IL220939D0 - Compounds and methods - Google Patents
Compounds and methodsInfo
- Publication number
- IL220939D0 IL220939D0 IL220939A IL22093912A IL220939D0 IL 220939 D0 IL220939 D0 IL 220939D0 IL 220939 A IL220939 A IL 220939A IL 22093912 A IL22093912 A IL 22093912A IL 220939 D0 IL220939 D0 IL 220939D0
- Authority
- IL
- Israel
- Prior art keywords
- compounds
- methods
- Prior art date
Links
- 150000001875 compounds Chemical class 0 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y02A50/38—Medical treatment of vector-borne diseases characterised by the agent
- Y02A50/408—Medical treatment of vector-borne diseases characterised by the agent the vector-borne disease being caused by a protozoa
- Y02A50/411—Medical treatment of vector-borne diseases characterised by the agent the vector-borne disease being caused by a protozoa of the genus Plasmodium, i.e. Malaria
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y02A50/46—Medical treatment of waterborne diseases characterized by the agent
- Y02A50/462—The waterborne disease being caused by a virus
- Y02A50/463—The waterborne disease being caused by a virus the virus being the Hepatitis A virus [HAV]
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29457510P true | 2010-01-13 | 2010-01-13 | |
| PCT/US2011/021089 WO2011088181A1 (en) | 2010-01-13 | 2011-01-13 | Compounds and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL220939D0 true IL220939D0 (en) | 2012-09-24 |
| IL220939A IL220939A (en) | 2016-11-30 |
Family
ID=44304635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL220939A IL220939A (en) | 2010-01-13 | 2012-07-12 | Compounds for the inhibition of hdac and pharmaceutical compositions comprising them |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8901156B2 (en) |
| EP (1) | EP2533783B8 (en) |
| JP (1) | JP6017313B2 (en) |
| KR (1) | KR101781663B1 (en) |
| CN (1) | CN103221047B (en) |
| AU (1) | AU2011205283B2 (en) |
| BR (1) | BR112012017441B1 (en) |
| CA (1) | CA2787018A1 (en) |
| EA (1) | EA022964B1 (en) |
| ES (1) | ES2560627T3 (en) |
| IL (1) | IL220939A (en) |
| MX (1) | MX341133B (en) |
| SG (1) | SG182401A1 (en) |
| WO (1) | WO2011088181A1 (en) |
| ZA (1) | ZA201205125B (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2013517281A (en) | 2010-01-13 | 2013-05-16 | テンペロ、ファーマシューティカルズ、インコーポレイテッドＴｅｍｐｅｒｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Compounds and methods |
| EA201490228A1 (en) * | 2011-07-08 | 2014-08-29 | Новартис Аг | New derivatives of triftoromethyloroxiazole and their application for the treatment of disease |
| WO2013066833A1 (en) * | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods to inhibit histone deacetylase (hdac) enzymes |
| WO2013066835A2 (en) * | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| JP5966014B2 (en) * | 2011-11-28 | 2016-08-10 | ノバルティス アーゲー | Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of diseases |
| WO2013113716A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113720A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113787A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| US9055750B2 (en) | 2012-02-03 | 2015-06-16 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113773A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113778A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| EA201400858A1 (en) | 2012-02-03 | 2015-01-30 | Басф Се | Fungicide pyrmidin compounds |
| WO2013113776A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| CN104736530A (en) * | 2012-08-23 | 2015-06-24 | 艾丽奥斯生物制药有限公司 | Compounds for the treatment of paramoxyvirus viral infections |
| CN102826985B (en) * | 2012-09-18 | 2015-08-19 | 厦门大学 | A kind of preparation method of 1-(3,4,5-trihydroxy-) phenyl-1-alkyl ketone |
| US9828345B2 (en) | 2013-02-28 | 2017-11-28 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors |
| TW201444798A (en) | 2013-02-28 | 2014-12-01 | Squibb Bristol Myers Co | Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors |
| CN103214327A (en) * | 2013-03-22 | 2013-07-24 | 郑州泰基鸿诺药物科技有限公司 | Aromatic ring or heteroaromatic trifluoromethyl ketone compound and preparation method thereof |
| NZ716822A (en) * | 2013-08-21 | 2017-10-27 | Alios Biopharma Inc | Antiviral compounds |
| MD4635B1 (en) | 2013-10-14 | 2019-06-30 | Eisai R&D Management Co., Ltd. | Selectively substituted quinoline compounds |
| RU2671496C2 (en) | 2013-10-14 | 2018-11-01 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | 5-piperidin-8-cyanochinoline derivatives |
| PL226024B1 (en) * | 2013-10-23 | 2017-06-30 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością | New application of N-[2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]ethyl]-2-oxo-1,5,6,7-tetrahydrocyclopenta[b] pyridyno-3-carboxyamide |
| AU2015270651B2 (en) | 2014-06-06 | 2018-11-15 | Basf Se | Use of substituted oxadiazoles for combating phytopathogenic fungi |
| WO2016031815A1 (en) * | 2014-08-26 | 2016-03-03 | 武田薬品工業株式会社 | Heterocyclic compound |
| US9896436B2 (en) | 2014-09-16 | 2018-02-20 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| WO2017161033A1 (en) * | 2016-03-15 | 2017-09-21 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| KR20170048590A (en) | 2014-09-16 | 2017-05-08 | 셀젠 콴티셀 리서치, 인크. | Histone demethylase inhibitors |
| CN104262281A (en) * | 2014-10-16 | 2015-01-07 | 湖南华腾制药有限公司 | Preparation method of 2-bromo-4(4-ethoxyphenyl) oxazole |
| WO2016065583A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Oxazole orexin receptor antagonists |
| US10183937B2 (en) * | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| US10174016B2 (en) | 2014-12-09 | 2019-01-08 | Beyer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| TW201636329A (en) | 2015-02-02 | 2016-10-16 | 佛瑪治療公司 | Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors |
| SG11201708622UA (en) | 2015-02-02 | 2017-11-29 | Forma Therapeutics Inc | 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors |
| WO2016164770A1 (en) | 2015-04-10 | 2016-10-13 | Bioresponse, L.L.C. | Self-emulsifying formulations of dim-related indoles |
| WO2016179550A1 (en) | 2015-05-07 | 2016-11-10 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
| WO2016179554A1 (en) | 2015-05-07 | 2016-11-10 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
| TW201713649A (en) | 2015-07-17 | 2017-04-16 | 武田藥品工業股份有限公司 | Heterocyclic compound |
| JPWO2017014170A1 (en) | 2015-07-17 | 2018-04-26 | 武田薬品工業株式会社 | Heterocyclic compounds |
| TW201712007A (en) | 2015-07-27 | 2017-04-01 | 鐘根堂股份有限公司 | 1,3,4-oxadiazole sulfamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| TWI639587B (en) * | 2015-07-27 | 2018-11-01 | 鐘根堂股份有限公司 | 1,3,4-oxadiazole sulfonamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| WO2017018804A1 (en) * | 2015-07-27 | 2017-02-02 | 주식회사 종근당 | 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same |
| EP3331864A4 (en) * | 2015-08-04 | 2019-05-01 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| JPWO2017033946A1 (en) | 2015-08-25 | 2018-06-07 | 武田薬品工業株式会社 | Heterocyclic compounds |
| JP2018535935A (en) | 2015-10-02 | 2018-12-06 | シンジェンタ パーティシペーションズ アーゲー | Microbicidal oxadiazole derivatives |
| AU2016338118B2 (en) * | 2015-10-12 | 2019-03-14 | Chong Kun Dang Pharmaceutical Corp. | Oxadiazole amine derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| EP3167716A1 (en) | 2015-11-10 | 2017-05-17 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| EP3373735A1 (en) | 2015-11-13 | 2018-09-19 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| AU2016354902A1 (en) | 2015-11-19 | 2018-05-10 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| CA3006911A1 (en) | 2015-12-22 | 2017-06-29 | Syngenta Participations Ag | Pesticidally active pyrazole derivatives |
| CN105503716A (en) * | 2016-01-30 | 2016-04-20 | 天长市淳峰精细材料合成厂 | Preparation method of 2,6-dicyanopyridine |
| WO2017222950A1 (en) * | 2016-06-23 | 2017-12-28 | Merck Sharp & Dohme Corp. | 3-heterocyclyl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
| AR109304A1 (en) | 2016-08-10 | 2018-11-21 | Sumitomo Chemical Co | Oxadiazole compound and its use |
| WO2018057933A1 (en) * | 2016-09-22 | 2018-03-29 | The Regents Of The University Of Colorado, A Body Corporate | Compounds, compositions, and methods for reducing oxidative stress in cardiomyocytes |
| US10435399B2 (en) | 2017-07-31 | 2019-10-08 | Takeda Pharmaceutical Company Limited | HDAC6 inhibitory heterocyclic compound |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5523312A (en) * | 1994-09-27 | 1996-06-04 | Sterling Winthrop Inc. | Antipicornaviral agents |
| JP2003518923A (en) * | 1999-09-08 | 2003-06-17 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | Deacetylase and crystal structure of the inhibitor |
| PE20020354A1 (en) | 2000-09-01 | 2002-06-12 | Novartis Ag | Hydroxamate compounds as inhibitors of histone deacetylase (HDA) |
| TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| ES2462341T3 (en) * | 2004-12-10 | 2014-05-22 | Msd Italia S.R.L. | Heterocyclic derivatives such as histone deacetylase inhibitors (HDAC) |
| EP1863756A1 (en) | 2005-03-24 | 2007-12-12 | Janssen Pharmaceutica N.V. | Biaryl derived amide modulators of vanilloid vr1 receptor |
| GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| JP2013517281A (en) | 2010-01-13 | 2013-05-16 | テンペロ、ファーマシューティカルズ、インコーポレイテッドＴｅｍｐｅｒｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Compounds and methods |
| JP2013517279A (en) | 2010-01-13 | 2013-05-16 | テンペロ、ファーマシューティカルズ、インコーポレイテッドＴｅｍｐｅｒｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Compounds and methods |
| WO2013006408A1 (en) | 2011-07-01 | 2013-01-10 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
| EA201490228A1 (en) | 2011-07-08 | 2014-08-29 | Новартис Аг | New derivatives of triftoromethyloroxiazole and their application for the treatment of disease |
-
2011
- 2011-01-13 BR BR112012017441A patent/BR112012017441B1/en active IP Right Grant
- 2011-01-13 WO PCT/US2011/021089 patent/WO2011088181A1/en active Application Filing
- 2011-01-13 MX MX2012008280A patent/MX341133B/en active IP Right Grant
- 2011-01-13 KR KR1020127021121A patent/KR101781663B1/en active IP Right Grant
- 2011-01-13 SG SG2012050076A patent/SG182401A1/en unknown
- 2011-01-13 JP JP2012549064A patent/JP6017313B2/en active Active
- 2011-01-13 EA EA201290638A patent/EA022964B1/en not_active IP Right Cessation
- 2011-01-13 AU AU2011205283A patent/AU2011205283B2/en active Active
- 2011-01-13 ES ES11733353.4T patent/ES2560627T3/en active Active
- 2011-01-13 CN CN201180013827.0A patent/CN103221047B/en active IP Right Grant
- 2011-01-13 CA CA2787018A patent/CA2787018A1/en not_active Abandoned
- 2011-01-13 EP EP11733353.4A patent/EP2533783B8/en active Active
- 2011-01-13 US US13/522,044 patent/US8901156B2/en active Active
-
2012
- 2012-07-10 ZA ZA2012/05125A patent/ZA201205125B/en unknown
- 2012-07-12 IL IL220939A patent/IL220939A/en active IP Right Grant
-
2014
- 2014-10-22 US US14/520,633 patent/US20150038534A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150038534A1 (en) | 2015-02-05 |
| JP2013517278A (en) | 2013-05-16 |
| EP2533783A4 (en) | 2013-07-17 |
| SG182401A1 (en) | 2012-08-30 |
| BR112012017441B1 (en) | 2019-11-19 |
| ZA201205125B (en) | 2013-03-27 |
| JP6017313B2 (en) | 2016-10-26 |
| ES2560627T3 (en) | 2016-02-22 |
| EP2533783A1 (en) | 2012-12-19 |
| US8901156B2 (en) | 2014-12-02 |
| AU2011205283B2 (en) | 2014-07-10 |
| US20130059883A1 (en) | 2013-03-07 |
| MX341133B (en) | 2016-08-08 |
| EA022964B1 (en) | 2016-03-31 |
| CN103221047B (en) | 2014-12-17 |
| EA201290638A1 (en) | 2013-02-28 |
| EP2533783B1 (en) | 2015-11-04 |
| WO2011088181A1 (en) | 2011-07-21 |
| IL220939A (en) | 2016-11-30 |
| BR112012017441A2 (en) | 2016-04-19 |
| MX2012008280A (en) | 2012-11-23 |
| WO2011088181A9 (en) | 2013-01-31 |
| CN103221047A (en) | 2013-07-24 |
| KR20130036093A (en) | 2013-04-10 |
| CA2787018A1 (en) | 2011-07-21 |
| KR101781663B1 (en) | 2017-09-25 |
| AU2011205283A1 (en) | 2012-08-02 |
| EP2533783B8 (en) | 2015-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |