IL222149A - A polypeptide comprising a variant human igg fc region that has increased fcrn binding affinity - Google Patents

A polypeptide comprising a variant human igg fc region that has increased fcrn binding affinity

Info

Publication number
IL222149A
IL222149A IL222149A IL22214912A IL222149A IL 222149 A IL222149 A IL 222149A IL 222149 A IL222149 A IL 222149A IL 22214912 A IL22214912 A IL 22214912A IL 222149 A IL222149 A IL 222149A
Authority
IL
Israel
Prior art keywords
polypeptide
binding affinity
fc region
human igg
igg fc
Prior art date
Application number
IL222149A
Other languages
Hebrew (he)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US11602399P priority Critical
Priority to PCT/US2000/000973 priority patent/WO2000042072A2/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL222149A publication Critical patent/IL222149A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
IL222149A 1999-01-15 2012-09-27 A polypeptide comprising a variant human igg fc region that has increased fcrn binding affinity IL222149A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11602399P true 1999-01-15 1999-01-15
PCT/US2000/000973 WO2000042072A2 (en) 1999-01-15 2000-01-14 Polypeptide variants with altered effector function

Publications (1)

Publication Number Publication Date
IL222149A true IL222149A (en) 2018-11-29

Family

ID=22364785

Family Applications (5)

Application Number Title Priority Date Filing Date
IL14405600A IL144056D0 (en) 1999-01-15 2000-01-14 Polypeptide variants with altered effector function
IL144056A IL144056A (en) 1999-01-15 2001-06-28 Polypeptide variants with altered effector function
IL222149A IL222149A (en) 1999-01-15 2012-09-27 A polypeptide comprising a variant human igg fc region that has increased fcrn binding affinity
IL223048A IL223048A (en) 1999-01-15 2012-11-15 Polypeptide variants that bind fcrn with increased binding affinity and methods for their preparation
IL223047A IL223047A (en) 1999-01-15 2012-11-15 Antibody comprising an fc region and uses thereof

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL14405600A IL144056D0 (en) 1999-01-15 2000-01-14 Polypeptide variants with altered effector function
IL144056A IL144056A (en) 1999-01-15 2001-06-28 Polypeptide variants with altered effector function

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL223048A IL223048A (en) 1999-01-15 2012-11-15 Polypeptide variants that bind fcrn with increased binding affinity and methods for their preparation
IL223047A IL223047A (en) 1999-01-15 2012-11-15 Antibody comprising an fc region and uses thereof

Country Status (17)

Country Link
US (4) US20060194290A1 (en)
EP (4) EP1141024B1 (en)
JP (4) JP2003512019A (en)
KR (4) KR20060067983A (en)
CN (2) CN1237076C (en)
AU (2) AU778683B2 (en)
BR (1) BR0008758A (en)
CA (1) CA2359067C (en)
ES (1) ES2694002T3 (en)
HK (1) HK1090066A1 (en)
HU (2) HU230769B1 (en)
IL (5) IL144056D0 (en)
MX (2) MXPA01007170A (en)
NZ (1) NZ539776A (en)
PL (3) PL209786B1 (en)
WO (1) WO2000042072A2 (en)
ZA (1) ZA200105484B (en)

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