IL233154D0 - Compounds - Google Patents

Compounds

Info

Publication number
IL233154D0
IL233154D0 IL233154A IL23315414A IL233154D0 IL 233154 D0 IL233154 D0 IL 233154D0 IL 233154 A IL233154 A IL 233154A IL 23315414 A IL23315414 A IL 23315414A IL 233154 D0 IL233154 D0 IL 233154D0
Authority
IL
Israel
Prior art keywords
compounds
Prior art date
Application number
IL233154A
Other languages
Hebrew (he)
Other versions
IL233154A (en
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB1122139.7A priority Critical patent/GB2497806A/en
Priority to GB201217290A priority patent/GB201217290D0/en
Priority to PCT/GB2012/053217 priority patent/WO2013093484A1/en
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of IL233154D0 publication Critical patent/IL233154D0/en
Publication of IL233154A publication Critical patent/IL233154A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
IL233154A 2011-12-21 2014-06-16 Compounds, pharmaceutical compositions comprising the same and uses thereof IL233154A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB1122139.7A GB2497806A (en) 2011-12-21 2011-12-21 Pyridinone and pyrimidinone derivatives as factor XIa inhibitors
GB201217290A GB201217290D0 (en) 2012-09-27 2012-09-27 Compounds
PCT/GB2012/053217 WO2013093484A1 (en) 2011-12-21 2012-12-20 Pyridinone and pyrimidinone derivatives as factor xia inhibitors

Publications (2)

Publication Number Publication Date
IL233154D0 true IL233154D0 (en) 2014-08-03
IL233154A IL233154A (en) 2016-12-29

Family

ID=47553259

Family Applications (1)

Application Number Title Priority Date Filing Date
IL233154A IL233154A (en) 2011-12-21 2014-06-16 Compounds, pharmaceutical compositions comprising the same and uses thereof

Country Status (24)

Country Link
US (2) US9732085B2 (en)
EP (2) EP2794597B1 (en)
JP (2) JP6137193B2 (en)
KR (1) KR102011534B1 (en)
CN (1) CN104136431B (en)
AU (1) AU2012356374B2 (en)
BR (1) BR112014015669A8 (en)
CA (1) CA2859604A1 (en)
DK (1) DK2794597T3 (en)
ES (1) ES2655669T3 (en)
HK (1) HK1198386A1 (en)
HU (1) HUE036010T2 (en)
IL (1) IL233154A (en)
IN (1) IN2014CN04676A (en)
MX (1) MX351471B (en)
NO (1) NO2794597T3 (en)
NZ (1) NZ626176A (en)
PH (1) PH12014501365A1 (en)
PL (1) PL2794597T3 (en)
PT (1) PT2794597T (en)
RU (1) RU2630677C2 (en)
SG (1) SG11201403402VA (en)
TW (1) TWI613199B (en)
WO (1) WO2013093484A1 (en)

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CN103987697B (en) 2011-10-14 2017-04-26 百时美施贵宝公司 Substituted tetrahydroisoquinoline compounds as factor XIA inhibitors
UY34393A (en) 2011-10-14 2013-04-30 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Substituted tetrahydroisoquinoline compounds as inhibitors of factor XIa
HUE036010T2 (en) * 2011-12-21 2018-06-28 Ono Pharmaceutical Co Pyridinone and pyrimidinone derivatives as factor xia inhibitors
US20130165483A1 (en) * 2011-12-23 2013-06-27 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
AU2013291098A1 (en) 2012-07-19 2015-02-05 Sumitomo Dainippon Pharma Co., Ltd. 1-(cycloalkyl-carbonyl)proline derivative
KR20150038369A (en) 2012-08-03 2015-04-08 브리스톨-마이어스 스큅 컴퍼니 Dihydropyridone p1 as factor xia inhibitors
LT2880026T (en) 2012-08-03 2017-04-25 Bristol-Myers Squibb Company Dihydropyridone p1 as factor xia inhibitors
WO2014059202A1 (en) 2012-10-12 2014-04-17 Bristol-Myers Squibb Company Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
CA2888100A1 (en) 2012-10-12 2014-04-17 Bristol-Myers Squibb Company Crystalline forms of a factor xia inhibitor
US9403774B2 (en) 2012-10-12 2016-08-02 Bristol-Myers Squibb Company Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
CN105228996B (en) 2013-03-25 2017-11-28 百时美施贵宝公司 The tetrahydroisoquinoline containing substituted azole as factor XI, plasma thromboplastin antecedent a inhibitor
US9809545B2 (en) 2013-03-27 2017-11-07 Merck Sharp & Dohme Corp. Factor XIa inhibitors
TWI633089B (en) * 2013-03-28 2018-08-21 拜耳製藥股份有限公司 Substituted oxopyridine derivatives
CN105555767B (en) * 2013-07-23 2018-03-23 拜耳制药股份公司 Substituted oxo pyridine derivative and its purposes as factor XI, plasma thromboplastin antecedent A/ blood plasma
US9765070B2 (en) * 2013-10-30 2017-09-19 Bayer Pharma Aktiengesellschaft Substituted oxopyridine derivatives
WO2015116885A1 (en) * 2014-01-31 2015-08-06 Bristol-Myers Squibb Company Macrocycles with aromatic p2' groups as factor xia inhibitors
NO2760821T3 (en) 2014-01-31 2018-03-10
EP3138839A4 (en) * 2014-02-14 2018-01-03 Sichuan Haisco Pharmaceutical Co., Ltd. Pyridone or pyrimidone derivative, preparation method therefor and application thereof
WO2016011940A1 (en) * 2014-07-25 2016-01-28 江苏恒瑞医药股份有限公司 Indole-amide derivative, preparation method therefor and application thereof in medicine
US9868727B2 (en) 2014-07-28 2018-01-16 Merck Sharp & Dohme Corp. Factor XIa inhibitors
EP3189047B1 (en) 2014-09-04 2018-12-26 Bristol-Myers Squibb Company Diamide macrocycles that are fxia inhibitors
CN104311537B (en) * 2014-09-19 2016-08-24 广东东阳光药业有限公司 Containing pyrimidone acetyl substituents pyrazole compound and combinations thereof thing and purposes
US10077265B2 (en) 2014-09-24 2018-09-18 Bayer Pharma Aktiengesellschaft Substituted oxopyridine derivatives
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
NO2721243T3 (en) * 2014-10-01 2018-10-20
WO2016093285A1 (en) * 2014-12-10 2016-06-16 小野薬品工業株式会社 Dihydroindolizinone derivative
GB201506658D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
RU2649141C2 (en) * 2015-04-20 2018-03-30 государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ПГФА Минздрава России) 3,4-dimethyl-6-(3-pyridyl)-n-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamide with antifungal activity against the candida albicans strain
GB201506660D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
US10421742B2 (en) 2015-07-09 2019-09-24 Bayer Pharma Aktiengesellschaft Substituted oxopyridine derivatives
RU2653511C2 (en) * 2015-07-29 2018-05-10 государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ПГФА Минздрава России) 4-methyl-n-2,4-dimethylphenyl-6-(3-fluorophenyl)-2-thyoxo-1,2,3,6-tetragydropyrimidine-5-carboxamide that has analgetic action
KR20180031037A (en) 2015-08-05 2018-03-27 브리스톨-마이어스 스큅 컴퍼니 Newly substituted glycine-induced FXIA inhibitors
CN106496249B (en) * 2015-09-07 2019-12-13 江苏恒瑞医药股份有限公司 Oxazoloindole derivative, preparation method and medical application thereof
WO2017074833A1 (en) * 2015-10-29 2017-05-04 Merck Sharp & Dohme Corp. Macrocyclic spirocarbamate derivatives as factor xia inhibitors, pharmaceutically acceptable compositions and their use
WO2018039094A1 (en) 2016-08-22 2018-03-01 Merck Sharp & Dohme Corp. Pyridine-1-oxide derivatives and their use as factor xia inhibitors
TW201811748A (en) * 2016-08-31 2018-04-01 江蘇恆瑞醫藥股份有限公司 Oxo-pyridine amide derivatives, preparation process thereof and pharmaceutical use thereof
CN106950319B (en) * 2017-04-20 2019-08-30 西安科技大学 A method of detection spy's Lu Quban optical isomer content
WO2019165951A1 (en) * 2018-02-27 2019-09-06 江苏恒瑞医药股份有限公司 Crystal form of oxopicolinamide derivative and preparation method therefor

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Also Published As

Publication number Publication date
PH12014501365B1 (en) 2014-09-22
EP2794597B1 (en) 2017-11-15
CN104136431A (en) 2014-11-05
KR20140103286A (en) 2014-08-26
EP3290413B1 (en) 2019-11-13
ES2655669T3 (en) 2018-02-21
MX351471B (en) 2017-10-17
JP2015500868A (en) 2015-01-08
IN2014CN04676A (en) 2015-09-18
AU2012356374A1 (en) 2014-07-10
BR112014015669A2 (en) 2017-06-13
EP3290413A1 (en) 2018-03-07
US9732085B2 (en) 2017-08-15
TW201339157A (en) 2013-10-01
HUE036010T2 (en) 2018-06-28
EP2794597A1 (en) 2014-10-29
DK2794597T3 (en) 2018-01-15
CA2859604A1 (en) 2013-06-27
AU2012356374A8 (en) 2014-08-07
BR112014015669A8 (en) 2017-07-04
US20150152112A1 (en) 2015-06-04
JP2017160239A (en) 2017-09-14
US20170305917A1 (en) 2017-10-26
JP6137193B2 (en) 2017-05-31
TWI613199B (en) 2018-02-01
IL233154A (en) 2016-12-29
KR102011534B1 (en) 2019-08-16
MX2014007269A (en) 2014-07-22
NO2794597T3 (en) 2018-04-14
NZ626176A (en) 2015-09-25
CN104136431B (en) 2017-03-15
PH12014501365A1 (en) 2014-09-22
JP6447660B2 (en) 2019-01-09
WO2013093484A1 (en) 2013-06-27
RU2014129797A (en) 2016-02-10
AU2012356374B2 (en) 2017-06-22
SG11201403402VA (en) 2015-01-29
HK1198386A1 (en) 2015-04-17
PT2794597T (en) 2018-01-16
RU2630677C2 (en) 2017-09-12
PL2794597T3 (en) 2018-03-30

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