IL189357D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
IL189357D0
IL189357D0 IL18935708A IL18935708A IL189357D0 IL 189357 D0 IL189357 D0 IL 189357D0 IL 18935708 A IL18935708 A IL 18935708A IL 18935708 A IL18935708 A IL 18935708A IL 189357 D0 IL189357 D0 IL 189357D0
Authority
IL
Israel
Prior art keywords
novel compounds
novel
compounds
Prior art date
Application number
IL18935708A
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US26050501P priority Critical
Priority to PCT/IB2001/002729 priority patent/WO2002055519A2/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of IL189357D0 publication Critical patent/IL189357D0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36Oxygen or sulfur atoms
    • C07D207/402,5-Pyrrolidine-diones
    • C07D207/4162,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
IL18935708A 2001-01-09 2008-02-07 Novel compounds IL189357D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US26050501P true 2001-01-09 2001-01-09
PCT/IB2001/002729 WO2002055519A2 (en) 2001-01-09 2001-12-27 Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2r, 4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide

Publications (1)

Publication Number Publication Date
IL189357D0 true IL189357D0 (en) 2008-06-05

Family

ID=22989433

Family Applications (4)

Application Number Title Priority Date Filing Date
IL15646101A IL156461D0 (en) 2001-01-09 2001-12-27 Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2r, 4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
IL18935908A IL189359D0 (en) 2001-01-09 2008-02-07 Novel process for the synthesis of 5 - (4 - fluorophenyl) - 1 - [2 - ((2r, 4r)- 4 - hydroxy - 6 - oxo -tetrahydro - pyran - 2 - yl) - ethyl] - 2 - isopropyl- 4 - phenyl - 1h - pyrrole - 3 - carboxylic acid phenylamide
IL18935708A IL189357D0 (en) 2001-01-09 2008-02-07 Novel compounds
IL18935808A IL189358D0 (en) 2001-01-09 2008-02-07 Novel process for the synthesis of 5 - (4 - fluorophenyl) - 1 - [2 - ((2r, 4r)- 4 - hydroxy - 6 - oxo -tetrahydro - pyran - 2 - yl) - ethyl] - 2 - isopropyl- 4 - phenyl - 1h - pyrrole - 3 - carboxylic acid phenylamide

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL15646101A IL156461D0 (en) 2001-01-09 2001-12-27 Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2r, 4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
IL18935908A IL189359D0 (en) 2001-01-09 2008-02-07 Novel process for the synthesis of 5 - (4 - fluorophenyl) - 1 - [2 - ((2r, 4r)- 4 - hydroxy - 6 - oxo -tetrahydro - pyran - 2 - yl) - ethyl] - 2 - isopropyl- 4 - phenyl - 1h - pyrrole - 3 - carboxylic acid phenylamide

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL18935808A IL189358D0 (en) 2001-01-09 2008-02-07 Novel process for the synthesis of 5 - (4 - fluorophenyl) - 1 - [2 - ((2r, 4r)- 4 - hydroxy - 6 - oxo -tetrahydro - pyran - 2 - yl) - ethyl] - 2 - isopropyl- 4 - phenyl - 1h - pyrrole - 3 - carboxylic acid phenylamide

Country Status (24)

Country Link
US (7) US6476235B2 (en)
EP (1) EP1353917B1 (en)
JP (2) JP4190285B2 (en)
KR (3) KR100582326B1 (en)
CN (4) CN101024626A (en)
AR (1) AR035680A1 (en)
AT (1) AT358126T (en)
BR (1) BR0116739A (en)
CA (1) CA2432064C (en)
CZ (1) CZ20031893A3 (en)
DE (1) DE60127583T2 (en)
DK (1) DK1353917T3 (en)
ES (1) ES2282200T3 (en)
HK (2) HK1060572A1 (en)
HU (1) HU0302647A3 (en)
IL (4) IL156461D0 (en)
MX (1) MXPA03005284A (en)
PL (1) PL365283A1 (en)
PT (1) PT1353917E (en)
RU (1) RU2244714C1 (en)
TW (1) TWI293073B (en)
WO (1) WO2002055519A2 (en)
YU (1) YU49003A (en)
ZA (1) ZA200304684B (en)

Families Citing this family (44)

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US7411075B1 (en) * 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
US20060020137A1 (en) * 2001-11-29 2006-01-26 Limor Tessler Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
US7501450B2 (en) * 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
IL156055D0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
JP2004533482A (en) * 2001-07-06 2004-11-04 テバ ファーマシューティカル インダストリーズ リミティド Method for producing 7-amino-syn-3,5-dihydroxyheptanoic acid derivative with 6-cyano-syn-3,5-dihydroxyhexanoic acid derivative
KR100765555B1 (en) * 2002-08-06 2007-10-09 워너-램버트 캄파니 엘엘씨 Process for preparing 5-4-fluorophenyl-1-[2-2r,4r-4-hydroxy-6-oxo-tetrahydro-pyran-2-ylethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
PL375415A1 (en) * 2002-08-06 2005-11-28 Warner-Lambert Company Llc Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
AU2003295684A1 (en) * 2002-11-15 2004-06-15 Teva Pharmaceutical Industries Ltd. Synthesis of 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids
WO2004089894A1 (en) 2003-04-14 2004-10-21 Warner-Lambert Company Llc Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
US7166638B2 (en) 2003-05-27 2007-01-23 Nicox S.A. Statin derivatives
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
EP1636243B1 (en) * 2003-06-13 2013-11-06 Boehringer Ingelheim International GmbH Chiral ligands for application in asymmetric syntheses
AU2004272365A1 (en) * 2003-09-17 2005-03-24 Warner-Lambert Company Llc Crystalline forms of `R-(R*,R*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-`(phenylamino)carbonyl!-1H-pyrrole-1-heptanoic acid
CN102030645A (en) 2003-10-24 2011-04-27 隆萨股份公司 Method for the production of 6,6,6-trihalo-3,5-dioxohexanoicacid esters
US20050152323A1 (en) * 2004-01-12 2005-07-14 Vincent Bonnassieux Plug-in Wi-Fi access point device and system
SI21745A (en) * 2004-04-09 2005-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Polymorphs of 1-pyrrol-1-heptanoic acid derivative, intermediat for preparation of atorvastatin
KR100829268B1 (en) * 2004-04-16 2008-05-13 화이자 프로덕츠 인코포레이티드 Process for forming amorphous atorvastatin calcium
CA2564030C (en) 2004-05-05 2010-06-08 Pfizer Products Inc. Salt forms of [r-(r*, r*)]-2-(4-fluorophenyl)-.beta., .delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid
CZ299175B6 (en) * 2004-06-17 2008-05-07 Zentiva, A. S Method of determining enantiomeric purity of 2-(4-fluorphenyl)-?,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4[phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid and salts thereof
PL1771455T3 (en) * 2004-07-16 2016-11-30 Oxidative degradation products of atorvastatin calcium
WO2006011041A2 (en) 2004-07-20 2006-02-02 Warner-Lambert Company Llc Crystalline forms of (r-(r*))-2-(4-fluorophenyl)-beta, gamma-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrole-1-hept anoic acid calcium salt (2:1)
SG155188A1 (en) * 2004-07-30 2009-09-30 Exelixis Inc Pyrrole derivatives as pharmaceutical agents
RU2007115543A (en) 2004-10-28 2008-12-10 Уорнер-Ламберт Компани Эл-Эл-Си (US) METHOD FOR PRODUCING amorphous atorvastatin
US20090088465A1 (en) * 2004-12-02 2009-04-02 Stephen Craig Dyar Pharmaceutical Compositions of Amorphous Atorvastatin and Process for Preparing Same
WO2006067795A2 (en) * 2004-12-23 2006-06-29 Jubilant Organosys Limited Novel polymorphic forms of atorvastatin lactone and process for preparing the same
AT509009T (en) * 2005-03-14 2011-05-15 C P Pharmaceuticals Internat C V Preparation of an atorvastatin intermediate product using a paal-knorr condensation
EP1705175A1 (en) * 2005-03-24 2006-09-27 ratiopharm GmbH Process for preparing C5 products and their use for Atorvastatin synthesis
CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
PT1957452E (en) * 2005-11-21 2010-05-25 Warner Lambert Co Novel forms of [r-(r*,r*)]-2-(4-fluorophenyl)-b,b-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-hept anoic acid magnesium
GB0523637D0 (en) * 2005-11-21 2005-12-28 Avecia Pharmaceuticals Ltd Process and compounds
CA2652412A1 (en) * 2006-05-15 2007-11-22 Ratiopharm Gmbh Process for preparing c5 intermediates and their use in the preparation of n-substituted pyrrole derivatives
KR101069698B1 (en) * 2008-08-28 2011-10-04 한국화학연구원 Method for preparing optically pure (4r, 6r)-6-(2-aminoethyl)-4-hydroxy-tetrahydropyran-2-one derivatives
CN101429195B (en) 2008-11-03 2010-12-15 华东师范大学 Process for producing important synthesis midbody of high purity atorvastatin
EP2373609B1 (en) 2008-12-19 2013-10-16 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
US9334266B2 (en) 2009-09-04 2016-05-10 The University Of Toledo Catalysts and related processes for producing optically pure beta-lactones from aldehydes and compositions produced thereby
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
KR100986755B1 (en) * 2009-12-29 2010-10-08 김우진 Apparatus for rotating nozzle and fountain having the same
CN101892276B (en) * 2010-06-12 2012-11-21 郝志艳 Atorvastatin calcium compound and new method thereof
WO2012034958A1 (en) 2010-09-16 2012-03-22 Dsm Sinochem Pharmaceuticals Netherlands B.V. Esters of hexanoic acids as intermediates for the preparation of atorvastatin
WO2012145808A1 (en) * 2011-04-25 2012-11-01 Universidade Estadual De Campinas - Unicamp Method for preparing atorvastatin calcium using new intermediates and resulting atorvastatin
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FI94339C (en) 1989-07-21 1995-08-25 Warner Lambert Co Method pharmaceutically usable / R- (R *, R *) / - 2- (4-fluorophenyl) - dihydroxy-5- (1-methylethyl) -3-phenyl-4 - / (phenylamino) carbonyl / -1 pyrrole-1-heptanoic acid and pharmaceutically acceptable salts thereof
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HRP960313B1 (en) 1995-07-17 2002-08-31 Warner Lambert Co Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)
WO1997037985A1 (en) * 1996-04-10 1997-10-16 Warner-Lambert Company Nonpeptide endothelin antagonists with increased water solubility
CN1093126C (en) 1996-07-29 2002-10-23 沃尼尔·朗伯公司 Improved process for the synthesis of protected esters of (s)-3,4-dihydroxytubyric acid

Also Published As

Publication number Publication date
JP2008100989A (en) 2008-05-01
KR100582326B1 (en) 2006-05-22
IL189359D0 (en) 2008-06-05
KR20030065594A (en) 2003-08-06
KR20060015698A (en) 2006-02-17
IL156461D0 (en) 2004-01-04
RU2244714C1 (en) 2005-01-20
CA2432064C (en) 2007-09-11
DE60127583T2 (en) 2007-12-06
DK1353917T3 (en) 2007-06-18
CN101024626A (en) 2007-08-29
US20050239869A1 (en) 2005-10-27
CA2432064A1 (en) 2002-07-18
AT358126T (en) 2007-04-15
KR100677008B1 (en) 2007-02-01
WO2002055519A3 (en) 2002-09-19
TWI293073B (en) 2008-02-01
CN1696129A (en) 2005-11-16
US7183408B2 (en) 2007-02-27
HK1060572A1 (en) 2005-12-23
CN100351252C (en) 2007-11-28
WO2002055519A2 (en) 2002-07-18
KR100833911B1 (en) 2008-06-03
US20070032664A1 (en) 2007-02-08
US20030195353A1 (en) 2003-10-16
HK1084114A1 (en) 2008-03-14
US7361771B2 (en) 2008-04-22
PT1353917E (en) 2007-05-31
CN1489587A (en) 2004-04-14
YU49003A (en) 2006-05-25
PL365283A1 (en) 2004-12-27
AR035680A1 (en) 2004-06-23
US20070032663A1 (en) 2007-02-08
US6545153B1 (en) 2003-04-08
KR20060114395A (en) 2006-11-06
ZA200304684B (en) 2004-06-28
US20020133026A1 (en) 2002-09-19
DE60127583D1 (en) 2007-05-10
ES2282200T3 (en) 2007-10-16
US20070032662A1 (en) 2007-02-08
HU0302647A2 (en) 2003-11-28
CN1907984A (en) 2007-02-07
MXPA03005284A (en) 2003-09-25
US7371855B2 (en) 2008-05-13
CN1222521C (en) 2005-10-12
AU2002222430B2 (en) 2007-05-17
JP2004520351A (en) 2004-07-08
EP1353917A2 (en) 2003-10-22
BR0116739A (en) 2003-09-30
CZ20031893A3 (en) 2004-03-17
US7399773B2 (en) 2008-07-15
JP4190285B2 (en) 2008-12-03
HU0302647A3 (en) 2009-03-30
IL189358D0 (en) 2008-06-05
US6933393B2 (en) 2005-08-23
EP1353917B1 (en) 2007-03-28
US6476235B2 (en) 2002-11-05

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