IL235826D0 - New diazaspirocycloalkane and azaspirocycloalkane - Google Patents

New diazaspirocycloalkane and azaspirocycloalkane

Info

Publication number
IL235826D0
IL235826D0 IL235826A IL23582614A IL235826D0 IL 235826 D0 IL235826 D0 IL 235826D0 IL 235826 A IL235826 A IL 235826A IL 23582614 A IL23582614 A IL 23582614A IL 235826 D0 IL235826 D0 IL 235826D0
Authority
IL
Israel
Prior art keywords
diazaspirocycloalkane
azaspirocycloalkane
new
Prior art date
Application number
IL235826A
Other languages
Hebrew (he)
Other versions
IL235826A (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP12171839 priority Critical
Priority to PCT/EP2013/061890 priority patent/WO2013186159A1/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL235826D0 publication Critical patent/IL235826D0/en
Publication of IL235826A publication Critical patent/IL235826A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41921,2,3-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/12Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18Benzotriazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
IL235826A 2012-06-13 2014-11-20 Diazaspirocycloalkane and azaspirocycloalkane compounds and process for their preparation IL235826A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP12171839 2012-06-13
PCT/EP2013/061890 WO2013186159A1 (en) 2012-06-13 2013-06-10 New diazaspirocycloalkane and azaspirocycloalkane

Publications (2)

Publication Number Publication Date
IL235826D0 true IL235826D0 (en) 2015-02-01
IL235826A IL235826A (en) 2017-07-31

Family

ID=48692428

Family Applications (1)

Application Number Title Priority Date Filing Date
IL235826A IL235826A (en) 2012-06-13 2014-11-20 Diazaspirocycloalkane and azaspirocycloalkane compounds and process for their preparation

Country Status (34)

Country Link
US (2) US9493486B2 (en)
EP (1) EP2861566B1 (en)
JP (1) JP6258928B2 (en)
KR (1) KR20150023373A (en)
CN (1) CN104364239B (en)
AR (1) AR091416A1 (en)
AU (1) AU2013276617B9 (en)
BR (1) BR112014030473A2 (en)
CA (1) CA2872213A1 (en)
CL (1) CL2014003136A1 (en)
CO (1) CO7121325A2 (en)
CR (1) CR20140501A (en)
CY (1) CY1118860T1 (en)
DK (1) DK2861566T3 (en)
EA (1) EA201492223A1 (en)
ES (1) ES2618703T3 (en)
HK (1) HK1202545A1 (en)
HR (1) HRP20161774T1 (en)
HU (1) HUE030526T2 (en)
IL (1) IL235826A (en)
IN (1) IN2014DN09346A (en)
LT (1) LT2861566T (en)
MA (1) MA37756B1 (en)
MX (1) MX358310B (en)
NZ (1) NZ702334A (en)
PE (1) PE20150230A1 (en)
PH (1) PH12014502697A1 (en)
PL (1) PL2861566T3 (en)
PT (1) PT2861566T (en)
RS (1) RS55717B1 (en)
SG (1) SG11201407534PA (en)
SI (1) SI2861566T1 (en)
TW (1) TWI633087B (en)
WO (1) WO2013186159A1 (en)

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WO2014152725A1 (en) 2013-03-15 2014-09-25 Biogen Idec Ma Inc. S1p and/or atx modulating agents
US9776979B2 (en) * 2013-09-26 2017-10-03 Sanford-Burnham Medical Research Institute EBI2 modulators
EA030068B1 (en) 2013-11-22 2018-06-29 Фармакеа, Инк. Autotaxin inhibitor compounds
AU2014356583B2 (en) * 2013-11-26 2019-02-28 F. Hoffmann-La Roche Ag New octahydro-cyclobuta (1,2-c;3,4-c')dipyrrol-2-yl
WO2015140132A1 (en) * 2014-03-17 2015-09-24 Remynd Nv 2,7-diazaspiro[3.5]nonane compounds
CN106103446B (en) 2014-03-26 2019-07-30 豪夫迈·罗氏有限公司 Bicyclic compound as autocrine motility factor (ATX) and lysophosphatidic acid (LPA) production inhibitor
EA201691840A1 (en) 2014-04-04 2017-03-31 Икс-Рикс, Инк. Substituted spyrocyclic inhibitors autotaxin
WO2015188051A1 (en) 2014-06-06 2015-12-10 Biogen Ma Inc. Atx modulating agents
US9051320B1 (en) 2014-08-18 2015-06-09 Pharmakea, Inc. Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor
CN104530046B (en) * 2014-12-10 2016-08-24 广东东阳光药业有限公司 Diaza spiro compounds and the application in medicine thereof
CN106146483A (en) * 2015-04-23 2016-11-23 上海迪诺医药科技有限公司 Heterocyclic method Buddhist nun's ester derivant X receptor modulators
EP3302465A1 (en) 2015-06-05 2018-04-11 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
CN108456208A (en) * 2017-02-22 2018-08-28 广州市恒诺康医药科技有限公司 Aza toroid compound and its preparation method and application
KR20190129924A (en) * 2017-03-16 2019-11-20 에프. 호프만-라 로슈 아게 Heterocyclic Compounds Useful as Dual Autotaxin (ATX) / Carbon Anhydrase (CA) Inhibitors

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Also Published As

Publication number Publication date
KR20150023373A (en) 2015-03-05
BR112014030473A2 (en) 2017-06-27
ES2618703T3 (en) 2017-06-22
PE20150230A1 (en) 2015-02-06
PH12014502697A1 (en) 2015-01-26
CN104364239B (en) 2017-08-25
MX2014015049A (en) 2015-03-03
US20150099734A1 (en) 2015-04-09
EA201492223A1 (en) 2015-03-31
MA37756A1 (en) 2018-01-31
CA2872213A1 (en) 2013-12-19
CO7121325A2 (en) 2014-11-20
JP2015519380A (en) 2015-07-09
SG11201407534PA (en) 2014-12-30
PL2861566T3 (en) 2017-06-30
RS55717B1 (en) 2017-07-31
EP2861566A1 (en) 2015-04-22
MA37756B1 (en) 2018-09-28
NZ702334A (en) 2016-11-25
CN104364239A (en) 2015-02-18
CY1118860T1 (en) 2018-01-10
CR20140501A (en) 2014-12-02
AU2013276617A1 (en) 2014-11-20
HK1202545A1 (en) 2015-10-02
AR091416A1 (en) 2015-02-04
DK2861566T3 (en) 2017-02-27
JP6258928B2 (en) 2018-01-10
TW201402545A (en) 2014-01-16
TWI633087B (en) 2018-08-21
PT2861566T (en) 2017-02-08
AU2013276617B2 (en) 2017-12-14
MX358310B (en) 2018-08-14
SI2861566T1 (en) 2017-03-31
IN2014DN09346A (en) 2015-07-17
IL235826A (en) 2017-07-31
CL2014003136A1 (en) 2015-02-27
PH12014502697B1 (en) 2015-01-26
US20170029425A1 (en) 2017-02-02
EP2861566B1 (en) 2016-12-21
LT2861566T (en) 2017-02-10
HUE030526T2 (en) 2017-05-29
AU2013276617B9 (en) 2018-03-29
US9493486B2 (en) 2016-11-15
WO2013186159A1 (en) 2013-12-19
HRP20161774T1 (en) 2017-02-24

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