IL220939D0 - Compounds and methods - Google Patents
Compounds and methodsInfo
- Publication number
- IL220939D0 IL220939D0 IL220939A IL22093912A IL220939D0 IL 220939 D0 IL220939 D0 IL 220939D0 IL 220939 A IL220939 A IL 220939A IL 22093912 A IL22093912 A IL 22093912A IL 220939 D0 IL220939 D0 IL 220939D0
- Authority
- IL
- Israel
- Prior art keywords
- compounds
- methods
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
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- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Y02A50/411—
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- Y02A50/463—
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29457510P true | 2010-01-13 | 2010-01-13 | |
| PCT/US2011/021089 WO2011088181A1 (en) | 2010-01-13 | 2011-01-13 | Compounds and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL220939D0 true IL220939D0 (en) | 2012-09-24 |
| IL220939A IL220939A (en) | 2016-11-30 |
Family
ID=44304635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL220939A IL220939A (en) | 2010-01-13 | 2012-07-12 | Compounds for the inhibition of hdac and pharmaceutical compositions comprising them |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8901156B2 (en) |
| EP (1) | EP2533783B8 (en) |
| JP (1) | JP6017313B2 (en) |
| KR (1) | KR101781663B1 (en) |
| CN (1) | CN103221047B (en) |
| AU (1) | AU2011205283B2 (en) |
| BR (1) | BR112012017441B1 (en) |
| CA (1) | CA2787018A1 (en) |
| EA (1) | EA022964B1 (en) |
| ES (1) | ES2560627T3 (en) |
| IL (1) | IL220939A (en) |
| MX (1) | MX341133B (en) |
| SG (1) | SG182401A1 (en) |
| WO (1) | WO2011088181A1 (en) |
| ZA (1) | ZA201205125B (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013517281A (en) | 2010-01-13 | 2013-05-16 | テンペロ、ファーマシューティカルズ、インコーポレイテッドＴｅｍｐｅｒｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Compounds and methods |
| CN103764635B (en) * | 2011-07-08 | 2016-01-20 | 诺华股份有限公司 | New trifluoromethyl-oxadiazole derivative and the purposes in disease treatment thereof |
| WO2013066833A1 (en) * | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods to inhibit histone deacetylase (hdac) enzymes |
| WO2013066835A2 (en) * | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| JP5966014B2 (en) * | 2011-11-28 | 2016-08-10 | ノバルティス アーゲー | Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of diseases |
| US9072301B2 (en) | 2012-02-03 | 2015-07-07 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113776A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113778A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| US9055750B2 (en) | 2012-02-03 | 2015-06-16 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113787A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113773A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113716A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113720A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| NZ704666A (en) * | 2012-08-23 | 2018-05-25 | Alios Biopharma Inc | Compounds for the treatment of paramoxyvirus viral infections |
| CN102826985B (en) * | 2012-09-18 | 2015-08-19 | 厦门大学 | A kind of preparation method of 1-(3,4,5-trihydroxy-) phenyl-1-alkyl ketone |
| JP6423372B2 (en) | 2013-02-28 | 2018-11-14 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors |
| AR094929A1 (en) | 2013-02-28 | 2015-09-09 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
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| JP6483666B2 (en) | 2013-10-14 | 2019-03-13 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Selectively substituted quinoline compounds |
| PL226024B1 (en) * | 2013-10-23 | 2017-06-30 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną | New application of N-[2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]ethyl]-2-oxo-1,5,6,7-tetrahydrocyclopenta[b] pyridyno-3-carboxyamide |
| CN106455572B (en) | 2014-06-06 | 2020-01-14 | 巴斯夫欧洲公司 | Use of substituted oxadiazoles for combating phytopathogenic fungi |
| JP6556146B2 (en) | 2014-08-26 | 2019-08-07 | 武田薬品工業株式会社 | Heterocyclic compounds |
| JP6660060B2 (en) | 2014-09-16 | 2020-03-04 | セルジーン クオンティセル リサーチ，インク． | Histone demethylase inhibitor |
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| WO2016065583A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Oxazole orexin receptor antagonists |
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| US10799479B2 (en) | 2015-04-10 | 2020-10-13 | Bioresponse, L.L.C. | Self-emulsifying formulations of DIM-related indoles |
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| WO2018057933A1 (en) * | 2016-09-22 | 2018-03-29 | The Regents Of The University Of Colorado, A Body Corporate | Compounds, compositions, and methods for reducing oxidative stress in cardiomyocytes |
| US10435399B2 (en) | 2017-07-31 | 2019-10-08 | Takeda Pharmaceutical Company Limited | HDAC6 inhibitory heterocyclic compound |
| CN112351981A (en) | 2018-06-29 | 2021-02-09 | 先正达农作物保护股份公司 | Microbicidal oxadiazole derivatives |
| KR20200012316A (en) * | 2018-07-26 | 2020-02-05 | 주식회사 종근당 | 1,3,4-Oxadiazole Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same |
| WO2020032071A1 (en) * | 2018-08-08 | 2020-02-13 | 日本農薬株式会社 | Oxadiazoline compound or salt thereof, agricultural or horticultural bactericide containing said compound, and use method therefor |
| CN112194620A (en) * | 2020-12-04 | 2021-01-08 | 苏州开元民生科技股份有限公司 | Preparation method of 2-ethyl-4-cyanopyridine |
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| US5523312A (en) | 1994-09-27 | 1996-06-04 | Sterling Winthrop Inc. | Antipicornaviral agents |
| EP1212357B1 (en) | 1999-09-08 | 2007-05-02 | Sloan-Kettering Institute For Cancer Research | Crystal structure of a deacetylase and inhibitors thereof |
| PE20020354A1 (en) | 2000-09-01 | 2002-06-12 | Novartis Ag | HYDROXAMATE COMPOUNDS AS HISTONE-DESACETILASE (HDA) INHIBITORS |
| TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| CA2590811C (en) * | 2004-12-10 | 2013-07-30 | Barbara Attenni | Heterocycle derivatives as histone deacetylase (hdac) inhibitors |
| US20060223837A1 (en) | 2005-03-24 | 2006-10-05 | Ellen Codd | Biaryl derived amide modulators of vanilloid VR1 receptor |
| GB0603041D0 (en) * | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| JP2013517281A (en) | 2010-01-13 | 2013-05-16 | テンペロ、ファーマシューティカルズ、インコーポレイテッドＴｅｍｐｅｒｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Compounds and methods |
| US20120322827A1 (en) | 2010-01-13 | 2012-12-20 | Erkan Baloglu | Compounds and methods |
| WO2013006408A1 (en) | 2011-07-01 | 2013-01-10 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
| CN103764635B (en) | 2011-07-08 | 2016-01-20 | 诺华股份有限公司 | New trifluoromethyl-oxadiazole derivative and the purposes in disease treatment thereof |
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| EP2533783B8 (en) | 2015-12-16 |
| CN103221047B (en) | 2014-12-17 |
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| AU2011205283A1 (en) | 2012-08-02 |
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| ES2560627T3 (en) | 2016-02-22 |
| US20150038534A1 (en) | 2015-02-05 |
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| EP2533783A1 (en) | 2012-12-19 |
| KR20130036093A (en) | 2013-04-10 |
| CN103221047A (en) | 2013-07-24 |
| IL220939A (en) | 2016-11-30 |
| MX2012008280A (en) | 2012-11-23 |
| WO2011088181A9 (en) | 2013-01-31 |
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| EP2533783A4 (en) | 2013-07-17 |
| CA2787018A1 (en) | 2011-07-21 |
| BR112012017441B1 (en) | 2019-11-19 |
| JP2013517278A (en) | 2013-05-16 |
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