A (en) 2006-04-19 2009-11-05 アプライド バイオシステムズ, エルエルシー Reagents, methods and libraries for gel-free bead-based sequencing
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US8143004B2 (en) 2006-09-27 2012-03-27 National University Corporation Tokyo University Of Agriculture And Technology Method of assaying target substance in sample, aptamer molecule method of constructing the same
AU2007333040B2 (en) 2006-12-13 2013-02-07 Luminex Corporation Systems and methods for multiplex analysis of PCR in real time
US8587214B2 (en) 2006-12-15 2013-11-19 Osram Gesellschaft Mit Beschrankter Haftung LED module with dedicated color regulation and corresponding method
EP2626436A3 (en) * 2007-07-17 2013-10-16 Somalogic, Inc. Method for detecting a target using chemically modified aptamers enriched for slow off-rates
JP5156829B2 (en) * 2007-07-25 2013-03-06 ユニバーシティー オブ ルイヴィル リサーチ ファウンデーション,インコーポレーテッドUniversity Of Louisville Research Foundation,Inc. Exosome-related microRNAs as diagnostic markers
US8431367B2 (en) 2007-09-14 2013-04-30 Predictive Biosciences Corporation Detection of nucleic acids and proteins
EP3112464A1 (en) 2007-09-14 2017-01-04 The Ohio State University Research Foundation Mirna expression in human peripheral blood microvesicles and uses thereof
US8975215B2 (en) 2007-09-17 2015-03-10 Postech Foundation Methods for producing surface bound oligonucleotide on solid substrate and uses thereof
ES2448426T3 (en) * 2007-10-12 2014-03-13 Pronota Nv Use of aptamers in proteomics
US8088601B2 (en) 2007-11-15 2012-01-03 Wisconsin Alumni Research Foundation Expression systems for functional membrane polypeptides
US8008019B2 (en) 2007-11-28 2011-08-30 Luminex Molecular Diagnostics Use of dual-tags for the evaluation of genomic variable repeat regions
CN102084000B (en) * 2008-02-01 2016-03-16 总医院有限公司 The purposes of microvesicle in the diagnosis of medical conditions and the patient's condition, prognosis and treatment
US9193968B2 (en) 2008-03-12 2015-11-24 Aptamatrix, Inc. Library compositions and methods for acyclic identification of aptamers
EP2260103A4 (en) 2008-03-12 2012-06-13 Univ Syracuse Direct selection of structurally defined aptamers
EP2159286A1 (en) 2008-09-01 2010-03-03 Consiglio Nazionale Delle Ricerche Method for obtaining oligonucleotide aptamers and uses thereof
US10359425B2 (en) 2008-09-09 2019-07-23 Somalogic, Inc. Lung cancer biomarkers and uses thereof
US20100221752A2 (en) 2008-10-06 2010-09-02 Somalogic, Inc. Ovarian Cancer Biomarkers and Uses Thereof
JP2012507300A (en) 2008-10-30 2012-03-29 カリス ライフ サイエンシズ ルクセンブルク ホールディングス Method for evaluating RNA patterns
BRPI0921043A2 (en) * 2008-11-12 2018-08-07 Caris Life Sciences Luxembourg Holdings methods and systems for using exosomes to determine phenotypes
EP2202522A1 (en) 2008-12-23 2010-06-30 Universiteit Leiden Methods for immobilizing microvesicles, means and methods for detecting them, and uses thereof
AU2010208035B2 (en) 2009-01-29 2016-06-23 Arbutus Biopharma Corporation Improved lipid formulation for the delivery of nucleic acids
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
US8633140B2 (en) 2009-02-27 2014-01-21 The Regents Of The University Of Michigan Functionalized polydiacetylene sensors
KR20120050429A (en) 2009-06-15 2012-05-18 알닐람 파마슈티칼스 인코포레이티드 Lipid formulated dsrna targeting the pcsk9 gene
WO2011031892A1 (en) * 2009-09-09 2011-03-17 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
US20120264810A1 (en) 2009-09-22 2012-10-18 The University Of British Columbia Compositions and methods for enhancing cellular uptake and intracellular delivery of lipid particles
WO2011056688A2 (en) 2009-10-27 2011-05-12 Caris Life Sciences, Inc. Molecular profiling for personalized medicine
US20130203061A1 (en) 2009-11-30 2013-08-08 Michael KLASS Methods and systems for isolating, storing, and analyzing vesicles
WO2011088226A2 (en) 2010-01-13 2011-07-21 Caris Life Sciences Luxembourg Holdings Detection of gastrointestinal disorders
JP2011193873A (en) 2010-02-26 2011-10-06 Canon Inc Method of screening nucleic acid ligand
US9128101B2 (en) 2010-03-01 2015-09-08 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
ES2667491T3 (en) 2010-04-12 2018-05-11 Somalogic, Inc. Modified pyrimidines in position 5 and their use
EP3254672A1 (en) 2010-06-03 2017-12-13 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
WO2012002541A1 (en) 2010-07-01 2012-01-05 独立行政法人産業技術総合研究所 Method for detection of target molecule
BR112012032537A2 (en) 2010-07-09 2017-05-23 Somalogic Inc lung cancer biomarkers and their uses
JP2013540995A (en) 2010-08-18 2013-11-07 カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス.アー.エール.エル. Circulating biomarkers for disease
EP3029153B1 (en) 2010-09-27 2018-08-01 Somalogic, Inc. Mesothelioma biomarkers and uses thereof
AU2011352167A1 (en) 2010-12-28 2013-07-11 Caris Mpi, Inc. Molecular profiling for cancer
CA2827894A1 (en) 2011-02-22 2012-08-30 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers
CA2838728A1 (en) 2011-06-07 2012-12-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for cancer
BR112013032232A2 (en) 2011-06-16 2016-09-20 Caris Life Sciences Switzerland Holdings S A R L Cancer characterization method using nucleic acid biomarker
AU2013229762A1 (en) 2012-03-09 2014-09-25 Caris Life Sciences Switzerland Holdings Gmbh Biomarker compositions and methods
AU2013340414B2 (en) 2012-10-23 2019-05-02 Caris Science, Inc. Aptamers and uses thereof
CA2892490A1 (en) 2012-11-26 2014-05-30 Caris Science, Inc. Biomarker compositions and methods
CA2922689A1 (en) 2013-08-28 2015-03-05 Caris Life Sciences Switzerland Holdings Gmbh Oligonucleotide probes and uses thereof
JP2016031772A (en) 2014-07-30 2016-03-07 株式会社日立ハイテクファインシステムズ Inspection method and apparatus of heat-assisted magnetic head element

Also Published As

Publication number Publication date
WO2014068408A2 (en) 2014-05-08
KR20150090072A (en) 2015-08-05
JP2019033750A (en) 2019-03-07
AU2019208237A1 (en) 2019-08-15
US9958448B2 (en) 2018-05-01
AU2013340414A1 (en) 2015-05-14
JP6404822B2 (en) 2018-10-17
AU2013340414B2 (en) 2019-05-02
IL238408A (en) 2019-09-26
IL269045D0 (en) 2019-10-31
WO2014068408A3 (en) 2014-11-27
US20160003835A1 (en) 2016-01-07
CN105452466A (en) 2016-03-30
EP2912182A2 (en) 2015-09-02
CA2928520A1 (en) 2014-05-08
JP2016506716A (en) 2016-03-07

Similar Documents

Publication Publication Date Title
DK2928496T3 (en) Crispr-based re-modification and regulation
GB2500915B (en) Arrangement and method
IL239289A (en) Zinc-lysine complex
EP2856340A4 (en) Integrating collarboratively proposed changes and publishing
HK1215183A1 (en) Protein-polymer-drug conjugates --
IL236355D0 (en) Peer-assisted shopping
EP2888238A4 (en) Benzocyclooctyne compounds and uses thereof
AP201508483A0 (en) Suspension device
HK1208025A1 (en) Aminoimidazopyridazines
GB2509400B (en) Rigid-stem lead-in-method and system
HK1205512A1 (en) Amino-substituted imidazopyridazines
HK1206009A1 (en) Amino-substituted imidazopyridazines
PL2861566T3 (en) New diazaspirocycloalkane and azaspirocycloalkane
IL253775D0 (en) נוגדנים בעלי שרשרת קלה מהונדסת היסטידין ובעלי חיים לא אנושיים שעברו שינוי גנטי להכנתם
KR20150090072A (en) Aptamers and uses thereof
EP2833926A4 (en) Neurophilic nanoparticles
EP2754580A4 (en) Dumptruck
HK1203493A1 (en) Substituted azabicycles and use thereof
HK1199023A1 (en) Substituted benzothienylpyrrolotriazines and uses thereof
IL236617D0 (en) Rspo3 binding agents and uses thereof
IL233051A (en) Anti-phf-tau-antibodies and their uses
GB201217018D0 (en) Methods
EP2934531A4 (en) Combination
EP2877996A4 (en) Dynamic sense circuitry
EP2829480A4 (en) Drug-supplying device and drug-counting device