IL191788D0 - Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and methods for using anti-ptk7 antibodies - Google Patents

Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and methods for using anti-ptk7 antibodies

Info

Publication number
IL191788D0
IL191788D0 IL191788A IL19178808A IL191788D0 IL 191788 D0 IL191788 D0 IL 191788D0 IL 191788 A IL191788 A IL 191788A IL 19178808 A IL19178808 A IL 19178808A IL 191788 D0 IL191788 D0 IL 191788D0
Authority
IL
Israel
Prior art keywords
ptk7
antibodies
anti
methods
tyrosine kinase
Prior art date
Application number
IL191788A
Other versions
IL191788A (en
Original Assignee
Medarex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US74837305P priority Critical
Priority to PCT/US2006/046837 priority patent/WO2007067730A2/en
Application filed by Medarex Inc filed Critical Medarex Inc
Publication of IL191788D0 publication Critical patent/IL191788D0/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38123515&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL191788(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of IL191788A publication Critical patent/IL191788A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell
IL191788A 2005-12-08 2008-05-28 Human monoclonal antibodies against human protein tyrosine kinase 7 (ptk7), immunoconjugates and compositions thereof IL191788A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US74837305P true 2005-12-08 2005-12-08
PCT/US2006/046837 WO2007067730A2 (en) 2005-12-08 2006-12-08 Human monoclonal antibodies to protein tyrosine kinase 7 ( ptk7 ) and their use

Publications (2)

Publication Number Publication Date
IL191788D0 true IL191788D0 (en) 2009-02-11
IL191788A IL191788A (en) 2014-06-30

Family

ID=38123515

Family Applications (1)

Application Number Title Priority Date Filing Date
IL191788A IL191788A (en) 2005-12-08 2008-05-28 Human monoclonal antibodies against human protein tyrosine kinase 7 (ptk7), immunoconjugates and compositions thereof

Country Status (22)

Country Link
US (3) US8222375B2 (en)
EP (1) EP1957539B1 (en)
JP (1) JP5401639B2 (en)
KR (1) KR101373464B1 (en)
CN (1) CN101360761B (en)
AU (1) AU2006321841C1 (en)
BR (1) BRPI0619582A2 (en)
CA (1) CA2632552C (en)
DK (1) DK1957539T3 (en)
EA (1) EA017812B1 (en)
ES (1) ES2406063T3 (en)
HK (1) HK1121174A1 (en)
IL (1) IL191788A (en)
ME (1) ME02002B (en)
NO (1) NO20082559L (en)
NZ (2) NZ594466A (en)
PL (1) PL1957539T3 (en)
PT (1) PT1957539E (en)
RS (1) RS52804B (en)
SG (1) SG177194A1 (en)
SI (1) SI1957539T1 (en)
WO (1) WO2007067730A2 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8222375B2 (en) 2005-12-08 2012-07-17 Medarex, Inc. Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies
WO2007067991A2 (en) * 2005-12-08 2007-06-14 Medarex, Inc. Human monoclonal antibodies to o8e
WO2009026274A1 (en) 2007-08-22 2009-02-26 Medarex, Inc. Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions
WO2009042209A2 (en) * 2007-09-25 2009-04-02 The Board Of Trustees Of The Leland Stanford Junior University Identification of thymically derived cd4 t cells by protein tyrosine kinase 7 expression
WO2009061996A2 (en) 2007-11-07 2009-05-14 Celldex Therapeutics Inc. Antibodies that bind human dendritic and epithelial cell 205 (dec-205)
US20120027782A1 (en) * 2007-11-30 2012-02-02 Bristol-Myers Squibb Company Monoclonal antibody partner molecule conjugates directed to protein tyrosine kinase 7 (ptk7)
KR101123130B1 (en) * 2008-03-17 2012-03-30 연세대학교 산학협력단 Inhibitors of cell migration, invasion, or angiogenesis by blocking the function of PTK7 protein
WO2009116764A2 (en) * 2008-03-17 2009-09-24 연세대학교 산학협력단 Cell migration, cell infiltration, or neovascularization inhibitor through degradation of function of ptk7 protein
JP5800809B2 (en) 2009-07-10 2015-10-28 イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. TLR3 binding agent
US8394922B2 (en) 2009-08-03 2013-03-12 Medarex, Inc. Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
EP2380909A1 (en) * 2010-04-26 2011-10-26 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. PTK-7 protein involved in breast cancer
EP2571361A4 (en) 2010-05-19 2013-11-13 Univ North Carolina Pyrazolopyrimidine compounds for the treatment of cancer
SA4398B1 (en) * 2011-02-18 2015-10-09 ستيم سينتركس، انك. Novel modulators and methods of use
US8852599B2 (en) 2011-05-26 2014-10-07 Bristol-Myers Squibb Company Immunoconjugates, compositions for making them, and methods of making and use
US9273056B2 (en) 2011-10-03 2016-03-01 The University Of North Carolina At Chapel Hill Pyrrolopyrimidine compounds for the treatment of cancer
JP6113194B2 (en) 2012-02-13 2017-04-12 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Endiyne compounds, conjugates thereof, and uses and methods thereof
JP2015517574A (en) 2012-05-22 2015-06-22 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル Pyrimidine compounds for cancer treatment
DK2855527T3 (en) 2012-05-31 2018-11-26 Innate Pharma Tlr3 binders
US9562047B2 (en) 2012-10-17 2017-02-07 The University Of North Carolina At Chapel Hill Pyrazolopyrimidine compounds for the treatment of cancer
US9771330B2 (en) 2012-11-27 2017-09-26 The University Of North Carolina At Chapel Hill Pyrimidine compounds for the treatment of cancer
SG11201506243XA (en) 2013-02-14 2015-09-29 Squibb Bristol Myers Co Tubulysin compounds, methods of making and use
JP6474404B2 (en) 2013-08-14 2019-02-27 ウィリアム マーシュ ライス ユニバーシティWilliam Marsh Rice University Unsialamycin derivatives, synthetic methods and their use as antitumor agents
AU2015244171A1 (en) 2014-04-11 2016-11-03 The University Of North Carolina At Chapel Hill MerTK-specific pyrimidine compounds
AU2015253422A1 (en) * 2014-04-30 2016-11-10 Abbvie Stemcentrx Llc Anti-PTK7 antibody-drug conjugates
US10077287B2 (en) 2014-11-10 2018-09-18 Bristol-Myers Squibb Company Tubulysin analogs and methods of making and use
BR112017014937A2 (en) 2015-01-14 2018-03-13 Squibb Bristol Myers Co heteroarylene bridged benzodiazepine dimers, conjugates thereof, and methods of preparation and use
AU2016377371A1 (en) 2015-12-21 2018-08-09 Bristol-Myers Squibb Company Variant antibodies for site-specific conjugation
AU2017209083A1 (en) 2016-01-22 2018-07-12 Adimab, Llc Anti-coagulation factor XI antibodies
WO2017196598A1 (en) 2016-05-10 2017-11-16 Bristol-Myers Squibb Company Antibody-drug conjugates of tubulysin analogs with enhanced stability
EP3500574A1 (en) 2016-08-19 2019-06-26 Bristol-Myers Squibb Company Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use
US10398783B2 (en) 2016-10-20 2019-09-03 Bristol-Myers Squibb Company Antiproliferative compounds and conjugates made therefrom
CA3064321A1 (en) 2017-05-25 2018-11-29 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
US10457681B2 (en) 2017-08-16 2019-10-29 Bristol_Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
US10494370B2 (en) 2017-08-16 2019-12-03 Bristol-Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
US10487084B2 (en) 2017-08-16 2019-11-26 Bristol-Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
US10508115B2 (en) 2017-08-16 2019-12-17 Bristol-Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor
US10472361B2 (en) 2017-08-16 2019-11-12 Bristol-Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor
WO2019209811A1 (en) 2018-04-24 2019-10-31 Bristol-Myers Squibb Company Macrocyclic toll-like receptor 7 (tlr7) agonists
WO2019231879A1 (en) 2018-05-29 2019-12-05 Bristol-Myers Squibb Company Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708930A (en) 1984-11-09 1987-11-24 Coulter Corporation Monoclonal antibody to a human carcinoma tumor associated antigen
AU6238696A (en) 1995-05-25 1996-12-11 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Cck-4, a receptor tyrosine kinase, and methods for diagnosis and treatment of cck-4 signal transduction disorders
WO1997012862A1 (en) 1995-10-03 1997-04-10 The Scripps Research Institute Cbi analogs of cc-1065 and the duocarmycins
WO1998045708A1 (en) 1997-04-08 1998-10-15 Sugen, Inc. Study and treatment of diseases related to specific cellular functions of receptor protein tyrosine kinases
WO1998052925A1 (en) 1997-05-22 1998-11-26 The Scripps Research Institute Analogs of duocarmycin and cc-1065
CA2380813A1 (en) 1999-07-29 2001-02-08 Medarex, Inc. Human monoclonal antibodies to her2/neu
WO2002059377A2 (en) 2001-01-24 2002-08-01 Protein Design Labs Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer
EP1463928A2 (en) 2001-04-18 2004-10-06 Protein Design Labs Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer
US7087600B2 (en) 2001-05-31 2006-08-08 Medarex, Inc. Peptidyl prodrugs and linkers and stabilizers useful therefor
GB0114033D0 (en) 2001-06-09 2001-08-01 Innovata Biomed Ltd Process
ES2364452T3 (en) 2001-06-11 2011-09-02 Medarex, Inc. Method for designing professional compounds activated by cd10.
MXPA03011365A (en) 2001-06-13 2005-03-07 Genmab As Human monoclonal antibodies to epidermal growth factor receptor (egfr).
US20040076955A1 (en) 2001-07-03 2004-04-22 Eos Biotechnology, Inc. Methods of diagnosis of bladder cancer, compositions and methods of screening for modulators of bladder cancer
EP1423110A4 (en) 2001-09-07 2005-04-27 Scripps Research Inst Cbi analogues of cc-1065 and the duocarmycins
JP2003088388A (en) * 2001-09-14 2003-03-25 Herikkusu Kenkyusho:Kk NEW FULL-LENGTH cDNA
AU2002330039A1 (en) 2001-09-17 2003-04-01 Eos Biotechnology, Inc. Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer
AU2002362646A1 (en) 2001-10-09 2003-04-22 The Johns Hopkins University A phosphatase associated with metastasis
WO2003042661A2 (en) 2001-11-13 2003-05-22 Protein Design Labs, Inc. Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
CA2471645A1 (en) 2002-01-03 2003-07-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Immunoconjugates useful for treatment of tumours
AT357460T (en) 2002-01-18 2007-04-15 Pf Medicament Antibodies to igf-ir and its uses
AU2003253880A1 (en) * 2002-07-15 2004-02-02 Sugen, Inc. Novel kinases
GB0219776D0 (en) * 2002-08-24 2002-10-02 Oxford Glycosciences Uk Ltd A protein involved in carcinoma
KR100818689B1 (en) 2003-03-10 2008-04-02 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 Method of distinguishing mesenchymal stem cell
KR20060031809A (en) 2003-06-09 2006-04-13 더 리젠츠 오브 더 유니버시티 오브 미시간 Compositions and methods for treating and diagnosing cancer
WO2005063987A1 (en) 2003-12-19 2005-07-14 Aveo Pharmaceuticals, Inc. Gp153: methods and compositions for treating cancer
JP2007535562A (en) 2004-04-29 2007-12-06 ジェンザイム・コーポレイションGenzyme Corporation Methods and compositions for the treatment of polycystic disease
NZ550934A (en) 2004-05-19 2010-05-28 Medarex Inc Chemical linkers and conjugates thereof
RU2402548C2 (en) 2004-05-19 2010-10-27 Медарекс, Инк. Chemical linkers and conjugates thereof
EP1781318A4 (en) 2004-06-23 2009-12-23 Genzyme Corp Methods and compositions for the treatment of polycystic diseases
WO2006110593A2 (en) 2005-04-07 2006-10-19 Macrogenics, Inc. Biological targets for the diagnosis, treatment and prevention of cancer
EP1940470B1 (en) 2005-09-26 2013-04-17 Medarex, Inc. Antibody-drug conjugates and their use
US8222375B2 (en) 2005-12-08 2012-07-17 Medarex, Inc. Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies
US20120027782A1 (en) 2007-11-30 2012-02-02 Bristol-Myers Squibb Company Monoclonal antibody partner molecule conjugates directed to protein tyrosine kinase 7 (ptk7)
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc human antibodies that bind to the gene 3 of lymphocyte activation (LAG-3) and uses these

Also Published As

Publication number Publication date
NZ594466A (en) 2012-08-31
JP2009518039A (en) 2009-05-07
AU2006321841A1 (en) 2007-06-14
HK1121174A1 (en) 2013-07-26
JP5401639B2 (en) 2014-01-29
WO2007067730A2 (en) 2007-06-14
IL191788A (en) 2014-06-30
BRPI0619582A2 (en) 2012-12-11
EP1957539B1 (en) 2013-04-17
EA017812B1 (en) 2013-03-29
PL1957539T3 (en) 2013-08-30
US20120207764A1 (en) 2012-08-16
US20100034826A1 (en) 2010-02-11
SI1957539T1 (en) 2013-05-31
CA2632552A1 (en) 2007-06-14
EP1957539A2 (en) 2008-08-20
ME02002B (en) 2013-10-31
DK1957539T3 (en) 2013-05-06
US9505845B2 (en) 2016-11-29
US20120219557A1 (en) 2012-08-30
PT1957539E (en) 2013-06-25
WO2007067730A3 (en) 2007-11-01
RS52804B (en) 2013-10-31
US9102738B2 (en) 2015-08-11
CA2632552C (en) 2015-02-03
KR20080082660A (en) 2008-09-11
CN101360761A (en) 2009-02-04
NO20082559L (en) 2008-07-07
AU2006321841C1 (en) 2013-01-24
AU2006321841B2 (en) 2012-08-30
US8222375B2 (en) 2012-07-17
CN101360761B (en) 2012-09-12
SG177194A1 (en) 2012-01-30
EA200801509A1 (en) 2008-12-30
ES2406063T3 (en) 2013-06-05
NZ569236A (en) 2012-06-29
KR101373464B1 (en) 2014-03-14

Similar Documents

Publication Publication Date Title
DE60333732D1 (en) Internalization of anti cd74 monoclonal antibodies and their uses
DK1687031T3 (en) Pharmaceutical preparation containing an antibody to the epidermal growth factor (EGF) receptor
DK1583830T3 (en) Process for Preparation of Recombinant Polyclonal Proteins
DK1682180T3 (en) Monoclonal antagonist anti-CD40 antibodies and methods for their use
DK1959014T5 (en) Antibodies to insulin-like growth factor 1 receptor and uses thereof
DK1735348T3 (en) Human anti-epidermal growth factor receptor antibody
DE60333387D1 (en) Triazolopyridazine as protein kinase inhibitors
TWI370136B (en) Il-23p40 specific immunoglobulin derived proteins, compositions, epitopes, methods and uses
DK1606317T3 (en) Anti-IL-22RA antibodies and binding partners as well as methods of use in inflammation
DK1558648T3 (en) Human monoclonal antibodies against CD20
DE60324094D1 (en) Use of a protein kinase a-inactivating compound in a cosmetically compatible composition for soleening the skin
DE60312639D1 (en) Antibodies to igf-ir and its uses
DE60329489D1 (en) Fusion proteins humanized g250-specific antibody and uses thereof
DE60139542D1 (en) Methods of preparing human monoclonal antibodies
DE60224383D1 (en) Procedure for detection in yeast to influence protein folding
DE50109784D1 (en) Stabilized protein preparation and process for its preparation
DK1610820T4 (en) High-concentration antibody and protein formulations
DK2316852T3 (en) Stabilized single-domain antibodies
DE50303749D1 (en) Process for the preparation of phthalocyaninpigment preparations
EP1814586A4 (en) Anti-properdin antibodies, and methods for making and using same
EP1372718A4 (en) Production and use of novel peptide-based agents for use with bi-specific antibodies
RU2005114482A (en) Specific erb-b antibodies and their application for treatment of tumors
SG10201404273QA (en) Novel anti-il 13 antibodies and uses thereof
IL246594D0 (en) Treatment with anti-vegf antibodies
RU2004127458A (en) Anti-cd20 antibodies, their hybrid proteins and ways of their use

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed