IL206100D0 - Process for the preparation of macrocycle - Google Patents

Process for the preparation of macrocycle

Info

Publication number
IL206100D0
IL206100D0 IL206100A IL20610010A IL206100D0 IL 206100 D0 IL206100 D0 IL 206100D0 IL 206100 A IL206100 A IL 206100A IL 20610010 A IL20610010 A IL 20610010A IL 206100 D0 IL206100 D0 IL 206100D0
Authority
IL
Israel
Prior art keywords
macrocycle
preparation
process
Prior art date
Application number
IL206100A
Other versions
IL206100A (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP07150287 priority Critical
Priority to PCT/EP2008/067309 priority patent/WO2009080542A1/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL206100D0 publication Critical patent/IL206100D0/en
Publication of IL206100A publication Critical patent/IL206100A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of products other than chlorine, adipic acid, caprolactam, or chlorodifluoromethane, e.g. bulk or fine chemicals or pharmaceuticals
    • Y02P20/55Synthetic design, e.g. reducing the use of auxiliary or protecting groups
IL206100A 2007-12-21 2010-05-31 Process for the preparation of sodium ((2r,6s,13as,14ar,16as,z)-6-(amino)-2-(4-haloisoindoline-2-carbonyloxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,15,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carbonyl)(cyclpropylsulfonyl)amide derivatives IL206100A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07150287 2007-12-21
PCT/EP2008/067309 WO2009080542A1 (en) 2007-12-21 2008-12-11 Process for the preparation of a macrocycle

Publications (2)

Publication Number Publication Date
IL206100D0 true IL206100D0 (en) 2010-11-30
IL206100A IL206100A (en) 2015-09-24

Family

ID=40456983

Family Applications (1)

Application Number Title Priority Date Filing Date
IL206100A IL206100A (en) 2007-12-21 2010-05-31 Process for the preparation of sodium ((2r,6s,13as,14ar,16as,z)-6-(amino)-2-(4-haloisoindoline-2-carbonyloxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,15,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carbonyl)(cyclpropylsulfonyl)amide derivatives

Country Status (12)

Country Link
US (1) US7910728B2 (en)
EP (1) EP2225249B1 (en)
JP (1) JP5439384B2 (en)
KR (1) KR101629523B1 (en)
CN (1) CN101903391B (en)
AU (1) AU2008340430B2 (en)
BR (1) BRPI0820733A2 (en)
CA (1) CA2709032C (en)
ES (1) ES2599927T3 (en)
IL (1) IL206100A (en)
MX (1) MX2010006659A (en)
WO (1) WO2009080542A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201071034A1 (en) 2008-04-15 2011-06-30 Интермьюн, Инк. New macrocyclic inhibitors of hepatitis c virus replications
JP5728752B2 (en) 2008-08-07 2015-06-03 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Process for producing macrocyclic compounds
UY32099A (en) 2008-09-11 2010-04-30 Enanta Pharm Inc macrocyclic serine protease inhibitors of hepatitis c
AR075584A1 (en) * 2009-02-27 2011-04-20 Intermune Inc THERAPEUTIC COMPOSITIONS COMPRISING beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine ACID AND DERIVATIVE isoindole carboxylic acid and its uses. COMPOUND.
US8377962B2 (en) 2009-04-08 2013-02-19 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors
US8232246B2 (en) 2009-06-30 2012-07-31 Abbott Laboratories Anti-viral compounds
WO2011017389A1 (en) 2009-08-05 2011-02-10 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv
WO2011038283A1 (en) * 2009-09-28 2011-03-31 Hoffmann-La Roche Inc. Novel macrocyclic inhibitors of hepatitis c virus replication
EP2483290A4 (en) * 2009-09-28 2013-05-01 Intermune Inc Cyclic peptide inhibitors of hepatitis c virus replication
NZ600608A (en) 2009-12-18 2015-01-30 Idenix Pharmaceuticals Inc 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors
JP5717768B2 (en) * 2010-03-10 2015-05-13 アッヴィ・バハマズ・リミテッド Solid composition
WO2012092411A2 (en) 2010-12-30 2012-07-05 Abbott Laboratories Phenanthridine macrocyclic hepatitis c serine protease inhibitors
JP2014502620A (en) 2010-12-30 2014-02-03 エナンタ ファーマシューティカルズ インコーポレイテッド Macrocyclic hepatitis C serine protease inhibitor
US9353100B2 (en) 2011-02-10 2016-05-31 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections
US20120252721A1 (en) 2011-03-31 2012-10-04 Idenix Pharmaceuticals, Inc. Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
EP2583680A3 (en) 2011-10-21 2013-06-12 Abbvie Inc. Mono (PSI-7977) or combination treatment of DAAs for use in treating HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
JP5677645B2 (en) 2011-10-21 2015-02-25 アッヴィ・インコーポレイテッド At least two direct acting antiviral agents and a method for treating HCV comprising ribavirin but not interferon
CN104822682A (en) 2012-10-08 2015-08-05 艾伯维公司 Compounds useful for making HCV protease inhibitors
WO2014062196A1 (en) 2012-10-19 2014-04-24 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9334279B2 (en) 2012-11-02 2016-05-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014070964A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2014070974A1 (en) 2012-11-05 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2964664B1 (en) 2013-03-07 2017-01-11 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2015042375A1 (en) 2013-09-20 2015-03-26 Idenix Pharmaceuticals, Inc. Hepatitis c virus inhibitors
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
US20170135990A1 (en) 2014-03-05 2017-05-18 Idenix Pharmaceuticals Llc Pharmaceutical compositions comprising a 5,5-fused heteroarylene flaviviridae inhibitor and their use for treating or preventing flaviviridae infection
EP3114122A1 (en) 2014-03-05 2017-01-11 Idenix Pharmaceuticals LLC Solid forms of a flaviviridae virus inhibitor compound and salts thereof
CN109280074A (en) * 2017-07-20 2019-01-29 歌礼药业(浙江)有限公司 Dan Nuoruiwei sodium crystal and preparation method thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5831108A (en) 1995-08-03 1998-11-03 California Institute Of Technology High metathesis activity ruthenium and osmium metal carbene complexes
EP1395616B1 (en) * 2001-04-16 2019-05-22 California Institute Of Technology Group 8 transition metal carbene complexes as enantioselective olefin metathesis catalysts
DE10335416A1 (en) * 2003-08-02 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg New ruthenium complexes containing an o-hydrocarbyloxycarbonylmethoxy-benzylidene ligand, used as catalysts for metathesis reactions, e.g. ring-closure metathesis and cross metathesis reactions
EP1680137B1 (en) * 2003-10-14 2012-11-21 F. Hoffmann-La Roche Ltd. Macrocyclic carboxylic acid and acylsulfonamide compound as inhibitor of HCV replication
US20070249637A1 (en) * 2004-10-21 2007-10-25 Collins Michael R Inhibitors Of Hepatitis C Virus Protease, And Compositions And Treatments Using The Same
EP2305696A3 (en) 2005-07-25 2011-10-12 Intermune, Inc. Macrocyclic inhibitors of Hepatitis C virus replication
DE102006008520A1 (en) * 2006-02-22 2007-08-23 Lanxess Deutschland Gmbh New catalyst system comprising a metathesis catalyst and a salt of a mono-, di- or tri-valent cation other than copper, used for metathesis reactions, e.g. for the degradation of nitrile rubber
PL379879A1 (en) * 2006-06-07 2007-12-10 Umicore Ag & Co.Kg. Ruthenium and osmium complex, the manner of their production and their application as (pre)catalytic agent of metathesis reaction
US20100323953A1 (en) 2007-01-08 2010-12-23 Phenomix Corporation Macrocyclic hepatitis c protease inhibitors

Also Published As

Publication number Publication date
KR20100106411A (en) 2010-10-01
CN101903391B (en) 2013-04-03
AU2008340430B2 (en) 2013-01-24
MX2010006659A (en) 2010-07-05
ES2599927T3 (en) 2017-02-06
CA2709032C (en) 2016-02-23
JP5439384B2 (en) 2014-03-12
EP2225249A1 (en) 2010-09-08
BRPI0820733A2 (en) 2015-06-16
US7910728B2 (en) 2011-03-22
CN101903391A (en) 2010-12-01
WO2009080542A1 (en) 2009-07-02
KR101629523B1 (en) 2016-06-10
EP2225249B1 (en) 2016-08-03
AU2008340430A1 (en) 2009-07-02
CA2709032A1 (en) 2009-07-02
US20090163706A1 (en) 2009-06-25
JP2011508729A (en) 2011-03-17
IL206100A (en) 2015-09-24

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees