IL237912B - Dihydro-6-azaphenalene derivatives for the treatment of cns, oncological diseases and related disorders - Google Patents
Dihydro-6-azaphenalene derivatives for the treatment of cns, oncological diseases and related disordersInfo
- Publication number
- IL237912B IL237912B IL237912A IL23791215A IL237912B IL 237912 B IL237912 B IL 237912B IL 237912 A IL237912 A IL 237912A IL 23791215 A IL23791215 A IL 23791215A IL 237912 B IL237912 B IL 237912B
- Authority
- IL
- Israel
- Prior art keywords
- cns
- dihydro
- treatment
- related disorders
- oncological diseases
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 2
- 201000010099 disease Diseases 0.000 title 1
- 230000000771 oncological effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261707444P | 2012-09-28 | 2012-09-28 | |
| PCT/US2013/062429 WO2014052906A1 (en) | 2012-09-28 | 2013-09-27 | Dihydro-6-azaphenalene derivatives for the treatment of cns, oncological diseases and related disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL237912A0 IL237912A0 (en) | 2015-05-31 |
| IL237912B true IL237912B (en) | 2019-08-29 |
Family
ID=50385790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL237912A IL237912B (en) | 2012-09-28 | 2015-03-23 | Dihydro-6-azaphenalene derivatives for the treatment of cns, oncological diseases and related disorders |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10047089B2 (en) |
| EP (1) | EP2900239B1 (en) |
| JP (1) | JP6345674B2 (en) |
| KR (1) | KR20150060775A (en) |
| CN (1) | CN104994853B (en) |
| AU (1) | AU2013323198B2 (en) |
| BR (1) | BR112015007095A8 (en) |
| CA (1) | CA2886749A1 (en) |
| IL (1) | IL237912B (en) |
| WO (1) | WO2014052906A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106316966A (en) * | 2015-06-15 | 2017-01-11 | 董运勤 | Preparation method of medical intermediate N-(2-methylpyrazine)benzylamine phosphate compound |
| WO2017083488A1 (en) | 2015-11-11 | 2017-05-18 | Warner Babcock Institute for Green Chemistry | Benzofuran derivatives for the treatment of cns and other disorders |
| US11286233B2 (en) | 2017-05-09 | 2022-03-29 | Ambient Photonics, Inc. | Stilbene derivatives for the treatment of CNS and other disorders |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3614414A1 (en) | 1986-04-29 | 1987-11-05 | Knoll Ag | NEW BENZO (DE) ISOCHINOLIN-1,3-DIONE, THEIR PRODUCTION AND USE |
| JPH03232858A (en) | 1990-02-07 | 1991-10-16 | Toyo Pharma- Kk | 1,8-naphthalic acid imide derivative, production and use thereof |
| US6417178B1 (en) | 1994-07-19 | 2002-07-09 | University Of Pittsburgh | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits |
| US6380193B1 (en) | 1998-05-15 | 2002-04-30 | Guilford Pharmaceuticals Inc. | Fused tricyclic compounds, methods and compositions for inhibiting PARP activity |
| WO1999059975A1 (en) | 1998-05-15 | 1999-11-25 | Guilford Pharmaceuticals Inc. | Fused tricyclic compounds which inhibit parp activity |
| US20040106548A1 (en) * | 2001-09-07 | 2004-06-03 | Schmidt Michelle A | Conformationally constrained labeled peptides for imaging and therapy |
| AU2002950217A0 (en) | 2002-07-16 | 2002-09-12 | Prana Biotechnology Limited | 8- Hydroxy Quinoline Derivatives |
| JP4824566B2 (en) * | 2003-05-28 | 2011-11-30 | エーザイ インコーポレーテッド | Compounds, methods and pharmaceutical compositions for inhibiting PARP |
| CN101304973A (en) | 2005-09-15 | 2008-11-12 | 佩因赛普托药物公司 | Methods of modulating neurotrophin-mediated activity |
| FR2927077B1 (en) * | 2008-01-31 | 2012-05-25 | Commissariat Energie Atomique | 1,8-NAPHTHALIMIDE DERIVATIVES AS SCINTILLATION AGENTS, IN PARTICULAR FOR THE DISCRIMINATION BETWEEN FAST NEUTRONS AND GAMMA RAYS |
| CN102603695B (en) * | 2012-02-10 | 2014-06-18 | 山东大学 | Amino acid-fluorophore compound and application thereof |
-
2013
- 2013-09-27 BR BR112015007095A patent/BR112015007095A8/en not_active Application Discontinuation
- 2013-09-27 AU AU2013323198A patent/AU2013323198B2/en not_active Ceased
- 2013-09-27 KR KR1020157009764A patent/KR20150060775A/en not_active Ceased
- 2013-09-27 CN CN201380062135.4A patent/CN104994853B/en not_active Expired - Fee Related
- 2013-09-27 WO PCT/US2013/062429 patent/WO2014052906A1/en not_active Ceased
- 2013-09-27 US US14/040,393 patent/US10047089B2/en active Active
- 2013-09-27 EP EP13842204.3A patent/EP2900239B1/en not_active Not-in-force
- 2013-09-27 JP JP2015534773A patent/JP6345674B2/en not_active Expired - Fee Related
- 2013-09-27 CA CA 2886749 patent/CA2886749A1/en not_active Abandoned
-
2015
- 2015-03-23 IL IL237912A patent/IL237912B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US20140094487A1 (en) | 2014-04-03 |
| EP2900239A4 (en) | 2016-04-20 |
| CN104994853B (en) | 2018-11-30 |
| US10047089B2 (en) | 2018-08-14 |
| AU2013323198A1 (en) | 2015-04-09 |
| BR112015007095A2 (en) | 2017-07-04 |
| CA2886749A1 (en) | 2014-04-03 |
| KR20150060775A (en) | 2015-06-03 |
| WO2014052906A1 (en) | 2014-04-03 |
| JP2015531379A (en) | 2015-11-02 |
| EP2900239A1 (en) | 2015-08-05 |
| AU2013323198B2 (en) | 2018-03-29 |
| JP6345674B2 (en) | 2018-06-20 |
| EP2900239B1 (en) | 2019-03-20 |
| BR112015007095A8 (en) | 2019-08-20 |
| IL237912A0 (en) | 2015-05-31 |
| CN104994853A (en) | 2015-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |