IL205354D0 - Spiroindolinone derivatives - Google Patents

Spiroindolinone derivatives

Info

Publication number
IL205354D0
IL205354D0 IL20535410A IL20535410A IL205354D0 IL 205354 D0 IL205354 D0 IL 205354D0 IL 20535410 A IL20535410 A IL 20535410A IL 20535410 A IL20535410 A IL 20535410A IL 205354 D0 IL205354 D0 IL 205354D0
Authority
IL
Israel
Prior art keywords
spiroindolinone derivatives
spiroindolinone
derivatives
Prior art date
Application number
IL20535410A
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US1369107P priority Critical
Priority to US10743108P priority
Priority to PCT/EP2008/066874 priority patent/WO2009077357A1/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL205354D0 publication Critical patent/IL205354D0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
IL20535410A 2007-12-14 2010-04-26 Spiroindolinone derivatives IL205354D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US1369107P true 2007-12-14 2007-12-14
US10743108P true 2008-10-22 2008-10-22
PCT/EP2008/066874 WO2009077357A1 (en) 2007-12-14 2008-12-05 Spiroindolinone derivatives

Publications (1)

Publication Number Publication Date
IL205354D0 true IL205354D0 (en) 2010-12-30

Family

ID=40289301

Family Applications (1)

Application Number Title Priority Date Filing Date
IL20535410A IL205354D0 (en) 2007-12-14 2010-04-26 Spiroindolinone derivatives

Country Status (12)

Country Link
US (1) US8134001B2 (en)
EP (1) EP2229396B1 (en)
JP (1) JP2011506380A (en)
KR (1) KR20100076037A (en)
CN (1) CN101896486A (en)
AT (1) AT519764T (en)
AU (1) AU2008337651A1 (en)
BR (1) BRPI0821255A2 (en)
CA (1) CA2707456A1 (en)
IL (1) IL205354D0 (en)
MX (1) MX2010006107A (en)
WO (1) WO2009077357A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776875B2 (en) * 2007-12-19 2010-08-17 Hoffman-La Roche Inc. Spiroindolinone derivatives
US8354444B2 (en) * 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
PE20121282A1 (en) 2009-11-12 2012-10-12 Univ Michigan Spiro-oxindole antagonists of mdm2
US8288431B2 (en) * 2010-02-17 2012-10-16 Hoffmann-La Roche Inc. Substituted spiroindolinones
UY33725A (en) 2010-11-12 2012-06-29 Sanofi Sa MDM2 antagonists spiro-oxindole
CN102584835B (en) * 2011-01-17 2014-08-27 苏州大学 Spiral heterocyclic compound containing indole structure and method for preparing same
WO2012121361A1 (en) 2011-03-10 2012-09-13 第一三共株式会社 Dispiropyrrolidine derivative
WO2012155066A2 (en) 2011-05-11 2012-11-15 Shaomeng Wang Spiro-oxindole mdm2 antagonists
CN102321095B (en) * 2011-05-26 2014-09-10 兰州大学 Chiral spiro indole-pyran pyridine alkaline compound and preparation and application thereof
WO2013049250A1 (en) * 2011-09-27 2013-04-04 Amgen Inc. Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer
CN102627650B (en) * 2012-03-08 2015-07-08 徐州师范大学 Chiral spiro(pyrrolidine-3, 2'-oxindole)compound and synthesis method thereof
TWI586668B (en) 2012-09-06 2017-06-11 第一三共股份有限公司 Crystals of dispiropyrrolidine derivative
WO2015027067A2 (en) * 2013-08-23 2015-02-26 Virginia Commonwealth University Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
JP6503386B2 (en) 2014-07-03 2019-04-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel spiro [3H-indol-3,2'-pyrrolidine] -2 (1H) -one compounds and derivatives as MDM2-p53 inhibitors
US10485794B2 (en) 2015-04-13 2019-11-26 Daiichi Sankyo Company, Limited Treatment method by combined use of MDM2 inhibitor and BTK inhibitor
PE20181205A1 (en) 2015-10-09 2018-07-23 Boehringer Ingelheim Int New spiro [indole-3,2'-3h-pyrrolidin] -2 (1H) -one and derivatives as inhibitors of mdm2-p53
JP2019522633A (en) 2016-05-20 2019-08-15 ジェネンテック, インコーポレイテッド PROTAC antibody conjugates and methods of use
CA3040840A1 (en) 2016-10-17 2018-04-26 Daiichi Sankyo Company, Limited Treatment method by combined use of mdm2 inhibitor and dna methyltransferase inhibitor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070213341A1 (en) 2006-03-13 2007-09-13 Li Chen Spiroindolinone derivatives
US7495007B2 (en) * 2006-03-13 2009-02-24 Hoffmann-La Roche Inc. Spiroindolinone derivatives
JP2009530236A (en) 2006-03-13 2009-08-27 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Spiroindolinone derivatives
US7638548B2 (en) * 2006-11-09 2009-12-29 Hoffmann-La Roche Inc. Spiroindolinone derivatives

Also Published As

Publication number Publication date
WO2009077357A1 (en) 2009-06-25
EP2229396A1 (en) 2010-09-22
US20090156610A1 (en) 2009-06-18
AT519764T (en) 2011-08-15
MX2010006107A (en) 2010-06-25
KR20100076037A (en) 2010-07-05
AU2008337651A1 (en) 2009-06-25
BRPI0821255A2 (en) 2015-06-16
EP2229396B1 (en) 2011-08-10
CN101896486A (en) 2010-11-24
CA2707456A1 (en) 2009-06-25
JP2011506380A (en) 2011-03-03
US8134001B2 (en) 2012-03-13

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