IL205753D0 - Isoxazolo-pyridazine derivatives - Google Patents

Isoxazolo-pyridazine derivatives

Info

Publication number
IL205753D0
IL205753D0 IL205753A IL20575310A IL205753D0 IL 205753 D0 IL205753 D0 IL 205753D0 IL 205753 A IL205753 A IL 205753A IL 20575310 A IL20575310 A IL 20575310A IL 205753 D0 IL205753 D0 IL 205753D0
Authority
IL
Israel
Prior art keywords
isoxazolo
pyridazine derivatives
pyridazine
derivatives
Prior art date
Application number
IL205753A
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP07122293 priority Critical
Priority to PCT/EP2008/066226 priority patent/WO2009071477A1/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL205753D0 publication Critical patent/IL205753D0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
IL205753A 2007-12-04 2010-05-13 Isoxazolo-pyridazine derivatives IL205753D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07122293 2007-12-04
PCT/EP2008/066226 WO2009071477A1 (en) 2007-12-04 2008-11-26 Isoxazolo-pyridazine derivatives

Publications (1)

Publication Number Publication Date
IL205753D0 true IL205753D0 (en) 2010-11-30

Family

ID=40328910

Family Applications (1)

Application Number Title Priority Date Filing Date
IL205753A IL205753D0 (en) 2007-12-04 2010-05-13 Isoxazolo-pyridazine derivatives

Country Status (15)

Country Link
US (1) US7943619B2 (en)
EP (1) EP2231651B1 (en)
JP (1) JP5301558B2 (en)
KR (1) KR101175855B1 (en)
CN (1) CN101868458B (en)
AR (1) AR069525A1 (en)
AU (1) AU2008333327B2 (en)
BR (1) BRPI0820113A2 (en)
CA (1) CA2707821C (en)
CL (1) CL2008003593A1 (en)
IL (1) IL205753D0 (en)
MX (1) MX2010006182A (en)
PE (1) PE20091446A1 (en)
TW (1) TW200924775A (en)
WO (1) WO2009071477A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2227467T1 (en) 2007-12-04 2015-03-31 F. Hoffmann-La Roche Ag Isoxazolo-pyridine derivatives
CN102186825A (en) * 2008-10-21 2011-09-14 麦它波莱克斯股份有限公司 Aryl gpr120 receptor agonists and uses thereof
US8227461B2 (en) * 2009-04-30 2012-07-24 Hoffmann-La Roche Inc. Isoxazoles
CA2759598C (en) * 2009-05-05 2017-09-12 F. Hoffmann-La Roche Ag Isoxazole-thiazole derivatives as gaba a receptor inverse agonists for use in the treatment of cognitive disorders
BRPI1013844A2 (en) * 2009-05-05 2016-04-12 Hoffmann La Roche pyridine-isoxazole derivatives
CN102414204B (en) 2009-05-05 2014-12-31 弗·哈夫曼-拉罗切有限公司 Isoxazole-pyridazine derivatives
BRPI1014454A2 (en) * 2009-05-05 2016-04-05 Hoffmann La Roche isoxazol-pyrazole derivatives
AR081626A1 (en) * 2010-04-23 2012-10-10 Cytokinetics Inc amino-pyridazine compounds, pharmaceutical compositions containing them and use thereof for treating cardiac and skeletal muscle disorders
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (en) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pyrimidines compositions thereof and methods of use thereof
CA2815741A1 (en) * 2010-11-09 2012-05-18 F. Hoffmann-La Roche Ag Triazole derivatives as ligands for gaba receptors
WO2012068161A1 (en) 2010-11-15 2012-05-24 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
JP6042438B2 (en) 2011-09-27 2016-12-14 ジェンフィットGenfit Derivatives of 6-substituted triazolopyridazines as Rev-erb agonists
US8604062B2 (en) 2011-10-20 2013-12-10 Hoffman-La Roche Inc. Process for the preparation of isoxazolyl-methoxy nicotinic acids
CA2853231A1 (en) * 2011-10-28 2013-05-02 Inhibitaxin Limited Pyridazine derivatives with autotaxin activity for use in therapy
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2014001279A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
CN104411699B (en) 2012-06-26 2017-06-13 萨尼奥纳有限责任公司 Phenyltriazole derivatives and its for adjusting GABAAThe purposes of Receptor Complex
JP6223443B2 (en) * 2012-06-26 2017-11-01 サニオナ・エイピイエス Use of phenyltriazole derivatives and GABAA receptor complex for modulating GABAA receptor complex
WO2014001278A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001280A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
JP2017500334A (en) 2013-12-20 2017-01-05 エージンバイオ, インコーポレイテッド Benzodiazepine derivatives, compositions and methods for treating cognitive impairment
AU2017373734A1 (en) 2016-12-08 2019-04-11 F. Hoffmann-La Roche Ag New isoxazolyl ether derivatives as GABA a α5 PAM
WO2019238633A1 (en) 2018-06-13 2019-12-19 F. Hoffmann-La Roche Ag New isoxazolyl ether derivatives as gaba a alpha5 pam
BR102019014802A2 (en) * 2018-07-20 2020-02-04 Boehringer Ingelheim Int difluoromethyl-phenyl triazoles

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3525205A1 (en) * 1984-09-11 1986-03-20 Hoechst Ag Pflanzenschuetzende medium on the basis of 1,2,4-triazole derivatives as well as new derivatives of 1,2,4-triazole
US6297235B1 (en) * 1997-08-28 2001-10-02 Merck Sharp & Dohme Ltd. Triazolopyridazine derivatives for treating anxiety and enhancing cognition
GB9808663D0 (en) 1998-04-23 1998-06-24 Merck Sharp & Dohme Therapeutic agents
US6262098B1 (en) * 1998-08-07 2001-07-17 Chiron Corporation Estrogen receptor modulators
US6660753B2 (en) * 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
IT1314191B1 (en) 1999-10-18 2002-12-06 Recordati Chem Pharm isossazolcarbossamidici Derivatives
BR0015420A (en) 1999-11-12 2002-07-16 Neurogen Corp Compound, pharmaceutical composition, methods of treating a disease or disorder associated with pathogen agonism, for locating gabaa receptors in a tissue sample, inhibiting the binding of a benzodiazepine compound to a gabaa receptor, and altering the signal transduction activity of gabaa receptors, inverse agonism or antagonism of the gabaa receptor, use of a compound, and packaged pharmaceutical composition
PA8535601A1 (en) 2000-12-21 2002-11-28 Pfizer Benzimidazole derivatives and pyridylimidazole as ligands for GABAA
GB0108475D0 (en) 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
CA2454613A1 (en) 2001-07-05 2003-01-16 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as mch selective antagonists
DE60131967D1 (en) 2001-08-13 2008-01-31 Phenex Pharmaceuticals Ag Nr1h4 nuclear receptor binding compounds
ES2299618T3 (en) 2001-11-20 2008-06-01 Eli Lilly And Company beta-3-adrenergic agonists.
GB0128160D0 (en) * 2001-11-23 2002-01-16 Merck Sharp & Dohme Novel compounds
US7319109B2 (en) 2002-11-22 2008-01-15 Smith Kline Beecham Corporation Farnesoid X receptor agonists
CN1960984B (en) 2004-06-01 2010-05-12 弗·哈夫曼-拉罗切有限公司 Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as MGLU5 receptor antagonists
GB0318447D0 (en) 2003-08-05 2003-09-10 Merck Sharp & Dohme Therapeutic agents
CA2564429A1 (en) * 2004-05-14 2005-12-01 Irm Llc Compounds and compositions as ppar modulators
US20080153869A1 (en) 2004-06-14 2008-06-26 Bressi Jerome C Kinase Inhibitors
BRPI0516842A (en) 2004-10-01 2008-09-23 Hoffmann La Roche compounds, process for their manufacture, pharmaceutical compositions comprising them, method for the therapeutic and / or prophylactic treatment of diseases that are modulated by lxr alpha and / or lxr beta agonists and use of such compounds
EP1812427A4 (en) 2004-10-15 2009-10-14 Scripps Research Inst Oxadiazole ketone inhibitors of fatty acid amide hydrolase
US20070060589A1 (en) 2004-12-21 2007-03-15 Purandare Ashok V Inhibitors of protein arginine methyl transferases
JPWO2006095882A1 (en) 2005-03-07 2008-08-21 パイオニア株式会社 Hologram apparatus and recording method
WO2006095822A1 (en) 2005-03-11 2006-09-14 Ono Pharmaceutical Co., Ltd. Sulfonamide compound and pharmaceutical thereof
EP1899299B1 (en) * 2005-06-27 2010-10-20 Bristol-Myers Squibb Company C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
WO2007009274A2 (en) 2005-07-20 2007-01-25 Prospective Concepts Ag Pneumatically adjustable side edges for vehicle seats
DE602006003777D1 (en) 2005-09-19 2009-01-02 Hoffmann La Roche Isoxazole derivatives as inverse gaba a alpha5 agonists
WO2007052843A1 (en) 2005-11-04 2007-05-10 Takeda Pharmaceutical Company Limited Heterocyclic amide compound and use thereof
AT526318T (en) 2005-12-19 2011-10-15 Glaxosmithkline Llc Farnesoid X RECEPTOR AGONISTS
JP2007230909A (en) 2006-03-01 2007-09-13 Univ Of Tokyo Substituted isoxazole derivative
EP1894928A1 (en) 2006-08-29 2008-03-05 PheneX Pharmaceuticals AG Heterocyclic fxr binding compounds
EP1894924A1 (en) 2006-08-29 2008-03-05 Phenex Pharmaceuticals AG Heterocyclic FXR binding compounds
EP2142551B1 (en) * 2007-04-17 2015-10-14 Bristol-Myers Squibb Company Fused heterocyclic 11-beta-hydroxysteroid dehydrogenase type i inhibitors

Also Published As

Publication number Publication date
EP2231651B1 (en) 2018-11-21
US7943619B2 (en) 2011-05-17
MX2010006182A (en) 2010-07-01
TW200924775A (en) 2009-06-16
AU2008333327A1 (en) 2009-06-11
JP5301558B2 (en) 2013-09-25
PE20091446A1 (en) 2009-09-24
KR20100074320A (en) 2010-07-01
EP2231651A1 (en) 2010-09-29
AU2008333327B2 (en) 2012-12-06
CN101868458B (en) 2012-11-28
CN101868458A (en) 2010-10-20
US20090143385A1 (en) 2009-06-04
KR101175855B1 (en) 2012-08-24
WO2009071477A1 (en) 2009-06-11
CA2707821A1 (en) 2009-06-11
CL2008003593A1 (en) 2010-01-04
CA2707821C (en) 2016-06-07
JP2011505402A (en) 2011-02-24
AR069525A1 (en) 2010-01-27
BRPI0820113A2 (en) 2015-05-05

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