IL191911D0 - Vaccine comprising streptococcus pneumoniae capsular polyaccharide conjugates - Google Patents
Vaccine comprising streptococcus pneumoniae capsular polyaccharide conjugatesInfo
- Publication number
- IL191911D0 IL191911D0 IL19191108A IL19191108A IL191911D0 IL 191911 D0 IL191911 D0 IL 191911D0 IL 19191108 A IL19191108 A IL 19191108A IL 19191108 A IL19191108 A IL 19191108A IL 191911 D0 IL191911 D0 IL 191911D0
- Authority
- IL
- Israel
- Prior art keywords
- polyaccharide
- conjugates
- vaccine
- streptococcus pneumoniae
- pneumoniae capsular
- Prior art date
Links
- 229940031000 Streptococcus pneumoniae Drugs 0 title 1
- 241000193998 Streptococcus pneumoniae Species 0 title 1
- 239000000562 conjugates Substances 0 title 1
- 229960005486 vaccines Drugs 0 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y02A50/38—Medical treatment of vector-borne diseases characterised by the agent
- Y02A50/408—Medical treatment of vector-borne diseases characterised by the agent the vector-borne disease being caused by a protozoa
- Y02A50/411—Medical treatment of vector-borne diseases characterised by the agent the vector-borne disease being caused by a protozoa of the genus Plasmodium, i.e. Malaria
- Y02A50/412—Medical treatment of vector-borne diseases characterised by the agent the vector-borne disease being caused by a protozoa of the genus Plasmodium, i.e. Malaria the medicinal preparation containing antigens or antibodies, e.g. vaccines, antisera
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0526232A GB0526232D0 (en) | 2005-12-22 | 2005-12-22 | Vaccine |
GBGB0607088.2A GB0607088D0 (en) | 2006-04-07 | 2006-04-07 | Vaccine |
GB0607087A GB0607087D0 (en) | 2006-04-07 | 2006-04-07 | Vaccine |
GB0609902A GB0609902D0 (en) | 2006-05-18 | 2006-05-18 | Novel composition |
GB0620337A GB0620337D0 (en) | 2006-10-12 | 2006-10-12 | Vaccine |
GBGB0620336.8A GB0620336D0 (en) | 2006-10-12 | 2006-10-12 | Vaccine |
GB0620816A GB0620816D0 (en) | 2006-10-19 | 2006-10-19 | vaccine |
GB0620815A GB0620815D0 (en) | 2006-10-19 | 2006-10-19 | Vaccine |
PCT/GB2006/004634 WO2007068907A2 (en) | 2005-12-13 | 2006-12-12 | Vaccine compositions comprising a saponin adjuvant |
PCT/EP2006/069977 WO2007071710A2 (en) | 2005-12-22 | 2006-12-20 | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
IL191911D0 true IL191911D0 (en) | 2008-12-29 |
IL191911A IL191911A (en) | 2015-09-24 |
Family
ID=39133667
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL19191308A IL191913A (en) | 2005-12-13 | 2008-06-03 | Streptococcus pneumoniae immunogenic composition comprising s. pneumoniae capsular saccharides conjugated to carrier proteins and its use in the manufacture of a medicament for treating diseases caused by s. pneumoniae infection |
IL191911A IL191911A (en) | 2005-12-13 | 2008-06-03 | Immunogenic composition comprising s. pneumoniae capsular saccharide conjugates and various aspects related thereto |
IL19208408A IL192084A (en) | 2005-12-13 | 2008-06-12 | Immunogenic composition for infants comprising a multivalent streptococcus pneumoniae vaccine and its use |
IL21166411A IL211664D0 (en) | 2005-12-13 | 2011-03-10 | Streptococcus pnevmoniae immunogenic |
IL219641A IL219641A (en) | 2005-12-13 | 2012-05-08 | Immunogenic composition comprising at least four s.pneumoniae capsular saccharide conjugates containing saccharides from different s.pneumoniae serotypes and various aspects related thereto |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL19191308A IL191913A (en) | 2005-12-13 | 2008-06-03 | Streptococcus pneumoniae immunogenic composition comprising s. pneumoniae capsular saccharides conjugated to carrier proteins and its use in the manufacture of a medicament for treating diseases caused by s. pneumoniae infection |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL19208408A IL192084A (en) | 2005-12-13 | 2008-06-12 | Immunogenic composition for infants comprising a multivalent streptococcus pneumoniae vaccine and its use |
IL21166411A IL211664D0 (en) | 2005-12-13 | 2011-03-10 | Streptococcus pnevmoniae immunogenic |
IL219641A IL219641A (en) | 2005-12-13 | 2012-05-08 | Immunogenic composition comprising at least four s.pneumoniae capsular saccharide conjugates containing saccharides from different s.pneumoniae serotypes and various aspects related thereto |
Country Status (37)
Country | Link |
---|---|
US (9) | US20090017072A1 (en) |
EP (10) | EP3130348A1 (en) |
JP (7) | JP5461838B2 (en) |
KR (4) | KR101367237B1 (en) |
CN (6) | CN101378778B (en) |
AR (3) | AR058592A1 (en) |
AT (1) | AT520415T (en) |
AU (4) | AU2006327040B2 (en) |
BR (3) | BRPI0620460B1 (en) |
CA (5) | CA2808919C (en) |
CL (1) | CL2013002106A1 (en) |
CR (2) | CR10119A (en) |
CY (4) | CY1112677T1 (en) |
DK (5) | DK3017827T3 (en) |
EA (3) | EA014165B1 (en) |
ES (4) | ES2539795T3 (en) |
HK (1) | HK1120230A1 (en) |
HR (4) | HRP20110685T1 (en) |
HU (3) | HUE032903T2 (en) |
IL (5) | IL191913A (en) |
JO (1) | JO2813B1 (en) |
LT (3) | LT1973564T (en) |
MA (3) | MA30062B1 (en) |
MX (2) | MX354843B (en) |
MY (4) | MY150719A (en) |
NO (3) | NO344187B1 (en) |
NZ (4) | NZ569077A (en) |
PE (2) | PE20071305A1 (en) |
PH (1) | PH12014502544A1 (en) |
PL (4) | PL1962899T3 (en) |
PT (5) | PT2384765T (en) |
SG (1) | SG168517A1 (en) |
SI (5) | SI1968631T1 (en) |
TR (1) | TR201900418T4 (en) |
TW (4) | TWI415622B (en) |
UA (2) | UA96583C2 (en) |
WO (3) | WO2007071710A2 (en) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ304795B6 (en) * | 2000-06-29 | 2014-10-29 | Glaxosmithkline Biologicals S. A. | Multivalent immunogenic composition |
ES2258108T3 (en) * | 2000-11-07 | 2006-08-16 | Immunovaccine Technologies Inc. | Vaccines with improved immune response and same preparation procedures. |
US7955605B2 (en) | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US9789179B2 (en) * | 2005-06-27 | 2017-10-17 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
TWI415622B (en) * | 2005-12-22 | 2013-11-21 | Glaxosmithkline Biolog Sa | Streptococcus pneumoniae immunogenic composition comprising capsular saccharide conjugates, vaccine and kit comprising the same and uses thereof |
JP5081243B2 (en) * | 2006-08-17 | 2012-11-28 | ザ ユーエービー リサーチ ファウンデーション | Method of using pneumococcal antigen as an index of pneumococcal pneumonia in a subject |
US8398985B2 (en) * | 2007-04-23 | 2013-03-19 | Serum Institute Of India Ltd. | Antigenic polysaccharides and process for their preparation |
CA2685506A1 (en) * | 2007-05-02 | 2008-11-13 | Glaxosmithkline Biologicals S.A. | Vaccine |
AU2008267208B2 (en) * | 2007-06-26 | 2012-01-19 | Glaxosmithkline Biologicals S.A. | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
US9498493B2 (en) | 2007-09-27 | 2016-11-22 | Immunovaccine Technologies Inc. | Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo |
ES2383231T3 (en) | 2007-10-19 | 2012-06-19 | Novartis Ag | Formulations for meningococcal vaccines |
US8226959B2 (en) | 2008-02-01 | 2012-07-24 | Newcastle Innovation Pty Ltd | Vaccine compositions |
WO2009127677A1 (en) * | 2008-04-16 | 2009-10-22 | Glaxosmithkline Biologicals S.A. | Vaccine |
US20120164178A1 (en) * | 2008-04-16 | 2012-06-28 | Ballou Jr William Ripley | Vaccine |
WO2009143413A1 (en) * | 2008-05-22 | 2009-11-26 | Children'smedical Center Corporation | Synergistic immunogenic fusion protein-polysaccharide conjugate |
GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
BRPI0923006A2 (en) | 2008-12-17 | 2016-03-08 | Novartis Ag | meningococcal vaccines including hemoglobin receptor |
US20120064104A1 (en) * | 2009-03-24 | 2012-03-15 | Novartis Ag | Combinations including pneumococcal serotype 14 saccharide |
AU2010227220B2 (en) * | 2009-03-24 | 2014-11-13 | Glaxosmithkline Biologicals S.A. | Combinations of meningococcal factor H binding protein and pneumococcal saccharide conjugates |
WO2010109323A1 (en) | 2009-03-24 | 2010-09-30 | Novartis Ag | Adjuvanting meningococcal factor h binding protein |
BRPI1014494A2 (en) * | 2009-04-30 | 2016-08-02 | Coley Pharm Group Inc | pneumococcal vaccine and its uses |
WO2010141312A2 (en) | 2009-06-01 | 2010-12-09 | Wake Forest University Health Sciences | Flagellin fusion proteins and conjugates comprising pneumococcus antigens and methods of using the same |
SG178904A1 (en) | 2009-09-10 | 2012-04-27 | Novartis Ag | Combination vaccines against respiratory tract diseases |
KR20110068831A (en) * | 2009-12-16 | 2011-06-22 | 재단법인 전라남도생물산업진흥재단 | A liposomal composition, a process for the preparation thereof, and a use thereof as a pneumococcal vaccine |
TW201136603A (en) * | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
GB201003924D0 (en) * | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
AU2011268507B2 (en) | 2010-06-25 | 2014-08-14 | Novartis Ag | Combinations of meningococcal factor H binding proteins |
AU2011300418B2 (en) | 2010-09-10 | 2016-05-12 | Glaxosmithkline Biologicals Sa | Meningococcus overexpressing NadA and/or NHBA and outer membrane vesicles derived therefrom |
WO2012072769A1 (en) | 2010-12-01 | 2012-06-07 | Novartis Ag | Pneumococcal rrgb epitopes and clade combinations |
CN103533954B (en) | 2011-03-02 | 2015-09-09 | 诺华股份有限公司 | Combination vaccine containing a low dose of antigens and / or adjuvants |
GB201103836D0 (en) * | 2011-03-07 | 2011-04-20 | Glaxosmithkline Biolog Sa | Conjugation process |
US20140072622A1 (en) * | 2011-05-17 | 2014-03-13 | Glaxosmithkline Biologicals S.A. | Vaccine against streptococcus pneumoniae |
SG11201401177WA (en) | 2011-10-06 | 2014-04-28 | Immunovaccine Technologies Inc | Liposome compositions comprising an adjuvant that activates or increases the activity of tlr2 and uses thereof |
CA2862247A1 (en) | 2011-12-29 | 2013-07-04 | Novartis Ag | Adjuvanted combinations of meningococcal factor h binding proteins |
HUE040914T4 (en) * | 2012-01-30 | 2019-05-28 | Serum Institute Of India Private Ltd | Immunogenic composition |
CN104114706A (en) | 2012-02-02 | 2014-10-22 | 诺华股份有限公司 | Promoters for increased protein expression in meningococcus |
US20150132339A1 (en) * | 2012-03-07 | 2015-05-14 | Novartis Ag | Adjuvanted formulations of streptococcus pneumoniae antigens |
WO2013132043A1 (en) | 2012-03-08 | 2013-09-12 | Novartis Ag | Combination vaccines with tlr4 agonists |
KR20130142574A (en) | 2012-06-20 | 2013-12-30 | 에스케이케미칼주식회사 | Multivalent pneumococcal polysaccharide-protein conjugate composition |
RU2510281C2 (en) * | 2012-06-22 | 2014-03-27 | Общество с ограниченной ответственностью "Эпитоп" (ООО "Эпитоп") | HYBRID PROTEIN VACCINE AGAINST PNEUMONIA CAUSED BY Streptococcus pneumoniae |
WO2014009971A2 (en) * | 2012-07-07 | 2014-01-16 | Bharat Biotech International Limited | Non-alcoholic vaccine compositions free from animal- origin and process for preparation thereof |
MX363511B (en) * | 2012-08-16 | 2019-03-26 | Pfizer | Glycoconjugation processes and compositions. |
AU2013311702A1 (en) | 2012-09-06 | 2015-02-19 | Novartis Ag | Combination vaccines with serogroup B meningococcus and D/T/P |
GB201218660D0 (en) | 2012-10-17 | 2012-11-28 | Glaxosmithkline Biolog Sa | Immunogenic composition |
KR20140075196A (en) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | Multivalent pneumococcal polysaccharide-protein conjugate composition |
KR20140075201A (en) * | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | Multivalent pneumococcal polysaccharide-protein conjugate composition |
CN105007935A (en) | 2012-12-18 | 2015-10-28 | 葛兰素史密丝克莱恩生物有限公司 | Conjugates for protecting against diphtheria and/or tetanus |
RU2544168C1 (en) * | 2014-01-17 | 2015-03-10 | Андрей Дмитриевич Протасов | Method for forming immunological memory to streptococcus pneumoniae antigens in patients with chronic obstructive pulmonary disease |
WO2015110942A2 (en) * | 2014-01-21 | 2015-07-30 | Pfizer Inc. | Streptococcus pneumoniae capsular polysaccharides and conjugates thereof |
AU2015208821B2 (en) * | 2014-01-21 | 2017-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
JP2017505792A (en) * | 2014-02-14 | 2017-02-23 | ファイザー・インク | Immunogenic glycoprotein conjugates |
CN103893751B (en) * | 2014-03-26 | 2016-04-20 | 天津康希诺生物技术有限公司 | Pneumococcal polysaccharide-protein conjugate vaccine and its preparation method |
CN103936842B (en) * | 2014-04-30 | 2016-03-23 | 重庆医科大学 | Application of pneumolysin mutants and their use as a mucosal immunoadjuvant |
US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
RU2600838C1 (en) * | 2015-06-08 | 2016-10-27 | Андрей Дмитриевич Протасов | Method of enhancing nonspecific protection factors activity in patients with chronic obstructive pulmonary disease |
KR20160146240A (en) | 2015-06-12 | 2016-12-21 | 전관구 | Manufacturing process of silver oxide nanoparticle and silver nanoparticle |
JP2018524380A (en) * | 2015-07-21 | 2018-08-30 | ファイザー・インク | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising them and their use |
GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
GB201522068D0 (en) * | 2015-12-15 | 2016-01-27 | Glaxosmithkline Biolog Sa | Dried composition |
JP2019526620A (en) * | 2016-08-05 | 2019-09-19 | サノフィ パスツール インコーポレイティッド | Polyvalent pneumococcal polysaccharide-protein conjugate composition |
BR112019006278A2 (en) | 2016-09-30 | 2019-07-02 | Biological E Ltd | multivalent pneumococcal vaccine compositions comprising polysaccharide-protein conjugates |
KR20180046893A (en) * | 2016-10-28 | 2018-05-09 | 주식회사 엘지화학 | A multivalent immunogenic composition with improved IgG titer and use thereof |
CN108144052A (en) * | 2016-12-02 | 2018-06-12 | 武汉博沃生物科技有限公司 | Streptococcus pneumoniae polysaccharides-protein conjugate and its preparation method and purposes |
WO2018134693A1 (en) * | 2017-01-20 | 2018-07-26 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
KR20190111952A (en) * | 2017-01-31 | 2019-10-02 | 머크 샤프 앤드 돔 코포레이션 | Method for producing capsular polysaccharide protein conjugate derived from Streptococcus pneumoniae serotype 19F |
WO2018144799A1 (en) * | 2017-02-03 | 2018-08-09 | SCHADECK, Eva, Barbara | Haemophilus influenzae saccharide-carrier conjugate compositions and uses thereof |
US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
CN107929728A (en) * | 2017-04-19 | 2018-04-20 | 武汉博沃生物科技有限公司 | A kind of pneumoprotein vaccine and preparation method thereof |
WO2019043245A1 (en) * | 2017-09-04 | 2019-03-07 | London School Of Hygiene And Tropical Medicine | Microbial cells expressing streptococcal serotypes |
WO2019050818A1 (en) * | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
CN108524926A (en) * | 2018-06-29 | 2018-09-14 | 康希诺生物股份公司 | A kind of formulation compositions of multivalent pneumococcal combined vaccine and its application |
Family Cites Families (177)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4057685A (en) | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
DE3071552D1 (en) | 1979-09-21 | 1986-05-22 | Hitachi Ltd | Semiconductor switch |
BE889979A (en) | 1981-08-14 | 1982-02-15 | Smith Kline Rit | polysaccharide preparation Method bacterial capsular antigenic purified, obtained products and their use |
US4673574A (en) | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
US4619828A (en) | 1982-07-06 | 1986-10-28 | Connaught Laboratories, Inc. | Polysaccharide exotoxoid conjugate vaccines |
SE8205892D0 (en) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogenic membrane protein complex, seen for the front up and tell priority over derav as immune stimulant and as vaccine |
US4459286A (en) | 1983-01-31 | 1984-07-10 | Merck & Co., Inc. | Coupled H. influenzae type B vaccine |
US4695624A (en) | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
US4808700A (en) | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
US4709017A (en) | 1985-06-07 | 1987-11-24 | President And Fellows Of Harvard College | Modified toxic vaccines |
IT1187753B (en) | 1985-07-05 | 1987-12-23 | Sclavo Spa | Glycoprotein conjugate to attivita 'trivalent immunogenic |
US5173294A (en) | 1986-11-18 | 1992-12-22 | Research Foundation Of State University Of New York | Dna probe for the identification of haemophilus influenzae |
US4950740A (en) | 1987-03-17 | 1990-08-21 | Cetus Corporation | Recombinant diphtheria vaccines |
AU614755B2 (en) | 1987-06-05 | 1991-09-12 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Autocrine motility factors in cancer diagnosis and management |
US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
US5785973A (en) * | 1988-02-01 | 1998-07-28 | Praxis Biologics, Inc. | Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines |
US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
US5278302A (en) | 1988-05-26 | 1994-01-11 | University Patents, Inc. | Polynucleotide phosphorodithioates |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
DE3841091A1 (en) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetic antigenic, process for their production and their use |
WO1990006951A1 (en) | 1988-12-16 | 1990-06-28 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Pneumolysin mutants and pneumococcal vaccines made therefrom |
EP0378881B1 (en) | 1989-01-17 | 1993-06-09 | ENIRICERCHE S.p.A. | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
AT115862T (en) | 1989-02-04 | 1995-01-15 | Akzo Nobel Nv | Tocols as a vaccine adjuvant. |
CA2017507C (en) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
FR2649013B1 (en) | 1989-07-03 | 1991-10-25 | Seppic Sa | Vaccines and fluids active principles of vectors containing a metabolizable oil |
FR2649012B1 (en) | 1989-07-03 | 1991-10-25 | Seppic Sa | injecting multiphase emulsions |
US5334379A (en) | 1989-07-14 | 1994-08-02 | American Cyanamid Company | Cytokine and hormone carriers for conjugate vaccines |
US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
IT1237764B (en) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Synthetic peptides useful as universal carriers for the preparation of immunogenic conjugates and their use for the development of synthetic vaccines. |
SE466259B (en) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein D - an IgD-binding protein FROM Haemophilus influenzae, and anvaendning this Foer analysis, vaccines and uppreningsaendamaal |
EP0468520A3 (en) | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
AT128628T (en) | 1990-08-13 | 1995-10-15 | American Cyanamid Co | Fiber hemagglutinin of Bordetella pertussis as carrier for conjugated vaccine. |
US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
CA2059692C (en) | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
CA2059693C (en) | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
US6592876B1 (en) | 1993-04-20 | 2003-07-15 | Uab Research Foundation | Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products |
US5476929A (en) | 1991-02-15 | 1995-12-19 | Uab Research Foundation | Structural gene of pneumococcal protein |
ES2118812T3 (en) | 1991-02-15 | 1998-10-01 | Uab Research Foundation | Pneumococcal protein structural gene. |
GB9105992D0 (en) | 1991-03-21 | 1991-05-08 | Smithkline Beecham Biolog | Vaccine |
US5552146A (en) | 1991-08-15 | 1996-09-03 | Board Of Regents, The University Of Texas System | Methods and compositions relating to useful antigens of Moraxella catarrhalis |
GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
KR950700081A (en) | 1992-02-11 | 1995-01-16 | W 로우 죤 | Dual carrier immunogenic composition |
IT1262896B (en) | 1992-03-06 | 1996-07-22 | Compounds conjugates formed by heat shock proteins (hsp) poly- and oligo-saccharides, their use for the production of vaccines. | |
MA22842A1 (en) | 1992-03-27 | 1993-10-01 | Smithkline Beecham Biolog | Process for the preparation of vaccine compositions. |
AU4230493A (en) | 1992-05-06 | 1993-11-29 | President And Fellows Of Harvard College | Diphtheria toxin receptor-binding region |
AT188508T (en) | 1992-06-18 | 2000-01-15 | Harvard College | Vaccines against diphtheria toxin |
EP0761231B1 (en) | 1992-06-25 | 2000-01-12 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccine composition containing adjuvants |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
GB9224584D0 (en) | 1992-11-23 | 1993-01-13 | Connaught Lab | Use of outer membrane protein d15 and its peptides as vaccine against haempohilus influenzae diseases |
JP4028593B2 (en) | 1993-03-23 | 2007-12-26 | グラクソスミスクライン・バイオロジカルス・ソシエテ・アノニムGlaxosmithkline Biologicals S.A. | 3-O deacylated monophosphoryl lipid A-containing vaccine composition |
DE69431624T2 (en) | 1993-05-18 | 2003-07-10 | Univ Ohio State Res Found | Vaccine against middle ear inflammation |
WO1995008348A1 (en) | 1993-09-22 | 1995-03-30 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Method of activating soluble carbohydrate using novel cyanylating reagents for the production of immunogenic constructs |
AU712981B2 (en) | 1995-03-22 | 1999-11-18 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Producing immunogenic constructs using soluble carbohydrates activated via organic cyanylating reagents |
SI0729473T1 (en) | 1993-11-17 | 2001-02-28 | Om Pharma | Glucosamine disaccharides, method for their preparation, pharmaceutical composition comprising same, and their use |
GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
WO1995026204A1 (en) | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
US6455673B1 (en) | 1994-06-08 | 2002-09-24 | President And Fellows Of Harvard College | Multi-mutant diphtheria toxin vaccines |
US5917017A (en) | 1994-06-08 | 1999-06-29 | President And Fellows Of Harvard College | Diphtheria toxin vaccines bearing a mutated R domain |
WO1996002555A1 (en) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
US5565204A (en) | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
CA2217178C (en) | 1995-04-25 | 2009-09-29 | Smithkline Beecham Biologicals S.A. | Vaccines containing a saponin and a sterol |
US6440425B1 (en) | 1995-05-01 | 2002-08-27 | Aventis Pasteur Limited | High molecular weight major outer membrane protein of moraxella |
US5843464A (en) | 1995-06-02 | 1998-12-01 | The Ohio State University | Synthetic chimeric fimbrin peptides |
US5695768A (en) * | 1995-06-07 | 1997-12-09 | Alberta Research Council | Immunostimulating activity of Streptococcus pneumoniae serotype 8 oligosaccharides |
GB9513074D0 (en) | 1995-06-27 | 1995-08-30 | Cortecs Ltd | Novel anigen |
US5666153A (en) | 1995-10-03 | 1997-09-09 | Virtual Shopping, Inc. | Retractable teleconferencing apparatus |
US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
US6290970B1 (en) | 1995-10-11 | 2001-09-18 | Aventis Pasteur Limited | Transferrin receptor protein of Moraxella |
US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
US6090576A (en) | 1996-03-08 | 2000-07-18 | Connaught Laboratories Limited | DNA encoding a transferrin receptor of Moraxella |
GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
AT323721T (en) | 1996-05-01 | 2006-05-15 | Univ Rockefeller | Cholin-binding protein used as a pneumokoken-targeted vaccine |
US7341727B1 (en) | 1996-05-03 | 2008-03-11 | Emergent Product Development Gaithersburg Inc. | M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same |
AT234129T (en) | 1996-06-18 | 2003-03-15 | Alza Corp | Apparatus for improving transdermal administration of medicaments or the acceptance of body fluids |
EP0956289A4 (en) | 1996-08-16 | 2004-10-13 | Smithkline Beecham Corp | Novel prokaryotic polynucleotides, polypeptides and their uses |
GB9620795D0 (en) | 1996-10-05 | 1996-11-20 | Smithkline Beecham Plc | Vaccines |
US6420135B1 (en) | 1996-10-31 | 2002-07-16 | Human Genome Sciences, Inc. | Streptococcus pneumoniae polynucleotides and sequences |
CA2269636A1 (en) | 1996-11-12 | 1998-05-22 | The Regents Of The University Of Minnesota | C3 binding protein of streptococcus pneumoniae |
US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
DK0957972T3 (en) | 1996-12-20 | 2003-07-21 | Alza Corp | A device and method for increasing the transdermal average flux |
DE19708537A1 (en) | 1997-03-03 | 1998-09-10 | Biotechnolog Forschung Gmbh | Novel surface protein (SpsA protein) of Streptococcus pneumoniae etc. |
US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
US6764840B2 (en) | 1997-05-08 | 2004-07-20 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
US6303347B1 (en) | 1997-05-08 | 2001-10-16 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
FR2763244B1 (en) * | 1997-05-14 | 2003-08-01 | Pasteur Merieux Serums Vacc | multivalent vaccine composition is mixed carrier |
US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
EP1000144B1 (en) | 1997-06-03 | 2007-12-12 | Sanofi Pasteur Limited | Lactoferrin receptor gene of moraxella |
GB9711990D0 (en) | 1997-06-11 | 1997-08-06 | Smithkline Beecham Biolog | Vaccine |
GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
EP0998557A2 (en) | 1997-07-21 | 2000-05-10 | North American Vaccine, Inc. | Modified immunogenic pneumolysin, compositions and their use as vaccines |
EP1279401B1 (en) | 1997-09-05 | 2008-01-09 | GlaxoSmithKline Biologicals S.A. | Oil in water emulsions containing saponins |
GB9718901D0 (en) | 1997-09-05 | 1997-11-12 | Smithkline Beecham Biolog | Vaccine |
EP1017828A1 (en) | 1997-09-24 | 2000-07-12 | American Cyanamid Company | HUMAN COMPLEMENT C3-DEGRADING PROTEINASE FROM $i(STREPTOCOCCUS PNEUMONIAE) |
US6224880B1 (en) * | 1997-09-24 | 2001-05-01 | Merck & Co., Inc. | Immunization against Streptococcus pneumoniae using conjugated and unconjugated pneumoccocal polysaccharide vaccines |
US5965714A (en) * | 1997-10-02 | 1999-10-12 | Connaught Laboratories, Inc. | Method for the covalent attachment of polysaccharides to protein molecules |
WO1999027961A1 (en) | 1997-12-02 | 1999-06-10 | Powderject Vaccines, Inc. | Transdermal delivery of particulate vaccine compositions |
IT1298087B1 (en) | 1998-01-08 | 1999-12-20 | Fiderm S R L | A device for controlling the depth 'of penetration of a needle, in particular applicable to a syringe for injections |
US7018637B2 (en) * | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
AU764811B2 (en) | 1998-04-07 | 2003-08-28 | Medimmune, Llc | A polypeptide comprising the amino acid of an n-terminal choline binding protein A truncate, vaccine derived therefrom and uses thereof |
CA2325340A1 (en) | 1998-04-07 | 1999-10-14 | Medimmune, Inc. | Derivatives of pneumococcal choline binding proteins for vaccines |
EP1073450A4 (en) | 1998-04-23 | 2003-04-23 | Uab Research Foundation | PNEUMOCOCCAL SURFACE PROTEIN C(PspC), EPITOPIC REGIONS AND STRAIN SELECTION THEREOF, AND USES THEREFOR |
HU0102332A3 (en) | 1998-06-08 | 2002-11-28 | Sca Emballage France | Fast flattening packaging |
GB9812613D0 (en) | 1998-06-11 | 1998-08-12 | Smithkline Beecham Biolog | Vaccine |
HU0102475A3 (en) | 1998-06-30 | 2001-12-28 | Om Pharma | Novel acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same |
AT446107T (en) | 1998-08-19 | 2009-11-15 | Baxter Healthcare Sa | Immunogenous beta-propionamido-bound polysaccharid protein conjugate is suitable for vaccination and manufacturing of n-acrylylated polysaccharide |
GB9818548D0 (en) | 1998-08-25 | 1998-10-21 | Microbiological Res Authority | Treatment of mucas hypersecretion |
AU6060899A (en) | 1998-09-24 | 2000-04-10 | American Cyanamid Company | Human complement c3-degrading polypeptide from (streptococcus pneumoniae) |
US6541616B1 (en) | 1998-10-01 | 2003-04-01 | Antex Biologics Inc. | Moraxella catarrhalis protein, gene sequence and uses thereof |
US7357936B1 (en) | 1998-10-16 | 2008-04-15 | Smithkline Beecham Biologicals, Sa | Adjuvant systems and vaccines |
GB2359228A (en) | 1998-11-17 | 2001-08-15 | Schlumberger Technology Corp | Transmitting information over a communication link |
WO2000029434A2 (en) | 1998-11-19 | 2000-05-25 | St. Jude Children's Research Hospital | PNEUMOCOCCAL CHOLINE BINDING PROTEINS, CbpG AND CbpD, DIAGNOSTIC AND THERAPEUTIC USES THEREOF |
EP2050464B1 (en) | 1998-12-21 | 2019-08-07 | Medimmune, Inc. | Streptococcus pneumoniae proteins and immunogenic fragments for vaccines |
EA007409B1 (en) | 1998-12-23 | 2006-10-27 | Шайе Биокем Инк. | Antigenic polypeptides streptococci, methods for their preparation and use |
EP1034792A1 (en) | 1999-03-11 | 2000-09-13 | Ingileif Jonsdottir | Intranasal delivery of pneumococcal polysaccharide vaccines |
BRPI0009163B1 (en) | 1999-03-19 | 2019-04-09 | Smithkline Beecham Biologicals S.A. | Immunogenic composition and vaccine comprising it |
JP2002541808A (en) | 1999-04-09 | 2002-12-10 | テクラブ, インコーポレイテッド | Recombinant toxin a protein carrier for the polysaccharide conjugate vaccine |
AU764969B2 (en) | 1999-04-19 | 2003-09-04 | Smithkline Beecham Biologicals (Sa) | Vaccines |
US6558670B1 (en) | 1999-04-19 | 2003-05-06 | Smithkline Beechman Biologicals S.A. | Vaccine adjuvants |
AU777856B2 (en) | 1999-06-10 | 2004-11-04 | Human Genome Sciences, Inc. | Streptococcus pneumoniae proteins and vaccines |
US6319224B1 (en) | 1999-08-20 | 2001-11-20 | Bioject Medical Technologies Inc. | Intradermal injection system for injecting DNA-based injectables into humans |
US6494865B1 (en) | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
US20040191834A1 (en) * | 1999-10-28 | 2004-09-30 | Laferriere Craig Antony Joseph | Novel method |
WO2001046127A1 (en) | 1999-12-22 | 2001-06-28 | Om Pharma | Acyl pseudopeptides bearing a functionalised auxiliary spacer |
FR2806304B1 (en) * | 2000-03-17 | 2002-05-10 | Aventis Pasteur | polysaccharide conjugate pneumococcal vaccine use has against tetanus and diphtheria |
GB0007432D0 (en) | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
KR100927767B1 (en) | 2000-06-20 | 2009-11-20 | 아이디 바이오메디칼 코포레이션 | Streptococcus antigens |
CZ304795B6 (en) * | 2000-06-29 | 2014-10-29 | Glaxosmithkline Biologicals S. A. | Multivalent immunogenic composition |
JP4843181B2 (en) | 2000-08-04 | 2011-12-21 | コリクサ コーポレイション | Immune effector compounds |
GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
EP1322656B1 (en) | 2000-09-26 | 2008-01-16 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes |
GB0103170D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
WO2002078673A1 (en) | 2001-03-29 | 2002-10-10 | Takeda Chemical Industries, Ltd. | Process for producing fine granulate drug |
US20030031684A1 (en) | 2001-03-30 | 2003-02-13 | Corixa Corporation | Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA) |
GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
US20030035806A1 (en) | 2001-05-11 | 2003-02-20 | D'ambra Anello J. | Novel meningitis conjugate vaccine |
FR2827199B1 (en) | 2001-07-10 | 2004-07-09 | Centre Nat Rech Scient | Method and ex situ production machine networks of low and medium integration biochips |
GB0123580D0 (en) | 2001-10-01 | 2001-11-21 | Glaxosmithkline Biolog Sa | Vaccine |
WO2003035836A2 (en) | 2001-10-24 | 2003-05-01 | Hybridon Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends |
GB0130215D0 (en) * | 2001-12-18 | 2002-02-06 | Glaxosmithkline Biolog Sa | Vaccine |
US7262024B2 (en) | 2001-12-20 | 2007-08-28 | Id Biomedical Corporation | Streptococcus antigens |
CA2474398A1 (en) | 2002-02-04 | 2003-08-14 | Corixa Corporation | New immunoeffector compounds |
WO2004011027A1 (en) | 2002-07-30 | 2004-02-05 | Baxter International Inc. | Chimeric multivalent polysaccharide conjugate vaccines |
AU2003250204B8 (en) | 2002-08-02 | 2008-07-10 | Glaxosmithkline Biologicals S.A. | Neisserial vaccine compositions comprising a combination of antigens |
GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
NZ541969A (en) | 2003-03-13 | 2008-01-31 | Glaxosmithkline Biolog Sa | Purifying pneumolysin from Streptococcus pneumoniae in a single chromatographic step by binding it to a hydrophobic interaction column in the presence of detergent and high salt |
US20060251675A1 (en) | 2003-03-17 | 2006-11-09 | Michael Hagen | Mutant cholera holotoxin as an adjuvant and an antigen carrier protein |
KR20060084789A (en) | 2003-06-23 | 2006-07-25 | 박스터 헬쓰케어 에스.에이. | Vaccines against group y neisseria meningitidis and meningococcal combinations thereof |
US8048432B2 (en) * | 2003-08-06 | 2011-11-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Polysaccharide-protein conjugate vaccines |
GB0323103D0 (en) * | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
GB0408977D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
EP2272531A3 (en) | 2004-04-30 | 2011-04-13 | Novartis Vaccines and Diagnostics S.r.l. | Integration of meningococcal conjugate vaccination |
JP5174457B2 (en) | 2004-05-11 | 2013-04-03 | デ スタート デール ネーダーランデン, フェルテヘンウォールディヒィト ドール デ ミニステール ファン フォルクスヘーゾンドハイド, フェルザイン アン スポルト | Neisseria meningitidis lgtBLOS as an adjuvant |
GB0421083D0 (en) | 2004-09-22 | 2004-10-27 | Glaxosmithkline Biolog Sa | Purification process |
GB0502096D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Purification of streptococcal capsular polysaccharide |
TWI386222B (en) | 2005-04-08 | 2013-02-21 | Wyeth Corp | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US7955605B2 (en) * | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US9789179B2 (en) | 2005-06-27 | 2017-10-17 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
CA2621023C (en) | 2005-09-01 | 2019-07-02 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | Multiple vaccination including serogroup c meningococcus |
EP1945249A2 (en) | 2005-11-01 | 2008-07-23 | Novartis AG | Compositions with antigens adsorbed to calcium phosphate |
TWI457133B (en) * | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | Novel composition |
TWI415622B (en) | 2005-12-22 | 2013-11-21 | Glaxosmithkline Biolog Sa | Streptococcus pneumoniae immunogenic composition comprising capsular saccharide conjugates, vaccine and kit comprising the same and uses thereof |
GB0607088D0 (en) * | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
AU2008267208B2 (en) | 2007-06-26 | 2012-01-19 | Glaxosmithkline Biologicals S.A. | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
MX346071B (en) | 2008-12-18 | 2017-03-02 | Wyeth Llc | Method for controlling streptococcus pneumoniae polysaccharide molecular weight using carbon. |
-
2006
- 2006-12-20 TW TW95148075A patent/TWI415622B/en not_active IP Right Cessation
- 2006-12-20 CA CA2808919A patent/CA2808919C/en active Active
- 2006-12-20 CN CN2006800531112A patent/CN101378778B/en active IP Right Grant
- 2006-12-20 EP EP16183732.3A patent/EP3130348A1/en not_active Withdrawn
- 2006-12-20 HU HUE06830744A patent/HUE032903T2/en unknown
- 2006-12-20 LT LTEP06830744.6T patent/LT1973564T/en unknown
- 2006-12-20 MX MX2012005031A patent/MX354843B/en unknown
- 2006-12-20 TR TR2019/00418T patent/TR201900418T4/en unknown
- 2006-12-20 EP EP10192663.2A patent/EP2384765B1/en active Active
- 2006-12-20 EP EP18200237.8A patent/EP3470080A1/en active Pending
- 2006-12-20 AR ARP060105674A patent/AR058592A1/en unknown
- 2006-12-20 KR KR20087017937A patent/KR101367237B1/en active IP Right Grant
- 2006-12-20 KR KR1020087017942A patent/KR101365001B1/en active IP Right Grant
- 2006-12-20 ES ES06841492.9T patent/ES2539795T3/en active Active
- 2006-12-20 HU HUE10192663A patent/HUE033081T2/en unknown
- 2006-12-20 PE PE2006001669A patent/PE20071305A1/en unknown
- 2006-12-20 MY MYPI20082271 patent/MY150719A/en unknown
- 2006-12-20 PL PL06830743T patent/PL1962899T3/en unknown
- 2006-12-20 DK DK15195398.1T patent/DK3017827T3/en active
- 2006-12-20 ES ES06830744.6T patent/ES2630759T3/en active Active
- 2006-12-20 SI SI200631931T patent/SI1968631T1/en unknown
- 2006-12-20 WO PCT/EP2006/069977 patent/WO2007071710A2/en active Application Filing
- 2006-12-20 PT PT101926632T patent/PT2384765T/en unknown
- 2006-12-20 PL PL15195398T patent/PL3017827T3/en unknown
- 2006-12-20 WO PCT/EP2006/069974 patent/WO2007071707A2/en active Application Filing
- 2006-12-20 CA CA2634885A patent/CA2634885C/en active Active
- 2006-12-20 SG SG201009538-8A patent/SG168517A1/en unknown
- 2006-12-20 BR BRPI0620460A patent/BRPI0620460B1/en active IP Right Grant
- 2006-12-20 EP EP15195398.1A patent/EP3017827B1/en active Active
- 2006-12-20 EP EP06830744.6A patent/EP1973564B1/en active Active
- 2006-12-20 EP EP15195408.8A patent/EP3020411A1/en active Pending
- 2006-12-20 MY MYPI2012004550A patent/MY160199A/en unknown
- 2006-12-20 DK DK06830743T patent/DK1962899T3/en active
- 2006-12-20 TW TW95148076A patent/TWI465248B/en not_active IP Right Cessation
- 2006-12-20 EP EP20060841492 patent/EP1968631B1/en active Active
- 2006-12-20 LT LTEP15195398.1T patent/LT3017827T/en unknown
- 2006-12-20 EA EA200801344A patent/EA014165B1/en not_active IP Right Cessation
- 2006-12-20 PL PL10192663T patent/PL2384765T3/en unknown
- 2006-12-20 PT PT15195398T patent/PT3017827T/en unknown
- 2006-12-20 AT AT06830743T patent/AT520415T/en unknown
- 2006-12-20 CN CN2006800529540A patent/CN101374548B/en active IP Right Grant
- 2006-12-20 ES ES10192663.2T patent/ES2614938T3/en active Active
- 2006-12-20 CN CN200680053139.6A patent/CN101378779B/en active IP Right Grant
- 2006-12-20 LT LTEP10192663.2T patent/LT2384765T/en unknown
- 2006-12-20 SI SI200632134T patent/SI1973564T1/en unknown
- 2006-12-20 AR ARP060105675 patent/AR058706A1/en unknown
- 2006-12-20 EA EA200801367A patent/EA014107B1/en not_active IP Right Cessation
- 2006-12-20 NZ NZ56907706A patent/NZ569077A/en not_active IP Right Cessation
- 2006-12-20 NZ NZ59650006A patent/NZ596500A/en not_active IP Right Cessation
- 2006-12-20 CN CN 201310036445 patent/CN103251940A/en active Search and Examination
- 2006-12-20 US US12/097,611 patent/US20090017072A1/en not_active Abandoned
- 2006-12-20 DK DK06841492.9T patent/DK1968631T3/en active
- 2006-12-20 PL PL06830744T patent/PL1973564T3/en unknown
- 2006-12-20 DK DK06830744.6T patent/DK1973564T3/en active
- 2006-12-20 WO PCT/EP2006/069979 patent/WO2007071711A2/en active Application Filing
- 2006-12-20 TW TW102129217A patent/TW201350129A/en unknown
- 2006-12-20 SI SI200632143A patent/SI2384765T1/en unknown
- 2006-12-20 CN CN201910504933.7A patent/CN110179974A/en active Search and Examination
- 2006-12-20 NZ NZ56916806A patent/NZ569168A/en not_active IP Right Cessation
- 2006-12-20 HU HUE15195398A patent/HUE041979T2/en unknown
- 2006-12-20 JP JP2008546439A patent/JP5461838B2/en active Active
- 2006-12-20 MX MX2008008140A patent/MX2008008140A/en active IP Right Grant
- 2006-12-20 JP JP2008546441A patent/JP5579387B2/en active Active
- 2006-12-20 AU AU2006327040A patent/AU2006327040B2/en active Active
- 2006-12-20 PT PT68414929T patent/PT1968631E/en unknown
- 2006-12-20 EP EP20110165377 patent/EP2402025A3/en active Pending
- 2006-12-20 MY MYPI20082272 patent/MY148141A/en unknown
- 2006-12-20 DK DK10192663.2T patent/DK2384765T3/en active
- 2006-12-20 AU AU2006327036A patent/AU2006327036B2/en active Active
- 2006-12-20 JP JP2008546442A patent/JP5792920B2/en active Active
- 2006-12-20 TW TW095148073A patent/TWI487534B/en not_active IP Right Cessation
- 2006-12-20 CA CA2634887A patent/CA2634887C/en active Active
- 2006-12-20 KR KR20137023760A patent/KR101441368B1/en active IP Right Grant
- 2006-12-20 MY MYPI20082270 patent/MY147495A/en unknown
- 2006-12-20 PE PE2006001671A patent/PE20071058A1/en unknown
- 2006-12-20 SI SI200631145T patent/SI1962899T1/en unknown
- 2006-12-20 AR ARP060105676 patent/AR058707A1/en unknown
- 2006-12-20 CN CN201310103804.XA patent/CN103585623B/en active IP Right Grant
- 2006-12-20 JO JO2006484A patent/JO2813B1/en active
- 2006-12-20 NZ NZ56907606A patent/NZ569076A/en not_active IP Right Cessation
- 2006-12-20 US US12/097,631 patent/US20090017059A1/en not_active Abandoned
- 2006-12-20 AU AU2006327041A patent/AU2006327041B2/en not_active Ceased
- 2006-12-20 EA EA200801374A patent/EA014649B1/en not_active IP Right Cessation
- 2006-12-20 CA CA2633772A patent/CA2633772C/en active Active
- 2006-12-20 UA UAA200807750A patent/UA96583C2/en unknown
- 2006-12-20 KR KR20087018023A patent/KR101418240B1/en active IP Right Grant
- 2006-12-20 ES ES15195398T patent/ES2707499T3/en active Active
- 2006-12-20 BR BRPI0620163A patent/BRPI0620163B1/en active IP Right Grant
- 2006-12-20 CA CA2816182A patent/CA2816182C/en active Active
- 2006-12-20 US US12/097,303 patent/US20090010959A1/en not_active Abandoned
- 2006-12-20 EP EP20060830743 patent/EP1962899B1/en active Active
- 2006-12-20 BR BRPI0620193-8A patent/BRPI0620193A2/en active Search and Examination
- 2006-12-20 SI SI200632305T patent/SI3017827T1/en unknown
- 2006-12-20 UA UAA200807749A patent/UA96934C2/en unknown
- 2006-12-20 EP EP20100194592 patent/EP2382986A3/en active Pending
- 2006-12-20 PT PT06830743T patent/PT1962899E/en unknown
- 2006-12-20 PT PT68307446T patent/PT1973564T/en unknown
-
2008
- 2008-06-03 IL IL19191308A patent/IL191913A/en active IP Right Grant
- 2008-06-03 IL IL191911A patent/IL191911A/en active IP Right Grant
- 2008-06-05 NO NO20082646A patent/NO344187B1/en unknown
- 2008-06-05 NO NO20082647A patent/NO343981B1/en unknown
- 2008-06-12 IL IL19208408A patent/IL192084A/en not_active IP Right Cessation
- 2008-06-13 NO NO20082718A patent/NO20082718L/en unknown
- 2008-06-18 MA MA31046A patent/MA30062B1/en unknown
- 2008-06-18 MA MA31050A patent/MA30066B1/en unknown
- 2008-06-18 MA MA31049A patent/MA30065B1/en unknown
- 2008-06-26 CR CR10119A patent/CR10119A/es not_active Application Discontinuation
- 2008-06-27 CR CR10122A patent/CR10122A/es unknown
-
2009
- 2009-02-04 HK HK09101006A patent/HK1120230A1/en not_active IP Right Cessation
- 2009-09-30 US US12/570,266 patent/US9107872B2/en active Active
-
2010
- 2010-11-05 AU AU2010241281A patent/AU2010241281B2/en not_active Ceased
-
2011
- 2011-03-10 IL IL21166411A patent/IL211664D0/en unknown
- 2011-09-23 HR HRP20110685 patent/HRP20110685T1/en unknown
- 2011-10-19 CY CY20111100993T patent/CY1112677T1/en unknown
-
2012
- 2012-05-08 IL IL219641A patent/IL219641A/en active IP Right Grant
- 2012-06-21 JP JP2012139824A patent/JP5615323B2/en active Active
- 2012-06-21 JP JP2012139738A patent/JP5749689B2/en active Active
- 2012-06-21 JP JP2012139558A patent/JP5600337B2/en active Active
-
2013
- 2013-07-23 CL CL2013002106A patent/CL2013002106A1/en unknown
-
2014
- 2014-05-14 JP JP2014100598A patent/JP5849125B2/en active Active
- 2014-08-14 US US14/459,312 patent/US20150190521A1/en not_active Abandoned
- 2014-11-14 PH PH12014502544A patent/PH12014502544A1/en unknown
-
2015
- 2015-06-03 US US14/729,408 patent/US9884113B2/en active Active
- 2015-06-19 CY CY20151100528T patent/CY1116407T1/en unknown
-
2016
- 2016-01-05 US US14/987,770 patent/US10279033B2/en active Active
- 2016-12-08 HR HRP20161682TT patent/HRP20161682T1/en unknown
- 2016-12-08 HR HRP20161681TT patent/HRP20161681T1/en unknown
- 2016-12-16 CY CY20161101312T patent/CY1118345T1/en unknown
-
2017
- 2017-01-18 CY CY20171100077T patent/CY1118535T1/en unknown
-
2018
- 2018-01-12 US US15/869,742 patent/US20180207262A1/en active Pending
-
2019
- 2019-01-04 HR HRP20190037TT patent/HRP20190037T1/en unknown
- 2019-02-21 US US16/281,567 patent/US20190262447A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1968631T3 (en) | Vaccine | |
DK2417983T3 (en) | Multivalent pneumococcal polysaccharide-protein conjugate composition | |
GB2427355B (en) | Combination mattress | |
GB2423943B (en) | Toys | |
AP2436A (en) | Immunogenic composition | |
DK1912671T3 (en) | BETA-glucuronide-LINKER-drug conjugates | |
EP1942105A4 (en) | Aminodihydrothiazine derivative | |
HK1084958A1 (en) | S. pneumoniae antigens | |
DK2074221T3 (en) | Improved methods for separating Streptococcus pneumoniae type 3 polysaccharides | |
IL197310D0 (en) | Vaccine | |
DK1868645T3 (en) | Multivalent pneumococcal saccharide-protein conjugate composition | |
PT1968630T (en) | Multivalent pcv2 immunogenic compositions | |
ZA200802051B (en) | Anti-CD3 antibody formulations | |
HK1121054A1 (en) | Molecular conjugate | |
AT492290T (en) | SACCHARIDE conjugate vaccines | |
EP1773878A4 (en) | Insulin-oligomer conjugates, formulations and uses thereof | |
IL220816A (en) | Process for preparing cell-binding agent-cytotoxic agent conjugates | |
HK1116697A1 (en) | Psma antibody-drug conjugates psma | |
HK1215189A1 (en) | Multivalent pneumococcal polysaccharide protein conjugate composition | |
PL378012A1 (en) | Anthracycline-antibody conjugates | |
GB0411411D0 (en) | Vaccines | |
PT1957647E (en) | Immunostimulatory oligoribonucleotides | |
EP1994057A4 (en) | Camptothecin-binding moiety conjugates | |
ME01965B (en) | Stabilizers for freeze-dried vaccines | |
PL1861572T3 (en) | Furniture |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed |