IL197937D0 - Antibodies to lymphotoxin-alpha - Google Patents

Antibodies to lymphotoxin-alpha

Info

Publication number
IL197937D0
IL197937D0 IL197937A IL19793709A IL197937D0 IL 197937 D0 IL197937 D0 IL 197937D0 IL 197937 A IL197937 A IL 197937A IL 19793709 A IL19793709 A IL 19793709A IL 197937 D0 IL197937 D0 IL 197937D0
Authority
IL
Israel
Prior art keywords
lymphotoxin
antibodies
alpha
Prior art date
Application number
IL197937A
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US82925706P priority Critical
Priority to US93899907P priority
Priority to PCT/US2007/081154 priority patent/WO2008063776A2/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL197937D0 publication Critical patent/IL197937D0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • C07K16/242Lymphotoxin [LT]
    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06QDATA PROCESSING SYSTEMS OR METHODS, SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORY OR FORECASTING PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORY OR FORECASTING PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q99/00Subject matter not provided for in other groups of this subclass
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
IL197937A 2006-10-12 2009-04-05 Antibodies to lymphotoxin-alpha IL197937D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US82925706P true 2006-10-12 2006-10-12
US93899907P true 2007-05-18 2007-05-18
PCT/US2007/081154 WO2008063776A2 (en) 2006-10-12 2007-10-11 Antibodies to lymphotoxin-alpha

Publications (1)

Publication Number Publication Date
IL197937D0 true IL197937D0 (en) 2011-08-01

Family

ID=39430415

Family Applications (1)

Application Number Title Priority Date Filing Date
IL197937A IL197937D0 (en) 2006-10-12 2009-04-05 Antibodies to lymphotoxin-alpha

Country Status (21)

Country Link
US (4) US7923011B2 (en)
EP (1) EP2084188A2 (en)
JP (1) JP5298021B2 (en)
KR (1) KR20090078349A (en)
AR (1) AR063257A1 (en)
AU (1) AU2007324135B2 (en)
BR (1) BRPI0715580A2 (en)
CA (1) CA2665644A1 (en)
CL (1) CL2007002926A1 (en)
CO (1) CO6220841A2 (en)
CR (1) CR10705A (en)
IL (1) IL197937D0 (en)
MA (1) MA30876B1 (en)
MX (1) MX2009003774A (en)
NO (1) NO20091841L (en)
NZ (1) NZ576032A (en)
PE (1) PE09802008A1 (en)
RU (1) RU2486201C2 (en)
TW (1) TWI414531B (en)
UA (1) UA94484C2 (en)
WO (1) WO2008063776A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012503656A (en) * 2008-09-26 2012-02-09 エウレカ セラピューティクス,インコーポレイテッド Cell lines and proteins with mutant glycosylation patterns
WO2010039714A1 (en) * 2008-09-30 2010-04-08 Genentech, Inc. Biological markers predictive of rheumatoid arthritis response to lymphotoxin antagonists
AR078161A1 (en) 2009-09-11 2011-10-19 Hoffmann La Roche highly concentrated anti-CD20 antibody of pharmaceutical formulations. Use of the formulation. treatment method.
WO2011060015A1 (en) 2009-11-11 2011-05-19 Genentech, Inc. Methods and compositions for detecting target proteins
RU2012147249A (en) 2010-04-07 2014-05-20 Эббви Инк. TNF-α- BINDING PROTEINS
US8858944B2 (en) 2010-06-02 2014-10-14 Sumitomo Dainippon Pharma Co., Ltd. Treatment drug for autoimmune diseases and allergic diseases
CN102621310B (en) * 2011-01-28 2014-07-02 上海科新生物技术股份有限公司 Colloidal gold chromatography anti-U1-RNP antibody detection test paper and preparation method thereof
KR20130036993A (en) * 2011-10-05 2013-04-15 삼성전자주식회사 Antibodies specifically binding to epitope in sema domain of c-met
WO2013114164A1 (en) * 2012-01-30 2013-08-08 Dr. Reddy's Laboratories Limited Method for obtaining glycoprotein composition with increased afucosylation content
GB201314052D0 (en) 2013-08-06 2013-09-18 Apitope Int Nv Peptides
JP2016538878A (en) * 2013-10-14 2016-12-15 シンアフィックス ビー.ブイ. Glycoengineered antibodies, antibody conjugates, and methods for their preparation
WO2015057906A1 (en) * 2013-10-16 2015-04-23 Janssen Biotech, Inc. Cd200 receptor 1 agonists
KR101820572B1 (en) * 2015-08-12 2018-01-19 가톨릭대학교 산학협력단 Method for providing the information for chronic myeloid leukemia

Family Cites Families (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
US4920196A (en) 1982-07-30 1990-04-24 Genentech, Inc. Human lymphotoxin
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US5683688A (en) 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
NZ212207A (en) * 1984-05-31 1991-07-26 Genentech Inc Recombinant lymphotoxin
US4959457A (en) 1984-05-31 1990-09-25 Genentech, Inc. Anti-lymphotoxin
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
IL85035D0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
AU600575B2 (en) 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
DE3850542D1 (en) 1987-09-23 1994-08-11 Bristol Myers Squibb Co Antibody heteroconjugates to Töting of HIV-infected cells.
JPH023698A (en) 1988-06-20 1990-01-09 Denka Seiken Co Ltd Monoclonal antibody against human lymphotoxin, hybridoma capable of producing the same antibody, method for purifying and measuring human lymphotoxin using the same antibody and measuring reagent
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US6475787B1 (en) 1989-07-28 2002-11-05 Wyeth Method for producing monoclonal antibodies
NZ235148A (en) 1989-09-05 1991-12-23 Immunex Corp Tumour necrosis factor receptor protein and dna sequences
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
EP0536299B1 (en) 1990-06-27 2001-06-06 Biogen, Inc. Surface complexed lymphotoxin
US7030080B2 (en) 1990-06-27 2006-04-18 Biogen, Inc. Lymphotoxin-β, lymphotoxin-β complexes, pharmaceutical preparations and therapeutic uses thereof
US5795964A (en) 1990-06-27 1998-08-18 Biogen, Inc. Lymphotoxin-beta and lymphotoxin-beta complexes
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
DK0546073T3 (en) 1990-08-29 1998-02-02 Genpharm Int Making and using transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
US5264365A (en) 1990-11-09 1993-11-23 Board Of Regents, The University Of Texas System Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides
US5508192A (en) 1990-11-09 1996-04-16 Board Of Regents, The University Of Texas System Bacterial host strains for producing proteolytically sensitive polypeptides
DE69129154D1 (en) 1990-12-03 1998-04-30 Genentech Inc A method for enrichment of protein variants with altered binding properties
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
US7192584B2 (en) 1991-03-18 2007-03-20 Centocor, Inc. Methods of treating psoriasis with anti-TNF antibodies
US20050260201A1 (en) 1993-01-29 2005-11-24 Centocor, Inc. Methods of treating rheumatoid arthritis using anti-TNF receptor fusion proteins
AT414768T (en) 1991-04-10 2008-12-15 Scripps Research Inst Libraries of heterodimeric receptors by phagemids
US6407213B1 (en) 1991-06-14 2002-06-18 Genentech, Inc. Method for making humanized antibodies
EP0604580A1 (en) 1991-09-19 1994-07-06 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES
ES2136092T3 (en) 1991-09-23 1999-11-16 Medical Res Council Procedures for the production of humanized antibodies.
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
RU2048521C1 (en) * 1992-05-25 1995-11-20 Научно-Исследовательский Конструкторско-Технологический Институт Биологически Активных Веществ Method of preparing polypeptide showing human lymphotoxin property
US6270766B1 (en) 1992-10-08 2001-08-07 The Kennedy Institute Of Rheumatology Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
CA2150262C (en) 1992-12-04 2008-07-08 Kaspar-Philipp Holliger Multivalent and multispecific binding proteins, their manufacture and use
US5747023A (en) 1994-07-01 1998-05-05 Genentech, Inc. Cancer therapy using lymphotoxin
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US6312691B1 (en) 1996-01-26 2001-11-06 Jeffrey L. Browning Lymphotoxin-α/β complexes and anti-lympotoxin-β receptor antibodies as anti-tumor agents
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5837234A (en) 1995-06-07 1998-11-17 Cytotherapeutics, Inc. Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane
US5925351A (en) 1995-07-21 1999-07-20 Biogen, Inc. Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
WO1997038123A1 (en) 1996-04-05 1997-10-16 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
US5747373A (en) * 1996-09-24 1998-05-05 Taiwan Semiconductor Manufacturing Company Ltd. Nitride-oxide sidewall spacer for salicide formation
US7255854B1 (en) 1996-10-25 2007-08-14 Biogen, Inc. Use of lymphotoxin-β receptor blocking agents for the treatment of antibody mediated immunological diseases
CZ142899A3 (en) 1996-10-25 1999-07-14 Biogen, Inc. Process of influencing immune response by making use of lt-{beta}-r blocking agent and pharmaceutical composition containing thereof
US6083715A (en) 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
EP2261229A3 (en) 1998-04-20 2011-03-23 GlycArt Biotechnology AG Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
JP4482233B2 (en) * 1998-07-29 2010-06-16 協和発酵キリン株式会社 Novel polypeptide
TR200504220T2 (en) 1998-12-17 2007-04-24 Biogen Idec Ma Inc. Active lymphotoxin-beta receptor immunoglogulin şimeaktif lymphotoxin-beta receptor immunoglogulin yöntem.ırıl to a method for high level expression and purification of high-level expression of the chimeric protein and saflaştrik protein.
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
HU0104865A3 (en) * 1999-01-15 2004-07-28 Genentech Inc Polypeptide variants with altered effector function
WO2000051637A1 (en) 1999-03-02 2000-09-08 Centocor, Inc. ANTI-TNFα ANTIBODIES IN THERAPY OF ASTHMA
DK2270149T3 (en) 1999-04-09 2016-05-09 Kyowa Hakko Kirin Co Ltd Procedure to control the activity of immunological functional molecule.
CA2388245C (en) 1999-10-19 2012-01-10 Tatsuya Ogawa The use of serum-free adapted rat cells for producing heterologous polypeptides
US7056695B2 (en) 2000-03-02 2006-06-06 Xencor TNF-α variants
CN101289511A (en) 2000-04-11 2008-10-22 杰南技术公司 Multivalent antibodies and uses therefore
ES2609016T3 (en) 2000-06-16 2017-04-18 Human Genome Sciences, Inc. Antibodies that bind immunospecifically to BLyS
US20060029604A1 (en) * 2000-06-28 2006-02-09 Gerngross Tillman U Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform
US20060034830A1 (en) 2000-06-28 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a GalGlcNAcMan5GLcNAc2 glycoform
NZ523476A (en) 2000-06-28 2004-04-30 Glycofi Inc Methods for humanizing glycosylation of recombinant glycoproteins expressed in lower eukaryotes
US20060034828A1 (en) 2000-06-28 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a GlcNAcMAN5GLCNAC2 glycoform
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US7064191B2 (en) 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
EE200300179A (en) 2000-10-13 2003-08-15 Biogen, Inc. Humanized LT-.beta.-R antibodies
EP2325205A3 (en) 2000-12-28 2011-10-12 Altus Pharmaceuticals Inc. Crystals of whole antibodies and fragments thereof and methods for making and using them
US20050271663A1 (en) 2001-06-28 2005-12-08 Domantis Limited Compositions and methods for treating inflammatory disorders
WO2003040307A2 (en) 2001-07-27 2003-05-15 Human Genome Sciences, Inc. Heteromultimeric tnf ligand family members
CN1555411A (en) 2001-08-03 2004-12-15 格黎卡特生物技术股份公司 Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
ES2326964T3 (en) * 2001-10-25 2009-10-22 Genentech, Inc. Glycoprotein compositions.
US20030143603A1 (en) 2001-11-30 2003-07-31 Jill Giles-Komar Anti-TNF antibodies, compositions, methods and uses
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
WO2003066834A2 (en) 2002-02-08 2003-08-14 Wyeth Composition and method for modulating an inflammatory response
JPWO2003084569A1 (en) 2002-04-09 2005-08-11 協和醗酵工業株式会社 Antibody composition containing pharmaceutical
PL373256A1 (en) 2002-04-09 2005-08-22 Kyowa Hakko Kogyo Co, Ltd. Cells with modified genome
JP4628679B2 (en) 2002-04-09 2011-02-09 協和発酵キリン株式会社 Cells in which the activity of a protein involved in GDP-fucose transport is reduced or deleted
US20040132140A1 (en) 2002-04-09 2004-07-08 Kyowa Hakko Kogyo Co., Ltd. Production process for antibody composition
US20040259150A1 (en) 2002-04-09 2004-12-23 Kyowa Hakko Kogyo Co., Ltd. Method of enhancing of binding activity of antibody composition to Fcgamma receptor IIIa
AU2003234706A1 (en) 2002-04-15 2003-11-03 Human Genome Sciences, Inc. Antibodies that specifically bind to tl5
TW200416044A (en) 2002-07-01 2004-09-01 Biogen Inc Humanized anti-lymphotoxin β receptor antibodies
US6873910B2 (en) * 2002-10-22 2005-03-29 Qualcomm Incorporated Procedure for searching for position determination signals using a plurality of search modes
US20060147448A1 (en) 2002-10-31 2006-07-06 Jennifer Gommerman Treatment of immunological renal disorders by lymphotoxin pathway inhibitors
DE60332957D1 (en) 2002-12-16 2010-07-22 Genentech Inc Immunoglobulinvarianten and their uses
EP1585547A4 (en) 2002-12-20 2006-10-25 Biogen Idec Inc Lymphotoxin beta receptor agents in combination with chemotherapeutic agents
ES2335005T5 (en) 2003-03-05 2013-04-17 Halozyme, Inc. Soluble hyaluronidase glycoprotein (shasegp), process to prepare it, uses and pharmaceutical compositions that comprise it
EP2502935B1 (en) 2003-08-22 2017-03-29 Biogen MA Inc. Improved antibodies having altered effector function and methods for making the same
JPWO2005035586A1 (en) 2003-10-08 2007-11-22 協和醗酵工業株式会社 Fusion protein composition
AU2004280065A1 (en) 2003-10-09 2005-04-21 Kyowa Hakko Kirin Co., Ltd. Process for producing antibody composition by using RNA inhibiting the function of alpha1,6-fucosyltransferase
EA015009B1 (en) 2003-11-05 2011-04-29 Гликарт Биотехнологи Аг Antigen-binding molecules have an increased affinity for binding to Fc-receptors and effector functions
KR100772800B1 (en) 2003-11-17 2007-11-01 주식회사유한양행 A variable region of the monoclonal antibody against a human tumor necrosis factor ? and a gene encoding the same
WO2005053742A1 (en) 2003-12-04 2005-06-16 Kyowa Hakko Kogyo Co., Ltd. Medicine containing antibody composition
EP1699486A4 (en) * 2003-12-08 2007-07-18 Centocor Inc Anti-human lymphotoxin alpha antibodies, compositions, methods and uses
US7527791B2 (en) 2004-03-31 2009-05-05 Genentech, Inc. Humanized anti-TGF-beta antibodies
AU2005269712A1 (en) 2004-07-21 2006-02-09 Glycofi, Inc. Immunoglobulins comprising predominantly a GlcNAcMan5GlcNAc2 glycoform
JP2008512354A (en) 2004-07-21 2008-04-24 グライコフィ, インコーポレイテッド Man3GlcNAc2 predominantly including immunoglobulin glycoforms
JP2008507535A (en) 2004-07-21 2008-03-13 グライコフィ, インコーポレイテッド Mainly immunoglobulins, including man5glcnac2 glycoform
AU2005269759A1 (en) 2004-07-21 2006-02-09 Glycofi, Inc. Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform
JP2008515772A (en) 2004-07-21 2008-05-15 グライコフィ, インコーポレイテッド Gal2GlcNAc2Man3GlcNAc2 predominantly including immunoglobulin glycoforms
RU2367667C2 (en) 2004-08-19 2009-09-20 Дженентек, Инк. Polypeptide variants with changed effector function
JP2006228261A (en) 2005-02-15 2006-08-31 Micron Technology Inc Negative voltage driving of digit line insulation gate
CA2605781A1 (en) 2005-05-09 2007-04-12 Glycart Biotechnology Ag Antigen binding molecules having modified fc regions and altered binding to fc receptors

Also Published As

Publication number Publication date
JP5298021B2 (en) 2013-09-25
AR063257A1 (en) 2009-01-14
TWI414531B (en) 2013-11-11
CO6220841A2 (en) 2010-11-19
US8541552B2 (en) 2013-09-24
CR10705A (en) 2009-05-07
MX2009003774A (en) 2009-04-22
NZ576032A (en) 2012-03-30
WO2008063776A2 (en) 2008-05-29
TW200825101A (en) 2008-06-16
AU2007324135B2 (en) 2013-06-27
UA94484C2 (en) 2011-05-10
MA30876B1 (en) 2009-11-02
KR20090078349A (en) 2009-07-17
WO2008063776A3 (en) 2009-03-05
EP2084188A2 (en) 2009-08-05
JP2010506568A (en) 2010-03-04
RU2009117680A (en) 2010-11-20
US20110208673A1 (en) 2011-08-25
US8642740B2 (en) 2014-02-04
US20110150865A1 (en) 2011-06-23
US8216807B2 (en) 2012-07-10
CL2007002926A1 (en) 2008-05-16
CA2665644A1 (en) 2008-05-29
NO20091841L (en) 2009-07-13
RU2486201C2 (en) 2013-06-27
US20090285830A1 (en) 2009-11-19
US20130011412A1 (en) 2013-01-10
US7923011B2 (en) 2011-04-12
AU2007324135A1 (en) 2008-05-29
PE09802008A1 (en) 2008-09-02
BRPI0715580A2 (en) 2014-06-10

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