IL232707D0 - Ketoreductase polypeptides for the production of azetidinone - Google Patents

Ketoreductase polypeptides for the production of azetidinone

Info

Publication number
IL232707D0
IL232707D0 IL232707A IL23270714A IL232707D0 IL 232707 D0 IL232707 D0 IL 232707D0 IL 232707 A IL232707 A IL 232707A IL 23270714 A IL23270714 A IL 23270714A IL 232707 D0 IL232707 D0 IL 232707D0
Authority
IL
Israel
Prior art keywords
azetidinone
production
ketoreductase polypeptides
ketoreductase
polypeptides
Prior art date
Application number
IL232707A
Other languages
Hebrew (he)
Other versions
IL232707A (en
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US97655507P priority Critical
Priority to PCT/US2008/078513 priority patent/WO2009046153A1/en
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of IL232707D0 publication Critical patent/IL232707D0/en
Publication of IL232707A publication Critical patent/IL232707A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10Nitrogen as only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184Carbonyl reductase (NADPH) (1.1.1.184)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of products other than chlorine, adipic acid, caprolactam, or chlorodifluoromethane, e.g. bulk or fine chemicals or pharmaceuticals
    • Y02P20/52Improvements relating to the production of products other than chlorine, adipic acid, caprolactam, or chlorodifluoromethane, e.g. bulk or fine chemicals or pharmaceuticals using catalysts, e.g. selective catalysts
IL232707A 2007-10-01 2014-05-20 Engineered ketoreductase polypeptides, compositions comprising them, methods of reducing substrates and methods for synthesizing intermediates IL232707A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US97655507P true 2007-10-01 2007-10-01
PCT/US2008/078513 WO2009046153A1 (en) 2007-10-01 2008-10-01 Ketoreductase polypeptides for the production of azetidinone

Publications (2)

Publication Number Publication Date
IL232707D0 true IL232707D0 (en) 2014-07-31
IL232707A IL232707A (en) 2015-11-30

Family

ID=40262027

Family Applications (2)

Application Number Title Priority Date Filing Date
IL204379A IL204379A (en) 2007-10-01 2010-03-09 Ketoreductase polypeptides, compositions comprising them, expression vector, host cell and methods of synthesis
IL232707A IL232707A (en) 2007-10-01 2014-05-20 Engineered ketoreductase polypeptides, compositions comprising them, methods of reducing substrates and methods for synthesizing intermediates

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL204379A IL204379A (en) 2007-10-01 2010-03-09 Ketoreductase polypeptides, compositions comprising them, expression vector, host cell and methods of synthesis

Country Status (10)

Country Link
US (11) US7883879B2 (en)
EP (1) EP2205727B1 (en)
JP (1) JP5646328B2 (en)
KR (1) KR20100065387A (en)
CN (1) CN101883846A (en)
ES (1) ES2547528T3 (en)
HU (1) HUE027683T2 (en)
IL (2) IL204379A (en)
SI (1) SI2205727T1 (en)
WO (1) WO2009046153A1 (en)

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US7820421B2 (en) * 2007-02-08 2010-10-26 Codexis, Inc. Ketoreductases and uses thereof
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EP2198018B1 (en) 2007-09-13 2013-11-20 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
AT547513T (en) * 2007-09-28 2012-03-15 Codexis Inc Ketoreductase polypeptides and uses thereof
JP5646328B2 (en) 2007-10-01 2014-12-24 コデクシス, インコーポレイテッド Ketreductase polypeptide for the production of azetidinone
WO2010027710A2 (en) 2008-08-27 2010-03-11 Codexis, Inc. Ketoreductase polypeptides and uses thereof
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8426178B2 (en) * 2008-08-27 2013-04-23 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2329014B1 (en) 2008-08-29 2014-10-22 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
SG10201405022PA (en) 2009-08-19 2014-10-30 Codexis Inc Ketoreductase polypeptides for the preparation of phenylephrine
CN102884178B (en) 2009-12-08 2014-12-03 科德克希思公司 Synthesis of prazole compounds
WO2011100265A2 (en) 2010-02-10 2011-08-18 Codexis, Inc. Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
HUE026367T2 (en) 2010-05-04 2016-06-28 Codexis Inc Biocatalysts for ezetimibe synthesis
US9267159B2 (en) 2010-12-08 2016-02-23 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
EP2697662B1 (en) 2011-04-13 2018-06-06 Codexis, Inc. Biocatalytic process for preparing eslicarbazepine and analogs thereof
CN104053771B (en) * 2011-11-18 2016-11-09 科德克希思公司 For the preparation of hydroxy-substituted urethane biocatalysts
DK2847214T3 (en) 2012-05-11 2018-03-12 Codexis Inc Constructed imine reductions and procedures for the reduced amining of keton and amine compounds
CN103045504B (en) * 2012-12-05 2014-06-04 浙江工业大学 Microorganism catalysis prepared (2S,3R)-2-benzoyl aminomethyl-3-hydroxybutyric acid ester and bacterial strain
WO2014150633A1 (en) 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Immobilized ketoreductases and process for making and using immobilized ketoreductase
CN103373934A (en) * 2013-06-14 2013-10-30 苏州汇和药业有限公司 Catalytic synthesis method of chiral intermediate for carbapenem and penem medicaments
CN104342412B (en) * 2013-08-09 2018-12-21 南京朗恩生物科技有限公司 For producing the Ketoreductase mutant of (S) -4- chloro-3-hydroxyl ethyl butyrate
SG11201601695WA (en) 2013-09-27 2016-04-28 Codexis Inc Automated screening of enzyme variants
EP3068793A4 (en) 2013-11-13 2017-09-20 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN106536725A (en) 2014-04-22 2017-03-22 C-乐克塔股份有限公司 System, method and apparatus for providing enrollment of devices in a network
CA2968275A1 (en) 2014-11-25 2016-06-02 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN104531627B (en) * 2014-12-23 2017-07-21 浙江大学 Carbonyl reductase, engineering bacteria and their application
US20180002676A1 (en) * 2015-02-10 2018-01-04 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
CN104846025B (en) * 2015-03-31 2018-06-01 浙江大学 A kind of method for preparing (2S, 3R) -2- benzoyl aminomethyls -3-hydroxybutyrate methyl esters
WO2017001907A1 (en) 2015-06-29 2017-01-05 Teva Pharmaceuticals International Gmbh Biocatalytic processes for the preparation of vilanterol
WO2018035249A1 (en) * 2016-08-16 2018-02-22 Imago Biosciences, Inc. Compositions and methods for producing stereoisomerically pure aminocyclopropanes
WO2019012095A1 (en) 2017-07-14 2019-01-17 C-Lecta Gmbh Ketoreductases

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EP1654354A1 (en) * 2003-08-11 2006-05-10 Codexis, Inc. Improved ketoreductase polypeptides and related polynucleotides
DE10345772A1 (en) 2003-10-01 2005-04-21 Basf Ag A process for the preparation of 3-methylamino-1- (thien-2-yl) -propan-1-ol
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EP1908845A4 (en) * 2005-07-20 2010-10-06 Kaneka Corp Method for producing optically active 2-(n-substituted aminomethyl)-3-hydroxybutyric acid ester
AT502395B1 (en) 2005-07-27 2007-03-15 Iep Gmbh Oxidoreducetases for the stereoselective reduction of ketover bindings
CN101528917B (en) 2006-10-02 2015-07-29 科德克希思公司 His compositions and methods for preparing stereoisomerically pure statin and synthetic intermediates
US7820421B2 (en) * 2007-02-08 2010-10-26 Codexis, Inc. Ketoreductases and uses thereof
JP2010536385A (en) 2007-08-24 2010-12-02 コデクシス, インコーポレイテッド Improved ketoreductase polypeptide for stereoselective production of (R) -3-hydroxythiolane
EP2198018B1 (en) 2007-09-13 2013-11-20 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
AT547513T (en) 2007-09-28 2012-03-15 Codexis Inc Ketoreductase polypeptides and uses thereof
JP5646328B2 (en) 2007-10-01 2014-12-24 コデクシス, インコーポレイテッド Ketreductase polypeptide for the production of azetidinone
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
US8426178B2 (en) * 2008-08-27 2013-04-23 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2329014B1 (en) * 2008-08-29 2014-10-22 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one

Also Published As

Publication number Publication date
HUE027683T2 (en) 2016-10-28
US20170121689A1 (en) 2017-05-04
EP2205727A1 (en) 2010-07-14
US9719071B2 (en) 2017-08-01
US20150337271A1 (en) 2015-11-26
US9580694B2 (en) 2017-02-28
WO2009046153A1 (en) 2009-04-09
JP5646328B2 (en) 2014-12-24
US10329540B2 (en) 2019-06-25
JP2010539952A (en) 2010-12-24
WO2009046153A4 (en) 2009-06-25
US8980606B2 (en) 2015-03-17
US20170002333A1 (en) 2017-01-05
IL232707A (en) 2015-11-30
US20140057330A1 (en) 2014-02-27
ES2547528T3 (en) 2015-10-07
US9476034B2 (en) 2016-10-25
US20160281067A1 (en) 2016-09-29
SI2205727T1 (en) 2015-09-30
US20110159567A1 (en) 2011-06-30
US9133442B2 (en) 2015-09-15
EP2205727B1 (en) 2015-06-24
US20090162909A1 (en) 2009-06-25
US8470572B2 (en) 2013-06-25
US9382519B2 (en) 2016-07-05
US20150197731A1 (en) 2015-07-16
KR20100065387A (en) 2010-06-16
US8257952B2 (en) 2012-09-04
US20190256825A1 (en) 2019-08-22
IL204379A (en) 2014-06-30
CN101883846A (en) 2010-11-10
US20130034895A1 (en) 2013-02-07
US20170313992A1 (en) 2017-11-02
US7883879B2 (en) 2011-02-08

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