IL235868D0 - Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators - Google Patents

Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

Info

Publication number
IL235868D0
IL235868D0 IL235868A IL23586814A IL235868D0 IL 235868 D0 IL235868 D0 IL 235868D0 IL 235868 A IL235868 A IL 235868A IL 23586814 A IL23586814 A IL 23586814A IL 235868 D0 IL235868 D0 IL 235868D0
Authority
IL
Israel
Prior art keywords
heteroaryl
receptor modulators
glucocorticoid receptor
fused azadecalin
ketone fused
Prior art date
Application number
IL235868A
Other languages
Hebrew (he)
Other versions
IL235868A (en
Original Assignee
Corcept Therapeutics Inc
Tony Johnson
Hazel Hunt
Nicholas Ray
Iain Walters
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201261651669P priority Critical
Priority to US201261691083P priority
Priority to US201261715907P priority
Priority to US201361759520P priority
Priority to US201361781629P priority
Priority to PCT/US2013/042732 priority patent/WO2013177559A2/en
Application filed by Corcept Therapeutics Inc, Tony Johnson, Hazel Hunt, Nicholas Ray, Iain Walters filed Critical Corcept Therapeutics Inc
Publication of IL235868D0 publication Critical patent/IL235868D0/en
Publication of IL235868A publication Critical patent/IL235868A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
IL235868A 2012-05-25 2014-11-23 Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators IL235868A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US201261651669P true 2012-05-25 2012-05-25
US201261691083P true 2012-08-20 2012-08-20
US201261715907P true 2012-10-19 2012-10-19
US201361759520P true 2013-02-01 2013-02-01
US201361781629P true 2013-03-14 2013-03-14
PCT/US2013/042732 WO2013177559A2 (en) 2012-05-25 2013-05-24 Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

Publications (2)

Publication Number Publication Date
IL235868D0 true IL235868D0 (en) 2015-01-29
IL235868A IL235868A (en) 2017-12-31

Family

ID=49624542

Family Applications (1)

Application Number Title Priority Date Filing Date
IL235868A IL235868A (en) 2012-05-25 2014-11-23 Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

Country Status (20)

Country Link
EP (3) EP3338781B1 (en)
JP (1) JP6172871B2 (en)
CN (1) CN104619328B (en)
AU (1) AU2013266110C1 (en)
CA (1) CA2872260A1 (en)
CL (1) CL2014003173A1 (en)
DK (2) DK2854814T3 (en)
ES (1) ES2665338T3 (en)
HK (1) HK1208818A1 (en)
IL (1) IL235868A (en)
MX (1) MX365423B (en)
NZ (1) NZ701469A (en)
PE (1) PE20150352A1 (en)
PH (1) PH12014502584A1 (en)
PL (1) PL2854814T3 (en)
PT (1) PT2854814T (en)
RU (1) RU2639867C2 (en)
SG (1) SG11201407682TA (en)
WO (1) WO2013177559A2 (en)
ZA (1) ZA201408182B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
DK3074011T3 (en) 2013-11-25 2019-09-30 Corcept Therapeutics Incorporated Octahydro-condensed azadecaline glucocorticoid receptor modulators
CN107530435A (en) * 2015-03-02 2018-01-02 科赛普特治疗学股份有限公司 Use glucocorticoid receptor antagonists and Somatostatin in Treating ACTH secreting type tumours
CA2984623A1 (en) * 2015-05-18 2016-11-24 Corcept Therapeutics, Inc. Methods for diagnosing and assessing treatment for cushing's syndrome
US9829495B2 (en) * 2015-08-13 2017-11-28 Corcept Therapeutics, Inc. Method for differentially diagnosing ACTH-dependent Cushing's syndrome
KR20180116372A (en) * 2016-03-01 2018-10-24 코어셉트 쎄라퓨틱스, 잉크. Use of glucocorticoid receptor modulators to enhance checkpoint inhibitors
US9943505B2 (en) * 2016-09-09 2018-04-17 Corcept Therapeutics, Inc. Glucocorticoid receptor modulators to treat pancreatic cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391904A (en) 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
GB8828669D0 (en) * 1988-12-08 1989-01-11 Lilly Industries Ltd Organic compounds
ES2313317T3 (en) * 2004-03-09 2009-03-01 Corcept Therapeutics, Inc. Condensed ring glucocorticoid receiver modulators of azadecaline.
US7640389B2 (en) * 2006-02-28 2009-12-29 Freescale Semiconductor, Inc. Non-volatile memory having a multiple block erase mode and method therefor
EP1932843A1 (en) * 2006-12-14 2008-06-18 sanofi-aventis Sulfonyl-phenyl-2H-(1,2,4) oxadiazole-5-one derivatives, processes for their preparation and their use as pharmaceuticals
KR20130106378A (en) * 2010-08-27 2013-09-27 코어셉트 쎄라퓨틱스, 잉크. Pyridyl-amine fused azadecalin modulators

Also Published As

Publication number Publication date
AU2013266110B2 (en) 2017-04-20
MX365423B (en) 2019-06-03
HK1208818A1 (en) 2016-03-18
EP3590517A1 (en) 2020-01-08
DK2854814T3 (en) 2018-03-12
EP3338781A1 (en) 2018-06-27
EP2854814B1 (en) 2018-01-31
RU2014152625A (en) 2016-07-20
WO2013177559A2 (en) 2013-11-28
NZ701469A (en) 2017-06-30
CA2872260A1 (en) 2013-11-28
RU2639867C2 (en) 2017-12-25
PH12014502584A1 (en) 2015-01-21
ZA201408182B (en) 2017-09-27
DK3338781T3 (en) 2019-12-09
MX2014014239A (en) 2015-08-05
EP3338781B1 (en) 2019-09-11
ES2665338T3 (en) 2018-04-25
KR20150021955A (en) 2015-03-03
PT2854814T (en) 2018-03-15
AU2013266110A1 (en) 2014-11-20
CN104619328A (en) 2015-05-13
PE20150352A1 (en) 2015-03-16
JP2015517580A (en) 2015-06-22
JP6172871B2 (en) 2017-08-02
WO2013177559A3 (en) 2014-01-16
AU2013266110C1 (en) 2018-07-12
CL2014003173A1 (en) 2015-02-27
IL235868A (en) 2017-12-31
EP2854814A2 (en) 2015-04-08
PH12014502584B1 (en) 2015-01-21
EP2854814A4 (en) 2016-01-27
PL2854814T3 (en) 2018-07-31
CN104619328B (en) 2018-10-02
SG11201407682TA (en) 2014-12-30

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