IL187184D0 - Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof - Google Patents

Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof

Info

Publication number
IL187184D0
IL187184D0 IL187184A IL18718407A IL187184D0 IL 187184 D0 IL187184 D0 IL 187184D0 IL 187184 A IL187184 A IL 187184A IL 18718407 A IL18718407 A IL 18718407A IL 187184 D0 IL187184 D0 IL 187184D0
Authority
IL
Israel
Prior art keywords
hydrates
process
pharmaceutically acceptable
acceptable salts
bisphosphonic acids
Prior art date
Application number
IL187184A
Original Assignee
Medichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US67842505P priority Critical
Priority to PCT/IB2006/002169 priority patent/WO2007023342A2/en
Application filed by Medichem Sa filed Critical Medichem Sa
Publication of IL187184D0 publication Critical patent/IL187184D0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839Polyphosphonic acids
    • C07F9/3873Polyphosphonic acids containing nitrogen substituents, e.g. N.....H or N-hydrocarbon rest which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839Polyphosphonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/58Pyridine rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/6512Six-membered rings having the nitrogen atoms in positions 1 and 3
IL187184A 2005-05-06 2007-11-06 Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof IL187184D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US67842505P true 2005-05-06 2005-05-06
PCT/IB2006/002169 WO2007023342A2 (en) 2005-05-06 2006-05-05 Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof

Publications (1)

Publication Number Publication Date
IL187184D0 true IL187184D0 (en) 2008-02-09

Family

ID=37761915

Family Applications (1)

Application Number Title Priority Date Filing Date
IL187184A IL187184D0 (en) 2005-05-06 2007-11-06 Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof

Country Status (7)

Country Link
US (1) US20080194525A1 (en)
EP (1) EP1883644A2 (en)
AR (1) AR057291A1 (en)
CA (1) CA2606879A1 (en)
ES (1) ES2324015T1 (en)
IL (1) IL187184D0 (en)
WO (1) WO2007023342A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5354858B2 (en) * 2006-05-09 2013-11-27 株式会社Adeka Polyester resin composition containing metal salt of sulfonamide compound
JP2009536639A (en) 2006-05-11 2009-10-15 アイエヌディー−スイフト ラボラトリーズ リミテッド Process for preparing pure risedronic acid or salt
WO2009050731A2 (en) * 2007-06-20 2009-04-23 Alkem Laboratories Ltd Novel process for preparing risedronic acid
US20160016982A1 (en) 2009-07-31 2016-01-21 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US9169279B2 (en) 2009-07-31 2015-10-27 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
SI2459176T1 (en) 2009-07-31 2018-01-31 Gruenenthal Gmbh Crystallization method and bioavailability
WO2011016738A1 (en) 2009-08-05 2011-02-10 Zaklady Farmaceutyczne Polpharma Sa A process for the synthesis of 1-hydroxy-3-(n-methylpentylamino) propylidene bisphosphonic acid monosodium salt, monohydrate
US8882740B2 (en) 2009-12-23 2014-11-11 Stryker Trauma Gmbh Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone
US9340565B2 (en) 2010-11-24 2016-05-17 Thar Pharmaceuticals, Inc. Crystalline forms
WO2012098255A1 (en) * 2011-01-21 2012-07-26 Straitmark Holding Ag METHOD FOR THE MANUFACTURE OF COMPOUNDS CONTAINING AN α-OXY PHOSPHORUS GROUP
WO2017208070A1 (en) 2016-05-31 2017-12-07 Grünenthal GmbH Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
ES2153794B1 (en) * 1999-08-06 2001-10-16 Medichem Sa Process for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid and of monosodium salt trihydrate.
PE20011061A1 (en) * 2000-02-01 2001-11-20 Procter & Gamble selective crystallization of the acid 3-pyridyl-1-hydroxy-ethylidene-1,1-bisphosphonic sodium as the hemipentahydrate or monohydrate
US20030195170A1 (en) * 2002-04-11 2003-10-16 Judith Aronhime Novel polymorphs and pseudopolymorphs of risedronate sodium
HU0300227A2 (en) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. A method for high-purity 2-substituted-1- (hydroxy-ethylidene) -1,1-bisphosphonic acids and salts thereof

Also Published As

Publication number Publication date
WO2007023342A3 (en) 2007-05-03
EP1883644A2 (en) 2008-02-06
CA2606879A1 (en) 2007-03-01
AR057291A1 (en) 2007-11-28
ES2324015T1 (en) 2009-07-29
US20080194525A1 (en) 2008-08-14
WO2007023342A2 (en) 2007-03-01

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