IL205759D0 - Isoxazolo-pyridine derivatives - Google Patents

Isoxazolo-pyridine derivatives

Info

Publication number
IL205759D0
IL205759D0 IL205759A IL20575910A IL205759D0 IL 205759 D0 IL205759 D0 IL 205759D0 IL 205759 A IL205759 A IL 205759A IL 20575910 A IL20575910 A IL 20575910A IL 205759 D0 IL205759 D0 IL 205759D0
Authority
IL
Israel
Prior art keywords
isoxazolo
pyridine derivatives
pyridine
derivatives
Prior art date
Application number
IL205759A
Other versions
IL205759A (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP07122240 priority Critical
Priority to PCT/EP2008/066225 priority patent/WO2009071476A1/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL205759D0 publication Critical patent/IL205759D0/en
Publication of IL205759A publication Critical patent/IL205759A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
IL205759A 2007-12-04 2010-05-13 Isoxazolo-pyridine derivatives, process for preparing same and medicaments containing same IL205759A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07122240 2007-12-04
PCT/EP2008/066225 WO2009071476A1 (en) 2007-12-04 2008-11-26 Isoxazolo-pyridine derivatives

Publications (2)

Publication Number Publication Date
IL205759D0 true IL205759D0 (en) 2010-11-30
IL205759A IL205759A (en) 2014-07-31

Family

ID=40329314

Family Applications (1)

Application Number Title Priority Date Filing Date
IL205759A IL205759A (en) 2007-12-04 2010-05-13 Isoxazolo-pyridine derivatives, process for preparing same and medicaments containing same

Country Status (34)

Country Link
US (6) US20090143371A1 (en)
EP (2) EP2227467B1 (en)
JP (1) JP5301557B2 (en)
KR (2) KR101237576B1 (en)
CN (1) CN101889010B (en)
AR (1) AR069523A1 (en)
AU (1) AU2008333326B2 (en)
BR (1) BRPI0820112B1 (en)
CA (1) CA2707648C (en)
CL (1) CL2008003591A1 (en)
CO (1) CO6351788A2 (en)
CR (1) CR11454A (en)
CY (2) CY1116119T1 (en)
DK (2) DK2767536T3 (en)
EC (1) ECSP10010230A (en)
ES (2) ES2550994T3 (en)
HK (1) HK1149756A1 (en)
HR (2) HRP20150348T1 (en)
HU (1) HUE025545T2 (en)
IL (1) IL205759A (en)
MA (1) MA31865B1 (en)
MX (1) MX2010005717A (en)
MY (1) MY156747A (en)
NZ (1) NZ585308A (en)
PE (2) PE20091073A1 (en)
PL (2) PL2227467T3 (en)
PT (2) PT2227467E (en)
RS (2) RS54355B1 (en)
RU (1) RU2484091C2 (en)
SI (2) SI2227467T1 (en)
TW (1) TWI363624B (en)
UA (1) UA100132C2 (en)
WO (1) WO2009071476A1 (en)
ZA (1) ZA201003631B (en)

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CN102186825A (en) * 2008-10-21 2011-09-14 麦它波莱克斯股份有限公司 Aryl gpr120 receptor agonists and uses thereof
US8748623B2 (en) 2009-02-17 2014-06-10 Syntrix Biosystems, Inc. Pyridinecarboxamides as CXCR2 modulators
US8389550B2 (en) * 2009-02-25 2013-03-05 Hoffmann-La Roche Inc. Isoxazoles / O-pyridines with ethyl and ethenyl linker
US8222246B2 (en) * 2009-04-02 2012-07-17 Hoffmann-La Roche Inc. Substituted isoxazoles
US8227461B2 (en) 2009-04-30 2012-07-24 Hoffmann-La Roche Inc. Isoxazoles
BRPI1014454A2 (en) * 2009-05-05 2016-04-05 Hoffmann La Roche isoxazol-pyrazole derivatives
BRPI1013844A2 (en) * 2009-05-05 2016-04-12 Hoffmann La Roche pyridine-isoxazole derivatives
CA2759598C (en) * 2009-05-05 2017-09-12 F. Hoffmann-La Roche Ag Isoxazole-thiazole derivatives as gaba a receptor inverse agonists for use in the treatment of cognitive disorders
ES2430223T3 (en) 2009-05-07 2013-11-19 F. Hoffmann-La Roche Ag Isoxazol-pyridine derivatives as GABA modulators
WO2011035324A1 (en) * 2009-09-21 2011-03-24 Vanderbilt University O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators
WO2011094545A2 (en) 2010-01-28 2011-08-04 President And Fellows Of Harvard College Compositions and methods for enhancing proteasome activity
CN103003265A (en) 2010-07-19 2013-03-27 先正达参股股份有限公司 Microbicides
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CA2811990A1 (en) 2010-08-23 2012-03-01 Dean Y. Maeda Aminopyridine- and aminopyrimidinecarboxamides as cxcr2 modulators
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CN103189062B (en) * 2010-11-05 2016-03-23 霍夫曼-拉罗奇有限公司 Active pharmaceutical compounds is used for the treatment of the purposes of central nervous system disorders
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US8785435B2 (en) * 2011-10-20 2014-07-22 Hoffmann-La Roche Inc. Solid forms
WO2013102145A1 (en) * 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
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WO2014001278A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
JP6223443B2 (en) 2012-06-26 2017-11-01 サニオナ・エイピイエス Use of phenyltriazole derivatives and GABAA receptor complex for modulating GABAA receptor complex
WO2014001280A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001279A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
US9849135B2 (en) 2013-01-25 2017-12-26 President And Fellows Of Harvard College USP14 inhibitors for treating or preventing viral infections
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2014145040A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US10450269B1 (en) 2013-11-18 2019-10-22 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
KR20190041548A (en) 2013-03-15 2019-04-22 글로벌 블러드 테라퓨틱스, 인크. Compounds and uses thereof for the modulation of hemoglobin
EP2792360A1 (en) 2013-04-18 2014-10-22 IP Gesellschaft für Management mbH (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV
US10561676B2 (en) 2013-08-02 2020-02-18 Syntrix Biosystems Inc. Method for treating cancer using dual antagonists of CXCR1 and CXCR2
US8969365B2 (en) 2013-08-02 2015-03-03 Syntrix Biosystems, Inc. Thiopyrimidinecarboxamides as CXCR1/2 modulators
US10046002B2 (en) 2013-08-02 2018-08-14 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
CA2916564A1 (en) 2014-02-07 2015-08-13 Global Blood Therapeutics, Inc. Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
JP2017071553A (en) * 2014-02-25 2017-04-13 味の素株式会社 Novel compound having hetero atom-methylene-heterocycle structure
TW201927299A (en) 2015-03-30 2019-07-16 美商全球血液治療公司 Aldehyde compounds and pharmaceutical composition and use thereof
TW201932440A (en) 2016-05-12 2019-08-16 美商全球血液治療公司 Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
TW201815384A (en) 2016-10-12 2018-05-01 美商全球血液治療公司 Tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
AU2017373734A1 (en) 2016-12-08 2019-04-11 F. Hoffmann-La Roche Ag New isoxazolyl ether derivatives as GABA a α5 PAM
UY38031A (en) * 2017-12-22 2019-07-31 Bayer Ag Hidroxiisoxazolinas and derivatives thereof
WO2019238633A1 (en) 2018-06-13 2019-12-19 F. Hoffmann-La Roche Ag New isoxazolyl ether derivatives as gaba a alpha5 pam
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Also Published As

Publication number Publication date
US9073908B2 (en) 2015-07-07
KR20100075669A (en) 2010-07-02
IL205759A (en) 2014-07-31
TW200924763A (en) 2009-06-16
ES2550994T3 (en) 2015-11-13
RS53877B1 (en) 2015-08-31
KR101237576B1 (en) 2013-03-04
BRPI0820112A2 (en) 2015-05-05
HRP20151250T1 (en) 2015-12-18
AU2008333326B2 (en) 2013-05-30
CO6351788A2 (en) 2011-12-20
CN101889010B (en) 2012-12-05
MY156747A (en) 2016-03-31
BRPI0820112B1 (en) 2019-01-15
PT2767536E (en) 2015-11-17
CA2707648A1 (en) 2009-06-11
US8877782B2 (en) 2014-11-04
HUE025545T2 (en) 2016-03-29
US20130281690A1 (en) 2013-10-24
KR20120102117A (en) 2012-09-17
TWI363624B (en) 2012-05-11
MA31865B1 (en) 2010-11-01
AR069523A1 (en) 2010-01-27
HK1149756A1 (en) 2013-08-30
WO2009071476A1 (en) 2009-06-11
RU2010123923A (en) 2012-01-10
CN101889010A (en) 2010-11-17
US20130274469A1 (en) 2013-10-17
RU2484091C2 (en) 2013-06-10
DK2227467T3 (en) 2015-01-19
CR11454A (en) 2010-06-28
CA2707648C (en) 2014-08-12
US8518974B2 (en) 2013-08-27
EP2227467A1 (en) 2010-09-15
RS54355B1 (en) 2016-04-28
PT2227467E (en) 2015-03-02
CY1116119T1 (en) 2017-02-08
AU2008333326A1 (en) 2009-06-11
US8877783B2 (en) 2014-11-04
US8846719B2 (en) 2014-09-30
JP5301557B2 (en) 2013-09-25
MX2010005717A (en) 2010-06-02
CL2008003591A1 (en) 2010-01-04
SI2767536T1 (en) 2015-12-31
ZA201003631B (en) 2013-10-30
EP2227467B1 (en) 2014-12-31
PL2227467T3 (en) 2015-05-29
ES2531023T3 (en) 2015-03-09
DK2767536T3 (en) 2015-10-19
US20120184538A1 (en) 2012-07-19
SI2227467T1 (en) 2015-03-31
ECSP10010230A (en) 2010-07-30
US20090143371A1 (en) 2009-06-04
NZ585308A (en) 2012-03-30
PE20130242A1 (en) 2013-03-04
US20130274468A1 (en) 2013-10-17
HRP20150348T1 (en) 2015-05-08
US20130274467A1 (en) 2013-10-17
PL2767536T3 (en) 2016-01-29
CY1116902T1 (en) 2017-04-05
UA100132C2 (en) 2012-11-26
JP2011505401A (en) 2011-02-24
EP2767536B1 (en) 2015-09-02
EP2767536A1 (en) 2014-08-20
PE20091073A1 (en) 2009-07-23

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