IL215147D0 - Compounds - Google Patents

Compounds

Info

Publication number
IL215147D0
IL215147D0 IL215147A IL21514711A IL215147D0 IL 215147 D0 IL215147 D0 IL 215147D0 IL 215147 A IL215147 A IL 215147A IL 21514711 A IL21514711 A IL 21514711A IL 215147 D0 IL215147 D0 IL 215147D0
Authority
IL
Israel
Prior art keywords
compounds
Prior art date
Application number
IL215147A
Original Assignee
Medical Res Council Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB0904746A priority Critical patent/GB0904746D0/en
Priority to US16202409P priority
Priority to GB0912238A priority patent/GB0912238D0/en
Priority to GBGB1001418.1A priority patent/GB201001418D0/en
Priority to PCT/GB2010/000498 priority patent/WO2010106333A1/en
Application filed by Medical Res Council Technology filed Critical Medical Res Council Technology
Publication of IL215147D0 publication Critical patent/IL215147D0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
IL215147A 2009-03-19 2011-09-14 Compounds IL215147D0 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB0904746A GB0904746D0 (en) 2009-03-19 2009-03-19 Compounds
US16202409P true 2009-03-20 2009-03-20
GB0912238A GB0912238D0 (en) 2009-07-14 2009-07-14 Compounds
GBGB1001418.1A GB201001418D0 (en) 2010-01-28 2010-01-28 Compounds
PCT/GB2010/000498 WO2010106333A1 (en) 2009-03-19 2010-03-19 Compounds

Publications (1)

Publication Number Publication Date
IL215147D0 true IL215147D0 (en) 2011-12-29

Family

ID=42226628

Family Applications (1)

Application Number Title Priority Date Filing Date
IL215147A IL215147D0 (en) 2009-03-19 2011-09-14 Compounds

Country Status (13)

Country Link
US (2) US20100317646A1 (en)
EP (1) EP2408772B1 (en)
JP (1) JP5732036B2 (en)
KR (1) KR101700229B1 (en)
CN (1) CN102428084B (en)
AU (1) AU2010224693B2 (en)
CA (1) CA2754605C (en)
CL (1) CL2011002267A1 (en)
IL (1) IL215147D0 (en)
MX (1) MX2011009807A (en)
PE (1) PE20120506A1 (en)
RU (1) RU2011142182A (en)
WO (1) WO2010106333A1 (en)

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AT503744T (en) * 2006-08-16 2011-04-15 Hoffmann La Roche Non-nucleosidic reverse transcriptase inhibitors
GB201008134D0 (en) * 2010-05-14 2010-06-30 Medical Res Council Technology Compounds
GB201015949D0 (en) 2010-09-22 2010-11-03 Genentech Inc Compounds
US9233977B2 (en) * 2010-10-29 2016-01-12 Merck Sharp & Dohme Corp. Leucine-rich repeat kinase enzyme activity
EP2680695A4 (en) * 2011-02-28 2014-09-10 Merck Sharp & Dohme Compounds inhibiting leucine-rich repeat kinase enzyme activity
US8791112B2 (en) 2011-03-30 2014-07-29 Arrien Pharmaceuticals Llc Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors
EP2699572B1 (en) * 2011-04-21 2016-08-10 Origenis GmbH Heterocyclic compounds as kinase inhibitors
CN103917525B (en) 2011-05-23 2016-08-17 依兰制药公司 The inhibitor of LRRK2 kinase activity
CN102558174B (en) * 2011-08-23 2014-03-19 天津市斯芬克司药物研发有限公司 New pyrazolo[4,3-c]pyridine compound and synthesis method thereof
HUE029728T2 (en) * 2011-09-30 2017-03-28 Ipsen Pharma Sas Macrocyclic lrrk2 kinase inhibitors
GB201204985D0 (en) 2012-03-21 2012-05-02 Genentech Inc Compounds
WO2013182612A1 (en) 2012-06-07 2013-12-12 Bayer Pharma Aktiengesellschaft Glucose transport inhibitors
SG11201408044QA (en) * 2012-06-29 2015-01-29 Pfizer NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS
WO2014026330A1 (en) * 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
WO2014060113A1 (en) 2012-10-19 2014-04-24 Origenis Gmbh Novel kinase inhibitors
US9944634B2 (en) 2012-10-31 2018-04-17 Raqualia Pharma Inc. Pyrazolopyridine derivatives as TTX-S blockers
MD20150037A2 (en) * 2012-11-08 2015-11-30 Pfizer Inc. Heteroaromatic compounds as dopamine D1 ligands
US9045477B2 (en) * 2013-03-15 2015-06-02 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
WO2014150981A1 (en) * 2013-03-15 2014-09-25 Elan Pharmaceuticals, Llc Inhibitors of lrrk2 kinase activity
TW201533043A (en) * 2013-04-18 2015-09-01 Lundbeck & Co As H Arylpyrrolopyridine derived compounds as LRRK2 inhibitors
AR096654A1 (en) 2013-06-20 2016-01-27 Ab Science Benzimidazole derivatives as selective protein kinase inhibitors
EP3035800B1 (en) * 2013-08-22 2019-10-09 Merck Sharp & Dohme Corp. Compounds inhibiting leucine-rich repeat kinase enzyme activity
JP6487921B2 (en) 2013-12-17 2019-03-20 ファイザー・インク Novel 3,4-disubstituted-1H-pyrrolo [2,3-b] pyridines and 4,5-disubstituted-7H-pyrrolo [2,3-c] pyridazines as LRRK2 inhibitors
US9868744B2 (en) 2014-04-25 2018-01-16 Pfizer Inc. Heteroaromatic compounds and their use as dopamine D1 ligands
JP2017515836A (en) 2014-05-14 2017-06-15 ファイザー・インク Pyrazolopyridine and pyrazolopyrimidine
US20180230152A1 (en) * 2014-09-03 2018-08-16 Merck Sharp & Dohme Corp. Compounds inhibiting leucine-rich repeat kinase enzyme activity
JP2018526422A (en) 2015-09-14 2018-09-13 ファイザー・インク Novel imidazo [4,5-c] quinoline and imidazo [4,5-c] [1,5] naphthyridine derivatives as LRRK2 inhibitors
US20190307763A1 (en) * 2016-06-15 2019-10-10 Lifearc Substituted tricyclic heterocyclic compounds and use thereof
KR101923852B1 (en) 2017-02-24 2018-11-29 재단법인 대구경북첨단의료산업진흥재단 Pharmaceutical composition for preventing or treating brain cancer comprising compounds penetrating blood-brain barrier
KR101990738B1 (en) * 2018-07-24 2019-06-19 재단법인 대구경북첨단의료산업진흥재단 Pharmaceutical composition for preventing or treating brain cancer comprising compounds penetrating blood-brain barrier

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Publication number Priority date Publication date Assignee Title
US3835144A (en) * 1972-06-16 1974-09-10 Squibb & Sons Inc Amino derivatives of (4,3-c pyrazolopyridine cabroxylic acids and esters
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US5478830A (en) * 1992-05-29 1995-12-26 The Du Pont Merck Pharmaceutical Company Fused-ring heterocycles for the treatment of atherosclerosis
US5300478A (en) * 1993-01-28 1994-04-05 Zeneca Limited Substituted fused pyrazolo compounds
EP1510516A4 (en) * 2002-05-31 2005-11-02 Eisai Co Ltd Pyrazole compound and medicinal composition containing the same
AU2003259749A1 (en) * 2002-08-12 2004-02-25 Sugen, Inc. 3-pyrrolyl-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors
US7348338B2 (en) * 2003-07-17 2008-03-25 Plexxikon, Inc. PPAR active compounds
CA2534509A1 (en) * 2003-08-06 2005-02-24 Sugen, Inc. Geometrically restricted 3-cyclopentylidene-1,3-dihydroindol-2-ones as potent protein kinase inhibitors
WO2005121094A1 (en) * 2004-06-09 2005-12-22 Pfizer Limited Piperazine and piperidine derivatives as anti-hiv-agents
EP1772454A4 (en) * 2004-07-23 2009-02-25 Mitsubishi Tanabe Pharma Corp Nitrogenous fused bicyclic compound
PE20061119A1 (en) 2005-01-19 2006-11-27 Aventis Pharma Sa PYRAZOLO pyridines AS FAK kinase inhibitors, KDR and Tie
WO2007089862A2 (en) * 2006-01-31 2007-08-09 Elan Pharmaceuticals, Inc. Alpha-synuclein kinase
JP2009531443A (en) * 2006-03-29 2009-09-03 フォールドアールエックス ファーマシューティカルズ インコーポレーティッド Inhibition of alpha-synuclein toxicity
CA2737472A1 (en) * 2008-09-26 2010-04-01 Boehringer Ingelheim International Gmbh Azaindazole compounds as ccr1 receptor antagonists
GB201015949D0 (en) * 2010-09-22 2010-11-03 Genentech Inc Compounds

Also Published As

Publication number Publication date
AU2010224693B2 (en) 2016-07-28
EP2408772B1 (en) 2015-07-01
WO2010106333A1 (en) 2010-09-23
US20170320870A1 (en) 2017-11-09
CN102428084B (en) 2016-05-18
MX2011009807A (en) 2011-09-29
RU2011142182A (en) 2013-04-27
CA2754605A1 (en) 2010-09-23
KR20110128925A (en) 2011-11-30
AU2010224693A1 (en) 2011-09-15
JP5732036B2 (en) 2015-06-10
CN102428084A (en) 2012-04-25
PE20120506A1 (en) 2012-05-14
CA2754605C (en) 2018-04-17
CL2011002267A1 (en) 2012-05-11
JP2012520861A (en) 2012-09-10
EP2408772A1 (en) 2012-01-25
US20100317646A1 (en) 2010-12-16
KR101700229B1 (en) 2017-01-26

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